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Cell, ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Journal Article
Circulation Research, ISSN 0009-7330, 05/2008, Volume 102, Issue 9, pp. 1091 - 1100
Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide... 
5′-3′ cyclic nucleotide phosphodiesterases | Compartmentation | cAMP | β-adrenergic receptors | L-type calcium current | 5 '-3 ' cyclic nucleotide phosphodiesterases | compartmentation | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHORYLATION | CARDIAC MYOCYTES | GATED CHANNELS | DEPENDENT PROTEIN-KINASE | HEART | beta-adrenergic receptors | IN-VIVO | PERIPHERAL VASCULAR DISEASE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | HEMATOLOGY | EXPRESSION | Phosphorylation | Rats, Wistar | Myocardial Contraction - drug effects | Male | Quinolones - pharmacology | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Phosphodiesterase 4 Inhibitors | Fluorescence Resonance Energy Transfer | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Receptors, Adrenergic, beta - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Receptors, Adrenergic, beta - metabolism | Cyclic AMP - metabolism | Sarcolemma - metabolism | Cyclic Nucleotide-Gated Cation Channels - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Phosphodiesterase 3 Inhibitors | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Cells, Cultured | Cyclic Nucleotide-Gated Cation Channels - genetics | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Animals | Myocytes, Cardiac - drug effects | Membrane Potentials | Microscopy, Fluorescence - methods | Signal Transduction - drug effects | Isoproterenol - pharmacology | Biosensing Techniques | Myocytes, Cardiac - metabolism | Cytosol - metabolism | Heart Ventricles - metabolism | Calcium Channels, L-Type - metabolism | Enzyme Activation | Kinetics
Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 539 - 550
PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed... 
Dimer | Oligomerization | CAMP | Cyclic nucleotide phosphodiesterase 4 (PDE4) | Phosphodiesterase | DOMAIN | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | dimer | GEL-FILTRATION | DENSITY GRADIENT CENTRIFUGATION | cyclic nucleotide phosphodiesterase 4 (PDE4) | ROD CGMP-PHOSPHODIESTERASE-6 | cAMP | CGMP-BINDING | oligomerization | PHOSPHATIDIC-ACID BINDING | phosphodiesterase | CATALYTIC SITE | Phosphorylation | Molecular Weight | Humans | Protein Multimerization | Cercopithecus aethiops | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Cytosol - enzymology | Cyclic AMP-Dependent Protein Kinases - genetics | Isoenzymes - metabolism | HEK293 Cells | Conserved Sequence | Luminescent Proteins - chemistry | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Dimerization | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Isoenzymes - genetics | Rats | Recombinant Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Recombinant Fusion Proteins - chemistry | Animals | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Enzyme Activation | COS Cells | Luminescent Proteins - metabolism | PDE4
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 88, pp. 29 - 38
Abstract In cardiac myocytes, the second messenger cAMP is synthesized within the β-adrenergic signaling pathway upon sympathetic activation. It activates... 
Cardiovascular | β-adrenergic pathway | Cyclic nucleotides | Computational model | Signaling networks | Cardiac myocytes | Phosphodiesterase | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTATIONAL MODELS | HEART-FAILURE | beta-adrenergic pathway | CAMP EARLY REPRESSOR | CGMP PHOSPHODIESTERASES | PROTEIN-KINASES | FEEDBACK LOOP | CELL BIOLOGY | CARDIOMYOCYTE APOPTOSIS | NITRIC-OXIDE | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | RAT VENTRICULAR MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Phosphorylation | Humans | Myocardial Contraction - physiology | Cyclic Nucleotide Phosphodiesterases, Type 2 - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | Myocardium - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Binding, Competitive | Cyclic AMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Models, Cardiovascular | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Gene Expression Regulation | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Feedback, Physiological | Animals | Cyclic GMP - metabolism | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Cyclic Nucleotide Phosphodiesterases, Type 1 - genetics
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2014, Volume 26, Issue 9, pp. 2016 - 2029
Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in... 
Phosphodiesterase inhibitor | Apremilast | Spondyloarthropathies | Psoriasis | Preclinical drug evaluation | Psoriatic arthritis | PROTEIN-KINASE-A | CONTROLLED-TRIAL | CAMP-SPECIFIC PHOSPHODIESTERASE | NECROSIS-FACTOR-ALPHA | KAPPA-B | PSORIATIC-ARTHRITIS | CELL BIOLOGY | ORAL PHOSPHODIESTERASE-4 INHIBITOR | CYCLIC-AMP | THALIDOMIDE ANALOGS | B-MEDIATED TRANSCRIPTION | Thalidomide - metabolism | Humans | Male | Thalidomide - pharmacology | Lung Diseases - drug therapy | Thalidomide - analogs & derivatives | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Vomiting - prevention & control | B-Lymphocytes - metabolism | Disease Models, Animal | Cell Line | Cytokines - metabolism | Immunity, Innate - drug effects | Jurkat Cells | Phosphodiesterase 4 Inhibitors - therapeutic use | Mice, Transgenic | Phosphodiesterase 4 Inhibitors - metabolism | Ferrets | Phosphodiesterase 4 Inhibitors - pharmacology | B-Lymphocytes - drug effects | Adaptive Immunity - drug effects | Animals | B-Lymphocytes - immunology | Protein Binding | T-Lymphocytes - immunology | Mice | Thalidomide - therapeutic use | Dendritic cells | Analysis | Development and progression | Genetic engineering | B cells | Biological response modifiers | T cells
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 02/2010, Volume 35, Issue 2, pp. 91 - 100
Journal Article
Oncogene, ISSN 0950-9232, 02/2013, Volume 32, Issue 9, pp. 1121 - 1134
Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that cyclic nucleotide phosphodiesterases (PDEs) are relevant in various cancer... 
lung cancer | phosphodiesterases | hypoxia | proliferation | angiogenesis | MIGRATION | CELLS | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPONENTS | CELL BIOLOGY | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | TARGETS | LEUKEMIA | TUMOR-GROWTH | EXPRESSION | Humans | Lung Neoplasms - metabolism | RNA, Small Interfering - pharmacology | Cyclic AMP | Transplantation, Heterologous | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Signal Transduction - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Nude | Cyclic Nucleotide Phosphodiesterases, Type 4 - physiology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Care and treatment | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Vascular endothelial growth factor | Angiogenesis | Pathology | Adenocarcinoma | Drugs | Protein kinase A | Carcinoma | Immunocytochemistry | Pyruvic acid | Regulatory sequences | Drug development | dehydrogenase | Western blotting | Reporter gene | Xenografts | Hypoxia-inducible factors | 3',5'-Cyclic-nucleotide phosphodiesterase | Colonies | Tumor cells | Data processing | siRNA | Tumor cell lines | phosphodiesterase IV | L-Lactate dehydrogenase | Polymerase chain reaction | Hypoxia | Mutation | phosphodiesterase | Tumors
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 59, Issue 24, pp. 2182 - 2190
Journal Article