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Journal of Neuroscience, ISSN 0270-6474, 03/2004, Volume 24, Issue 13, pp. 3370 - 3378
The mechanisms of action of human synthetic and naturally secreted cell-derived amyloid beta-peptide (Abeta)(1-42) on the induction of long-term potentiation... 
Metabotropic glutamate receptors | Cdk5 | JNK | LTP | Amyloid β-protein | Alzheimer's disease | p38 MAPK | Hippocampus | NEURONAL APOPTOSIS | hippocampus | ALZHEIMERS-DISEASE | MAP KINASE | metabotropic glutamate receptors | amyloid beta-protein | SYNAPTIC PLASTICITY | FREQUENCY STIMULATION | AREA CA1 | NEUROSCIENCES | IN-VITRO | PATHWAY | MICE | PRECURSOR PROTEIN | Receptors, Metabotropic Glutamate - drug effects | Cyclin-Dependent Kinases - metabolism | Amyloid beta-Peptides - pharmacology | Humans | Amyloid beta-Peptides - secretion | Peptide Fragments - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Ovary - cytology | Excitatory Postsynaptic Potentials - drug effects | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - genetics | JNK Mitogen-Activated Protein Kinases | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Female | Electric Stimulation - methods | Peptide Fragments - genetics | p38 Mitogen-Activated Protein Kinases | CHO Cells | Ovary - metabolism | Cricetinae | Enzyme Inhibitors - pharmacology | Peptide Fragments - secretion | Rats | Excitatory Amino Acid Antagonists - pharmacology | Cyclin-Dependent Kinase 5 | Animals | Ovary - secretion | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Plasticity | Development | amyloid β-protein | Repair
Journal Article
Oncogene, ISSN 0950-9232, 01/2001, Volume 20, Issue 2, pp. 147 - 155
The anti-cancer agent paclitaxel (Taxol) stabilizes microtubules leading to G2/M cell cycle arrest and apoptotic cell death. In order to analyse the molecular... 
MAP kinase | Her-2 | Taxol | Cell cycle | Apoptosis | p53 | CARCINOMA-CELLS | ACTIVATED PROTEIN-KINASE | cell cycle | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | PHOSPHOINOSITIDE 3-KINASE | HEREGULIN | CELL BIOLOGY | BREAST-CANCER CELLS | BCL-2 | ONCOLOGY | GROWTH ARREST | GENETICS & HEREDITY | taxol | DIFFERENTIATION | HUMAN TUMOR-CELLS | Cyclin-Dependent Kinases - metabolism | Paclitaxel - pharmacology | Receptor, ErbB-2 - genetics | Apoptosis - drug effects | Humans | Receptor, ErbB-2 - metabolism | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Cyclin-Dependent Kinases - drug effects | Cyclin-Dependent Kinase 2 | Cyclins - metabolism | Cyclins - drug effects | Retinoblastoma Protein - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Flavonoids - pharmacology | Tumor Cells, Cultured | Carcinoma - pathology | Receptor, ErbB-2 - drug effects | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Carcinoma - drug therapy | CDC2-CDC28 Kinases | Cyclin-Dependent Kinase Inhibitor p21 | Retinoblastoma Protein - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Rats | Imidazoles - pharmacology | Breast Neoplasms - drug therapy | Tumor Suppressor Protein p53 - drug effects | Animals | MAP Kinase Signaling System - drug effects | Mitosis - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Breast Neoplasms - pathology | Protein-Serine-Threonine Kinases - drug effects | Pyridines - pharmacology | Carcinoma - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Mitogen-Activated Protein Kinases - drug effects | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 09/2013, Volume 20, Issue 9, pp. 1241 - 1249
When the cell cycle becomes arrested, MTOR (mechanistic Target of Rapamycin) converts reversible arrest into senescence (geroconversion). Hyperexpression of... 
