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1. Full Text Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery
by Baranowska-Kuczko, Marta and MacLean, Margaret R and Kozłowska, Hanna and Malinowska, Barbara
Pharmacological research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin | Index Medicus
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2. Full Text Sulfonylurea Induced β-Cell Apoptosis in Cultured Human Islets
by Maedler, Kathrin and Carr, Richard D and Bosco, Domenico and Zuellig, Richard A and Berney, Thierry and Donath, Marc Y
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 01/2005, Volume 90, Issue 1, pp. 501 - 506
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Endocrinopathies | Medical sciences | Vertebrates: endocrinology | Insulin - pharmacology | Islets of Langerhans - drug effects | Phenylalanine - analogs & derivatives | Apoptosis - drug effects | Calcium - metabolism | Phenylalanine - pharmacology | Cyclohexanes - pharmacology | Humans | Middle Aged | Cells, Cultured | Hypoglycemic Agents - pharmacology | Dose-Response Relationship, Drug | Glyburide - pharmacology | Piperidines - pharmacology | Islets of Langerhans - cytology | Adult | Aged | Carbamates - pharmacology | Index Medicus | Abridged Index Medicus
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3. Full Text Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
by Thomas, A and Baillie, G L and Phillips, A M and Razdan, R K and Ross, R A and Pertwee, R G
British journal of pharmacology, ISSN 0007-1188, 03/2007, Volume 150, Issue 5, pp. 613 - 623
cannabidiol | CB2 receptor | CP55940 | O‐2654 | GTPγS assay | CB1 receptor | mouse brain | inverse agonism | neutral antagonism | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cricetulus | Cyclohexanols | Receptor, Cannabinoid, CB2 - agonists | Cannabinoid Receptor Antagonists | Cyclohexanes - pharmacology | Humans | Bornanes - pharmacology | Anti-Inflammatory Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Receptors, Cannabinoid - metabolism | Receptor, Cannabinoid, CB1 - agonists | Transfection | Piperidines - pharmacology | Morpholines - antagonists & inhibitors | Phenols - antagonists & inhibitors | Cyclohexanes - antagonists & inhibitors | Benzoxazines - antagonists & inhibitors | Cell Membrane - metabolism | Cell Membrane - drug effects | Receptors, Cannabinoid - genetics | CHO Cells | Phenols - pharmacology | Pyrazoles - pharmacology | Cricetinae | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Morpholines - pharmacology | Cannabidiol - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Brain - drug effects | Cannabinoid Receptor Agonists | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Benzoxazines - pharmacology | Protein Binding | Mice | Cannabidiol - metabolism | In Vitro Techniques | Naphthalenes - antagonists & inhibitors | Index Medicus | O-2654 | Research Papers
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4. Full Text The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant
by Al Suleimani, Yousuf M and Al Mahruqi, Ahmed S
European journal of pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 209 - 215
Na+/Ca2+ exchanger | Vasorelaxation | Nitric oxide | N-arachidonoyl glycine | Hypotensive | Ca | exchanger | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Glycine - analogs & derivatives | Kidney - blood supply | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Endothelium, Vascular - drug effects | Male | Thiourea - pharmacology | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Regional Blood Flow - drug effects | Piperidines - pharmacology | Oxadiazoles - pharmacology | Blood Pressure - drug effects | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Rats | Capsaicin - analogs & derivatives | Arachidonic Acids - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Glycine - pharmacology | Endothelium, Vascular - metabolism | Anilides - pharmacology | Endothelium, Vascular - pathology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | Medical colleges | Dilatation | Vasodilators | Blood vessels | Indomethacin | Glycine | Endothelium | Index Medicus
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5. Full Text Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists
by Rama Kondru and Jun Zhang and Changhua Ji and Tara Mirzadegan and David Rotstein and Surya Sankuratri and Marianna Dioszegi
Molecular pharmacology, ISSN 0026-895X, 03/2008, Volume 73, Issue 3, pp. 789 - 800
