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PLoS Genetics, ISSN 1553-7390, 11/2016, Volume 12, Issue 11, pp. e1006429 - e1006429
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 9, pp. 3761 - 3766
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2005, Volume 102, Issue 26, pp. 9182 - 9187
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 08/2004, Volume 36, Issue 8, pp. 1424 - 1439
E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. The activity of cyclin E is... 
G1 progression | Cyclin E | Cdk | Cell cycle | Cancer | S-PHASE ENTRY | CDK-ACTIVATING KINASE | cell cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE GENE-TRANSCRIPTION | T-CELL LYMPHOMAGENESIS | CENTROSOME DUPLICATION | CELL BIOLOGY | cyclin E | EARLY CERVICAL NEOPLASIA | BREAST-CANCER CELLS | RETINOBLASTOMA PROTEIN | cancer | DEPENDENT KINASE 2 | UBIQUITIN-PROTEASOME PATHWAY
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 4/2012, Volume 132, Issue 2, pp. 575 - 588
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2005, Volume 7, Issue 8, pp. 831 - 836
The cyclin-dependent kinase inhibitor p27Kip1 is known as a negative regulator of cell-cycle progression and as a tumour suppressor. Cdk2 is the main target of... 
CYCLIN-E | ENTRY | CDK2 | GROWTH | MOUSE | DEPENDENT-KINASE INHIBITOR | HYPERPLASIA | MAMMALIAN-CELLS | MICE LACKING | P27(KIP1) | CELL BIOLOGY | Cell Proliferation | Cyclin-Dependent Kinases - metabolism | Ovarian Neoplasms - pathology | Gonads - pathology | Male | Mitosis - genetics | Body Weight - genetics | CDC2 Protein Kinase - metabolism | Ovarian Neoplasms - genetics | Cyclin-Dependent Kinase 2 | Cyclins - metabolism | 2-Aminopurine - analogs & derivatives | Cyclin-Dependent Kinases - antagonists & inhibitors | Thymus Gland - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Pituitary Neoplasms - genetics | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | CDC2-CDC28 Kinases - metabolism | Mice, Knockout | Fibroblasts - drug effects | Fibroblasts - cytology | Mice | Interphase - genetics | Interphase - physiology | Infertility - genetics | Transfection | Tumor Suppressor Proteins - genetics | Thymus Gland - pathology | Cell Cycle Proteins - genetics | Female | G1 Phase - genetics | CDC2 Protein Kinase - genetics | Mice, Inbred C57BL | Pituitary Neoplasms - pathology | 2-Aminopurine - pharmacology | G1 Phase - physiology | S Phase - genetics | Cyclin-Dependent Kinase Inhibitor p27 | Animals | Spleen - metabolism | RNA, Double-Stranded - genetics | Sex Factors | Protein Binding | S Phase - physiology | S Phase - drug effects | Cyclin E - metabolism | CDC2-CDC28 Kinases - genetics | Interphase - drug effects | Crosses, Genetic | Physiological aspects | Tumor suppressor genes | Control | Cellular signal transduction | Research | Cell cycle | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15916 - 15916
Deregulation of the cell cycle machinery is a hallmark of cancer. While CDK4/6 inhibitors are FDA approved (palbociclib) for treating advanced estrogen... 
PALBOCICLIB | APOPTOSIS | CELLS | OXIDATIVE STRESS | ADVANCED BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | REGULATES AUTOPHAGY | LETROZOLE | G1 ARREST | DEPENDENT KINASE INHIBITOR | ANTITUMOR-ACTIVITY | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Cyclin-Dependent Kinase 4 - genetics | Humans | Cellular Senescence - drug effects | Cytoplasm - metabolism | Antineoplastic Agents - administration & dosage | Breast Neoplasms - physiopathology | Cyclin E - genetics | Autophagy - drug effects | Breast Neoplasms - metabolism | Female | Cytoplasm - genetics | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Pyridines - administration & dosage | Retinoblastoma Protein - metabolism | Cyclin-Dependent Kinase 6 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Breast Neoplasms - drug therapy | Drug Synergism | Protein Kinase Inhibitors - administration & dosage | Animals | Breast Neoplasms - genetics | Mice, Nude | Retinoblastoma Protein - genetics | Cell Line, Tumor | Mice | Cyclin E - metabolism | Cell Cycle - drug effects | Cytoplasm - drug effects | Senescence | Deregulation | Estrogens | Estrogen | Estrogen receptors | Breast cancer | In vitro testing | Autophagy | Machinery | Cyclin-dependent kinase 4 | Inhibitors | Cell cycle | Xenografts | Biomarkers | Breast | Cyclin E | Bioindicators | Inhibition | Phagocytosis | Tumors | Cancer | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 281 - 294
The kinase inhibitor p27 regulates the G cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through... 
GROWTH-FACTOR RECEPTOR | FACTOR-BETA | HUMAN-BREAST-CANCER | DEPENDENT-KINASE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE | CDK INHIBITOR | MEDIATED G ARREST | ESTROGEN-RECEPTOR | C-SRC | CELL BIOLOGY | Phosphorylation | Protein Binding - genetics | Humans | Cyclin E - genetics | Antineoplastic Agents, Hormonal - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Cell Cycle Proteins - genetics | Female | Tamoxifen - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Cell Cycle Proteins - metabolism | Cyclin-Dependent Kinase 2 - genetics | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Drug Resistance, Neoplasm - genetics | Tyrosine - metabolism | Breast Neoplasms - genetics | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Feedback, Physiological - genetics | Tamoxifen - pharmacology | Cell Line, Tumor | Carcinoma - genetics | Carcinoma - therapy | Carcinoma - metabolism | Cyclin E - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2017, Volume 23, Issue 12, pp. 2991 - 3002
Journal Article
Journal Article