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Clinical Pharmacokinetics, ISSN 0312-5963, 10/2010, Volume 49, Issue 10, pp. 661 - 669
Journal Article
Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 158 - 169
Group III metabotropic glutamate (mGlu) receptors are localized in presynaptic terminals within basal ganglia (BG) circuitry that become hyperactive due to... 
Striatum | Basal ganglia | Akinesia | Rat | Lu AF21934 | l-DOPA-induced dyskinesia | Electrophysiology | HIGH-FREQUENCY STIMULATION | NEUROLOGICAL DISEASES | NEUROSCIENCES | RAT MODEL | STRIATAL SYNAPTIC PLASTICITY | MEDIATED MODULATION | SUBTHALAMIC NUCLEUS | UNILATERAL 6-HYDROXYDOPAMINE LESIONS | PHARMACOLOGY & PHARMACY | DEEP BRAIN-STIMULATION | L-DOPA-induced dyskinesia | MOLECULAR-MECHANISMS | Anilides - therapeutic use | Catalepsy - drug therapy | Synaptic Transmission - physiology | Excitatory Amino Acid Agonists - therapeutic use | Receptors, Metabotropic Glutamate - physiology | Male | Aminobutyrates - pharmacology | Anilides - pharmacokinetics | Parkinson Disease - drug therapy | Oxidopamine | Aminobutyrates - therapeutic use | Excitatory Postsynaptic Potentials - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Haloperidol - antagonists & inhibitors | Allosteric Regulation - physiology | Dyskinesia, Drug-Induced - drug therapy | Catalepsy - chemically induced | Synaptic Transmission - drug effects | Haloperidol - pharmacology | Disease Models, Animal | Allosteric Regulation - drug effects | Aminobutyrates - agonists | Levodopa - pharmacology | Cyclohexanecarboxylic Acids - therapeutic use | Phosphinic Acids - agonists | Levodopa - therapeutic use | Phosphinic Acids - therapeutic use | Rats | Excitatory Amino Acid Agonists - pharmacology | Rats, Sprague-Dawley | Drug Synergism | Animals | Cyclohexanecarboxylic Acids - pharmacology | Levodopa - adverse effects | Phosphinic Acids - pharmacology | Anilides - pharmacology | Excitatory Amino Acid Agonists - pharmacokinetics | Cyclohexanecarboxylic Acids - pharmacokinetics | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Physiological aspects | Phenols | Amino acids | Parkinson's disease | Glutamate | Drug therapy | 6-Hydroxydopamine | Phosphinic Acids | Excitatory Amino Acid Agonists | Allosteric Regulation | Catalepsy | Haloperidol | Aminobutyrates | Cellular Biology | Synaptic Transmission | Receptors, Metabotropic Glutamate | Parkinson Disease | Anilides | Life Sciences | Excitatory Postsynaptic Potentials | Cyclohexanecarboxylic Acids | Dyskinesia, Drug-Induced | Levodopa
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 07/2007, Volume 82, Issue 1, pp. 21 - 32
The low productivity and escalating costs of drug development have been well documented over the past several years. Less than 10% of new compounds that enter... 
TRIPTANS SEROTONIN | METAANALYSIS | PAIN | DOSE-RESPONSE | INTEGRATION | 5-HT1B/1D AGONISTS | CLINICAL-TRIALS | DISEASE | PHARMACOLOGY & PHARMACY | SIMULATION | MIGRAINE | Analgesics - pharmacology | Muscarinic Agonists - pharmacology | Cholesterol - blood | Humans | Glycoproteins - pharmacology | Caproates - therapeutic use | Amines - therapeutic use | Alzheimer Disease - psychology | Neutrophil Infiltration - drug effects | United States Food and Drug Administration | Glycoproteins - therapeutic use | Alzheimer Disease - drug therapy | gamma-Aminobutyric Acid - pharmacology | Stroke - drug therapy | Cognition - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Models, Biological | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Amines - pharmacology | Immunologic Factors - pharmacology | Clinical Trials as Topic - legislation & jurisprudence | Guidelines as Topic | Meta-Analysis as Topic | Clinical Trials as Topic - statistics & numerical data | United States | Caproates - pharmacology | Muscarinic Agonists - therapeutic use | Oximes - therapeutic use | Drug Approval | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Computer Simulation | Drug Design | gamma-Aminobutyric Acid - therapeutic use | Stroke - immunology | Analgesics - therapeutic use | Cyclohexanecarboxylic Acids - therapeutic use | Hypercholesterolemia - blood | Reproducibility of Results | Neuralgia, Postherpetic - drug therapy | Pharmacology | Models, Statistical | Animals | Anticholesteremic Agents - therapeutic use | Cyclohexanecarboxylic Acids - pharmacology | Oximes - pharmacology | Clinical Trials as Topic - methods | Pharmacokinetics | Research Design | Anticholesteremic Agents - pharmacology | Immunologic Factors - therapeutic use
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9853, pp. 1583 - 1589
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9697, pp. 1252 - 1261
Journal Article
Glia, ISSN 0894-1491, 01/2011, Volume 59, Issue 1, pp. 152 - 165
GABA is assumed to function in brain only as an inhibitory neurotransmitter. Here we report a much broader CNS role. We show that human astrocytes are... 
