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Nature Communications, ISSN 2041-1723, 04/2016, Volume 7, Issue 1, pp. 11360 - 11360
The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported that the small-molecule... 
Small Molecule Libraries - pharmacology | Epithelial Cells - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Epithelial Cells - drug effects | Humans | Pancreatic Ducts - drug effects | Gene Expression Regulation, Neoplastic | Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors | Crystallography, X-Ray | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Pancreatic Ducts - pathology | Benzimidazoles - chemistry | Pancreatic Ducts - metabolism | Pyrazoles - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Phosphodiesterase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Protein Interaction Domains and Motifs | Phosphodiesterase Inhibitors - chemistry | Binding Sites | Proto-Oncogene Proteins p21(ras) - metabolism | Pyrazoles - pharmacology | Recombinant Proteins - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Gene Expression | Protein Structure, Secondary | Signal Transduction | Phosphodiesterase Inhibitors - pharmacology | Recombinant Proteins - chemistry | Small Molecule Libraries - chemical synthesis | Epithelial Cells - pathology | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Pyrazines - chemical synthesis | Pyrazines - chemistry | Small Molecule Libraries - chemistry | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Cell Line, Tumor | Protein Binding | Benzimidazoles - pharmacology | Molecular Docking Simulation | Pyrazines - pharmacology | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2012, Volume 14, Issue 2, pp. 148 - 158
Journal Article
Cellular Signalling, ISSN 0898-6568, 09/2017, Volume 37, pp. 74 - 80
Mutations in genes encoding the effector enzymes in rods and cones underlie severe retinal diseases including retinitis pigmentosa (RP), autosomal dominant... 
Retina | AIPL1 | Phosphodiesterases | Achromatopsia | Chaperone | Photoreceptor | PHOTORECEPTOR PHOSPHODIESTERASE | DOMAIN | RECESSIVE RETINITIS-PIGMENTOSA | ROD CGMP-PHOSPHODIESTERASE | CATALYTIC SUBUNITS | CELL BIOLOGY | GENE | GAMMA-SUBUNIT | BETA-SUBUNIT | CONGENITAL AMAUROSIS | STATIONARY NIGHT BLINDNESS | Retinal Diseases - genetics | Night Blindness - metabolism | Humans | Retinal Diseases - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Mutation, Missense | Protein Prenylation | Color Vision Defects - genetics | Myopia - metabolism | HEK293 Cells | Genetic Diseases, X-Linked - genetics | Eye Proteins - genetics | Night Blindness - genetics | Color Vision Defects - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - analysis | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Gene Expression | Models, Molecular | Genetic Diseases, X-Linked - metabolism | Eye Proteins - analysis | Protein Folding | Eye Diseases, Hereditary - genetics | Myopia - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Eye Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Eye Diseases, Hereditary - metabolism | Physiological aspects | Enzymes | Retinal diseases | Analysis | Index Medicus | phosphodiesterases | chaperone | achromatopsia | retina | photoreceptor
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2016, Volume 36, Issue 27, pp. 7184 - 7197
Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs, with five subtypes named M1-M5) are a unique subclass of RGCs with axons... 