senescence | MEK | cancer | aging | cell cycle | rapamycin | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | PROLIFERATION | CELLULAR SENESCENCE | REPLICATIVE SENESCENCE | CELL BIOLOGY | ONCOGENIC RAS | GROWTH ARREST | EXPRESSION | HUMAN TUMOR-CELLS | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Cyclin D1 - metabolism | Antibiotics, Antineoplastic - pharmacology | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Cellular Senescence - drug effects | Neoplasm Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | MAP Kinase Kinase 1 - genetics | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | RNA Interference | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Cycle Checkpoints - genetics | Benzamides - pharmacology | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | TOR Serine-Threonine Kinases - drug effects | Cellular Senescence - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | Cyclin D1 - biosynthesis | Piperazines - pharmacology | Sirolimus - pharmacology | Cell Division - drug effects | Cyclin D1 - genetics | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Pyridines - pharmacology | RNA, Small Interfering | Index Medicus | Original Paper
Journal Article
Neuron, ISSN 0896-6273, 08/2008, Volume 59, Issue 4, pp. 621 - 633
Journal Article
Oncology Reports, ISSN 1021-335X, 10/2014, Volume 32, Issue 4, pp. 1748 - 1756
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with high incidence and mortality worldwide. Diallyl disulfide (DADS) is a natural... 
MEK-ERK | G2/M | apoptosis | p53/p21 | diallyl disulfide | Diallyl disulfide | Apoptosis | ACTIVATION | MCF-7 | CYCLE ARREST | PROLIFERATION | HUMAN GASTRIC-CANCER | DAMAGE | SULFIDE | INHIBITION | ONCOLOGY | CDC2 Protein Kinase | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Humans | RNA, Messenger - metabolism | cdc25 Phosphatases - drug effects | Cyclin-Dependent Kinases - drug effects | G2 Phase Cell Cycle Checkpoints - drug effects | Esophageal Neoplasms | Disulfides - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinases - genetics | Esophageal Squamous Cell Carcinoma | RNA, Messenger - drug effects | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | Cyclin B1 - genetics | cdc25 Phosphatases - genetics | Allyl Compounds - pharmacology | Tumor Suppressor Protein p53 - drug effects | Carcinoma, Squamous Cell | rho GTP-Binding Proteins - drug effects | Cyclin B1 - drug effects | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Cell Line, Tumor | Drug Screening Assays, Antitumor | Sulfur compounds | Care and treatment | Squamous cell carcinoma | Genetic aspects | Esophageal cancer | Testing | Phosphorylation | Chemotherapy | Cell cycle | Software | Experiments | Cancer therapies | Esophagus | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | DRB, 1-(β | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | ribofuranosyl)-5,6-dichlorobenzimidazole | PKA, cAMP-dependent protein kinase | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 10/2016, Volume 233, Issue 19-20, pp. 3527 - 3536
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2003, Volume 410, Issue 1, pp. 177 - 185
Epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent present in green tea, is a promising chemopreventive agent. We recently showed that green... 
Green tea | Prostate cancer | Epigallocatechin-3-gallate | Cell cycle | Apoptosis | GROWTH-INHIBITION | cell cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | green tea | apoptosis | INDUCTION | P53 | epigallocatechin-3-gallate | prostate cancer | POLYPHENOLS | CARCINOGENESIS | BIOPHYSICS | TEA CONSTITUENT (-)-EPIGALLOCATECHIN-3-GALLATE | EPIGALLOCATECHIN GALLATE | HUMAN CANCER | PROGRESSION | Prostatic Neoplasms - metabolism | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Humans | Male | G1 Phase - drug effects | Carrier Proteins - drug effects | Cyclin-Dependent Kinase Inhibitor p18 | Cyclin-Dependent Kinases - drug effects | Dose-Response Relationship, Drug | Cyclin-Dependent Kinase Inhibitor p16 - drug effects | Cyclins - metabolism | Cyclins - drug effects | Carcinoma - pathology | Catechin - pharmacology | Prostatic Neoplasms - drug therapy | Carcinoma - drug therapy | Prostatic Neoplasms - pathology | Tumor Suppressor Proteins - metabolism | Enzyme Inhibitors - metabolism | Signal Transduction | Cyclin-Dependent Kinase Inhibitor p21 | Intracellular Signaling Peptides and Proteins | Cyclin-Dependent Kinase Inhibitor p27 | Carrier Proteins - metabolism | Cell Cycle - physiology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Catechin - analogs & derivatives | Tumor Suppressor Proteins - drug effects | Apoptosis - physiology | Carcinoma - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Cell Cycle Proteins | Index Medicus
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2014, Volume 73, Issue 7, pp. 1405 - 1413
Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration. Objective To determine whether... 