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Anti-HIV Agents - pharmacology | Benzoates - metabolism | Humans | Receptors, CCR5 - genetics | Piperazines - chemistry | Pyrimidines - metabolism | Receptors, CCR5 - metabolism | Piperidines - pharmacology | Amides - metabolism | Anti-HIV Agents - metabolism | Radioligand Assay | Binding Sites | Amides - pharmacology | Anti-HIV Agents - classification | Amino Acid Sequence | Piperidines - metabolism | Models, Molecular | Pyrimidines - pharmacology | HIV Fusion Inhibitors - pharmacology | Piperazines - pharmacology | Triazoles - metabolism | Anti-HIV Agents - chemistry | Amides - chemistry | Benzoates - pharmacology | Hydrophobic and Hydrophilic Interactions | Receptors, CCR5 - chemistry | Quaternary Ammonium Compounds - pharmacology | Cricetulus | Triazoles - chemistry | Benzoates - chemistry | Cyclohexanes - pharmacology | Molecular Sequence Data | Piperazines - metabolism | Quaternary Ammonium Compounds - chemistry | Pyrimidines - chemistry | Cyclohexanes - metabolism | Transfection | Inhibitory Concentration 50 | Cyclohexanes - chemistry | Molecular Structure | Membrane Fusion - drug effects | Spiro Compounds - chemistry | CCR5 Receptor Antagonists | CHO Cells | Protein Structure, Tertiary | Cricetinae | Piperidines - chemistry | Mutagenesis, Site-Directed | Protein Structure, Secondary | HIV-1 - drug effects | Static Electricity | Sequence Homology, Amino Acid | Triazoles - pharmacology | Animals | Quaternary Ammonium Compounds - metabolism | Spiro Compounds - pharmacology | Spiro Compounds - metabolism | Index Medicus
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6. Full Text Efficient Single Tobamoviral Vector-Based Bioproduction of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 in Nicotiana benthamiana Plants and Utility of VRC01 in Combination Microbicides
by Krystal Teasley Hamorsky and Tiffany W. Grooms-Williams and Adam S. Husk and Lauren J. Bennett and Kenneth E. Palmer and Nobuyuki Matoba
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2013, Volume 57, Issue 5, pp. 2076 - 2086
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Immunopathology | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Immunodeficiencies. Immunoglobulinopathies | Immunodeficiencies | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antibodies, Monoclonal - biosynthesis | Antiviral Agents - immunology | Cyclohexanes - pharmacology | Humans | HIV Envelope Protein gp120 - antagonists & inhibitors | Neutralization Tests | Antiviral Agents - metabolism | Recombinant Proteins - biosynthesis | HIV Envelope Protein gp120 - metabolism | Tenofovir | Antibodies, Neutralizing - immunology | HIV-1 - growth & development | Tobamovirus - genetics | HIV Antibodies - immunology | Immunoglobulin G - biosynthesis | Immunoglobulin G - immunology | HIV Antibodies - biosynthesis | Immunoglobulin G - pharmacology | HIV Antibodies - pharmacology | Antibodies, Monoclonal - immunology | Antiviral Agents - pharmacology | Adenine - analogs & derivatives | HIV-1 - drug effects | Antibodies, Monoclonal - pharmacology | Antibodies, Neutralizing - pharmacology | Plant Lectins - pharmacology | Adenine - pharmacology | Recombinant Proteins - pharmacology | Drug Synergism | Triazoles - pharmacology | Organophosphonates - pharmacology | Animals | Chromatography, Affinity | Recombinant Proteins - immunology | Antibodies, Neutralizing - biosynthesis | Tobacco - genetics | Genetic Vectors | Drug Combinations | Index Medicus | Antiviral Agents
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7. Full Text Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
by Morgan, Paul and Van Der Graaf, Piet H and Arrowsmith, John and Feltner, Doug E and Drummond, Kira S and Wegner, Craig D and Street, Steve D.A
Drug discovery today, ISSN 1359-6446, 05/2012, Volume 17, Issue 9-10, pp. 419 - 424
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Cyclohexanes - pharmacology | Humans | Drug Evaluation | Neuralgia - metabolism | Sexual Dysfunction, Physiological - drug therapy | Morpholines - pharmacology | Neuralgia - drug therapy | Triazoles - pharmacology | Cyclohexanes - therapeutic use | Receptors, Dopamine D3 - agonists | Pharmaceutical Preparations - metabolism | Animals | Aminopyridines - therapeutic use | Aminopyridines - pharmacology | HIV Infections - drug therapy | Pharmacokinetics | Morpholines - therapeutic use | Sexual Dysfunction, Physiological - metabolism | CCR5 Receptor Antagonists | Clinical Trials, Phase II as Topic | HIV Infections - metabolism | Triazoles - therapeutic use | Clinical trials | Analysis | Index Medicus
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8. Full Text Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors
by Zhufang Li and Nannan Zhou and Yongnian Sun and Neelanjana Ray and Max Lataillade and George J. Hanna and Mark Krystal
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2013, Volume 57, Issue 9, pp. 4172 - 4180
