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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2014, Volume 289, Issue 10, pp. 6799 - 6808
Background: The oxicams are anti-inflammatory drugs targeting the cyclooxygenase enzymes. Results: Crystal complexes of mCOX-2isoxicam, mCOX-2meloxicam, and... 
Enzyme Structure | SELECTIVE-INHIBITION | NONSTEROIDAL ANTIINFLAMMATORY DRUG | COX-2 | X-ray Crystallography | Protein Drug Interactions | CRYSTAL-STRUCTURE | OXYGENATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARACHIDONIC-ACID | Cyclooxygenase (COX) Pathway | NSAID BINDING | PROSTAGLANDIN H-2 SYNTHASE | REFINEMENT | STRUCTURAL BASIS | Drug Action | Water | Thiazoles - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Thiazines - metabolism | Cyclooxygenase 2 - genetics | Arginine - genetics | Cyclooxygenase 1 - chemistry | Piroxicam - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Leucine - genetics | Tyrosine - chemistry | Leucine - metabolism | Catalytic Domain | Cyclooxygenase 1 - genetics | Cyclooxygenase Inhibitors - metabolism | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Serine - genetics | Cyclooxygenase Inhibitors - chemistry | Serine - chemistry | Serine - metabolism | Thiazines - chemistry | Arginine - chemistry | Leucine - chemistry | Piroxicam - metabolism | Tyrosine - metabolism | Animals | Piroxicam - chemistry | Hydrogen Bonding | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Mice | Cyclooxygenase 1 - metabolism | Mutation | Arginine - metabolism | Amino Acid Substitution | Tyrosine - genetics | Index Medicus | Lipids
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2010, Volume 429, Issue 2, pp. 273 - 282
Journal Article
Journal Article
FEMS Yeast Research, ISSN 1567-1356, 2003, Volume 3, Issue 4, pp. 417 - 432
Abstract Species of Saccharomyces, Arxiozyma, Eremothecium, Hanseniaspora (anamorph Kloeckera), Kazachstania, Kluyveromyces, Pachytichospora, Saccharomycodes,... 
Cytochrome oxidase II | Actin-1 | Multigene phylogeny | Ribosomal DNA | Saccharomyces | Molecular systematics | RNA polymerase II | Kluyveromyces | Elongation factor 1α | Actin‐1 | multigene phylogeny | cytochrome oxidase II | ribosomal DNA | CEREVISIAE | MICROBIOLOGY | Khuyveromyces | BAYANUS | BRETTANOMYCES | elongation factor 1 alpha | ASCOMYCETOUS YEASTS | DNA | ZYGOSACCHAROMYCES | SP-NOV | actin-1 | molecular systematics | DEBARYOMYCES | RNA GENE-SEQUENCES | SUBUNIT | DNA, Fungal - genetics | Cyclooxygenase 2 | Molecular Sequence Data | DNA, Fungal - chemistry | Isoenzymes - chemistry | Phylogeny | RNA, Ribosomal - genetics | Saccharomyces - genetics | Actins - genetics | Genetic Variation | Candida - classification | DNA, Mitochondrial - genetics | DNA, Ribosomal Spacer - genetics | Prostaglandin-Endoperoxide Synthases - chemistry | Base Sequence | Actins - chemistry | Kluyveromyces - classification | Peptide Elongation Factor 1 - genetics | RNA Polymerase II - chemistry | DNA, Mitochondrial - chemistry | Prostaglandin-Endoperoxide Synthases - genetics | Candida - genetics | Isoenzymes - genetics | RNA, Ribosomal, 18S - genetics | RNA, Ribosomal - chemistry | DNA, Ribosomal Spacer - chemistry | Sequence Analysis, DNA | RNA, Ribosomal, 18S - chemistry | Peptide Elongation Factor 1 - chemistry | RNA Polymerase II - genetics | Kluyveromyces - genetics | Saccharomyces - classification | Evolution, Molecular | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
A new series of 2-substituted mercapto-4(3 )-quinazolinone were synthesized and assessed for anti-inflammatory and analgesic activities and inhibition of... 
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | SELECTIVE-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ANALOGS | ANTITUMOR-ACTIVITY | DRUGS | BIOLOGICAL EVALUATION | DERIVATIVES | PROSTAGLANDIN SYNTHESIS | QUINAZOLINES | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2018, Volume 80, pp. 24 - 35
Designing of hybrid drugs with specific multitarget profile is a promising line of attack against inflammation. In light of this, a series of benzimidazole... 
Multitarget profile | TNF-α | COXs | Anti-inflammatory | Hybrid drugs | LOXs | Benzimidazole scaffold | DESIGN | ASSAY | TNF-alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | INDOMETHACIN | CHEMISTRY, ORGANIC | IDENTIFICATION | DISCOVERY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INHIBITORS | 5-LIPOXYGENASE | DERIVATIVES | Analgesics - pharmacology | Benzimidazoles - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 2 Inhibitors - therapeutic use | Drug Design | Lipid Peroxidation - drug effects | Cyclooxygenase 1 - chemistry | Binding Sites | Benzimidazoles - therapeutic use | Cyclooxygenase 2 Inhibitors - chemical synthesis | Analgesics - therapeutic use | Catalytic Domain | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Lipoxygenase Inhibitors - therapeutic use | Edema - drug therapy | Macrophages - cytology | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Benzimidazoles - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Edema - pathology | Lipoxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - therapeutic use | Enzymes | Analysis | Protein binding | Index Medicus
Journal Article
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 04/2019, Volume 99, Issue 6, pp. 2939 - 2946
Background Raspberry and strawberry are high value-added food products that can contribute to human health due to the abundance of polyphenols that they... 
