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1. Full Text Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5
by Wang, Qinwen and Walsh, Dominic M and Rowan, Michael J and Selkoe, Dennis J and Anwyl, Roger
Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 13, pp. 3370 - 3378
The mechanisms of action of human synthetic and naturally secreted cell-derived amyloid beta-peptide (Abeta)(1-42) on the induction of long-term potentiation... 
Metabotropic glutamate receptors | Cdk5 | JNK | LTP | Amyloid β-protein | Alzheimer's disease | p38 MAPK | Hippocampus | NEURONAL APOPTOSIS | hippocampus | ALZHEIMERS-DISEASE | MAP KINASE | metabotropic glutamate receptors | amyloid beta-protein | SYNAPTIC PLASTICITY | FREQUENCY STIMULATION | AREA CA1 | NEUROSCIENCES | IN-VITRO | PATHWAY | MICE | PRECURSOR PROTEIN | Receptors, Metabotropic Glutamate - drug effects | Cyclin-Dependent Kinases - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Ovary - cytology | Excitatory Postsynaptic Potentials - drug effects | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | JNK Mitogen-Activated Protein Kinases | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Female | Electric Stimulation - methods | Peptide Fragments - genetics | p38 Mitogen-Activated Protein Kinases | CHO Cells | Ovary - metabolism | Cricetinae | Enzyme Inhibitors - pharmacology | Peptide Fragments - secretion | Rats | Excitatory Amino Acid Antagonists - pharmacology | Cyclin-Dependent Kinase 5 | Animals | Ovary - secretion | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Plasticity | Development | amyloid β-protein | Repair
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2. Full Text The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation
by Florian Plattner and Marco Angelo and K. Peter Giese
Journal of Biological Chemistry, ISSN 0021-9258, 09/2006, Volume 281, Issue 35, pp. 25457 - 25465
Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of neurodegenerative tauopathies including Alzheimer disease.... 
NEUROFIBRILLARY TANGLES | PHOSPHORYLATES TAU | MICROTUBULE-BINDING | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | PAIRED HELICAL FILAMENTS | AMYLOID PRECURSOR PROTEIN | P25 EXPRESSION | ACTIVATOR P25 | TRANSGENIC MICE | Glycogen Synthase Kinase 3 - physiology | Phosphorylation | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | Epitopes | Phosphoproteins - metabolism | tau Proteins - chemistry | Proline - chemistry | Hippocampus - metabolism | Animals | tau Proteins - physiology | Cyclin-Dependent Kinase 5 - physiology | Heterozygote | Mice
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3. Full Text Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration
by Lampropoulou, Evgenia and Logoviti, Ioanna and Koutsioumpa, Marina and Hatziapostolou, Maria and Polytarchou, Christos and Skandalis, Spyros S and Hellman, Ulf and Fousteris, Manolis and Nikolaropoulos, Sotirios and Choleva, Efrosini and Lamprou, Margarita and Skoura, Angeliki and Megalooikonomou, Vasileios and Papadimitriou, Evangelia and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för medicinsk biokemi och mikrobiologi and Uppsala universitet
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5893 - 14
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTP beta/zeta) and... 
VITRO | AFFIN REGULATORY PEPTIDE | PROTEIN | NEURITE OUTGROWTH | CDK5 | SIGNALING PATHWAY | ANGIOGENESIS IN-VIVO | MULTIDISCIPLINARY SCIENCES | TYROSINE-PHOSPHATASE BETA/ZETA | GENE-EXPRESSION | BRAIN | Tyrosine | Immunoprecipitation | Threonine | Cyclin-dependent kinases | Pleiotrophin | Extracellular signal-regulated kinase | Mass spectroscopy | Src protein | Kinases | Carbazole | Cyclin-dependent kinase 5 | Endothelial cells | Cell adhesion & migration | 1-Phosphatidylinositol 3-kinase | Cyclin-dependent kinase | Angiogenesis | Next-generation sequencing | Protein-serine/threonine kinase | Cell migration | Protein-tyrosine-phosphatase | Biological Sciences | Biochemistry and Molecular Biology | Naturvetenskap | Natural Sciences | Biokemi och molekylärbiologi | Biologiska vetenskaper
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4. Full Text Cyclin dependent kinase 5: A novel avenue for Alzheimer's disease
by Bhounsule, Anisha S and Bhatt, Lokesh Kumar and Prabhavalkar, Kedar S and Oza, Manisha
Brain Research Bulletin, ISSN 0361-9230, 06/2017, Volume 132, pp. 28 - 38
Alzheimer's disease (AD) is one of the most frequently encountered diseases in adults with progressive loss of memory and behavioral changes. Inspite of there... 
