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Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed... 
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | DOMAIN | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | dimer | GEL-FILTRATION | DENSITY GRADIENT CENTRIFUGATION | cyclic nucleotide phosphodiesterase 4 (PDE4) | ROD CGMP-PHOSPHODIESTERASE-6 | cAMP | CGMP-BINDING | oligomerization | PHOSPHATIDIC-ACID BINDING | phosphodiesterase | CATALYTIC SITE | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | Index Medicus | PDE4
Journal Article
Cell, ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/1999, Volume 127, Issue 1, pp. 65 - 74
The effects of several phosphodiesterase (PDE) inhibitors on the L‐type Ca current ( I Ca ) and intracellular cyclic AMP concentration ([cAMP] i ) were... 
cilostamide (PDE3 inhibitor) | intracellular cyclic AMP | phosphodiesterase subtypes | current | Ro20‐1724 (PDE4 inhibitor) | L‐type Ca | EHNA (PDE2 inhibitor) | phosphodiesterase inhibitors | MIMX (PDE1 inhibitor) | β‐adrenoceptor agonist | Rat heart | Cilostamide (PDE3 inhibitor) | β-adrenoceptor agonist | Intracellular cyclic AMP | Phosphodiesterase subtypes | L-type Ca | Phosphodiesterase inhibitors | Ro20-1724 (PDE4 inhibitor) | MYOCARDIUM | CELLS | ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | L-type Ca2+ current | beta-adrenoceptor agonist | CARDIAC MYOCYTES | CALCIUM CURRENT | rat heart | DEPENDENT PROTEIN-KINASE | FATTY-ACIDS | AMP PHOSPHODIESTERASES | GMP | PHARMACOLOGY & PHARMACY | HUMAN ATRIAL MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 1 | Heart Ventricles - cytology | Calcium Channels - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 | Rats, Wistar | Cyclic Nucleotide Phosphodiesterases, Type 3 | Calcium Channels, L-Type | Male | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Cyclic AMP - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - biosynthesis | Calcium - physiology | Heart Ventricles - enzymology | Myocardium - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - biosynthesis | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Reverse Transcriptase Polymerase Chain Reaction | Myocardium - cytology | Phosphoric Diester Hydrolases | Myocardium - enzymology | Patch-Clamp Techniques | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors | Isoproterenol - pharmacology | Heart Ventricles - metabolism | In Vitro Techniques | Index Medicus | Papers
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e28899 - e28899
Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic AMP (cAMP) modulates inflammation and the inhibition of... 
SELECTIVE-INHIBITION | RAT AORTA | CELLS | RESPONSES | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | AMP-PHOSPHODIESTERASES | TISSUE | ROLIPRAM BINDING-SITE | 9-BENZYLADENINE | ERYTHEMATOSUS | Humans | Lupus Erythematosus, Systemic - mortality | Xanthines - therapeutic use | Pentoxifylline - therapeutic use | Kidney - metabolism | Mice, Inbred MRL lpr | Adenine - therapeutic use | Lupus Erythematosus, Systemic - drug therapy | Mice, Inbred CBA | Female | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Proteinuria - etiology | Proteinuria - mortality | Lupus Erythematosus, Systemic - enzymology | Adenine - analogs & derivatives | Kidney - drug effects | Isoenzymes | Tumor Necrosis Factor-alpha - secretion | Phosphodiesterase 4 Inhibitors - therapeutic use | Survival Rate | Kidney - cytology | Disease Progression | Animals | Proteinuria - drug therapy | Lipopolysaccharides - pharmacology | Mice | Pentoxifylline | Lupus | Medical research | Systemic lupus erythematosus | Tumor necrosis factor | Medicine, Experimental | Cyclic adenylic acid | Comparative analysis | Smooth muscle | Kinases | Lipopolysaccharides | Proteins | Genotype & phenotype | Biological effects | Lymphocytes | Peripheral blood | Deoxyribonucleic acid--DNA | Phosphodiesterase | Adenosine | 3',5'-Cyclic-nucleotide phosphodiesterase | Kidneys | AMP | Secretion | Cyclic AMP | Tumor necrosis factor-α | Studies | Chronic conditions | Rolipram | Inhibitors | Coronary vessels | Phenols | Affinity | Autoimmune diseases | Binding sites | Proteinuria | rolipram | Inflammation | Survival | Inflammatory diseases | Kidney | Evolution | phosphodiesterase | Tumor necrosis factor- alpha | Index Medicus | Life Sciences | Human health and pathology | Immunology | Immunotherapy | Rhumatology and musculoskeletal system | Pharmacology | Pharmaceutical sciences | Deoxyribonucleic acid | DNA
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2016, Volume 75, Issue 3, pp. 494 - 503.e6
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2015, Volume 194, Issue 1, pp. 101 - 112
A subset of chronic lymphocytic leukemia (CLL) BCRs interacts with Ags expressed on apoptotic cells, suggesting that CLL BCRs have the potential to internalize... 
