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Genes and Development, ISSN 0890-9369, 10/2010, Volume 24, Issue 20, pp. 2303 - 2316
Drosophila contains one (dCDK12) and humans contain two (hCDK12 and hCDK13) proteins that are the closest evolutionary relatives of yeast Ctk1, the catalytic... 
Transcription | C-terminal repeat domain | CTD kinase | RNA polymerase II | P-TEFb | RNA-POLYMERASE-II | RECRUITMENT | COMPLEX | transcription | TERMINAL REPEAT DOMAIN | PHOSPHORYLATION | PROTEIN-KINASE | CYCLIN-DEPENDENT KINASE | DEVELOPMENTAL BIOLOGY | PHOSPHOCTD | CELL BIOLOGY | IN-VIVO | GENETICS & HEREDITY | LARGEST SUBUNIT | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Cyclin T - metabolism | Cyclin-Dependent Kinases - metabolism | Saccharomyces cerevisiae - genetics | Humans | RNA Polymerase II - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Genetic Complementation Test | Recombinant Fusion Proteins - metabolism | CDC2 Protein Kinase - metabolism | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | RNA Interference | Cyclin-Dependent Kinases - genetics | Cell Line | CDC2 Protein Kinase - genetics | Cyclin-Dependent Kinase 9 - genetics | Cyclin T - genetics | Drosophila melanogaster - cytology | Chromosome Mapping | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | Animals | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | RNA Polymerase II - genetics | Cyclin-Dependent Kinase 9 - metabolism | Drosophila Proteins - genetics | HeLa Cells | Mutation | Microscopy, Fluorescence | Saccharomyces cerevisiae - growth & development | Usage | Transcription factors | Drosophila | Physiological aspects | Genetic aspects | Chemical properties | Research | Structure | Brewer's yeast | Phosphotransferases | Fluorescence microscopy | RNA polymerases | Research Paper
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 328 - 337
The Hippo/YAP signaling pathway is a crucial regulator of tissue growth, stem cell activity, and tumorigenesis. However, the mechanism by which YAP controls... 
REGULATOR | COACTIVATOR | ACTIVATION | COMPLEX | CHROMATIN | YORKIE | MEDIATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIZE | CELL | REQUIREMENT | CELL BIOLOGY | Chromatin - metabolism | Mediator Complex - metabolism | Humans | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Cholangiocarcinoma - metabolism | DNA Polymerase II - metabolism | Phosphoproteins - metabolism | Carcinogenesis - metabolism | Piperidines - pharmacology | Transcription, Genetic | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Bile Duct Neoplasms - genetics | DNA Polymerase II - genetics | Intracellular Signaling Peptides and Proteins - genetics | Bile Duct Neoplasms - drug therapy | Chromatin - chemistry | Bile Duct Neoplasms - metabolism | Signal Transduction | Cyclin-Dependent Kinase 9 - genetics | Carcinogenesis - genetics | Mediator Complex - genetics | Mice, Transgenic | Phosphoproteins - genetics | Carcinogenesis - drug effects | Carcinogenesis - pathology | Xenograft Model Antitumor Assays | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - drug therapy | Enhancer Elements, Genetic | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cholangiocarcinoma - genetics | Protein Binding | Cyclin-Dependent Kinase 9 - metabolism | Mice | Bile Duct Neoplasms - pathology | Adaptor Proteins, Signal Transducing - metabolism | Genetic aspects | Genetic transcription | Growth | Analysis | Genomics | Stem cells | Yuan (China) | Chromatin
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2017, Volume 67, Issue 1, pp. 5 - 18.e19
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory... 
transcription elongation | core regulatory circuitry | CRBN | targeted degradation | T-ALL | RNA polymerase II | BRD4 | P-TEFb | RNA-POLYMERASE-II | PAUSE | CELLS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBLON | E3 UBIQUITIN LIGASE | CELL BIOLOGY | Peptide Hydrolases - genetics | Humans | Multiprotein Complexes | RNA Polymerase II - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | Time Factors | Proteolysis | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Protein Stability | Nuclear Proteins - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Peptide Hydrolases - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Cyclin-Dependent Kinase 9 - genetics | Jurkat Cells | HCT116 Cells | Mice, Transgenic | Nuclear Proteins - metabolism | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Transcription Elongation, Genetic - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Mice, Inbred NOD | Cyclin-Dependent Kinase 9 - metabolism | Proteins | Promoters (Genetics) | RNA | Analysis | Leukemia | Genetic transcription | Research institutes | T cells
Journal Article