metabolic syndrome | elicitation | COX2 | berries | secondary metabolism | SYSTEMIC RESISTANCE | RISK-FACTORS | FOOD SCIENCE & TECHNOLOGY | ALPHA-GLUCOSIDASE | LEAVES | FLAVONOIDS | CYCLOOXYGENASE-1 | ISOFLAVONE METABOLISM | AMYLASE | AGRICULTURE, MULTIDISCIPLINARY | INHIBITORS | CHEMISTRY, APPLIED | Plant Extracts - chemistry | Humans | Pseudomonas fluorescens - metabolism | alpha-Amylases - genetics | Plant Extracts - metabolism | Fruit - microbiology | Enzyme Inhibitors - chemistry | Cyclooxygenase 1 - chemistry | Metabolic Syndrome - diet therapy | Rubus - microbiology | Fruit - metabolism | Rubus - metabolism | Metabolic Syndrome - enzymology | Enzyme Inhibitors - metabolism | Fragaria - metabolism | Fruit - chemistry | Cyclooxygenase 2 - chemistry | alpha-Amylases - metabolism | Phenols - metabolism | Rubus - chemistry | Anthocyanins - metabolism | Anthocyanins - chemistry | Fragaria - microbiology | Cyclooxygenase 2 - metabolism | Phenols - chemistry | Bacillus amyloliquefaciens - metabolism | Cyclooxygenase 1 - metabolism | alpha-Glucosidases - metabolism | alpha-Glucosidases - chemistry | Anthocyanin | Antioxidants | Chemical industry | Herbicides | Pesticides industry | Amylases | Biological products | Physiological aspects | Polyphenols | Plant metabolites | Food | Enzymes | Plants (botany) | Berries | Glucosidase | Food production | Pseudomonas fluorescens | Metabolic syndrome | Phenolic compounds | Fruits | Plant extracts | Organic chemistry | Strawberries | Secondary metabolites | Enzymatic activity | Metabolites | Plant growth | Phenols | Plant metabolism | Cyclooxygenase-2 | Metabolic disorders | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2012, Volume 20, Issue 1, pp. 101 - 107
Journal Article
Molecules, ISSN 1420-3049, 09/2017, Volume 22, Issue 9, p. 1520
Quercetin (Q) was used as substrate for regioselective glycosylation at the C-7 position catalyzed by Beauveria bassiana AM278 strain. As a result the... 
Antioxidants | Human serum albumin | Microbial glycosylation | COX-2 | Fluidity | COX-1 | Liposomes | Quercetin glycoside | ANTIOXIDANT ACTIVITY | quercetin glycoside | LIPID-PEROXIDATION | liposomes | antioxidants | HUMAN SERUM-ALBUMIN | CHEMISTRY, ORGANIC | XANTHOHUMOL | MODEL | BILAYERS | GLYCOSYLATION | microbial glycosylation | fluidity | INHIBITION | FLAVONOID QUERCETIN | human serum albumin | BINDING | Diphenylhexatriene - chemistry | Fluorescent Dyes - chemistry | Dihydropyridines - chemistry | Quercetin - chemistry | Antioxidants - chemistry | Stereoisomerism | Cyclooxygenase 2 - chemistry | Humans | Glycosylation | Phosphatidylcholines - chemistry | Beauveria - growth & development | Beauveria - metabolism | Liposomes - chemistry | Quercetin - isolation & purification | Solutions | Antioxidants - isolation & purification | Glycosides - isolation & purification | Cyclooxygenase 1 - chemistry | Diphenylhexatriene - analogs & derivatives | Culture Media - chemistry | Serum Albumin, Human - chemistry | Glycosides - chemistry | Beauveria - chemistry | Membranes | Nuclear magnetic resonance--NMR | Lecithin | Fluorescence | Beauveria | Hydrophobicity | Hydrogen bonding | Beauveria bassiana | Lipid membranes | Packing | Chemical bonds | Bonding | Free radicals | Inflammation | Serum albumin | Biological activity | Quenching | Cyclooxygenase-1 | Quercetin | Process parameters | Cyclooxygenase-2 | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 28 - 33
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A₂... 
Enzymes | Prostaglandins | Active sites | Cyclooxygenase inhibitors | Atoms | Dimers | Platelet aggregation | Platelets | Fatty acids | Monomers | Platelet | Prostaglandin | Arachidonic acid | Adrenic acid | Nonsteroidal antiinflammatory drugs | arachidonic acid | SELECTIVE-INHIBITION | adrenic acid | MECHANISM | prostaglandin | ENDOPEROXIDE-H SYNTHASE-1 | OXYGENATION | MULTIDISCIPLINARY SCIENCES | INDOMETHACIN | FATTY-ACIDS | CELECOXIB | nonsteroidal antiinflammatory drugs | platelet | HEALTHY-VOLUNTEERS | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Aspirin - metabolism | Isoenzymes - metabolism | Cyclooxygenase 1 - chemistry | Platelet Aggregation Inhibitors - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Platelet Aggregation - drug effects | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Platelet Aggregation Inhibitors - metabolism | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Dogs | Aspirin - chemistry | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Cyclooxygenase 1 - metabolism | Aspirin | Usage | Physiological aspects | Cyclooxygenases | Genetic aspects | Research | Health aspects | Pain | Protein synthesis | Binding sites | Crystal structure | Index Medicus | CATALYSIS | MONOMERS | THROMBOSIS | ARACHIDONIC ACID | PROCESSING | DIMERS | 60 APPLIED LIFE SCIENCES | ACETYLSALICYLIC ACID | PROSTAGLANDINS | IN VITRO | INFLAMMATION | TARGETS | SIDE EFFECTS | Biological Sciences
Journal Article