PLASMACYTOID DENDRITIC CELLS | TOLL-LIKE-RECEPTORS | HEAVY-CHAIN IIA | AUTOIMMUNE-DISEASES | TYROSINE KINASE | APOPTOTIC PATHWAY | NECROSIS-FACTOR-ALPHA | IL-6 PRODUCTION | IMMUNOLOGY | NF-KAPPA-B | NUCLEIC-ACIDS | Toll-Like Receptor 7 - antagonists & inhibitors | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Middle Aged | Interferon Regulatory Factors - metabolism | Male | Monocytes - immunology | Lipopolysaccharide Receptors - metabolism | Toll-Like Receptor 8 - antagonists & inhibitors | Base Sequence | Aged, 80 and over | Deoxyribonucleases - pharmacology | Adult | Female | Active Transport, Cell Nucleus | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Rolipram - pharmacology | Cyclic AMP - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Toll-Like Receptor 9 - antagonists & inhibitors | Signal Transduction | Interferon-alpha - biosynthesis | Cells, Cultured | Phosphodiesterase 4 Inhibitors - therapeutic use | Sequence Analysis, DNA | Transcription Factor RelA - metabolism | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Aged | Cell Proliferation - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus | Abridged Index Medicus
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2010, Volume 28, Issue 1, pp. 63 - 70
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of conditions. Here we present seven... 
CAMP-SPECIFIC PHOSPHODIESTERASE | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-KINASE | GENE COMPOSER | SUNCUS-MURINUS | AMP-SPECIFIC PHOSPHODIESTERASE | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | ROLIPRAM BINDING | ANTIDEPRESSANT DRUGS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Benzhydryl Compounds - chemistry | Benzhydryl Compounds - adverse effects | Phenylurea Compounds - adverse effects | Phenylurea Compounds - chemistry | Drug Design | Phosphodiesterase 4 Inhibitors | Behavior, Animal - drug effects | Biological Assay | Phosphodiesterase Inhibitors - chemistry | Benzhydryl Compounds - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Catalytic Domain | Models, Molecular | Phenylurea Compounds - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Vomiting - drug therapy | Cognition - drug effects | Animals | Benzhydryl Compounds - pharmacology | Mice | Phenylurea Compounds - pharmacology | Kinetics | Care and treatment | Schizophrenia | Physiological aspects | Genetic aspects | Cellular signal transduction | Cyclic adenylic acid | Research | Phosphodiesterases | Enzymes | Biotechnology | Cellular biology | Molecular biology | Cognitive ability | Crystal structure | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 05/2008, Volume 102, Issue 9, pp. 1091 - 1100
Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide... 
5′-3′ cyclic nucleotide phosphodiesterases | Compartmentation | cAMP | β-adrenergic receptors | L-type calcium current | 5 '-3 ' cyclic nucleotide phosphodiesterases | compartmentation | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHORYLATION | CARDIAC MYOCYTES | GATED CHANNELS | DEPENDENT PROTEIN-KINASE | HEART | beta-adrenergic receptors | IN-VIVO | PERIPHERAL VASCULAR DISEASE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | HEMATOLOGY | EXPRESSION | Phosphorylation | Rats, Wistar | Myocardial Contraction - drug effects | Male | Quinolones - pharmacology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Phosphodiesterase 4 Inhibitors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Sarcolemma - metabolism | Cyclic Nucleotide-Gated Cation Channels - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Phosphodiesterase 3 Inhibitors | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Cells, Cultured | Cyclic Nucleotide-Gated Cation Channels - genetics | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Animals | Myocytes, Cardiac - drug effects | Membrane Potentials | Microscopy, Fluorescence - methods | Signal Transduction - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Heart Ventricles - metabolism | Calcium Channels, L-Type - metabolism | Enzyme Activation | Kinetics | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2008, Volume 43, Issue 4, pp. 816 - 829
Journal Article