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Molecular cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 2, pp. 193 - 208
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 09/2019, Volume 116, Issue 36, pp. 17990 - 18000
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Cyclin-Dependent Kinase 4 - genetics | Humans | Protein-Arginine N-Methyltransferases - antagonists & inhibitors | Drug Resistance, Neoplasm | Tumor Suppressor Protein p53 - genetics | MCF-7 Cells | Melanoma - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Protein-Arginine N-Methyltransferases - genetics | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Cell Cycle Proteins - metabolism | Cyclin-Dependent Kinase 6 - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase 2 - genetics | Proto-Oncogene Proteins - genetics | Cyclin-Dependent Kinase 6 - metabolism | Melanoma - pathology | Cyclin-Dependent Kinase 4 - metabolism | Piperazines - pharmacology | Protein-Arginine N-Methyltransferases - metabolism | Melanoma - drug therapy | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | RNA | Tumor proteins | Analysis | Melanoma | GTP-binding protein | p53 Protein | Estrogens | Menopause | mRNA | Kinases | Cyclin-dependent kinase 4 | Proteins | Cell activation | Pancreatic carcinoma | Arginine | Inhibition | Pancreas | Esophageal carcinoma | Splicing | Cyclin-dependent kinases | Protein arginine methyltransferase | Breast cancer | Esophagus | Cyclin-dependent kinase 2 | Sensitivity | Inhibitors | Tumor suppressor genes | Tumors | Index Medicus | Biological Sciences | PRMT5 | PNAS Plus | CDK4 | MDM4 | acquired resistance | p53
Journal Article
Journal Article
The lancet oncology, ISSN 1470-2045, 01/2015, Volume 16, Issue 1, pp. 25 - 35
Summary Background Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs... 
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Triazoles - administration & dosage | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptors, Estrogen - analysis | Molecular Targeted Therapy | North America | Nitriles - administration & dosage | Breast Neoplasms - enzymology | Time Factors | Postmenopause | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Republic of Korea | Aromatase Inhibitors - administration & dosage | Pyridines - administration & dosage | Drug Administration Schedule | Administration, Oral | Biomarkers, Tumor - analysis | Europe | Proportional Hazards Models | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Treatment Outcome | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Breast Neoplasms - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Breast Neoplasms - genetics | Cyclin D1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Intention to Treat Analysis | South Africa | Aged | Biomarkers, Tumor - genetics | Receptor, ErbB-2 - analysis | Antimitotic agents | Care and treatment | Oncology, Experimental | Estrogen | Breast cancer | Research | Antineoplastic agents | Phosphotransferases | Cancer | Index Medicus
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 04/2017, Volume 486, Issue 2, pp. 385 - 390
TEA domain transcription factor 4 (TEAD4), which has critical functions in the process of embryonic development, is expressed in various cancers. However, the... 
TEA domain transcription factor 4 | Human oral squamous cell carcinoma | Yes-associated protein (YAP) | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Male | Cyclin E - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Muscle Proteins - antagonists & inhibitors | Transcription, Genetic | Mouth Neoplasms - genetics | Cyclin-Dependent Kinase 2 - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Muscle Proteins - genetics | Cell Nucleus - genetics | Cyclin D1 - genetics | Mouth Neoplasms - surgery | Cell Line, Tumor | RNA, Small Interfering - metabolism | Cyclin D1 - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Cyclin-Dependent Kinase 4 - genetics | Gene Expression Regulation, Neoplastic | Carcinoma, Squamous Cell - surgery | Mouth Neoplasms - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Muscle Proteins - metabolism | G1 Phase Cell Cycle Checkpoints | Female | Cyclin-Dependent Kinase 6 - genetics | Transcription Factors - antagonists & inhibitors | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mouth Neoplasms - pathology | Aged | Cyclin E - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Immunohistochemistry | Medical colleges | Embryonic development | Squamous cell carcinoma | Growth | Analysis | DNA polymerases | Genetic transcription | Health aspects | Development and progression | Index Medicus | TRANSCRIPTION FACTORS | CHAIN REACTIONS | BIOLOGICAL MARKERS | CELL PROLIFERATION | CELL CYCLE | INTERACTIONS | 60 APPLIED LIFE SCIENCES | PLANT GROWTH
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 12/2017, Volume 66, Issue 6, pp. 1952 - 1967
Journal Article
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 09/2012, Volume 16, Issue 9, pp. 2208 - 2218
Cells derived from the amniotic foetal membrane of human term placenta have drawn particular attention mainly for their plasticity and immunological... 
placenta | mesenchymal stem/stromal cells | cancer cell lines | cell proliferation | amniotic membrane | amnion‐derived cells | Cell proliferation | Amniotic membrane | Placenta | Amnion-derived cells | Cancer cell lines | Mesenchymal stem/stromal cells | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Cyclin D2 - genetics | Oncogene Proteins - genetics | Up-Regulation | Cyclin D2 - metabolism | Coculture Techniques | Cyclin-Dependent Kinase 4 - genetics | Humans | G1 Phase - drug effects | RNA, Messenger - metabolism | Cyclin E - genetics | Amnion - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | U937 Cells | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Amnion - cytology | Down-Regulation | RNA, Messenger - genetics | Cyclin-Dependent Kinase 6 - genetics | Oncogene Proteins - metabolism | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Cell Division - drug effects | Cyclin H - metabolism | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Cyclin E - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | HeLa Cells | Cyclin H - genetics | RNA | Dendritic cells | Oncology, Experimental | Cell cycle | Stem cells | Research | Gene expression | Cancer | Biotechnology | Mesenchyme | Leukemia | Metastasis | Kinases | Experiments | Cyclin-dependent kinase 4 | Cyclin D2 | Cell growth | Immunology | Lymphocytes | Penicillin | Fibroblasts | G1 phase | Therapeutic applications | Tumor cell lines | Cyclins | Cyclin-dependent kinase 2 | Studies | Monocytes | Biopsy | S phase | Lymphomas | Apoptosis | Tumors | Index Medicus | amnion-derived cells | mesenchymal stem | stromal cells | Original
Journal Article
Nature (London), ISSN 1476-4687, 08/2017, Volume 548, Issue 7668, pp. 471 - 475
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies(1,2... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Viruses - genetics | Breast Neoplasms - immunology | Humans | Transcriptome | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - cytology | Female | Biological Mimicry - drug effects | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Disease Models, Animal | Viruses - drug effects | Viruses - immunology | Antigen Presentation - immunology | Breast Neoplasms - drug therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Breast Neoplasms - genetics | Repressor Proteins - biosynthesis | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | RNA, Double-Stranded - genetics | Cell Line, Tumor | Interferons - metabolism | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Cancer cells | Physiological aspects | Research | Protein kinases | Immunity | Cyclins | Cancer | Cell proliferation | Flow cytometry | Animal models | Phosphorylation | Senescence | Peptides | Genomics | Immune clearance | Cytotoxicity | Lymphocytes T | Genomes | Kinases | Cancer therapies | Cyclin-dependent kinase 4 | E2F protein | Breast carcinoma | Cell growth | Lymphocytes | New combinations | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Medical research | Immune response | Immunoregulation | Intracellular levels | Double-stranded RNA | Breast cancer | Pharmacology | Gene expression | Ribonucleic acid--RNA | Inhibitors | Immune checkpoint | Immunogenicity | DNA methyltransferase | Interferon | Retinoblastoma | Tumors | Apoptosis | Index Medicus
Journal Article