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The EMBO Journal, ISSN 0261-4189, 11/2009, Volume 28, Issue 22, pp. 3613 - 3622
The inhibitory interaction of phosphodiesterase‐6 (PDE6) with its γ‐subunit (Pγ) is pivotal in vertebrate phototransduction. Here, crystal structures of a... 
transducin | X‐ray crystallography | phototransduction | phosphodiesterase 6 | X-ray crystallography | Transducin | Phosphodiesterase 6 | Phototransduction | PDE6 | MAXIMUM-LIKELIHOOD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | ROD CGMP-PHOSPHODIESTERASE | CATALYTIC SUBUNITS | G-PROTEIN | CYCLIC-GMP PHOSPHODIESTERASE | CELL BIOLOGY | ENZYME | DOMAINS | Cyclic Nucleotide Phosphodiesterases, Type 5 - chemistry | Humans | Cyclic Nucleotide Phosphodiesterases, Type 6 - antagonists & inhibitors | Molecular Sequence Data | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Peptide Fragments - pharmacology | Piperazines - metabolism | Piperazines - chemistry | Structure-Activity Relationship | Sulfones - pharmacology | Recombinant Fusion Proteins - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 6 - physiology | Sildenafil Citrate | 1-Methyl-3-isobutylxanthine - chemistry | Cattle | Sulfones - chemistry | Enzyme Inhibitors - chemistry | Protein Subunits - physiology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Amino Acid Sequence | Catalytic Domain | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Peptide Fragments - metabolism | Enzyme Inhibitors - metabolism | Purines - metabolism | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Models, Molecular | Sulfones - metabolism | Recombinant Fusion Proteins - chemistry | Piperazines - pharmacology | 1-Methyl-3-isobutylxanthine - pharmacology | Sequence Homology, Amino Acid | Peptide Fragments - chemistry | Animals | Purines - chemistry | Protein Binding | Protein Subunits - chemistry | 1-Methyl-3-isobutylxanthine - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 48, pp. 19691 - 19696
Journal Article
Journal Article
Cellular and molecular life sciences : CMLS, 03/2010, Volume 67, Issue 5, pp. 817 - 828
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/1999, Volume 127, Issue 1, pp. 65 - 74
The effects of several phosphodiesterase (PDE) inhibitors on the L‐type Ca current ( I Ca ) and intracellular cyclic AMP concentration ([cAMP] i ) were... 
cilostamide (PDE3 inhibitor) | intracellular cyclic AMP | phosphodiesterase subtypes | current | Ro20‐1724 (PDE4 inhibitor) | L‐type Ca | EHNA (PDE2 inhibitor) | phosphodiesterase inhibitors | MIMX (PDE1 inhibitor) | β‐adrenoceptor agonist | Rat heart | Cilostamide (PDE3 inhibitor) | β-adrenoceptor agonist | Intracellular cyclic AMP | Phosphodiesterase subtypes | L-type Ca | Phosphodiesterase inhibitors | Ro20-1724 (PDE4 inhibitor) | MYOCARDIUM | CELLS | ISOFORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | L-type Ca2+ current | beta-adrenoceptor agonist | CARDIAC MYOCYTES | CALCIUM CURRENT | rat heart | DEPENDENT PROTEIN-KINASE | FATTY-ACIDS | AMP PHOSPHODIESTERASES | GMP | PHARMACOLOGY & PHARMACY | HUMAN ATRIAL MYOCYTES | Cyclic Nucleotide Phosphodiesterases, Type 1 | Heart Ventricles - cytology | Calcium Channels - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 | Rats, Wistar | Cyclic Nucleotide Phosphodiesterases, Type 3 | Calcium Channels, L-Type | Male | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Cyclic AMP - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - biosynthesis | Calcium - physiology | Heart Ventricles - enzymology | Myocardium - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - biosynthesis | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | Adrenergic beta-Agonists - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Rats | Reverse Transcriptase Polymerase Chain Reaction | Myocardium - cytology | Phosphoric Diester Hydrolases | Myocardium - enzymology | Patch-Clamp Techniques | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors | Isoproterenol - pharmacology | Heart Ventricles - metabolism | In Vitro Techniques | Index Medicus | Papers
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2006, Volume 116, Issue 12, pp. 3240 - 3251
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 24, pp. 20111 - 20121
As the central effector of visual transduction, the regulation of photoreceptor phosphodiesterase (PDE6) is controlled by both allosteric mechanisms and... 
ALLOSTERIC REGULATION | INHIBITORY GAMMA-SUBUNIT | ANALYTICAL ULTRACENTRIFUGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLUORESCENCE-DETECTED SEDIMENTATION | GAF DOMAINS | RETINAL PHOSPHODIESTERASE | NUCLEOTIDE PHOSPHODIESTERASES | CGMP-BINDING-SITES | CYCLIC-GMP PHOSPHODIESTERASE | OUTER SEGMENTS | Protein Structure, Tertiary | Transducin - genetics | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - chemistry | Humans | Protein Multimerization | Eye Proteins - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 6 - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Transducin - chemistry | Animals | Allosteric Regulation - physiology | Cyclic GMP - metabolism | Eye Proteins - metabolism | Cattle | Cyclic GMP - chemistry | Retinal Rod Photoreceptor Cells - cytology | Cyclic GMP - genetics | Protein Structure, Quaternary | Retinal Rod Photoreceptor Cells - enzymology | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Transducin - metabolism | Eye Proteins - genetics | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Index Medicus | Analytical Ultracentrifugation | PDE6 | Prenyl-binding Protein | Signal Transduction | Allosteric Regulation | Transducin | Photoreceptors | Protein Conformation | Visual Transduction | Phosphodiesterases | Cyclic Nucleotides | Cyclic GMP (cGMP)
Journal Article