GABAB receptor | muscimol | anti‐inflammation | GABA transaminase | GABAA receptor | baclofen | glutamic acid decarboxylase | receptor | Baclofen | GABA | Glutamic acid decarboxylase | Muscimol | Anti-inflammation | OPTIC-NERVE | GLUTAMIC-ACID DECARBOXYLASE | IMMUNOREACTIVITY | CULTURE | NEUROSCIENCES | HUMAN NEUROBLASTOMA | antiinflammation | GABA(B) receptor | GABA(A) receptor | FUNCTIONAL EXPRESSION | AIRWAY SMOOTH-MUSCLE | DIFFERENTIATION | BRAIN | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Muscimol - pharmacology | gamma-Aminobutyric Acid - metabolism | Humans | Male | Protozoan Proteins | Brain - metabolism | 4-Aminobutyrate Transaminase - metabolism | Vigabatrin - pharmacology | GABA-A Receptor Agonists - pharmacology | Aged, 80 and over | Interleukin-6 - metabolism | Astrocytes - drug effects | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Annexins | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cyclohexanecarboxylic Acids - pharmacology | Receptors, GABA - metabolism | Glutamate Decarboxylase - metabolism | Aged | Astrocytes - metabolism | Brain | Enzymes | Antiinflammatory agents | 4-Aminobutyrate transaminase | Astrocytes | Central nervous system | MAP kinase | Glutamate decarboxylase | Inflammation | mRNA | Lipopolysaccharides | Microglia | gamma -Aminobutyric acid B receptors | Neurotoxicity | Neurotransmitters | gamma -Aminobutyric acid A receptors | Tumor necrosis factor | Interferon | Index Medicus
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 06/2011, Volume 136, Issue 2, pp. 355 - 362
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2006, Volume 533, Issue 1-3, pp. 110 - 117
Phosphodiesterases hydrolyse intracellular cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into inactive 5′... 
Phosphodiesterase inhibitor | Rolipram | Chronic obstructive pulmonary disease | Roflumilast | Cilomilast | Phosphodiesterase | Asthma | roflumilast | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | EOSINOPHIL INFILTRATION | rolipram | asthma | NECROSIS-FACTOR-ALPHA | GM-CSF RELEASE | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | phosphodiesterase inhibitor | CAMP-PHOSPHODIESTERASES | PHARMACOLOGY & PHARMACY | CD8(+) T-LYMPHOCYTES | phosphodiesterase | TNF-ALPHA | cilomilast | ANTIINFLAMMATORY DRUGS | chronic obstructive pulmonary disease | Phosphodiesterase Inhibitors - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 | Nitriles - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Cyclopropanes - therapeutic use | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Isoenzymes - metabolism | Anti-Inflammatory Agents - therapeutic use | Carboxylic Acids - therapeutic use | Benzamides - pharmacology | Carboxylic Acids - pharmacology | Cyclopropanes - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Phosphoric Diester Hydrolases - metabolism | Anti-Inflammatory Agents - pharmacology | Asthma - enzymology | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Asthma - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Aminopyridines - pharmacology | 3',5'-Cyclic-GMP Phosphodiesterases | Cyclohexanecarboxylic Acids | Cyclic Nucleotide Phosphodiesterases, Type 7 | Isoenzymes - antagonists & inhibitors | Nitriles - therapeutic use | Pulmonary Disease, Chronic Obstructive - drug therapy | Hydrolysis | Hypertension | Isoenzymes | Guanosine | Cyclic adenylic acid | Esterases | T cells | Adenylic acid | Cyclic guanylic acid
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 06/2011, Volume 71, Issue 11, pp. 3912 - 3920
MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G(2)-M cell-cycle arrest. Growth and survival of multiple lymphoma cell lines were... 
APOPTOSIS | TARGETING BCL2 | CANCER CELLS | GENE | RNA | ONCOLOGY | TELOMERASE ACTIVITY | MYELOID-LEUKEMIA | DIFFERENTIATION | MYELOGENOUS LEUKEMIA-CELLS | ALTERED EXPRESSION | Piperazines - administration & dosage | Humans | Histone Deacetylase Inhibitors - administration & dosage | Immunoblotting | Thiazoles - administration & dosage | Genes, myc | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Aurora Kinase A | Lymphoma - metabolism | Lymphoma - drug therapy | Proto-Oncogene Proteins c-myc - biosynthesis | Telomerase - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Hydroxamic Acids - administration & dosage | Lymphoma - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hydroxamic Acids - pharmacology | Cell Survival - drug effects | Cell Growth Processes - drug effects | Cyclohexanecarboxylic Acids - administration & dosage | Lymphoma - genetics | MicroRNAs - biosynthesis | Aurora Kinases | Piperazines - pharmacology | Drug Synergism | Protein Kinase Inhibitors - administration & dosage | Telomerase - biosynthesis | Cyclohexanecarboxylic Acids - pharmacology | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Thiazoles - pharmacology | Cell Cycle - drug effects
Journal Article