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Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 1, pp. 25 - 35
Summary Background Palbociclib (PD-0332991) is an oral, small-molecule inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 with preclinical evidence of... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | EXEMESTANE | ONCOLOGY | CELL-CYCLE | POSTMENOPAUSAL WOMEN | HER2 | PLUS | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Triazoles - administration & dosage | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Receptors, Estrogen - analysis | Molecular Targeted Therapy | North America | Nitriles - administration & dosage | Breast Neoplasms - enzymology | Time Factors | Postmenopause | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Republic of Korea | Aromatase Inhibitors - administration & dosage | Pyridines - administration & dosage | Drug Administration Schedule | Administration, Oral | Biomarkers, Tumor - analysis | Europe | Proportional Hazards Models | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Treatment Outcome | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Breast Neoplasms - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Breast Neoplasms - genetics | Cyclin D1 - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Intention to Treat Analysis | South Africa | Aged | Biomarkers, Tumor - genetics | Receptor, ErbB-2 - analysis | Antimitotic agents | Care and treatment | Oncology, Experimental | Estrogen | Breast cancer | Research | Antineoplastic agents | Phosphotransferases | Cancer | Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 03/2012, Volume 104, Issue 6, pp. 476 - 487
Background Cyclin-dependent kinases (CDKs) regulate cell proliferation and coordinate the cell cycle checkpoint response to DNA damage. Although inhibitors... 
CELL LUNG-CANCER | PHASE-III TRIAL | BASAL-LIKE | COLONY-STIMULATING FACTORS | ONCOLOGY | METASTATIC BREAST-CANCER | CDK4/6 INHIBITION | GENE-EXPRESSION | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | LARGE T-ANTIGEN | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Apoptosis - drug effects | Retinoblastoma - drug therapy | Receptor, ErbB-2 - metabolism | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - enzymology | Pyridines - adverse effects | Caspases - metabolism | Flow Cytometry | Protective Agents - pharmacology | Female | Blood Platelets - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | DNA Damage - drug effects | Breast Neoplasms - drug therapy | DNA, Neoplasm - drug effects | Piperazines - adverse effects | Piperazines - pharmacology | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Enzyme Activation | Carboplatin - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Doxorubicin - pharmacology | Care and treatment | Enzyme inhibitors | Physiological aspects | Carboplatin | Dosage and administration | Research | Cyclins | Cancer | Inhibitor drugs | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4055 - 4065
Purpose: Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor-positive (ER+) breast cancer. This single-arm phase II neoadjuvant... 
TRIAL | AROMATASE INHIBITOR | 1ST-LINE TREATMENT | RETINOBLASTOMA PROTEIN | ONCOLOGY | INTRINSIC SUBTYPE | IN-VIVO | DOUBLE-BLIND | LETROZOLE | CELL-PROLIFERATION | POSTMENOPAUSAL WOMEN | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Breast Neoplasms - surgery | Triazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Class I Phosphatidylinositol 3-Kinases - genetics | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Nitriles - administration & dosage | Pyridines - adverse effects | Adult | Female | Neoadjuvant Therapy | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Pyridines - administration & dosage | Breast Neoplasms - drug therapy | Piperazines - adverse effects | Disease-Free Survival | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Breast Neoplasms - pathology | Aged | Cell Proliferation - drug effects | Mutation | Neoplasm Staging | Cell proliferation | Anastrozole | Estrogens | Cyclin-dependent kinases | Estrogen | Estrogen receptors | Breast cancer | Kinases | Gene expression | Patients | ErbB-2 protein | Cyclin-dependent kinase 4 | Cyclin-dependent kinase | E2F protein | Inhibitors | Experimental design | Surgery | Cell cycle | Breast | Cancer | Index Medicus | breast cancer | neoadjuvant | anastrozole | CDK4 | palbociclib
Journal Article
Breast Cancer Research, ISSN 1465-5411, 10/2009, Volume 11, Issue 5, pp. R77 - R77
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2004, Volume 3, Issue 11, pp. 1427 - 1437
Journal Article
Cancer Letters, ISSN 0304-3835, 2011, Volume 317, Issue 1, pp. 24 - 32
Abstract P21-activated kinase 4 (PAK4), a serine/threonine protein kinase, has involved in the regulation of cytoskeletal reorganization, cell proliferation,... 
Hematology, Oncology and Palliative Medicine | Inhibitor | Proliferation | Gastric cancer | Invasion | PAK4 | MIGRATION | SURVIVAL | HGF | RECEPTOR | ONCOLOGY | POOR-PROGNOSIS | RESISTANCE | ANCHORAGE-INDEPENDENT GROWTH | Cyclin D1 - metabolism | p21-Activated Kinases - chemistry | Humans | p21-Activated Kinases - antagonists & inhibitors | Stomach Neoplasms - pathology | Structure-Activity Relationship | Lim Kinases - metabolism | Actin Depolymerizing Factors - metabolism | Dose-Response Relationship, Drug | Pseudopodia - drug effects | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Transfection | Pseudopodia - enzymology | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | p21-Activated Kinases - genetics | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Models, Molecular | MAP Kinase Kinase 1 - metabolism | Antineoplastic Agents - chemistry | p21-Activated Kinases - metabolism | Cell Movement - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Proto-Oncogene Proteins pp60(c-src) - metabolism | Cell Line, Tumor | Protein Conformation | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Stomach cancer | Cancer cells | Cancer | Proteins | Competition | Cell culture | Cyclin-dependent kinases | Mortality | Cell cycle | Kinases | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 8, pp. 1913 - 1918
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2005, Volume 48, Issue 7, pp. 2388 - 2406
Journal Article