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Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2016, Volume 59, Issue 23, pp. 10435 - 10450
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 12/2011, Volume 71, Issue 23, pp. 7226 - 7237
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2012, Volume 55, Issue 7, pp. 3364 - 3386
Journal Article
Cancer Research, ISSN 0008-5472, 09/2007, Volume 67, Issue 17, pp. 8051 - 8057
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2007, Volume 193, Issue 1, pp. 121 - 136
Data from both preclinical and clinical studies have provided proof of concept that modulation of limbic and forebrain glutamate, via mGlu2/3 receptor... 
Animal models | Biomedicine | mGlu2/3 receptor agonist | Schizophrenia | Antipsychotic | Anxiety | Pharmacology/Toxicology | Psychiatry | Psychiatric disorders | Anxiolytic | Metabotropic glutamate (mGlu) receptors | MGlu2/3 receptor agonist | SINGLY HOUSED MICE | animal models | METABOTROPIC GLUTAMATE-RECEPTOR | RAT | PSYCHIATRY | ACID LY354740 | schizophrenia | metabotropic glutamate (mGlu) receptors | NEUROSCIENCES | NUCLEUS-ACCUMBENS | PHENCYCLIDINE | anxiety | MESSENGER-RNA | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | antipsychotic | anxiolytic | psychiatric disorders | STRESS-INDUCED HYPERTHERMIA | Cyclic S-Oxides - chemistry | Phencyclidine - pharmacology | Rats, Inbred F344 | Motor Activity - drug effects | Male | Amino Acids - pharmacology | Diazepam - pharmacology | Dose-Response Relationship, Drug | Prefrontal Cortex - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Behavior, Animal - drug effects | Cyclic S-Oxides - pharmacology | Molecular Structure | Xanthenes - pharmacology | Disease Models, Animal | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Amphetamine - pharmacology | Rats | Rats, Sprague-Dawley | Mental Disorders - psychology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Cyclic S-Oxides - therapeutic use | Animals | Mental Disorders - drug therapy | Prefrontal Cortex - metabolism | Mice | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Neurology | Brain | Pharmacology | Psychology | Rodents
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2013, Volume 19, Issue 8, pp. 1972 - 1980
Purpose: The cancer stem cell theory postulates that tumors contain a subset of cells with stem cell properties of self-renewal, differentiation, and tumor... 
BREAST-CANCER | PRESENILIN | ACTIVATION | EPITHELIAL-CELLS | HEDGEHOG-GLI | ONCOLOGY | PROLIFERATION | ACUTE MYELOID-LEUKEMIA | PROTEOLYSIS | TUMOR-GROWTH | ASSOCIATION | Immunohistochemistry | Cell Cycle - genetics | Lung Neoplasms - drug therapy | Multivariate Analysis | Transcription Factor HES-1 | Adenocarcinoma - pathology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Lung Neoplasms - pathology | Receptors, Notch - genetics | Green Fluorescent Proteins - genetics | Receptors, Notch - antagonists & inhibitors | Flow Cytometry | Protein Isoforms - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Adenocarcinoma - genetics | Cyclic S-Oxides - pharmacology | Thiadiazoles - pharmacology | Lung Neoplasms - genetics | Green Fluorescent Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Kaplan-Meier Estimate | Signal Transduction - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice, Inbred NOD | Mice | Cell Cycle - drug effects | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Cancer Stem cells | Notch pathway | Lung cancer
Journal Article
Journal Article
Basic Research in Cardiology, ISSN 0300-8428, 11/2010, Volume 105, Issue 6, pp. 771 - 785
Journal Article
Cancer Research, ISSN 0008-5472, 09/2015, Volume 75, Issue 18, pp. 3812 - 3822
STAT3 is an oncogenic transcription factor with potent immunosuppressive functions. We found that pharmacologic inhibition of STAT3 or its selective knockout... 
IMMUNITY | RECRUITMENT | ACTIVATION | ONCOLOGY | IMMUNOTHERAPY | RESISTANCE | DEATH | DIFFERENTIATION | TRANSCRIPTION FACTOR STAT3 | TUMORS | T-CELLS | Doxorubicin - therapeutic use | Cyclic S-Oxides - administration & dosage | Antibiotics, Antineoplastic - pharmacology | Chemokine CXCL9 - biosynthesis | Dendritic Cells - immunology | Neoplasm Proteins - physiology | Transcriptional Activation | Fibrosarcoma - immunology | Neoplasm Proteins - antagonists & inhibitors | Receptor, Interferon alpha-beta - antagonists & inhibitors | Interferon Type I - biosynthesis | Chemokine CXCL10 - biosynthesis | Colorectal Neoplasms - therapy | STAT3 Transcription Factor - physiology | Colorectal Neoplasms - drug therapy | Female | Cyclic S-Oxides - pharmacology | Immunocompetence | Receptors, CXCR3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | STAT3 Transcription Factor - genetics | Doxorubicin - administration & dosage | T-Lymphocytes, Cytotoxic - immunology | Neoplasm Proteins - biosynthesis | Mice, Inbred C57BL | Fibrosarcoma - therapy | Combined Modality Therapy | Chemokine CXCL9 - genetics | Antibiotics, Antineoplastic - administration & dosage | Drug Synergism | Cyclic S-Oxides - therapeutic use | Animals | Colorectal Neoplasms - immunology | Antibiotics, Antineoplastic - therapeutic use | Signal Transduction - drug effects | Chemokine CXCL10 - genetics | Mice, Nude | Receptors, CXCR3 - physiology | Cell Line, Tumor | Interferon Type I - genetics | Mice | Mice, Inbred BALB C | STAT3 Transcription Factor - antagonists & inhibitors | Doxorubicin - pharmacology | Fibrosarcoma - drug therapy | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article