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Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2016, Volume 22, Issue 1, pp. 78 - 83
Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)(1-6). Clearance of SCs in a progeroid mouse model... 
MEDICINE, RESEARCH & EXPERIMENTAL | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | P16(INK4A) | CELLULAR SENESCENCE | FAMILY | CELL BIOLOGY | POTENT | IN-VIVO | IONIZING-RADIATION | INHIBITOR | EXPRESSION | Whole-Body Irradiation | Apoptosis - drug effects | Humans | bcl-X Protein - genetics | Hematopoietic Stem Cells - pathology | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Gene Knockdown Techniques | Myoblasts - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - drug effects | Cellular Senescence | Ganciclovir - pharmacology | Antineoplastic Agents - pharmacology | Colony-Forming Units Assay | RNA, Messenger - drug effects | Hematopoietic Stem Cells - drug effects | Cell Line | Cell Survival - drug effects | Antiviral Agents - pharmacology | Aniline Compounds - pharmacology | Rejuvenation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Myoblasts - pathology | Sulfonamides - pharmacology | Blotting, Western | B-Lymphocytes - drug effects | Animals | Cell Cycle | Microscopy | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice | DNA Damage | Proto-Oncogene Proteins c-bcl-2 - genetics | Physiological aspects | Aging | Genetic aspects | Research | Hematopoietic stem cells | Cells | Bone marrow | Cytotoxicity | Senescence | Molecular biology | Stem cells | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 374 - 379
Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss... 
BOX PROTEIN SKP2 | TUMOR SUPPRESSION | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PTEN | ACCUMULATION | ONCOGENE-INDUCED SENESCENCE | EXPRESSION | CANCER | P53 | Proto-Oncogene Proteins p21(ras) - genetics | Cellular Senescence - drug effects | Male | Prostate - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Adenovirus E1A Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | PTEN Phosphohydrolase - deficiency | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | PTEN Phosphohydrolase - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Tumor Suppressor Protein p53 - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Adenovirus E1A Proteins - genetics | Prostate - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | S-Phase Kinase-Associated Proteins - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Prevention | Care and treatment | Physiological aspects | Aging | Tumor suppressor genes | Genetic aspects | Research | Cells | Tumors | Cell cycle | Apoptosis | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 2017, Volume 23, Issue 6, pp. 775 - 781
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7437, pp. 361 - 365
Journal Article