MAMMALIAN TARGET | RAPAMYCIN | ARREST | MESSENGER-RNA | GENE-EXPRESSION | RHEUMATOLOGY | TRANSLATION | CELLULAR SENESCENCE | PROTEIN-SYNTHESIS | HUMAN ENDOTHELIAL-CELLS | P53 | Sirtuin 1 - metabolism | Glucocorticoids - therapeutic use | Cyclin-Dependent Kinase Inhibitor p21 - drug effects | TOR Serine-Threonine Kinases - metabolism | Tendons - drug effects | Humans | Middle Aged | Cellular Senescence - drug effects | Rotator Cuff | Male | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Tendons - cytology | Dexamethasone - pharmacology | beta-Galactosidase - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Adult | Female | TOR Serine-Threonine Kinases - drug effects | Tendons - metabolism | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Tumor Suppressor Protein p53 - drug effects | Dexamethasone - therapeutic use | Signal Transduction - drug effects | beta-Galactosidase - drug effects | Glucocorticoids - pharmacology | Sirtuin 1 - drug effects | Aged | Cell Cycle - drug effects | In Vitro Techniques | Tendinopathy - drug therapy | Aging | Care and treatment | Corticosteroids | Health aspects | Analysis | Cell cycle | Polymerase chain reaction | Cell culture | Cell growth | Senescence | Pain | Biopsy | Shoulder | Kinases | Index Medicus | Tendinitis | Chondrocytes | Basic and Translational Research | Fibroblasts | Inflammation | 1506
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/2009, Volume 29, Issue 1, pp. 65 - 75
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro... 
Allosteric modulator | Acetylcholinesterase | Kinase | Synaptic plasticity | PROTEIN-KINASE-A | acetylcholinesterase | SPATIAL MEMORY RETENTION | ELEMENT-BINDING PROTEIN | HIGH-FREQUENCY STIMULATION | HIPPOCAMPAL CA1 REGION | NEUROSCIENCES | allosteric modulator | GROWTH-FACTOR RECEPTOR | kinase | CENTRAL-NERVOUS-SYSTEM | synaptic plasticity | LONG-TERM POTENTIATION | SIGNAL-REGULATED KINASE | CYCLIN-DEPENDENT KINASE-5 | Phosphotransferases - metabolism | Synaptic Transmission - physiology | Rats, Wistar | Male | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | src-Family Kinases - drug effects | Mitogen-Activated Protein Kinase 3 - drug effects | Allosteric Regulation - physiology | Dentate Gyrus - drug effects | Long-Term Potentiation - drug effects | Up-Regulation - physiology | src-Family Kinases - metabolism | Long-Term Potentiation - physiology | Synaptic Transmission - drug effects | Cyclic AMP-Dependent Protein Kinases - drug effects | Nicotinic Agonists - pharmacology | Organ Culture Techniques | Allosteric Regulation - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Nicotinic - drug effects | Receptors, Nicotinic - metabolism | Dentate Gyrus - metabolism | Rats | Isoxazoles - pharmacology | Up-Regulation - drug effects | Animals | Cholinesterase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Phenylurea Compounds - pharmacology | alpha7 Nicotinic Acetylcholine Receptor | Tyrosine | Physiological aspects | Cholinesterase inhibitors | Protein kinases | Index Medicus
Journal Article