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Circulation Research, ISSN 0009-7330, 05/2008, Volume 102, Issue 9, pp. 1091 - 1100
Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide... 
5′-3′ cyclic nucleotide phosphodiesterases | Compartmentation | cAMP | β-adrenergic receptors | L-type calcium current | 5 '-3 ' cyclic nucleotide phosphodiesterases | compartmentation | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHORYLATION | CARDIAC MYOCYTES | GATED CHANNELS | DEPENDENT PROTEIN-KINASE | HEART | beta-adrenergic receptors | IN-VIVO | PERIPHERAL VASCULAR DISEASE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | HEMATOLOGY | EXPRESSION | Phosphorylation | Rats, Wistar | Myocardial Contraction - drug effects | Male | Quinolones - pharmacology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Phosphodiesterase 4 Inhibitors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Sarcolemma - metabolism | Cyclic Nucleotide-Gated Cation Channels - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Phosphodiesterase 3 Inhibitors | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Cells, Cultured | Cyclic Nucleotide-Gated Cation Channels - genetics | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Animals | Myocytes, Cardiac - drug effects | Membrane Potentials | Microscopy, Fluorescence - methods | Signal Transduction - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Heart Ventricles - metabolism | Calcium Channels, L-Type - metabolism | Enzyme Activation | Kinetics
Journal Article
Cell Stem Cell, ISSN 1934-5909, 07/2015, Volume 17, Issue 1, pp. 89 - 100
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19532 - 19537
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may... 
Protein isoforms | T lymphocytes | Chronic lymphocytic leukemia | Messenger RNA | Cyclic nucleotides | B lymphocytes | Medical treatment | Apoptosis | Vehicles | B cell leukemia | B cell | Survivin | cAMP | survivin | CELLS | CAMP-SPECIFIC PHOSPHODIESTERASE | AMP | INHIBITOR-INDUCED APOPTOSIS | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | apoptosis | HUMAN B-LYMPHOCYTES | THEOPHYLLINE | PATHWAY | THERAPEUTIC TARGET | GENE-EXPRESSION | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Humans | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | RNA, Messenger - metabolism | Enzyme Activation - immunology | Cell Division - immunology | Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology | Membrane Potential, Mitochondrial | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Phosphodiesterase 3 Inhibitors | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Gene Expression Regulation, Leukemic | Gene Expression Regulation, Enzymologic | Apoptosis - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Physiological aspects | Genetic aspects | Cyclic adenylic acid | Research | Drug therapy | Phosphodiesterases | Biological Sciences
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Abstract In cardiac myocytes, the second messenger cAMP is synthesized within the β-adrenergic signaling pathway upon sympathetic activation. It activates... 
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTATIONAL MODELS | HEART-FAILURE | beta-adrenergic pathway | CAMP EARLY REPRESSOR | CGMP PHOSPHODIESTERASES | PROTEIN-KINASES | FEEDBACK LOOP | CELL BIOLOGY | CARDIOMYOCYTE APOPTOSIS | NITRIC-OXIDE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | RAT VENTRICULAR MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics
Journal Article
Circulation research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1304 - 1311
Rationale: Cyclic nucleotides are second messengers that regulate cardiomyocyte function through compartmentalized signaling in discrete subcellular... 
phosphodiesterase 3 inhibitors | membrane microdomains | 3',5'-cyclic-AMP phosphodiesterases | hypertrophy | atrial natriuretic factor | receptors, adrenergic | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ATRIAL-NATRIURETIC-PEPTIDE | MYOCYTES | HEART-FAILURE | RECEPTOR | CARDIOMYOCYTES | 3 ',5 '-cyclic-AMP phosphodiesterases | PERIPHERAL VASCULAR DISEASE | MICE | GUANYLYL CYCLASE-A | HEMATOLOGY | COMPARTMENTATION | CAMP | Myocardial Contraction - drug effects | Cardiomegaly - pathology | Receptors, Adrenergic, beta-2 - drug effects | Myocytes, Cardiac - enzymology | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Fluorescence Resonance Energy Transfer | Female | Receptors, Adrenergic, beta-1 - drug effects | Atrial Natriuretic Factor - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Disease Models, Animal | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Second Messenger Systems - drug effects | Membrane Microdomains - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Adrenergic beta-Agonists - pharmacology | Cardiomegaly - physiopathology | Mice, Transgenic | Receptors, Adrenergic, beta-1 - metabolism | Cardiomegaly - enzymology | Receptors, Adrenergic, beta-2 - metabolism | Protein Transport | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Membrane Microdomains - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Mice | Enzyme Activation | Receptor Cross-Talk - drug effects | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 11, pp. 6763 - 6776
Journal Article
Oncogene, ISSN 0950-9232, 02/2013, Volume 32, Issue 9, pp. 1121 - 1134
Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that cyclic nucleotide phosphodiesterases (PDEs) are relevant in various cancer... 
lung cancer | phosphodiesterases | hypoxia | proliferation | angiogenesis | MIGRATION | CELLS | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPONENTS | CELL BIOLOGY | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | TARGETS | LEUKEMIA | TUMOR-GROWTH | EXPRESSION | Humans | Lung Neoplasms - metabolism | RNA, Small Interfering - pharmacology | Cyclic AMP | Transplantation, Heterologous | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Signal Transduction - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Nude | Cyclic Nucleotide Phosphodiesterases, Type 4 - physiology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Care and treatment | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Vascular endothelial growth factor | Angiogenesis | Pathology | Adenocarcinoma | Drugs | Protein kinase A | Carcinoma | Immunocytochemistry | Pyruvic acid | Regulatory sequences | Drug development | dehydrogenase | Western blotting | Reporter gene | Xenografts | Hypoxia-inducible factors | 3',5'-Cyclic-nucleotide phosphodiesterase | Colonies | Tumor cells | Data processing | siRNA | Tumor cell lines | phosphodiesterase IV | L-Lactate dehydrogenase | Polymerase chain reaction | Hypoxia | Mutation | phosphodiesterase | Tumors
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2012, Volume 123, Issue 6, pp. 1019 - 1029
Traumatic brain injury (TBI) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic AMP... 
traumatic brain injury | phosphodiesterase | cAMP | fluid‐percussion | inflammation | isoform | fluid-percussion | FUNCTIONAL RECOVERY | LOCALIZATION | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPLICE VARIANTS | NEUROSCIENCES | PDE4 INHIBITORS | ROLIPRAM | RAT-BRAIN | TNF-ALPHA | CAMP-SPECIFIC PHOSPHODIESTERASES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphoric Diester Hydrolases - biosynthesis | Male | Cyclic Nucleotide Phosphodiesterases, Type 1 - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Phosphorylation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - biosynthesis | Disease Models, Animal | Phosphoric Diester Hydrolases - metabolism | Isoenzymes - genetics | Brain Injuries - enzymology | Rats | Phosphoric Diester Hydrolases - genetics | Brain Injuries - genetics | Brain Injuries - therapy | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 3 - biosynthesis | Cyclic AMP - antagonists & inhibitors | Animals | Cyclic AMP - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Isoenzymes - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Brain | Neurons | Analysis | Injuries | Neurochemistry | Enzymes | Brain damage | Gene expression | Trauma | Ca super(2+)/calmodulin-dependent phosphodiesterase | Phosphorylation | Traumatic brain injury | Cortex (parietal) | Cyclic AMP | Inflammation | Glia | Western blotting
Journal Article
Circulation, ISSN 0009-7322, 10/2012, Volume 126, Issue 17, pp. 2073 - 2083
Journal Article