Retina | Dopamine | Amacrine cell | Vision | Melanopsin | Ganglion cell | GANGLION-CELL PHOTORECEPTORS | amacrine cell | AXON COLLATERALS | CA2+ CHANNELS | SYNAPTIC-TRANSMISSION | NEUROSCIENCES | INNER PLEXIFORM LAYER | melanopsin | DOPAMINERGIC AMACRINE CELLS | vision | CALCIUM-CHANNELS | retina | RECEPTOR ACTIVATION | MOUSE RETINA | dopamine | LIGHT ADAPTATION | ganglion cell | Tyrosine 3-Monooxygenase - metabolism | Membrane Potentials - genetics | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Excitatory Postsynaptic Potentials - drug effects | Vision, Ocular - physiology | Visual Pathways - physiology | Rod Opsins - genetics | Retina - cytology | Light | Rod Opsins - metabolism | beta-Galactosidase - metabolism | Female | Transducin - metabolism | Tetrodotoxin - pharmacology | Cyclic Nucleotide-Gated Cation Channels - metabolism | Excitatory Postsynaptic Potentials - genetics | Animals, Newborn | Transducin - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Retinal Ganglion Cells - classification | Retinal Ganglion Cells - physiology | GTP-Binding Protein alpha Subunits - metabolism | Mice, Inbred C57BL | Cyclic Nucleotide-Gated Cation Channels - genetics | Proto-Oncogene Proteins c-fos - metabolism | GTP-Binding Protein alpha Subunits - genetics | Mice, Transgenic | Sodium Channel Blockers - pharmacology | Membrane Potentials - physiology | Nerve Tissue Proteins - metabolism | Tyrosine 3-Monooxygenase - genetics | Vision, Ocular - genetics | Animals | Mice | Retinal Ganglion Cells - drug effects | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2016, Volume 126, Issue 12, pp. 4659 - 4673
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 02/2011, Volume 20, Issue 4, pp. 719 - 730
Journal Article
Human Mutation, ISSN 1059-7794, 01/2014, Volume 35, Issue 1, pp. 137 - 146
Joubert syndrome ( JS ) is characterized by a distinctive cerebellar structural defect, namely the « molar tooth sign ». JS is genetically heterogeneous,... 
PDE | D | 5 | E | oubert syndrome | primary cilia | 6 | INPP | prenylation | J | Prenylation | PDE6D | Primary cilia | Joubert syndrome | INPP5E | IMMUNITY | ZEBRAFISH | CILIOPATHIES | PRENYL-BINDING PROTEIN | DEFICIENCY | CYCLIC-GMP PHOSPHODIESTERASE | SEQUENCING-BASED DISCOVERY | DELTA-SUBUNIT | TRANSPORT | GENETICS & HEREDITY | ARL2-GTP | Retina - metabolism | Humans | Zebrafish - abnormalities | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Cerebellum - abnormalities | Protein Prenylation | Exome | Kidney Diseases, Cystic - genetics | Female | ADP-Ribosylation Factors - metabolism | Eye Abnormalities - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Genetic Predisposition to Disease | Phosphoric Monoester Hydrolases - genetics | Cerebellar Diseases - metabolism | Zebrafish Proteins - metabolism | Abnormalities, Multiple | Models, Molecular | Eye Abnormalities - genetics | Sequence Analysis, DNA | Cilia - metabolism | Zebrafish - genetics | Homozygote | Kidney Diseases, Cystic - metabolism | Animals | Cerebellar Diseases - genetics | Pedigree | Proteomics | Retina - abnormalities | Zebrafish Proteins - genetics | Phosphoric Monoester Hydrolases - metabolism | Genetic disorders | Analysis | Genomics | Genetic research | Genetic aspects | Tubulins | Mental illness | Protein binding | Mutation | Index Medicus
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2019, Volume 144, Issue 4, pp. 767 - 776
Ras proteins, most notably KRas, are prevalent oncogenes in human cancer. Plasma membrane localization and thereby signaling of KRas is regulated by the... 
KRas | colorectal cancer | proliferation | PDEδ | HUMAN COLON | ACTIVATION | PDE delta | IMPAIRS | ANTIBODY | PLASMA-MEMBRANE | EGFR | CETUXIMAB | GENE | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | MUTATIONS | Cell Survival - drug effects | Cell Proliferation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Apoptosis - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | HCT116 Cells | Humans | Cell Survival - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors | Apoptosis - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | HT29 Cells | RNA Interference | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Adenocarcinoma | Biotechnology | Cell survival | Epidermal growth factor receptors | Colorectal carcinoma | Colorectal cancer | Pharmacology | Tumor cell lines | Survival | K-Ras protein | Proteins | Cell lines | Dependence | Inhibition | Pancreas | Localization | Cancer | Index Medicus | Molecular Cancer Biology
Journal Article