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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2016, Volume 113, Issue 39, pp. E5721 - E5730
We previously showed that guanine nucleotide-binding (G) protein α subunit (Gα)-interacting vesicle-associated protein (GIV), a guanine-nucleotide exchange... 
Cancer invasion | Growth factor receptor tyrosine kinase | Heterotrimeric G proteins | CAMP | Guanine nucleotide dissociation inhibitor | guanine nucleotide dissociation inhibitor | BIOSENSORS REVEAL | MULTIDISCIPLINARY SCIENCES | G-PROTEINS | GUANINE-NUCLEOTIDE EXCHANGE | GROWTH-FACTOR RECEPTORS | cAMP | PEPTIDE | ENDOSOMES | cancer invasion | STRUCTURAL BASIS | GIV | ADENYLYL-CYCLASE | CELL-MIGRATION | heterotrimeric G proteins | growth factor receptor tyrosine kinase | GTP-Binding Protein alpha Subunits, Gs - metabolism | Vesicular Transport Proteins - metabolism | Humans | Guanosine Triphosphate - metabolism | Structure-Activity Relationship | Extracellular Signal-Regulated MAP Kinases - metabolism | Endosomes - metabolism | Endosomes - drug effects | Fluorescence Resonance Energy Transfer | Microfilament Proteins - metabolism | Phosphorylation - drug effects | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Amino Acid Sequence | Microfilament Proteins - chemistry | Mutant Proteins - metabolism | Vesicular Transport Proteins - chemistry | Chemotaxis - drug effects | Down-Regulation - drug effects | Amino Acid Motifs | Cyclin-Dependent Kinase 5 - metabolism | Signal Transduction - drug effects | Protein Kinase C-theta - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | GTP-Binding Protein gamma Subunits | Protein Binding | Cell Proliferation - drug effects | Epidermal Growth Factor - pharmacology | GTP-Binding Protein beta Subunits | HeLa Cells | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Biological Sciences | PNAS Plus
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2017, Volume 12, Issue 16, pp. 1279 - 1285
Together with estrogen receptors ERα and ERβ, the G protein‐coupled estrogen receptor (GPER) mediates important pathophysiological signaling pathways induced... 
breast cancer | estrogen | pyrrolo[1,2-a]quinoxaline | 5-dihydropyrrolo[1,2-a]quinoxaline | GPER | Cyclin D1 - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Estrogen Receptor beta - metabolism | Quinoxalines - pharmacology | MCF-7 Cells | HEK293 Cells | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Estrogen Receptor alpha - metabolism | Female | Antineoplastic Agents - pharmacology | Binding Sites | Estrogen Receptor beta - antagonists & inhibitors | Protein Structure, Tertiary | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | Quinoxalines - chemistry | Estrogen Receptor alpha - antagonists & inhibitors | Quinoxalines - metabolism | Antineoplastic Agents - chemistry | Breast Neoplasms - pathology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | CHEMISTRY, MEDICINAL | MITOCHONDRIAL-FUNCTION | DIAZEPAM-BINDING INHIBITOR | 5-dihydropyrrolo[1,2-a] quinoxaline | 18-KDA TRANSLOCATOR PROTEIN | CHOLESTEROL-BINDING | KETO-CARBOXYLIC-ACIDS | ANION CHANNEL VDAC | 18 KDA TSPO | IN-VITRO EVALUATION | PERIPHERAL BENZODIAZEPINE-RECEPTOR | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | Phenols | Breast cancer | G proteins | Tumor proteins | Estrogen
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2018, Volume 13, Issue 1, pp. 48 - 66
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 12/2008, Volume 116, Issue 12, pp. 1648 - 1655
Journal Article
