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Nature (London), ISSN 1476-4687, 02/2010, Volume 464, Issue 7287, pp. 409 - 412
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12655 - 12660
.... In this nucleoprotein complex, CTIP2 significantly represses the Cdk9 kinase activity of P-TEFb. Accordingly, we show that CTIP2 inhibits large sets of P-TEFb-and 7SK snRNA-sensitive genes... 
T lymphocytes | Pathology | RNA | HEK293 cells | Genes | Cell lines | Antibodies | Small nuclear RNA | Gene expression regulation | HIV 1 | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Binding Proteins - genetics | Humans | Myosin Heavy Chains - genetics | Cardiomegaly - pathology | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Myosin Heavy Chains - metabolism | RNA, Small Nuclear - genetics | Tumor Suppressor Proteins - genetics | HEK293 Cells | Cardiac Myosins - metabolism | Repressor Proteins - metabolism | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Cyclin-Dependent Kinase 9 - genetics | Cardiac Myosins - genetics | Repressor Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Cyclin-Dependent Kinase 9 - metabolism | Mice | RNA, Small Nuclear - metabolism | Cardiomegaly - genetics | RNA-Binding Proteins - metabolism | Cardiomegaly - metabolism | Physiological aspects | Transcription factors | Genetic aspects | Heart enlargement | Health aspects | Myosin | Proteins | Heart | Acquired immune deficiency syndrome--AIDS | Ribonucleic acid--RNA | Cancer | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33742 - e33742
Background: N-butylidenephthalide (BP) exhibits antitumor effect in a variety of cancer cell lines. The objective of this study was to obtain additional... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Male | Transplantation, Heterologous | Endoribonucleases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 9 - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Prostatic Neoplasms | RNA Interference | Phthalic Anhydrides - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | G1 Phase Cell Cycle Checkpoints | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Protein-Serine-Threonine Kinases - genetics | Transcription Factor CHOP - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice, Inbred NOD | Mice | Transcription Factor CHOP - metabolism | RNA, Small Interfering - metabolism | Proteins | Gene expression | Prostate cancer | Cancer cells | Apoptosis | Biotechnology | Transcription factors | Toxicity | Genes | Clinical trials | Cytotoxicity | Kinases | Cancer therapies | Blockage | Anticancer properties | Buddhism | Rodents | Xenografts | Cell cycle | Oxidation | Drug dosages | G1 phase | Stresses | Medical research | Mortality | JNK protein | siRNA | Tumor cell lines | Stress | Signaling | Androgens | Chemotherapy | DNA microarrays | Cell death | Protein synthesis | Cyclin-dependent kinase inhibitor p27 | Antitumor activity | Gene therapy | Endoplasmic reticulum | Viability | Prostate | CHOP protein | Cancer | Index Medicus
Journal Article
Journal Article
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 11/2012, Volume 84, Issue 4, pp. e507 - e514
.... This preclinical study evaluated the efficacy of a new-generation cyclin-dependent kinase (Cdk) inhibitor, AZD5438, as a radiosensitizer in several NSCLC models that are specifically resistant to conventional fractionated RT... 
Radiology | Hematology, Oncology and Palliative Medicine | Oncology | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Carcinoma, Non-Small-Cell Lung - radiotherapy | Humans | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | DNA Breaks, Double-Stranded | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Cyclin-Dependent Kinases - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | CDC2 Protein Kinase - genetics | CDC2 Protein Kinase - antagonists & inhibitors | Cyclin-Dependent Kinase 9 - genetics | Radiation-Sensitizing Agents - pharmacology | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Imidazoles - pharmacology | Pyrimidines - pharmacology | Cell Survival - radiation effects | Radiation Tolerance - drug effects | Xenograft Model Antitumor Assays | Animals | Cell Cycle | Mice, Nude | DNA Repair | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Mice | Apoptosis | Development and progression | Metastasis | Radiotherapy | Lung cancer, Non-small cell | Nuclear radiation | Analysis | Index Medicus | APOPTOSIS | LYMPH NODES | LUNGS | METASTASES | EVALUATION | RADIATION DOSES | IN VIVO | IONIZING RADIATIONS | STRAND BREAKS | IRRADIATION | DNA | IN VITRO | CARCINOMAS | DNA REPAIR | RADIOSENSITIZERS | RADIOLOGY AND NUCLEAR MEDICINE | CELL CYCLE | MICE | RADIOSENSITIVITY | RADIOTHERAPY
Journal Article