Deregulation | Neurofibrillary tangles | Cdk5 | Alzheimer's disease | Amyloid precursor protein | OXIDATIVE STRESS | AXONAL-TRANSPORT | CDK5 ACTIVITY | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CASCADE RELEVANCE | MITOCHONDRIAL FISSION | S-NITROSYLATION | A-BETA-PRODUCTION | Alzheimer Disease - drug therapy | Animals | Alzheimer Disease - enzymology | Humans | Cyclin-Dependent Kinase 5 - metabolism | Proline | Drug discovery | Amyloid beta-protein | Target marketing
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5. Full Text Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis
by Liebl, Johanna and Weitensteiner, Sabine B and Vereb, György and Takács, Lili and Fürst, Robert and Vollmar, Angelika M and Zahler, Stefan
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 46, pp. 35932 - 35943
Angiogenesis contributes to various pathological conditions. Due to the resistance against existing antiangiogenic therapy, an urgent need exists to understand... 
NEURONAL MIGRATION | ROSCOVITINE | METASTASIS | CDK5 | PHOSPHORYLATION | ACTIN POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL ADHESION KINASE | RHO-GTPASES | CANCER | RAC1 ACTIVITY | Neovascularization, Physiologic - drug effects | Humans | Cell Movement - physiology | Cyclin-Dependent Kinase 5 - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Microtubules - metabolism | RNA Interference | Chorioallantoic Membrane - drug effects | Female | Phosphorylation - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Chorioallantoic Membrane - blood supply | Purines - pharmacology | Mice, Inbred C57BL | Umbilical Cord - enzymology | Cells, Cultured | Cell Adhesion | Chick Embryo | Serine - metabolism | Blotting, Western | Cyclin-Dependent Kinase 5 - metabolism | Cell Movement - drug effects | Microscopy, Confocal | Neovascularization, Physiologic - physiology | Cyclin-Dependent Kinase 5 - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | Mice | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | CDK (Cyclin-dependent Kinase) | Protein Kinases | Signal Transduction | Tumor Therapy | Cell Motility | Rho | Cytoskeleton | Confocal Microscopy | Chemotaxis | Cell Biology | Endothelium
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6. Full Text Steered Molecular Dynamics Simulations for Studying Protein–Ligand Interaction in Cyclin-Dependent Kinase 5
by Patel, Jagdish Suresh and Berteotti, Anna and Ronsisvalle, Simone and Rocchia, Walter and Cavalli, Andrea
Journal of Chemical Information and Modeling, ISSN 1549-9596, 02/2014, Volume 54, Issue 2, pp. 470 - 480
In this study, we applied steered molecular dynamics (SMD) simulations to investigate the unbinding mechanism of nine inhibitors of the enzyme cyclin-dependent... 
CHEMISTRY, MEDICINAL | MECHANISM | BINDING AFFINITIES | DOCKING | DRUG DESIGN | COMPUTER SCIENCE, INFORMATION SYSTEMS | ATOMISTIC SIMULATIONS | FREE-ENERGIES | TAU-PHOSPHORYLATION | CHEMISTRY, MULTIDISCIPLINARY | AQUAGLYCEROPORIN GLPF | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | FORCE-FIELD | INHIBITORS | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - antagonists & inhibitors | Inhibitory Concentration 50 | Protein Binding | Ligands | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Molecular Dynamics Simulation | Cyclin-Dependent Kinase 5 - metabolism | Protein Kinase Inhibitors - metabolism
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7. Full Text Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
by Hawasli, Ammar H and Benavides, David R and Nguyen, Chan and Kansy, Janice W and Hayashi, Kanehiro and Chambon, Pierre and Greengard, Paul and Powell, Craig M and Cooper, Donald C and Bibb, James A
Nature Neuroscience, ISSN 1097-6256, 07/2007, Volume 10, Issue 7, pp. 880 - 886
Learning is accompanied by modulation of postsynaptic signal transduction pathways in neurons. Although the neuronal protein kinase cyclin-dependent kinase 5... 
