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Nature Reviews Cancer, ISSN 1474-175X, 01/2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1999, Volume 96, Issue 8, pp. 4325 - 4329
Recent studies identified a short peptide motif that serves as a docking site for cyclin/cyclin-dependent kinase (cdk) 2 complexes. Peptides containing this... 
Cell culture techniques | Diploidy | HCT116 cells | B lymphocytes | Cell lines | Fibroblasts | Transformed cell line | Viability | Cyclins | Apoptosis | APOPTOSIS | DNA-BINDING | S-PHASE ENTRY | RETINOBLASTOMA PROTEIN | MULTIDISCIPLINARY SCIENCES | CYCLIN-A | TRANSCRIPTION | E2F-1 | MAMMALIAN-CELLS | EXPRESSION | CANCER | Phosphorylation | Research | Genetic transcription | Peptides | Protein kinases
Journal Article
BMC Cancer, ISSN 1471-2407, 01/2014, Volume 14, Issue 1, p. 32
Background: Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically... 
Cyclin-dependent kinase | Breast cancer | Synthetic lethality | MYC | SYNTHETIC LETHAL | C-MYC | TUMOR-CELLS | PROLIFERATION | INHIBITION | GENE | ONCOLOGY | PATHWAY | ESTROGEN | THERAPEUTIC TARGETS | EXPRESSION | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Phosphorylation | Cyclin-Dependent Kinase 4 - genetics | Humans | Molecular Targeted Therapy | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Breast Neoplasms - enzymology | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Cell Death - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Cyclin-Dependent Kinase 2 - metabolism | CDC2 Protein Kinase - genetics | CDC2 Protein Kinase - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Care and treatment | Patient outcomes | Cancer cells | Physiological aspects | Genetic aspects | Research | Risk factors | Cyclins
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Organic chemistry | Chemical Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1988 - 1997
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14349 - 14354
The conformational flexibility of target proteins continues to be a major challenge in accurate modeling of protein-inhibitor interactions. A fundamental... 
Datasets | Enzymes | Statistical variance | Thumb | Ubiquitins | Correlation coefficients | Ligands | Principal components analysis | Modeling | HIV 1 | Anisotropic network model | Conformational flexibility | Ensemble of structures | Pre-existing equilibrium | Principal component analysis | ALLOSTERIC REGULATION | ensemble of structures | MULTIDISCIPLINARY SCIENCES | UNBOUND STATE | conformational flexibility | NETWORK MODEL | INDUCED-FIT | anisotropic network model | pre-existing equilibrium | PROTEIN DYNAMICS | CONFORMATIONAL-CHANGE | LIGAND DOCKING | NATIVE ENSEMBLES | HIV-1 REVERSE-TRANSCRIPTASE | principal component analysis | Protein Structure, Tertiary | Cyclin-Dependent Kinase 2 - metabolism | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | Cyclin-Dependent Kinase 2 - chemistry | Structure-Activity Relationship | HIV Reverse Transcriptase - metabolism | Thermodynamics | Algorithms | Enzyme Inhibitors - chemistry | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Protein Conformation | p38 Mitogen-Activated Protein Kinases - metabolism | Kinetics | p38 Mitogen-Activated Protein Kinases - chemistry | HIV Reverse Transcriptase - chemistry | Research | Properties | Protein binding | Biological Sciences
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2013, Volume 19, Issue 10, pp. 2677 - 2687
Purpose: To analyze the antimyeloma potential of TG02, an ERK5/CDK inhibitory drug. Experimental Design: Utilizing different multiple myeloma cell lines we... 
MULTIPLE-MYELOMA | CANCER-CELLS | ACTIVATION | ONCOLOGY | INDUCED APOPTOSIS | CYCLIN D1 | PHOSPHORYLATION | SENSITIVITY | TRANSDUCTION | DEPENDENT KINASE INHIBITOR | EXPRESSION | Cell Cycle - genetics | Gene Expression Regulation, Enzymologic - drug effects | Cyclin-Dependent Kinases - metabolism | Humans | Cell Survival - genetics | Thalidomide - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacology | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Thalidomide - analogs & derivatives | Mitogen-Activated Protein Kinase 7 - antagonists & inhibitors | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinases - genetics | Multiple Myeloma - enzymology | Cell Survival - drug effects | Cyclin-Dependent Kinase 2 - metabolism | CDC2 Protein Kinase - genetics | Bortezomib | CDC2 Protein Kinase - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - genetics | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 7 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - metabolism | Protein Kinase Inhibitors - pharmacology | Multiple Myeloma - prevention & control | Cell Cycle - drug effects | Pyrazines - pharmacology | Boronic Acids - pharmacology
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 7, pp. 1862 - 1874
Journal Article