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Journal Article
Cancer Research, ISSN 0008-5472, 08/2007, Volume 67, Issue 15, pp. 7406 - 7420
This study is the first to investigate the anticancer effect of isoobtusilactone A (IOA) in two human breast cancer cell lines, MCF-7 and MDA-MB-231. IOA... 
INHIBITS APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | REACTIVE OXYGEN | THERAPY | ONCOLOGY | THIOREDOXIN | ASK1 | REGULATING KINASE-1 | DEATH | FACTOR RECEPTOR | Immunoprecipitation | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Cyclin B1 | Lactones - pharmacology | Breast Neoplasms - metabolism | CDC2 Protein Kinase - metabolism | Caspases - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinase 5 - metabolism | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | MAP Kinase Kinase Kinase 5 - genetics | Cyclin A - metabolism | Cytochromes c - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Alkanes - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Antioxidants - pharmacology | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Breast Neoplasms - pathology | Mice, Nude | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Cyclin B - metabolism | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Cell Cycle - drug effects | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4908 - 4927
synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the... 
NMDA RECEPTOR | DOMAIN | STIMULATION | INHIBITION | CALPAIN | CLONING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | HIPPOCAMPAL-NEURONS | PLASTICITY | Oncogene Proteins - genetics | ras Proteins - genetics | Phosphorylation | ras GTPase-Activating Proteins - chemistry | rap1 GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | ras Proteins - metabolism | Neurons - cytology | GTPase-Activating Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - genetics | ras GTPase-Activating Proteins - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | ras Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | rap1 GTP-Binding Proteins - metabolism | ras GTPase-Activating Proteins - metabolism | Oncogene Proteins - chemistry | Cells, Cultured | Oncogene Proteins - metabolism | Rats | Synapses - enzymology | GTPase-Activating Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Neurons - enzymology | GTPase-Activating Proteins - genetics | rap1 GTP-Binding Proteins - genetics | rap GTP-Binding Proteins | Index Medicus | Ras Protein | Ras-related Protein 1 (Rap1) | Postsynaptic Density | Ca2 | Synaptic Plasticity | Small GTPase | Neurobiology | Mass Spectrometry (MS) | Cyclin-dependent Kinase 5 (CDK5) | Protein Kinase | Calmodulin-dependent Protein Kinase II (CaMKII) | Synaptic GTPase-activating Protein (synGAP)
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15556 - 15570
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 09/2012, Volume 23, Issue 18, pp. 3722 - 3730
In response to neurotoxic signals, postmitotic neurons make attempts to reenter the cell cycle, which results in their death. Although several cell cycle... 
SURVIVAL | NEUROFIBRILLARY TANGLES | POSTMITOTIC NEURONS | CDK5 | ALZHEIMERS-DISEASE | PROTEIN-KINASE | SYMPATHETIC NEURONS | NEURODEGENERATION | DEATH | DNA-REPLICATION | CELL BIOLOGY | Cell Cycle - genetics | Cyclin D1 - metabolism | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Apoptosis - drug effects | Amyloid beta-Peptides - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Apoptosis - genetics | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Cyclin-Dependent Kinase 5 - genetics | MAP Kinase Signaling System - genetics | RNA Interference | HEK293 Cells | Cell Cycle Proteins - genetics | Neurons - metabolism | Neurons - drug effects | Butadienes - pharmacology | Cell Cycle Proteins - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Blotting, Western | Cyclin-Dependent Kinase 5 - metabolism | Animals | MAP Kinase Signaling System - drug effects | Cyclin D1 - genetics | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Cell Cycle - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Cell Cycle - drug effects | Microscopy, Fluorescence | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2008, Volume 28, Issue 10, pp. 2624 - 2632
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e64946 - e64946