MEMORY | CALPAIN | NR2B SUBUNIT | LONG-TERM-POTENTIATION | NEURONS | RECEPTOR | MICE | CDK5 ACTIVITY | RAT-BRAIN | EXPRESSION | NEUROSCIENCES | Synapses - drug effects | Receptors, N-Methyl-D-Aspartate - drug effects | Immunoprecipitation | Learning - drug effects | Synapses - physiology | Neuronal Plasticity - drug effects | Male | Hippocampus - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Excitatory Postsynaptic Potentials - drug effects | Receptors, N-Methyl-D-Aspartate - physiology | Blotting, Western | Brain Chemistry - physiology | Mice, Knockout | Learning - physiology | Animals | Neuronal Plasticity - physiology | Cyclin-Dependent Kinase 5 - physiology | Mice | Hippocampus - physiology | Brain Chemistry - genetics | Neuroplasticity | Control | Physiological aspects | Cyclic adenylic acid | Research | Protein kinases | Motor learning | Neurotransmitter receptors | Biochemistry, Molecular Biology | Receptors, N-Methyl-D-Aspartate | Cyclin-Dependent Kinase 5 | Learning | Life Sciences | Neuronal Plasticity | Excitatory Postsynaptic Potentials | Brain Chemistry | Molecular biology | Synapses | Hippocampus
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8. Full Text Cyclin‐Dependent kinase 5 targeting prevents β‐Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases
by Castro‐Alvarez, John Fredy and Uribe‐Arias, Alejandro and Cardona‐Gómez, Gloria Patricia
Journal of Neuroscience Research, ISSN 0360-4012, 08/2015, Volume 93, Issue 8, pp. 1258 - 1266
Inappropriate activation of cyclin‐dependent kinase 5 (CDK5) resulting from proteolytic release of the activator fragment p25 from the membrane contributes to... 
β‐amyloid plaques | PP2A | GSK3β Ser9 | Alzheimer's disease | CDK5 RNAi | β-amyloid plaques | TAU-PROTEIN | ABNORMAL HYPERPHOSPHORYLATION | PHOSPHORYLATION | ALZHEIMERS-DISEASE | NEUROSCIENCES | GSK3 beta Ser9 | beta-amyloid plaques | PROTEIN PHOSPHATASES | CDK5 | A-BETA | NEUROFIBRILLARY DEGENERATION | MICE | Gene Targeting - methods | Phosphoric Monoester Hydrolases - genetics | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Mice, Transgenic | Glycogen Synthase Kinase 3 - metabolism | Cyclin-Dependent Kinase 5 - metabolism | Cyclin-Dependent Kinase 5 - genetics | Amyloid beta-Peptides - antagonists & inhibitors | Cyclin-Dependent Kinase 5 - antagonists & inhibitors | Animals | Glycogen Synthase Kinase 3 - genetics | Amyloid beta-Peptides - genetics | Protein Aggregation, Pathological - prevention & control | Amyloid beta-Peptides - metabolism | Mice | Phosphoric Monoester Hydrolases - metabolism | Protein Aggregation, Pathological - genetics | Protein Aggregation, Pathological - metabolism | Phosphoric Monoester Hydrolases - antagonists & inhibitors
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9. Full Text Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach
by Ehrlich, Sandra M and Liebl, Johanna and Ardelt, Maximilian A and Lehr, Thorsten and De Toni, Enrico N and Mayr, Doris and Brandl, Lydia and Kirchner, Thomas and Zahler, Stefan and Gerbes, Alexander L and Vollmar, Angelika M
Journal of Hepatology, ISSN 0168-8278, 2015, Volume 63, Issue 1, pp. 102 - 113
Background & Aims For a long time cyclin dependent kinase 5 (Cdk5) was thought to be exclusively important in neuronal cells. However, increasing evidence... 
