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Journal Article
Journal of NeuroVirology, ISSN 1355-0284, 06/2017, Volume 23, Issue 3, pp. 347 - 357
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2013, Volume 133, Issue 7, pp. 1732 - 1742
Journal Article
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 5/2012, Volume 68, Issue 5, pp. 853 - 856
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 02/2013, Volume 344, Issue 2, pp. 378 - 387
B-cell receptor (BCR) associated kinases including spleen tyrosine kinase (SYK) contribute to the pathogenesis of B-cell malignancies. SYK is persistently... 
MIGRATION | SURVIVAL | TYROSINE KINASE SYK | ACTIVATION | INFLAMMATION | NEUTROPHILS | PHARMACOLOGY & PHARMACY | FOLLICULAR LYMPHOMA | PROLIFERATION | COMBINATION | EXPRESSION | Phosphorylation | Apoptosis - drug effects | Humans | Antineoplastic Agents - therapeutic use | Lymphoma, Non-Hodgkin - enzymology | Spleen - drug effects | Antineoplastic Agents - administration & dosage | Cyclohexylamines - pharmacokinetics | Lymphoma, Non-Hodgkin - pathology | Dose-Response Relationship, Drug | Cyclohexylamines - administration & dosage | Flow Cytometry | Spleen - enzymology | Cyclohexylamines - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Syk Kinase | Lymphoma, Non-Hodgkin - drug therapy | Cell Survival - drug effects | B-Lymphocytes - enzymology | Pyrimidines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Vidarabine - analogs & derivatives | Pyrimidines - pharmacology | Vidarabine - therapeutic use | Mice, SCID | Cyclohexylamines - therapeutic use | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Drug Synergism | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Vidarabine - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Animals | Pyrimidines - therapeutic use | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Vidarabine - pharmacokinetics | Mice | Mice, Inbred BALB C | Vidarabine - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2008, Volume 4, Issue 6, pp. 347 - 356
Calcium-dependent protein kinases play a crucial role in intracellular calcium signaling in plants, some algae and protozoa. In Plasmodium falciparum,... 
DISCHARGE | COMPLEX | NETWORK | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL INVASION | CALCIUM | ONTOLOGY | GLIDING MOTILITY | MALARIA PARASITES | IDENTIFICATION | MYOSIN-A | Plasmodium falciparum - enzymology | Protein Kinases - genetics | Molecular Weight | Parasitic Sensitivity Tests | Protozoan Proteins - antagonists & inhibitors | Humans | Male | Tissue Distribution | Adenine - therapeutic use | Life Cycle Stages - drug effects | Recombinant Proteins - antagonists & inhibitors | Adenine - analogs & derivatives | Oligonucleotide Array Sequence Analysis - methods | Malaria - immunology | Cyclohexylamines - chemistry | Models, Molecular | Antimalarials - therapeutic use | Cyclohexylamines - therapeutic use | Gene Expression Regulation, Enzymologic - genetics | Small Molecule Libraries | Malaria - parasitology | Mice | Mice, Inbred BALB C | HeLa Cells | Gene Expression Regulation, Enzymologic - drug effects | Cricetulus | Stereoisomerism | Structure-Activity Relationship | Protozoan Proteins - genetics | Adenine - chemistry | Cyclohexylamines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | CHO Cells | Cell Line | Movement - drug effects | Cricetinae | Protein Kinases - drug effects | Adenine - pharmacology | Recombinant Proteins - genetics | Enzyme Activation - drug effects | Protozoan Proteins - physiology | Antimalarials - pharmacology | Animals | Protein Kinases - physiology | Antimalarials - chemistry | Cell Proliferation - drug effects | Malaria - drug therapy | Plasmodium falciparum - growth & development | Parasitology | Biochemistry | Calcium | Malaria | Kinases | Gene expression
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 350 - 359
Based on genetic studies that establish the role of spleen tyrosine kinase (Syk) in immune function, inhibitors of this kinase are being investigated as... 
ANTIBODIES | SURVIVAL | B-CELL LYMPHOMA | COLLAGEN | SYK | PLATELETS | DISEASE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | MICE | INDUCTION | Edema - complications | Synovitis - prevention & control | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Precursor Cells, B-Lymphoid - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Precursor Cells, B-Lymphoid - drug effects | Receptors, Antigen, B-Cell - metabolism | Blood - metabolism | Cyclohexylamines - administration & dosage | Lymphocyte Activation - immunology | Synovitis - etiology | Phosphorylation - drug effects | Syk Kinase | B-Lymphocytes - metabolism | Disease Models, Animal | Edema - prevention & control | Protein Kinase Inhibitors - pharmacokinetics | Rats | Pyrimidines - pharmacology | Cyclohexylamines - therapeutic use | Synovitis - pathology | Protein Kinase Inhibitors - administration & dosage | B-Lymphocytes - immunology | Signal Transduction - drug effects | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Leukocytes - drug effects | Mice | Mice, Inbred BALB C | Edema - pathology | Leukocytes - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Blood - immunology | Rats, Inbred Lew | Precursor Cells, B-Lymphoid - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Cyclohexylamines - pharmacokinetics | Arthritis, Experimental - pathology | Leukocytes - immunology | Signal Transduction - immunology | Biocatalysis - drug effects | Cyclohexylamines - pharmacology | Arthritis, Experimental - prevention & control | Basophils - immunology | Protein-Tyrosine Kinases - drug effects | Inhibitory Concentration 50 | Female | Receptors, Antigen, B-Cell - agonists | Molecular Structure | Foot - pathology | Basophils - drug effects | Cell Line | Pyrimidines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Blood - drug effects | Arthritis, Experimental - complications | B-Lymphocytes - drug effects | Animals | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Cell Degranulation - drug effects
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 03/2015, Volume 93, Issue 3, pp. 454 - 465
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2017, Volume 114, Issue 31, pp. E6420 - E6426
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 2014, Volume 34, Issue 3, pp. 733 - 741
The aberrant activation of the Hedgehog (Hh) signaling pathway has been implicated in a variety of malignancies, including hepatocellular carcinoma (HCC). The... 
Glioma-associated oncogene 1 | Hepatocellular carcinoma | Hedgehog | 5′ adenosine monophosphate-activated protein kinase | Interaction | MEDICINE, RESEARCH & EXPERIMENTAL | METFORMIN | ACTIVATION | NETWORK | PHOSPHORYLATION | PROTEIN-KINASE | INVOLVEMENT | MUSCLE | MECHANISMS | glioma-associated oncogene 1 | BREAST-CANCER | PATHWAY | interaction | 5 ' adenosine monophosphate-activated protein kinase | hepatocellular carcinoma | Thiophenes - therapeutic use | Transcription, Genetic - drug effects | Prognosis | Humans | Hedgehog Proteins - metabolism | Male | RNA, Messenger - metabolism | Carcinoma, Hepatocellular - drug therapy | Cyclohexylamines - pharmacology | Adenylate Kinase - metabolism | Carcinoma, Hepatocellular - genetics | Protein Binding - drug effects | Veratrum Alkaloids - pharmacology | Female | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - enzymology | Veratrum Alkaloids - therapeutic use | Liver Neoplasms - genetics | RNA, Messenger - genetics | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Proportional Hazards Models | Thiophenes - pharmacology | Carcinoma, Hepatocellular - enzymology | Transcription Factors - genetics | Cyclohexylamines - therapeutic use | Hep G2 Cells | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Zinc Finger Protein GLI1
Journal Article