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Biochemical journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | Index Medicus | phosphodiesterase | oligomerization | cAMP | PDE4 | dimer
Journal Article
Cell (Cambridge), ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Sirtuin 1 - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Stilbenes - administration & dosage | Signal Transduction | Caloric Restriction | Models, Molecular | Ryanodine Receptor Calcium Release Channel - metabolism | Rolipram - administration & dosage | Glucose Intolerance - prevention & control | 3',5'-Cyclic-AMP Phosphodiesterases - chemistry | Animals | Diet | Guanine Nucleotide Exchange Factors - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Muscle, Skeletal - drug effects | Obesity - prevention & control | Mice | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Adipose Tissue, White - drug effects | NAD - metabolism | Aging - metabolism | Wine | Developmental biology | Resveratrol | Dietary supplements | Genetic aspects | Phospholipases | Glucose | Dextrose | Index Medicus
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 12/2012, Volume 123, Issue 6, pp. 1019 - 1029
traumatic brain injury | phosphodiesterase | cAMP | fluid‐percussion | inflammation | isoform | fluid-percussion | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Injuries of the nervous system and the skull. Diseases due to physical agents | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Traumas. Diseases due to physical agents | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphoric Diester Hydrolases - biosynthesis | Male | Cyclic Nucleotide Phosphodiesterases, Type 1 - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Phosphorylation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - biosynthesis | Disease Models, Animal | Phosphoric Diester Hydrolases - metabolism | Isoenzymes - genetics | Brain Injuries - enzymology | Rats | Phosphoric Diester Hydrolases - genetics | Brain Injuries - genetics | Brain Injuries - therapy | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 3 - biosynthesis | Cyclic AMP - antagonists & inhibitors | Animals | Cyclic AMP - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Isoenzymes - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Brain | Neurons | Analysis | Injuries | Neurochemistry | Enzymes | Brain damage | Gene expression | Trauma | Index Medicus | Ca super(2+)/calmodulin-dependent phosphodiesterase | Phosphorylation | Traumatic brain injury | Cortex (parietal) | Cyclic AMP | Inflammation | Glia | Western blotting
Journal Article
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 05/2008, Volume 102, Issue 9, pp. 1091 - 1100
5′-3′ cyclic nucleotide phosphodiesterases | Compartmentation | cAMP | β-adrenergic receptors | L-type calcium current | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vertebrates: cardiovascular system | Phosphorylation | Rats, Wistar | Myocardial Contraction - drug effects | Male | Quinolones - pharmacology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Phosphodiesterase 4 Inhibitors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Sarcolemma - metabolism | Cyclic Nucleotide-Gated Cation Channels - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Phosphodiesterase 3 Inhibitors | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Cells, Cultured | Cyclic Nucleotide-Gated Cation Channels - genetics | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Animals | Myocytes, Cardiac - drug effects | Membrane Potentials | Microscopy, Fluorescence - methods | Signal Transduction - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Heart Ventricles - metabolism | Calcium Channels, L-Type - metabolism | Enzyme Activation | Kinetics | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, pp. 10856 - 10856
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Enzyme Activators - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Hepatocytes - metabolism | Amino Acid Motifs | Mice, Knockout | Animals | Glucagon - metabolism | Mice | Enzyme Activation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | AMP-Activated Protein Kinases - genetics | Hepatocytes - enzymology | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 06/2006, Volume 66, Issue 11, pp. 5624 - 5632
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | Cyclic Nucleotide Phosphodiesterases, Type 4 | Phenols - toxicity | Epigenesis, Genetic | Male | Dose-Response Relationship, Drug | Prostatic Neoplasms - genetics | Prostate - drug effects | Female | Animals, Newborn | Genetic Predisposition to Disease | Precancerous Conditions - enzymology | Benzhydryl Compounds | Isoenzymes - genetics | Rats | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Precancerous Conditions - genetics | Rats, Sprague-Dawley | Genomic Imprinting - drug effects | Pregnancy | Animals | Estradiol - toxicity | Prostatic Neoplasms - enzymology | Precancerous Conditions - chemically induced | DNA Methylation - drug effects | Prostatic Neoplasms - chemically induced | Index Medicus
Journal Article
Cell stem cell, ISSN 1934-5909, 07/2015, Volume 17, Issue 1, pp. 89 - 100
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | Cardiomyopathy, Dilated - pathology | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Epigenesis, Genetic | Humans | Myocardial Contraction - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Heart Rate - drug effects | Troponin T - metabolism | Cell Differentiation | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - metabolism | Cardiomyopathy, Dilated - genetics | Induced Pluripotent Stem Cells - pathology | Troponin T - genetics | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Signal Transduction | Models, Cardiovascular | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Mutant Proteins - genetics | Adrenergic beta-Agonists - pharmacology | Mutant Proteins - metabolism | Cardiomyopathy, Dilated - metabolism | Myocytes, Cardiac - pathology | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Mutation | Index Medicus
Journal Article