Gastroenterology and Hepatology | Roscovitine | HCC | Cdk5 | Chemosensitization | DNA damage | Sn38 | CELLS | MULTICENTER | DNA-DAMAGE | FLUOROURACIL | METASTATIC COLORECTAL-CANCER | NUCLEAR-LOCALIZATION | COMBINATION CHEMOTHERAPY | IRINOTECAN | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | Camptothecin - therapeutic use | Liver Neoplasms - genetics | Cyclin-Dependent Kinase 5 - drug effects | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms - drug therapy | Treatment Outcome | Antineoplastic Agents - therapeutic use | Mice, SCID | Cyclin-Dependent Kinase 5 - genetics | Animals | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | RNA, Neoplasm - genetics | Female | Mice | Purines - therapeutic use | Cyclin-Dependent Kinase 5 - biosynthesis | Cyclin-Dependent Kinases - antagonists & inhibitors | Camptothecin - analogs & derivatives | Carcinoma, Hepatocellular - metabolism | Development and progression | Health aspects | Hepatoma
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10. Full Text Discovery of 8‑Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3‑d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)
by Reddy, M. V. Ramana and Akula, Balireddy and Cosenza, Stephen C and Athuluridivakar, Saikrishna and Mallireddigari, Muralidhar R and Pallela, Venkat R and Billa, Vinay K and Subbaiah, D. R. C. Venkata and Bharathi, E. Vijaya and Vasquez-Del Carpio, Rodrigo and Padgaonkar, Amol and Baker, Stacey J and Reddy, E. Premkumar
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 578 - 599
The success of imatinib, a BCR-ABL inhibitor for the treatment of chronic myelogenous leukemia, has created a great impetus for the development of additional... 
G ARREST | TUMOR INVASION | IN-VITRO | DESIGN | CHEMISTRY, MEDICINAL | BIOLOGICAL EVALUATION | CELL-CYCLE | PHARMACOLOGICAL INHIBITION | PD 0332991 | PHASE-I | CANCER | Neoplasm Transplantation | Apoptosis - drug effects | Pyridines - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Repressor Proteins - antagonists & inhibitors | Heterografts | Female | Antineoplastic Agents - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Pyridines - chemical synthesis | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Animals | Protein Kinases | Mice, Nude | Cell Line, Tumor | Mice | Molecular Docking Simulation | Pyridines - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Index Medicus
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11. Full Text Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B
by Xing, Bao-Ming and Yang, Yan-Rui and Du, Jun-Xia and Chen, Hai-Jing and Qi, Cai and Huang, Zhi-Hua and Zhang, Ying and Wang, Yun
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 42, pp. 14709 - 14721
The number of functional transient receptor potential vanilloid 1 (TRPV1) channels at the surface, especially at the peripheral terminals of primary sensory... 
CAPSAICIN RECEPTOR | TRANSPORT | ACTIVATED ION-CHANNEL | PROTEIN | ROOT GANGLION NEURONS | PHOSPHORYLATION | HYPERALGESIA | PRIMARY SENSORY NEURONS | FHA DOMAIN | NEUROSCIENCES | CELL-LINE | Animals, Newborn | Protein Structure, Tertiary | Pain Threshold - physiology | Cricetinae | Phosphorylation | Cricetulus | Hot Temperature - adverse effects | Membrane Glycoproteins - metabolism | Cells, Cultured | Rats | Male | Protein Transport - physiology | Threonine - metabolism | Rats, Sprague-Dawley | TRPV Cation Channels - metabolism | Animals | TRPV Cation Channels - antagonists & inhibitors | Cell Line, Tumor | Cyclin-Dependent Kinase 5 - physiology | Kinesin - physiology | Nociceptors - metabolism | CHO Cells | Protein Binding - physiology
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12. Full Text The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons
by Lee, Juhyung and Ko, Yeon Uk and Chung, Yuhyun and Yun, Nuri and Kim, Myungjin and Kim, Kyungjin and Oh, Young J
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 13676 - 19
Cyclin-dependent kinase 5 (CDK5) plays a pivotal role in neural development and neurodegeneration. CDK5 activity can be regulated by posttranslational... 
