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Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2016, Volume 12, Issue 10, pp. 876 - 884
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2012, Volume 109, Issue 9, pp. 3287 - 3292
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2010, Volume 9, Issue 8, pp. 2344 - 2353
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2009, Volume 52, Issue 2, pp. 379 - 388
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 14, pp. 3658 - 3670
In order to increase the success rate for developing new Cdc7 inhibitors for cancer therapy, we explored a new chemotype which can comply with the... 
Thieno[3,2-d]pyrimidin-4(3H)-one | Cell division cycle 7 (Cdc7) | Time-dependent Cdc7 inhibition | CELLS | COMPLEX | CHEMISTRY, MEDICINAL | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DNA-REPLICATION | Humans | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Pyrimidinones - chemistry | rho-Associated Kinases - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | rho-Associated Kinases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Inhibitory Concentration 50 | Pyrimidinones - chemical synthesis | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Protein Kinase Inhibitors - pharmacokinetics | Protein Structure, Tertiary | Cyclin-Dependent Kinase 2 - metabolism | Protein Kinase Inhibitors - chemical synthesis | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | rho-Associated Kinases - genetics | Recombinant Proteins - genetics | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Pyrimidinones - pharmacokinetics | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Molecular Docking Simulation | Kinetics | Thiophenes - chemistry | Methyl ether | Cytokinins | Dimethylformamide | Pyridine | Chemical tests and reagents | Dimethyl sulfoxide | Index Medicus
Journal Article
Proteins: Structure, Function and Bioinformatics, ISSN 0887-3585, 08/2009, Volume 76, Issue 3, pp. 731 - 746
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2013, Volume 12, Issue 8, pp. 1442 - 1452
Inhibition of the DNA damage checkpoint kinase WEE1 potentiates genotoxic chemotherapies by abrogating cell-cycle arrest and proper DNA repair. However, WEE1... 
CYCLIN-DEPENDENT KINASES | CANCER-CELLS | DNA-DAMAGING AGENTS | GROWTH-INHIBITION | IN-VITRO | CHK1 | ONCOLOGY | GENOME INTEGRITY | GENE-EXPRESSION | S-PHASE | ANTITUMOR-ACTIVITY | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Antineoplastic Agents - administration & dosage | Gene Knockdown Techniques | Cell Cycle Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Drug Evaluation, Preclinical | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Pyrazoles - pharmacology | DNA Damage - drug effects | Membrane Proteins - genetics | Pyrimidines - administration & dosage | Protein-Serine-Threonine Kinases - genetics | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Pyrazoles - administration & dosage | Animals | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2005, Volume 280, Issue 35, pp. 31208 - 31219
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6769 - 6769
CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and... 
CONTROL GENE CDC2 | COMPLEX | ACTIVATING KINASE | MITOTIC ENTRY | ANAPHASE-PROMOTING COMPLEX/CYCLOSOME | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DRUG DESIGN | DEPENDENT KINASES | P-TEFB | CDC2 Protein Kinase | Humans | Substrate Specificity | Crystallography, X-Ray | Cyclin A - genetics | Cell Cycle Proteins - chemistry | Protein Kinase Inhibitors - chemistry | Cyclin B - genetics | Peptides - chemical synthesis | Cattle | Cell Cycle Proteins - genetics | Conserved Sequence | Carrier Proteins - chemistry | Cyclin-Dependent Kinases - antagonists & inhibitors | Protein Stability | Cyclin-Dependent Kinases - genetics | Binding, Competitive | Protein Structure, Tertiary | Gene Expression | Cyclin-Dependent Kinases - chemistry | Peptides - chemistry | Protein Structure, Secondary | CDC2-CDC28 Kinases - chemistry | Cyclin-Dependent Kinase 2 - genetics | Models, Molecular | Cyclin-Dependent Kinase 2 - chemistry | Recombinant Fusion Proteins - chemistry | Carrier Proteins - genetics | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Cyclin B - chemistry | Kinetics | Adenosine Triphosphate - chemistry | CDC2-CDC28 Kinases - genetics | Cyclin A - chemistry | Cyclin-dependent kinase | Cyclin-dependent kinase 2 | Eukaryotes | Cyclin B | Cyclin A | Cell cycle | Dephosphorylation | Thermal stability | Substrates | Nature conservation | Crystal structure | Cancer | Index Medicus
Journal Article