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Nature (London), ISSN 1476-4687, 2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 08/2015, Volume 93, Issue 8, pp. 1258 - 1266
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4908 - 4927
...), lacking 102 residues at the N terminus, can be purified in soluble form and is phosphorylated by cyclin-dependent kinase 5 (CDK5... 
NMDA RECEPTOR | DOMAIN | STIMULATION | INHIBITION | CALPAIN | CLONING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | HIPPOCAMPAL-NEURONS | PLASTICITY | Oncogene Proteins - genetics | ras Proteins - genetics | Phosphorylation | ras GTPase-Activating Proteins - chemistry | rap1 GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | ras Proteins - metabolism | Neurons - cytology | GTPase-Activating Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - genetics | ras GTPase-Activating Proteins - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | ras Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | rap1 GTP-Binding Proteins - metabolism | ras GTPase-Activating Proteins - metabolism | Oncogene Proteins - chemistry | Cells, Cultured | Oncogene Proteins - metabolism | Rats | Synapses - enzymology | GTPase-Activating Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Neurons - enzymology | GTPase-Activating Proteins - genetics | rap1 GTP-Binding Proteins - genetics | rap GTP-Binding Proteins | Ras Protein | Ras-related Protein 1 (Rap1) | Postsynaptic Density | Ca2 | Synaptic Plasticity | Small GTPase | Neurobiology | Mass Spectrometry (MS) | Cyclin-dependent Kinase 5 (CDK5) | Protein Kinase | Calmodulin-dependent Protein Kinase II (CaMKII) | Synaptic GTPase-activating Protein (synGAP)
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 13, pp. 3370 - 3378
.... The involvement of various kinases in Abeta-mediated inhibition of LTP induction was investigated by applying Abeta in the presence of inhibitors of these kinases... 
Metabotropic glutamate receptors | Cdk5 | JNK | LTP | Amyloid β-protein | Alzheimer's disease | p38 MAPK | Hippocampus | NEURONAL APOPTOSIS | hippocampus | ALZHEIMERS-DISEASE | MAP KINASE | metabotropic glutamate receptors | amyloid beta-protein | SYNAPTIC PLASTICITY | FREQUENCY STIMULATION | AREA CA1 | NEUROSCIENCES | IN-VITRO | PATHWAY | MICE | PRECURSOR PROTEIN | Receptors, Metabotropic Glutamate - drug effects | Cyclin-Dependent Kinases - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Ovary - cytology | Excitatory Postsynaptic Potentials - drug effects | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | JNK Mitogen-Activated Protein Kinases | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Female | Electric Stimulation - methods | Peptide Fragments - genetics | p38 Mitogen-Activated Protein Kinases | CHO Cells | Ovary - metabolism | Cricetinae | Enzyme Inhibitors - pharmacology | Peptide Fragments - secretion | Rats | Excitatory Amino Acid Antagonists - pharmacology | Cyclin-Dependent Kinase 5 | Animals | Ovary - secretion | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Plasticity | Development | amyloid β-protein | Repair
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 09/2012, Volume 23, Issue 18, pp. 3722 - 3730
.... The MEK-ERK pathway regulates CRNA by elevating the levels of cyclin D1. The increase in cyclin D1 attenuates the activation of cyclin-dependent kinase 5 (cdk5... 
SURVIVAL | NEUROFIBRILLARY TANGLES | POSTMITOTIC NEURONS | CDK5 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | SYMPATHETIC NEURONS | NEURODEGENERATION | DEATH | DNA-REPLICATION | CELL BIOLOGY | Cell Cycle - genetics | Cyclin D1 - metabolism | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Apoptosis - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Apoptosis - genetics | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Cyclin-Dependent Kinase 5 - genetics | MAP Kinase Signaling System - genetics | RNA Interference | HEK293 Cells | Cell Cycle Proteins - genetics | Neurons - metabolism | Neurons - drug effects | Butadienes - pharmacology | Cell Cycle Proteins - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Blotting, Western | Cyclin-Dependent Kinase 5 - metabolism | Animals | MAP Kinase Signaling System - drug effects | Cyclin D1 - genetics | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Cell Cycle - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle - drug effects | Microscopy, Fluorescence | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Biochimica et biophysica acta. Molecular cell research, ISSN 0167-4889, 2007, Volume 1773, Issue 8, pp. 1311 - 1340
Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit many of the responses that are evoked in cells by changes in certain... 
Mkk1 | Ssk2 | Signal propagation | Mkk2 | Yeast | Budding yeast | Kss1 | Ste20 | Signaling fidelity | Pheromone response | Filamentous growth response | Smk1 | MAPKK | MAPKKKK | Hyperosmotic stress response | Signal transduction mechanisms | Ste7 | Pbs2 | Baker's yeast | Mitogen_activated protein kinase kinase kinase kinase | Bck1 | p21_activated protein kinase | Snf1 | Meiosis and sporulation | Spatial and temporal regulation | Ste11 | Tpk3 | Tpk2 | Tpk1 | Mitogen_activated protein kinase kinase | PKA | Cell wall integrity | 5′_AMP_activated protein kinase | MAPK | Ssk22 | Pkc1 | Fus3 | Mitogen_activated protein kinase | MAPKKK | Signaling | Hog1 | Mpk1/Slt2 | 3′,5′_cyclic AMP_dependent protein kinase | Mitogen_activated protein kinase kinase kinase | AMPK | PAK | Saccharomyces cerevisiae | CELL-WALL INTEGRITY | filamentous growth response | hyperosmotic stress response | CELL BIOLOGY | P21_activated protein kinase | KELCH-REPEAT PROTEINS | mitogen_activated protein kinase kinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | signaling fidelity | CYCLIN-DEPENDENT KINASE | yeast | MITOGEN-ACTIVATED PROTEIN | G-BETA-GAMMA | PHEROMONE RESPONSE PATHWAY | cell wall integrity | DUAL-SPECIFICITY PHOSPHATASE | 5'_AMP_activated protein kinase | mitogen_activated protein kinase kinase kinase kinase | budding yeast | signaling | 3',5'_cyclic AMP_dependent protein kinase | signal transduction mechanisms | HIGH-AFFINITY INTERACTION | spatial and temporal regulation | NUCLEOTIDE EXCHANGE FACTOR | meiosis and sporulation | SPORULATION-SPECIFIC GENES | signal propagation | mitogen_activated protein kinase kinase kinase | pheromone response | mitogen_activated protein kinase | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | MAP Kinase Signaling System - physiology | Protein Biosynthesis | Cell Cycle | Models, Biological | Saccharomyces cerevisiae - genetics | Transcription, Genetic | Enzyme Activation | Saccharomyces cerevisiae - growth & development | Protein kinases
Journal Article