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1. Full Text The upstream conserved regions (UCRs) mediate homo-and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
by Xie, Moses and Blackman, Brigitte and Scheitrum, Colleen and Mika, Delphine and Blanchard, Elise and Lei, Tao and Conti, Marco and Richter, Wito
Biochemical journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | Index Medicus | phosphodiesterase | oligomerization | cAMP | PDE4 | dimer
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2. Full Text Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
by Park, Sung-Jun and Ahmad, Faiyaz and Philp, Andrew and Baar, Keith and Williams, Tishan and Luo, Haibin and Ke, Hengming and Rehmann, Holger and Taussig, Ronald and Brown, Alexandra L and Kim, Myung K and Beaven, Michael A and Burgin, Alex B and Manganiello, Vincent and Chung, Jay H
Cell (Cambridge), ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Sirtuin 1 - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Stilbenes - administration & dosage | Signal Transduction | Caloric Restriction | Models, Molecular | Ryanodine Receptor Calcium Release Channel - metabolism | Rolipram - administration & dosage | Glucose Intolerance - prevention & control | 3',5'-Cyclic-AMP Phosphodiesterases - chemistry | Animals | Diet | Guanine Nucleotide Exchange Factors - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Muscle, Skeletal - drug effects | Obesity - prevention & control | Mice | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Adipose Tissue, White - drug effects | NAD - metabolism | Aging - metabolism | Wine | Developmental biology | Resveratrol | Dietary supplements | Genetic aspects | Phospholipases | Glucose | Dextrose | Index Medicus
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3. Full Text Phosphodiesterase isoform‐specific expression induced by traumatic brain injury
by Oliva, Anthony A and Kang, Yuan and Furones, Concepcion and Alonso, Ofelia F and Bruno, Olga and Dietrich, W. Dalton and Atkins, Coleen M
Journal of neurochemistry, ISSN 0022-3042, 12/2012, Volume 123, Issue 6, pp. 1019 - 1029
traumatic brain injury | phosphodiesterase | cAMP | fluid‐percussion | inflammation | isoform | fluid-percussion | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Injuries of the nervous system and the skull. Diseases due to physical agents | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Traumas. Diseases due to physical agents | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphoric Diester Hydrolases - biosynthesis | Male | Cyclic Nucleotide Phosphodiesterases, Type 1 - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Phosphorylation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - biosynthesis | Disease Models, Animal | Phosphoric Diester Hydrolases - metabolism | Isoenzymes - genetics | Brain Injuries - enzymology | Rats | Phosphoric Diester Hydrolases - genetics | Brain Injuries - genetics | Brain Injuries - therapy | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 3 - biosynthesis | Cyclic AMP - antagonists & inhibitors | Animals | Cyclic AMP - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Isoenzymes - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Brain | Neurons | Analysis | Injuries | Neurochemistry | Enzymes | Brain damage | Gene expression | Trauma | Index Medicus | Ca super(2+)/calmodulin-dependent phosphodiesterase | Phosphorylation | Traumatic brain injury | Cortex (parietal) | Cyclic AMP | Inflammation | Glia | Western blotting
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4. Full Text Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway
by Zhao, Claire Y and Greenstein, Joseph L and Winslow, Raimond L
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Index Medicus
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5. Full Text Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases
by Leroy, Jérôme and Abi-Gerges, Aniella and Nikolaev, Viacheslav O and Richter, Wito and Lechêne, Patrick and Mazet, Jean-Luc and Conti, Marco and Fischmeister, Rodolphe and Vandecasteele, Grégoire
Circulation research, ISSN 0009-7330, 05/2008, Volume 102, Issue 9, pp. 1091 - 1100
5′-3′ cyclic nucleotide phosphodiesterases | Compartmentation | cAMP | β-adrenergic receptors | L-type calcium current | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vertebrates: cardiovascular system | Phosphorylation | Rats, Wistar | Myocardial Contraction - drug effects | Male | Quinolones - pharmacology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Phosphodiesterase 4 Inhibitors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Sarcolemma - metabolism | Cyclic Nucleotide-Gated Cation Channels - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Phosphodiesterase 3 Inhibitors | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Cells, Cultured | Cyclic Nucleotide-Gated Cation Channels - genetics | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Animals | Myocytes, Cardiac - drug effects | Membrane Potentials | Microscopy, Fluorescence - methods | Signal Transduction - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Heart Ventricles - metabolism | Calcium Channels, L-Type - metabolism | Enzyme Activation | Kinetics | Index Medicus
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6. Full Text AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
by Johanns, M and Lai, Y.-C and Hsu, M.-F and Jacobs, R and Vertommen, D and Van Sande, J and Dumont, J.E and Woods, A and Carling, D and Hue, L and Viollet, B and Foretz, M and Rider, M.H
Nature communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, pp. 10856 - 10856
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Enzyme Activators - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Hepatocytes - metabolism | Amino Acid Motifs | Mice, Knockout | Animals | Glucagon - metabolism | Mice | Enzyme Activation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | AMP-Activated Protein Kinases - genetics | Hepatocytes - enzymology | Index Medicus
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7. Full Text Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4
by Ho, Shuk-Mei and Tang, Wan-Yee and Belmonte De Frausto, Jessica and Prins, Gail S
Cancer research (Chicago, Ill.), ISSN 0008-5472, 06/2006, Volume 66, Issue 11, pp. 5624 - 5632
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | Cyclic Nucleotide Phosphodiesterases, Type 4 | Phenols - toxicity | Epigenesis, Genetic | Male | Dose-Response Relationship, Drug | Prostatic Neoplasms - genetics | Prostate - drug effects | Female | Animals, Newborn | Genetic Predisposition to Disease | Precancerous Conditions - enzymology | Benzhydryl Compounds | Isoenzymes - genetics | Rats | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Precancerous Conditions - genetics | Rats, Sprague-Dawley | Genomic Imprinting - drug effects | Pregnancy | Animals | Estradiol - toxicity | Prostatic Neoplasms - enzymology | Precancerous Conditions - chemically induced | DNA Methylation - drug effects | Prostatic Neoplasms - chemically induced | Index Medicus
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8. Full Text Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy
by Wu, Haodi and Lee, Jaecheol and Vincent, Ludovic G and Wang, Qingtong and Gu, Mingxia and Lan, Feng and Churko, Jared M and Sallam, Karim I and Matsa, Elena and Sharma, Arun and Gold, Joseph D and Engler, Adam J and Xiang, Yang K and Bers, Donald M and Wu, Joseph C
Cell stem cell, ISSN 1934-5909, 07/2015, Volume 17, Issue 1, pp. 89 - 100
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | Cardiomyopathy, Dilated - pathology | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Epigenesis, Genetic | Humans | Myocardial Contraction - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Heart Rate - drug effects | Troponin T - metabolism | Cell Differentiation | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - metabolism | Cardiomyopathy, Dilated - genetics | Induced Pluripotent Stem Cells - pathology | Troponin T - genetics | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Signal Transduction | Models, Cardiovascular | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Mutant Proteins - genetics | Adrenergic beta-Agonists - pharmacology | Mutant Proteins - metabolism | Cardiomyopathy, Dilated - metabolism | Myocytes, Cardiac - pathology | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Mutation | Index Medicus
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