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Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed... 
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | DOMAIN | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | dimer | GEL-FILTRATION | DENSITY GRADIENT CENTRIFUGATION | cyclic nucleotide phosphodiesterase 4 (PDE4) | ROD CGMP-PHOSPHODIESTERASE-6 | cAMP | CGMP-BINDING | oligomerization | PHOSPHATIDIC-ACID BINDING | phosphodiesterase | CATALYTIC SITE | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | PDE4
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Abstract In cardiac myocytes, the second messenger cAMP is synthesized within the β-adrenergic signaling pathway upon sympathetic activation. It activates... 
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTATIONAL MODELS | HEART-FAILURE | beta-adrenergic pathway | CAMP EARLY REPRESSOR | CGMP PHOSPHODIESTERASES | PROTEIN-KINASES | FEEDBACK LOOP | CELL BIOLOGY | CARDIOMYOCYTE APOPTOSIS | NITRIC-OXIDE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | RAT VENTRICULAR MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2012, Volume 123, Issue 6, pp. 1019 - 1029
Traumatic brain injury ( TBI ) results in significant inflammation which contributes to the evolving pathology. Previously, we have demonstrated that cyclic... 
traumatic brain injury | phosphodiesterase | cAMP | fluid‐percussion | inflammation | isoform | fluid-percussion | FUNCTIONAL RECOVERY | LOCALIZATION | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPLICE VARIANTS | NEUROSCIENCES | PDE4 INHIBITORS | ROLIPRAM | RAT-BRAIN | TNF-ALPHA | CAMP-SPECIFIC PHOSPHODIESTERASES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphoric Diester Hydrolases - biosynthesis | Male | Cyclic Nucleotide Phosphodiesterases, Type 1 - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Phosphorylation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - biosynthesis | Disease Models, Animal | Phosphoric Diester Hydrolases - metabolism | Isoenzymes - genetics | Brain Injuries - enzymology | Rats | Phosphoric Diester Hydrolases - genetics | Brain Injuries - genetics | Brain Injuries - therapy | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Rats, Sprague-Dawley | Cyclic Nucleotide Phosphodiesterases, Type 3 - biosynthesis | Cyclic AMP - antagonists & inhibitors | Animals | Cyclic AMP - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Isoenzymes - biosynthesis | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics | Isoenzymes - antagonists & inhibitors | Brain | Neurons | Analysis | Injuries | Neurochemistry | Enzymes | Brain damage | Gene expression | Trauma | Ca super(2+)/calmodulin-dependent phosphodiesterase | Phosphorylation | Traumatic brain injury | Cortex (parietal) | Cyclic AMP | Inflammation | Glia | Western blotting
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 07/2017, Volume 11, Issue 7, p. e0005680
Background Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of... 
CAENORHABDITIS-ELEGANS | PHARMACOLOGICAL VALIDATION | SCHISTOSOMA-MANSONI | PROTEIN-KINASE | ALZHEIMERS-DISEASE | 5 INHIBITOR ANALOGS | MIRACIDIAL TRANSFORMATION | TRYPANOSOMA-BRUCEI PHOSPHODIESTERASES | CONSERVED REGIONS UCRS | PARASITOLOGY | TROPICAL MEDICINE | CAMP-SPECIFIC PHOSPHODIESTERASES | Schistosoma mansoni - drug effects | Schistosoma mansoni - physiology | Catalytic Domain | Caenorhabditis elegans - genetics | Schistosoma mansoni - anatomy & histology | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Caenorhabditis elegans - drug effects | Animals, Genetically Modified - genetics | Anthelmintics - pharmacology | Cloning, Molecular | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Locomotion - drug effects | Caenorhabditis elegans | Schistosomiasis | Care and treatment | Lung diseases, Obstructive | Genetic aspects | Research | Phosphodiesterases | Alzheimer's disease | Asthma | Drugs | Transgenic | Phosphodiesterase IV | Genomes | Parasites | Nucleotides | Drug development | Kinases | Gene sequencing | Parasitic diseases | Tropical environment | Degeneration | Chronic obstructive pulmonary disease | cDNA | Aquatic invertebrates | Catalysis | Phosphodiesterase | Spurs | 3',5'-Cyclic-nucleotide phosphodiesterase | Lung diseases | Catechol | Gene expression | Diseases | Inhibitors | DNA | Obstructive lung disease | Nematodes | Hypothermia | Lines
Journal Article
Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, p. 11240
Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. As secretory immunoglobulin A... 
OBSTRUCTIVE PULMONARY-DISEASE | NONTYPABLE HAEMOPHILUS-INFLUENZAE | MUCOSAL IMMUNITY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | EMPHYSEMA | SECRETORY IGA | CIGARETTE-SMOKE | ADAPTIVE IMMUNE-RESPONSES | ROFLUMILAST | EXPRESSION | Lung - microbiology | Respiratory Mucosa - drug effects | Pulmonary Disease, Chronic Obstructive - microbiology | Humans | NF-kappa B - immunology | Matrix Metalloproteinase 12 - genetics | Airway Remodeling - immunology | Receptors, Polymeric Immunoglobulin - immunology | Pulmonary Emphysema - microbiology | Respiratory Mucosa - pathology | Respiratory Mucosa - microbiology | Aging - immunology | Immunoglobulin A, Secretory - genetics | Respiratory Mucosa - immunology | Pulmonary Emphysema - genetics | Benzamides - pharmacology | Cyclopropanes - pharmacology | Disease Models, Animal | Pulmonary Disease, Chronic Obstructive - genetics | Lung - pathology | Microbiota - immunology | Receptors, Polymeric Immunoglobulin - deficiency | Matrix Metalloproteinase 12 - immunology | Mice, Inbred C57BL | Gene Expression Regulation | Leukocyte Elastase - genetics | Pulmonary Emphysema - drug therapy | Receptors, Polymeric Immunoglobulin - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Immunity, Innate | Phosphodiesterase 4 Inhibitors - pharmacology | Pulmonary Emphysema - immunology | Aging - pathology | Mice, Knockout | Host-Pathogen Interactions | Animals | NF-kappa B - genetics | Aminopyridines - pharmacology | Lung - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - immunology | Mice | Leukocyte Elastase - immunology | Pulmonary Disease, Chronic Obstructive - immunology | Lung - immunology | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2012, Volume 586, Issue 19, pp. 3410 - 3414
► Novel boron-containing small molecule inhibitors of phosphodiesterase 4. ► Co-crystal structure shows unique binding compared to catechol inhibitors. ► Boron... 
Cytokine inhibition | Phenoxybenzoxaborole | PDE4 | Crystal structure | phosphodiesterase 4 | NUCLEOTIDE | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | ROFLUMILAST | SELECTIVITY | CELL BIOLOGY | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Metals - chemistry | Isoenzymes - metabolism | Leukocytes, Mononuclear - immunology | Phosphodiesterase Inhibitors - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Binding, Competitive | Boron Compounds - chemistry | Recombinant Proteins - metabolism | Boron Compounds - pharmacology | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Leukocytes, Mononuclear - drug effects | Isoenzymes - genetics | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Models, Molecular | Phosphodiesterase Inhibitors - pharmacology | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Kinetics | In Vitro Techniques | Cytokines - biosynthesis | Isoenzymes - antagonists & inhibitors | Enzymes | Catechin | Enzyme inhibitors | Crystals | Laminated metals | Chemical properties | Structure
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2013, Volume 168, Issue 4, pp. 1001 - 1014
Journal Article