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Cellular and Molecular Life Sciences, ISSN 1420-682X, 04/2009, Volume 66, Issue 7, pp. 1163 - 1177
Protein kinase inhibitors represent an important and still emerging class of targeted therapeutic agents. Drug discovery and development strategies have... 
Life Sciences | Biochemistry, general | kinase inhibitor | Life Sciences, general | drug discovery | Protein kinase | kinase signaling | Biomedicine general | Cell Biology | Kinase signaling | Drug discovery | Kinase inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | PP60(C-SRC) TYROSINE KINASE | ORAL MEK INHIBITOR | PHASE-II | MONOCLONAL-ANTIBODY | ADVANCED COLORECTAL-CANCER | CELL BIOLOGY | CELL LUNG-CANCER | CYCLIN-DEPENDENT KINASES | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | ATP COMPETITIVE INHIBITORS | Protein Kinases - metabolism | Signal Transduction | Humans | Models, Molecular | Neoplasms - enzymology | Antibodies, Monoclonal - therapeutic use | Neoplasms - blood supply | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Protein Kinase Inhibitors - adverse effects | Antineoplastic Agents - chemistry | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Neoplasms - drug therapy | Protein Kinase Inhibitors - chemistry | Antineoplastic Agents - adverse effects | Protein Kinase Inhibitors - therapeutic use | Angiogenesis Inhibitors - therapeutic use | Molecular Structure | Angiogenesis Inhibitors - adverse effects | Angiogenesis Inhibitors - chemistry | Tyrosine | Care and treatment | Health aspects | Protein kinases | Biopharmaceutics | Cancer | Studies | Kinases | Drug therapy | Molecular biology | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Science, ISSN 0036-8075, 3/2004, Volume 303, Issue 5665, pp. 1800 - 1805
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Organic chemistry | Chemical Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, p. e12214
Predicting off-targets by computational methods is getting increasing importance in early drug discovery stages. We herewith present a computational method... 
F-ACTIN | SMALL-MOLECULE | DATA-BANK | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | PYRIDOXAL KINASE | SYNAPTIC VESICLE PHOSPHOPROTEINS | STRUCTURAL GENOMICS | SILICO PHARMACOLOGY | DEPENDENT MANNER | ATP-BINDING | Computational Biology - methods | Proto-Oncogene Proteins c-pim-1 - chemistry | Humans | Actins - metabolism | Proto-Oncogene Proteins c-pim-1 - metabolism | Models, Molecular | Synapsins - metabolism | Synapsins - chemistry | Staurosporine - metabolism | Animals | Cattle | Proto-Oncogene Proteins c-pim-1 - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Protein Binding - drug effects | Ligands | Protein Conformation | Protein Kinase Inhibitors - pharmacology | Binding Sites | Staurosporine - pharmacology | Protein Kinase Inhibitors - metabolism | Measurement | Heat shock proteins | Drug discovery | Comparative analysis | Muscle proteins | Protein kinases | Protein binding | Synapsin I | Protein kinase A | Cross-reaction | Phosphorylation | Neurosciences | Similarity | Laboratories | Computational neuroscience | Staurosporine | Identification | Kinases | Proteins | Casein | Actin | Target detection | Deoxyribonucleic acid--DNA | DNA topoisomerase (ATP-hydrolysing) | Neurotransmitter release | Cross-reactivity | CHK1 protein | DNA topoisomerase | Protein kinase inhibitors | Muscle contraction | Cyclin-dependent kinase 2 | Studies | Musculoskeletal system | Inhibitors | Algorithms | Computation | Computer applications | Powder injection molding | ATP-binding protein | ATP | Binding sites | Synapsins | Computational Biology | Actins | Adenosine Triphosphate | Proto-Oncogene Proteins c-pim-1 | Life Sciences | Protein Kinase Inhibitors | Protein Binding | Pharmaceutical sciences | Deoxyribonucleic acid | DNA
Journal Article