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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 05/2003, Volume 23, Issue 5, pp. 795 - 801
OBJECTIVE—We investigated the comparative roles of mitogen-activated protein (MAP) kinases, including c-Jun NH2-terminal kinase (JNK), extracellular... 
Vascular smooth muscle cell | Platelet-derived growth factor | Proliferation | Gene transfer | Gene expression | PATHWAYS | FACTOR-BETA | gene transfer | proliferation | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | platelet-derived growth factor | RAT MODEL | PDGF | DISEASE | PERIPHERAL VASCULAR DISEASE | vascular smooth muscle cell | ACTIVATED PROTEIN-KINASES | C-JUN | HEMATOLOGY | SIGNAL-REGULATED KINASE | gene expression | SMOOTH-MUSCLE CELLS | Mitogen-Activated Protein Kinase Kinases - genetics | Hyperplasia | Cyclins - genetics | Mitogen-Activated Protein Kinase Kinases - physiology | Recombinant Fusion Proteins - physiology | Mitogen-Activated Protein Kinase 1 - deficiency | Male | Transforming Growth Factor beta - biosynthesis | Cyclins - biosynthesis | MAP Kinase Kinase 4 | Mitogen-Activated Protein Kinase 1 - genetics | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | JNK Mitogen-Activated Protein Kinases | Plasminogen Activator Inhibitor 1 - genetics | p38 Mitogen-Activated Protein Kinases | Carotid Artery Injuries - pathology | Muscle, Smooth, Vascular - drug effects | Transforming Growth Factor beta1 | Transduction, Genetic | Mitogen-Activated Protein Kinase 1 - physiology | Cyclin-Dependent Kinase Inhibitor p21 | Proto-Oncogene Proteins c-sis | Rats | Chemokine CCL2 - genetics | Cell Cycle Proteins - biosynthesis | Mitogen-Activated Protein Kinase Kinases - deficiency | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Cell Division - drug effects | Cyclin-Dependent Kinase Inhibitor p27 | Gene Expression Regulation - drug effects | Mitogen-Activated Protein Kinases - deficiency | Cell Movement - drug effects | Plasminogen Activator Inhibitor 1 - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Tunica Intima - pathology | Mitogen-Activated Protein Kinases - physiology | Chemokine CCL2 - biosynthesis | Mitogen-Activated Protein Kinases - genetics | Tumor Suppressor Proteins - biosynthesis | Muscle, Smooth, Vascular - enzymology | Mitogen-Activated Protein Kinase 3 | Index Medicus
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 2, pp. 586 - 597.e6
Background & Aims Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of... 
Gastroenterology and Hepatology | Kras | Pancreatic Cancer | LKb1 | p21 | PEUTZ-JEGHERS-SYNDROME | MUTATION CARRIERS | KINASE | P53 | LUNG-CANCER | GENE | POLYPOSIS | TUMOR-SUPPRESSOR | MICE | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | Haplotypes | Protein-Serine-Threonine Kinases - deficiency | Pancreatic Neoplasms - metabolism | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - deficiency | Carcinoma, Pancreatic Ductal - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Time Factors | Cell Transformation, Neoplastic - genetics | Proto-Oncogene Proteins p21(ras) - deficiency | Trans-Activators - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Carcinoma, Pancreatic Ductal - mortality | Pancreatic Neoplasms - mortality | Genes, Tumor Suppressor | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Promoter Regions, Genetic | Risk Assessment | Pancreatic Neoplasms - pathology | Proportional Hazards Models | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Genotype | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Disease Progression | Homeodomain Proteins - genetics | Mice, Knockout | Homozygote | Phenotype | Animals | Heterozygote | Mice | Cell Transformation, Neoplastic - pathology | Deregulation | Gene mutations | Pancreatic cancer | Oncology, Experimental | Research | Protein kinases | Cancer | Index Medicus | Abridged Index Medicus | Basic—Liver, Pancreas, and Biliary Tract | AMPK, adenosine monophosphate–activated protein kinase | PanIN, pancreatic intraepithelial neoplasia | PDAC, pancreatic ductal adenocarcinoma
Journal Article
Stem Cells, ISSN 1066-5099, 08/2009, Volume 27, Issue 8, pp. 1987 - 1998
Ataxia-telangiectasia (A-T) is a genetic disorder caused by a mutation of the Atm gene, which controls DNA repair, cell cycling, and redox homeostasis. Even... 
Oxidative stress | Neural stem cells | p38 mitogen-activated protein kinase | p27 | Ataxia-telangiectasia mutated | p21 | PROGENITOR CELLS | ADULT NEUROGENESIS | p21(cip1) | DEFICIENT MICE | ASTROCYTES | p27(kip1) | CELL & TISSUE ENGINEERING | CELL BIOLOGY | MUTANT MICE | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ANTIOXIDANT | NEURONS | HEMATOLOGY | ATAXIA-TELANGIECTASIA | PRECURSOR CELLS | Protein-Serine-Threonine Kinases - deficiency | Reactive Oxygen Species - metabolism | Oxidative Stress - physiology | Cell Growth Processes - physiology | Neurons - cytology | Stem Cells - cytology | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | MAP Kinase Signaling System | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Neurons - drug effects | Oncogene Protein v-akt - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Cells, Cultured | Hydrogen Peroxide - pharmacology | Protein-Serine-Threonine Kinases - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Mice, Knockout | Animals | Cyclin-Dependent Kinase Inhibitor p27 - biosynthesis | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | Stem Cells - drug effects | Mice | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 03/2014, Volume 33, Issue 12, pp. 1538 - 1547
The accumulation of genetic and epigenetic alterations mediates colorectal cancer (CRC) formation by deregulating key signaling pathways in cancer cells. In... 
PTEN | Transforming growth factor-beta | Colon cancer | APC MUTATION | colon cancer | RECEPTOR-TYPE-II | MICROSATELLITE INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | p21(Cip1) | CELL-PROLIFERATION | CELL BIOLOGY | transforming growth factor-beta | GENE | ONCOLOGY | PATHWAY | COLORECTAL-CANCER | GROWTH | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | EXPRESSION | Cell Cycle - genetics | Protein-Serine-Threonine Kinases - deficiency | Colonic Neoplasms - genetics | Receptors, Transforming Growth Factor beta - genetics | Humans | Colonic Neoplasms - metabolism | Intestinal Mucosa - drug effects | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cyclin-Dependent Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Carcinogenesis - genetics | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Gene Knockout Techniques | Disease Progression | Carcinogenesis - drug effects | Animals | Signal Transduction - drug effects | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Cell Cycle - drug effects | Transforming Growth Factor beta - metabolism | Intestinal Mucosa - pathology | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus | p21Cip1 | colorectal cancer | transforming growth factor beta
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2004, Volume 431, Issue 7011, pp. 997 - 1002
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2012, Volume 109, Issue 52, pp. 21516 - 21521
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKLS) gene have been identified in neurodevelopmental disorders including atypical Rett syndrome... 
Phosphorylation | P