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Immunopathology | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Viral diseases of the lymphoid tissue and the blood. Aids | Biological and medical sciences | Medical sciences | Human viral diseases | Immunodeficiencies. Immunoglobulinopathies | Immunodeficiencies | Antibiotics. Antiinfectious agents. Antiparasitic agents | Anti-HIV Agents - pharmacology | Organophosphates - metabolism | Receptors, Virus - metabolism | Cyclohexanes - pharmacology | Humans | Peptide Fragments - pharmacology | Piperazines - metabolism | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Prodrugs - metabolism | HIV Envelope Protein gp41 - pharmacology | Receptors, CCR5 - metabolism | HIV-1 - growth & development | Enfuvirtide | Maraviroc | HEK293 Cells | CCR5 Receptor Antagonists | HIV-1 - metabolism | HIV-1 - drug effects | Receptors, CXCR4 - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Piperazines - pharmacology | Receptors, CXCR4 - metabolism | Organophosphates - pharmacology | Triazoles - pharmacology | Drug Resistance, Viral - drug effects | Receptors, Virus - antagonists & inhibitors | Prodrugs - pharmacology | CD4 Antigens - metabolism | Index Medicus | CCR5 protein | Antiviral Agents
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9. Full Text Antibacterial and smear layer removal ability of a novel irrigant, QMiX
by Stojicic, S and Shen, Y and Qian, W and Johnson, B and Haapasalo, M
International endodontic journal, ISSN 0143-2885, 04/2012, Volume 45, Issue 4, pp. 363 - 371
smear layer | antibacterial | QMiX | planktonic | MTAD | biofilm | Biofilm | Smear layer | Antibacterial | Planktonic | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Biofilms - drug effects | Biguanides - pharmacology | Dentin - microbiology | Plankton - drug effects | Anti-Infective Agents, Local - pharmacology | Chlorhexidine - pharmacology | Citric Acid - pharmacology | Root Canal Irrigants - pharmacology | Dental Plaque - microbiology | Microscopy, Confocal | Polysorbates - pharmacology | Smear Layer | Polymers - pharmacology | Doxycycline - pharmacology | Sodium Hypochlorite - pharmacology | Drug Combinations | Analysis | Cyclohexane | Hydroxylapatite | Sodium hypochlorite | Bacteria | Universities and colleges | Root canal therapy | Antibacterial agents | Dentistry
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10. Full Text Preclinical efficacy and safety of the novel antidiabetic, antiobesity metap2 inhibitor ZGN-1061
by Burkey, Bryan F and Hoglen, Niel C and Inskeep, Philip and Wyman, Margaret and Hughes, Thomas E and Vath, James E
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 05/2018, Volume 365, Issue 2, pp. 301 - 313
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Obesity - drug therapy | Cyclohexanes - pharmacology | Humans | Sesquiterpenes - pharmacokinetics | Cinnamates - pharmacokinetics | Male | Azetidines - pharmacology | Epoxy Compounds - pharmacokinetics | Tissue Distribution | Epoxy Compounds - pharmacology | Enzyme Inhibitors - pharmacokinetics | Female | Safety | Morpholines - adverse effects | Morpholines - therapeutic use | Enzyme Inhibitors - adverse effects | Hypoglycemic Agents - therapeutic use | Metalloendopeptidases - antagonists & inhibitors | Hypoglycemic Agents - pharmacokinetics | Mice, Inbred C57BL | Azetidines - adverse effects | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Azetidines - pharmacokinetics | Aminopeptidases - antagonists & inhibitors | Cinnamates - pharmacology | Enzyme Inhibitors - therapeutic use | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Animals | Azetidines - therapeutic use | Blood Coagulation - drug effects | Dogs | Mice | Obesity - enzymology | Morpholines - pharmacokinetics | Sesquiterpenes - pharmacology | Cyclohexanes - pharmacokinetics | Hypoglycemic Agents - adverse effects | Index Medicus
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11. Full Text Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats
by Ide, Soichiro and Hara, Taiki and Ohno, Atsushi and Tamano, Ryuta and Koseki, Kana and Naka, Tomonori and Maruyama, Chikashi and Kaneda, Katsuyuki and Yoshioka, Mitsuhiro and Minami, Masabumi
The Journal of neuroscience, ISSN 0270-6474, 04/2013, Volume 33, Issue 14, pp. 5881 - 5894
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Septal Nuclei - drug effects | Cyclohexanes - pharmacology | Septal Nuclei - physiology | Male | Peptide Fragments - pharmacology | Hormones - adverse effects | Pain - chemically induced | Pyridazines - pharmacology | Septal Nuclei - cytology | Arginine - analogs & derivatives | Affective Symptoms - etiology | Pain - complications | Hormones - agonists | Corticotropin-Releasing Hormone - antagonists & inhibitors | Kynurenic Acid - pharmacology | Neuropeptide Y - agonists | Formaldehyde - toxicity | Neurons - drug effects | Neuropeptide Y - antagonists & inhibitors | Action Potentials - drug effects | Xanthenes - pharmacology | Disease Models, Animal | Membrane Potentials - drug effects | Aniline Compounds - pharmacology | Corticotropin-Releasing Hormone - adverse effects | Neuropeptide Y - therapeutic use | Rats | Corticotropin-Releasing Hormone - agonists | Excitatory Amino Acid Antagonists - pharmacology | Pyrimidines - pharmacology | Rats, Sprague-Dawley | GABA Antagonists - pharmacology | Hormone Antagonists - pharmacology | Affective Symptoms - drug therapy | Animals | Microdialysis | Analysis of Variance | Arginine - pharmacology | In Vitro Techniques | Pain Measurement | Index Medicus
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