S-NITROSYLATION | NERVOUS-SYSTEM | RETINOIC ACID | CDK5 | NEUROTROPHIC FACTOR | BDNF TRANSCRIPTION | MULTIDISCIPLINARY SCIENCES | DEACETYLASE SIRT1 | TRANSCRIPTION FACTOR | NEURODEGENERATIVE DISEASES | CEREBRAL-CORTEX | Phosphorylation | Transcription | Axonogenesis | Gene regulation | Cyclin-dependent kinases | Fetuses | Kinases | SIRT1 protein | Embryos | Cyclin-dependent kinase 5 | Cyclin-dependent kinase | Brain-derived neurotrophic factor | Deacetylation | Neurodegeneration | Lysine | Acetylation | Hippocampus
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13. Full Text Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons
by Bianchetta, Michael J and Lam, TuKiet T and Jones, Stephen N and Morabito, Maria A
Journal of Neuroscience, ISSN 0270-6474, 08/2011, Volume 31, Issue 33, pp. 12029 - 12035
Cyclin-dependent kinase 5 (Cdk5) and its activator p35 have been implicated in drug addiction, neurodegenerative diseases such as Alzheimer's, learning and... 
GLUTAMATE RECEPTORS | NMDA RECEPTORS | CDK5 | MAGUK SCAFFOLDING PROTEINS | SURFACE EXPRESSION | TRAFFICKING | DEGRADATION | MICE | ENDOCYTOSIS | SYNAPTIC PLASTICITY | NEUROSCIENCES | Disks Large Homolog 4 Protein | Male | Mice, Knockout | Protein Interaction Mapping | Hippocampus - metabolism | Animals | Neurons - enzymology | Guanylate Kinases - metabolism | Cyclin-Dependent Kinase 5 - physiology | Female | Hippocampus - enzymology | Membrane Proteins - metabolism | Mice | Neurons - metabolism | Ubiquitination - physiology | Organ Culture Techniques
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14. Full Text Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors
by Boulahjar, Rajâa and Ouach, Aziz and Bourg, Stéphane and Bonnet, Pascal and Lozach, Olivier and Meijer, Laurent and Guguen-Guillouzo, Christiane and Le Guevel, Rémy and Lazar, Saïd and Akssira, Mohamed and Troin, Yves and Guillaumet, Gérald and Routier, Sylvain
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2015, Volume 101, pp. 274 - 287
An efficient synthetic strategy was developed to modulate the structure of the tetrahydropyridine isoindolone (Valmerin) skeleton. A library of more than 30... 
Pyridoisoindolone | Valmerin | In vitro assays | CDK5 | GSK3 | Kinase research | In vitro assays | THERAPEUTICS | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | PYRIDINE | DYRK1A | CDK INHIBITORS | NEUROINFLAMMATION | BIOLOGICAL EVALUATION | CYTOTOXIC AGENTS | CDK5/P25 | DERIVATIVES | Isoindoles - chemistry | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Humans | Models, Molecular | Isoindoles - chemical synthesis | Structure-Activity Relationship | Glycogen Synthase Kinase 3 - metabolism | Piperidines - chemical synthesis | Cyclin-Dependent Kinase 5 - metabolism | Dose-Response Relationship, Drug | Cyclin-Dependent Kinase 5 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Piperidines - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Isoindoles - pharmacology | Glycogen | Synthesis | Analysis | Medicinal Chemistry | Life Sciences | Chemical Sciences | Cancer
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15. Full Text Regulation of androgen receptor and prostate cancer growth by cyclin-dependent kinase 5
by Hsu, Fu-Ning and Chen, Mei-Chih and Chiang, Ming-Ching and Lin, Eugene and Lee, Yueh-Tsung and Huang, Pao-Hsuan and Lee, Guan-Shun and Lin, Ho
Journal of Biological Chemistry, ISSN 0021-9258, 09/2011, Volume 286, Issue 38, pp. 33141 - 33149
Prostate cancer is the most frequently diagnosed male malignancy. The normal prostate development and prostate cancer progression are mediated by androgen... 
CELLS | TRANSCRIPTIONAL ACTIVITY | ACTIVATION | PROTEIN | CDK5 | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | NEURODEGENERATION | PHOSPHORYLATION SITES | SIGNAL TRANSDUCER | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Phosphorylation | Transcriptional Activation - genetics | Cell Proliferation | Humans | Receptors, Androgen - metabolism | Male | Phosphoserine - metabolism | Cyclin-Dependent Kinase 5 - metabolism | Animals | Receptors, Androgen - genetics | Models, Biological | Cell Line, Tumor | Mice | Protein Processing, Post-Translational | Protein Stability | Protein Translocation | Androgen Receptor | p35 | Signal Transduction | Cdk5 | Prostate Cancer | Protein Phosphorylation | Serine Threonine Protein Kinase | Protein Degradation | Protein-Protein Interactions
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