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PLoS neglected tropical diseases, ISSN 1935-2735, 07/2017, Volume 11, Issue 7, pp. e0005680 - e0005680
.... Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel drugs to treat a range of chronic indications including asthma, chronic obstructive pulmonary disease and Alzheimer's disease... 
Infectious Diseases | Parasitology | Life Sciences & Biomedicine | Science & Technology | Tropical Medicine | Schistosoma mansoni - drug effects | Schistosoma mansoni - physiology | Catalytic Domain | Caenorhabditis elegans - genetics | Schistosoma mansoni - anatomy & histology | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Caenorhabditis elegans - drug effects | Animals, Genetically Modified - genetics | Anthelmintics - pharmacology | Cloning, Molecular | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Locomotion - drug effects | Caenorhabditis elegans | Schistosomiasis | Care and treatment | Lung diseases, Obstructive | Genetic aspects | Research | Phosphodiesterases | Alzheimer's disease | Asthma | Drugs | Transgenic | Phosphodiesterase IV | Genomes | Parasites | Nucleotides | Drug development | Kinases | Gene sequencing | Parasitic diseases | Tropical environment | Degeneration | Chronic obstructive pulmonary disease | cDNA | Aquatic invertebrates | Catalysis | Phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | Lung diseases | Catechol | Gene expression | Diseases | Inhibitors | DNA | Obstructive lung disease | Nematodes | Hypothermia | Lines | Index Medicus
Journal Article
Cell (Cambridge), ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 12/2006, Volume 116, Issue 12, pp. 3240 - 3251
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e47826 - e47826
Background: We investigated the role of cyclic nucleotide phosphodiesterases (PDEs) in the spatiotemporal control of intracellular cAMP concentrations in rat aortic smooth muscle cells... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Aorta - metabolism | Adrenergic beta-Antagonists - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Time Factors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Myocytes, Smooth Muscle - drug effects | Cyclic AMP - metabolism | Myocytes, Smooth Muscle - cytology | Cell Membrane - drug effects | Muscle, Smooth, Vascular - drug effects | Myocytes, Smooth Muscle - enzymology | Aorta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism | Adrenergic beta-Agonists - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Phosphodiesterase Inhibitors - pharmacology | Rats | Muscle, Smooth, Vascular - cytology | Cell Membrane - enzymology | Animals | Signal Transduction - drug effects | Isoproterenol - pharmacology | Signal Transduction - physiology | Aorta - cytology | Primary Cell Culture | Muscle, Smooth, Vascular - enzymology | Laboratories | Fluorescence | Smooth muscle | Antagonists | Isoproterenol | Kinases | Recovery | Experiments | Proteins | Dynamic control | Rodents | Aorta | Physiology | Inhibition | Fluorescence resonance energy transfer | Localization | Phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | Muscles | Cyclic AMP | Biophysics | Gene expression | Endothelium | Studies | Inhibitors | Coronary vessels | Nitric oxide | Adrenergic receptors | Kinetics | Intracellular | Energy transfer | Index Medicus | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
Journal Article
PloS one, ISSN 1932-6203, 03/2009, Volume 4, Issue 3, pp. e4906 - e4906
Journal Article
Journal Article