by Curtis, Bruce A and Curtis, Bruce A and Tanifuji, Goro and Tanifuji, Goro and Burki, Fabien and Maruyama, Shinichiro and Gruber, Ansgar and Gile, Gillian H and Irimia, Manuel and Hopkins, Julia F and Maruyama, Shinichiro and Eveleigh, Robert J. M and Arias, Maria C and Nakayama, Takuro and Ball, Steven G and Malik, Shehre-Banoo and Onodera, Naoko T and Gile, Gillian H and Slamovits, Claudio H and Hirakawa, Yoshihisa and Spencer, David F and Hopkins, Julia F and Lane, Christopher E and Kuo, Alan and Gray, Michael W and Rensing, Stefan A and Archibald, John M and Schmutz, Jeremy and Symeonidi, Aikaterini and Burki, Fabien and Hirakawa, Yoshihisa and Elias, Marek and Reyes-Prieto, Adrian and Eveleigh, Robert J. M and Herman, Emily K and Keeling, Patrick J and Fast, Naomi M and Klute, Mary J and Green, Beverley R and Nakayama, Takuro and Oborník, Miroslav and Grisdale, Cameron J and Gruber, Ansgar and Reyes-Prieto, Adrian and Kroth, Peter G and Virginia Armbrust, E and Aves, Stephen J and Irimia, Manuel and Arias, Maria C and Beiko, Robert G and Coutinho, Pedro and Ball, Steven G and Dacks, Joel B and Kuo, Alan and Durnford, Dion G and Schmutz, Jeremy and Grimwood, Jane and Fast, Naomi M and Green, Beverley R and Lindquist, Erika and Grisdale, Cameron J and Lucas, Susan and Hempel, Franziska and Salamov, Asaf and Henrissat, Bernard and Grigoriev, Igor V and Höppner, Marc P and Rensing, Stefan A and Ishida, Ken-Ichiro and Symeonidi, Aikaterini and Kim, Eunsoo and Elias, Marek and Herman, Emily K and Kořený, Luděk and Kroth, Peter G and Klute, Mary J and Dacks, Joel B and Liu, Yuan and Oborník, Miroslav and Malik, Shehre-Banoo and Kořený, Luděk and Maier, Uwe G and McRose, Darcy and Durnford, Dion G and Mock, Thomas and Neilson, Jonathan A. D and Armbrust, E. Virginia and Neilson, Jonathan A. D and Rocap, Gabrielle and Onodera, Naoko T and Poole, Anthony M and Aves, Stephen J and Liu, Yuan and Pritham, Ellen J and Richards, Thomas A and Beiko, Robert G and Rocap, Gabrielle and Coutinho, Pedro and Henrissat, Bernard and Roy, Scott W and ... and Joint Genome Institute (JGI) and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för medicinsk biokemi och mikrobiologi and Uppsala universitet
Nature, ISSN 0028-0836, 12/2012, Volume 491, Issue 7427, pp. 59 - 65
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1184 - 1194
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 380 - 392
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 3, pp. 1118 - 1123
Journal Article
CURRENT OPINION IN CELL BIOLOGY, ISSN 0955-0674, 12/2000, Volume 12, Issue 6, pp. 676 - 684
Journal Article
by Chan, QKY and Lam, HM and Ng, CF and Lee, AYY and Chan, ESY and Ng, HK and Ho, SM and Lau, KM
Cell Death and Differentiation, ISSN 1350-9047, 09/2010, Volume 17, Issue 9, pp. 1511 - 1523
G-protein-coupled receptor-30 (GPR30) shows estrogen-binding affinity and mediates non-genomic signaling of estrogen to regulate cell growth. We here showed... 
COUPLED RECEPTOR GPR30 | ER-BETA | signal transduction | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-protein-coupled receptor-30 | G2/M | PROLIFERATION | G-PROTEIN | non-genomic estrogen signaling | ESTROGEN-RECEPTOR | 17-BETA-ESTRADIOL | CELL BIOLOGY | NUCLEAR ACCUMULATION | Y TRANSCRIPTION FACTOR | EXPRESSION | 1-[4-(6-bromobenzo[1,3]dioxol-5yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, G-Protein-Coupled - agonists | G2 Phase - drug effects | Quinolines - pharmacology | Cell Nucleus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Phosphorylation - drug effects | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins c-jun - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins c-fos - metabolism | Receptors, Estrogen - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Cyclopentanes - pharmacology | Xenograft Model Antitumor Assays | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Mice, Nude | Proto-Oncogene Proteins c-jun - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Receptors, G-Protein-Coupled - genetics | Cell Cycle - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1727 - 1731
[Display omitted] We demonstrate an innovative approach for optimization of kinase inhibitor potency and selectivity utilising kinase mini-panels and... 
Kinome selectivity | 4-anilinoquinoline | 4-Anilinoquinazoline | Mini-kinome panel | Cyclin G associated kinase (GAK) | MULTIPLE ROLES | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | Case studies | Drugstores | Quinoline | Medical colleges | Pharmacy
Journal Article