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1. Full Text In situ click chemistry generation of cyclooxygenase-2 inhibitors
by Bhardwaj, Atul and Kaur, Jatinder and Wuest, Melinda and Wuest, Frank
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hindlimb | Pyrazoles - chemical synthesis | Humans | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Thermodynamics | Cyclooxygenase 2 - genetics | Drug Design | Cyclooxygenase 1 - chemistry | Female | Triazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 1 - genetics | Gene Expression | Cyclooxygenase 2 Inhibitors - pharmacology | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Click Chemistry - methods | Rats | Edema - enzymology | Edema - drug therapy | Triazoles - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Carrageenan | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Kinetics | Edema - pathology | Drugs | COX-2 inhibitors | Side effects | Inhibitors | Pain | Cyclooxygenase-1 | Inflammation | Cyclooxygenase-2 | Chemical synthesis | Anti-inflammatory agents | Index Medicus
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2. Full Text Antimicrobial and selected in vitro enzyme inhibitory effects of leaf extracts, flavonols and indole alkaloids isolated from Croton menyharthii
by Aderogba, Mutalib A and Ndhlala, Ashwell R and Rengasamy, Kannan R.R and Van Staden, Johannes
Molecules (Basel, Switzerland), ISSN 1420-3049, 10/2013, Volume 18, Issue 10, pp. 12633 - 12644
Antimicrobial | Flavonols | Alkaloid | COX-2 | Croton menyharthii Pax | Alpha-glucosidase | Mutagenicity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Extracts - chemistry | Plant Extracts - pharmacology | Escherichia coli - drug effects | Humans | Alkaloids - isolation & purification | Cholinesterase Inhibitors - chemistry | Antifungal Agents - chemistry | Flavonols - isolation & purification | Indoles - isolation & purification | Cyclooxygenase 2 Inhibitors - chemistry | Microbial Sensitivity Tests | Candida albicans - drug effects | Anti-Bacterial Agents - chemistry | Inhibitory Concentration 50 | Indoles - pharmacology | Cholinesterase Inhibitors - isolation & purification | Antifungal Agents - pharmacology | Plant Leaves - chemistry | Alkaloids - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Fish Proteins - chemistry | Cyclooxygenase 2 - chemistry | Cyclooxygenase 2 Inhibitors - isolation & purification | Electrophorus | Plant Extracts - isolation & purification | Acetylcholinesterase - chemistry | Anti-Bacterial Agents - isolation & purification | Flavonols - chemistry | Antifungal Agents - isolation & purification | Animals | Cholinesterase Inhibitors - pharmacology | Croton - chemistry | Anti-Bacterial Agents - pharmacology | Flavonols - pharmacology | Staphylococcus aureus - drug effects | Indoles - chemistry | Alkaloids - chemistry | Bacillus subtilis - drug effects | Index Medicus | antimicrobial | mutagenicity | alpha-glucosidase | flavonols | alkaloid
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3. Full Text Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
by Lai, Yisheng and Ma, Lin and Huang, Wenxing and Yu, Xing and Zhang, Yihua and Ji, Hui and Tian, Jide
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2010, Volume 20, Issue 24, pp. 7349 - 7353
Cyclooxygenase | Amino/methylsufonylphenyl | Anti-inflammatory agents | Indolin-2-one derivatives | 5-Lipoxygenase | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Analgesics - pharmacology | Indoles - chemical synthesis | Male | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Benzylidene Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Benzylidene Compounds - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzylidene Compounds - pharmacology | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Mice | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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4. Full Text Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS
by Xie, Linlin and Lee, David Yue-wei and Shang, Ying and Cao, Xiaotong and Wang, Siqi and Liao, Jun and Zhang, Teng and Dai, Ronghua
Phytomedicine (Stuttgart), ISSN 0944-7113, 10/2020, Volume 77, pp. 153284 - 153284
Saponins | AUF-LC-MS | Inflammation | Cyclooxygenase-2 | 5-lipoxygenase | Dual targeted inhibitors | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Spirostans - pharmacology | Arachidonate 5-Lipoxygenase - genetics | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Chromatography, High Pressure Liquid | Cyclooxygenase 2 Inhibitors - chemistry | Saponins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ultrafiltration | Anemarrhena - chemistry | Lipoxygenase Inhibitors - chemistry | Rhizome - chemistry | Cyclooxygenase 2 - genetics | Inflammation - drug therapy | Mass Spectrometry | Arachidonate 5-Lipoxygenase - chemistry | Steroids - pharmacology | Spirostans - chemistry | Drug Evaluation, Preclinical | Glycosides - chemistry | Steroids - chemistry | Sterols - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Sterols - chemistry | Cyclooxygenase 2 - chemistry | Rats | Glycosides - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Lipoxygenase Inhibitors - pharmacology | Saponins - pharmacology | Index Medicus
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5. Full Text [3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H-Azirines and Aldehydes
by Zeng, Ting-Ting and Xuan, Jun and Ding, Wei and Wang, Kuan and Lu, Liang-Qiu and Xiao, Wen-Jing
Organic letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 16, pp. 4070 - 4073
Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Oxidation-Reduction | Cyclooxygenase 2 Inhibitors - chemistry | Cycloaddition Reaction | Oxazoles - chemistry | Alkenes - chemistry | Azirines - chemistry | Oxazoles - chemical synthesis | Light | Imines - chemistry | Molecular Structure | Oxazoles - pharmacology | Catalysis | Aldehydes - chemistry | Index Medicus
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6. Full Text Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study
by El-Sayed, Magda A.-A and Abdel-Aziz, Naglaa I and Abdel-Aziz, Alaa A.-M and El-Azab, Adel S and Asiri, Yousif A and ElTahir, Kamal E.H
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3416 - 3424
Hydrazone and pyrazole derivatives | Selective COX-2 inhibitors | Molecular docking | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Rats | Edema - drug therapy | Hydrazones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Hydrazones - chemistry | Hydrazones - pharmacology | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Computer Simulation | Cyclooxygenase 2 - metabolism | Drug Design | Cyclooxygenase 1 - chemistry | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Binding Sites | Disease Models, Animal | Pyrazoles - pharmacology | Index Medicus
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7. Full Text Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones
by Abdel-Aziz, Alaa A.-M and Abou-Zeid, Laila A and ElTahir, Kamal Eldin H and Ayyad, Rezk R and El-Sayed, Magda A.-A and El-Azab, Adel S
European journal of medicinal chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
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8. Full Text Fluorophore‐Labeled Cyclooxygenase‐2 Inhibitors for the Imaging of Cyclooxygenase‐2 Overexpression in Cancer: Synthesis and Biological Studies
by Bhardwaj, Atul and Kaur, Jatinder and Wuest, Frank and Knaus, Edward E
ChemMedChem, ISSN 1860-7179, 01/2014, Volume 9, Issue 1, pp. 109 - 116
inhibitors | enzymes | cancer | fluorescence | cyclooxygenases | medicinal chemistry | Humans | 4-Chloro-7-nitrobenzofurazan - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Colonic Neoplasms - metabolism | Pyrazoles - chemistry | Ibuprofen - chemistry | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Fluorescent Dyes - chemistry | Cyclooxygenase Inhibitors - metabolism | Sulfonamides - chemistry | Cyclooxygenase 2 - chemistry | HCT116 Cells | Cyclooxygenase Inhibitors - chemistry | Naproxen - chemistry | 4-Chloro-7-nitrobenzofurazan - analogs & derivatives | Celecoxib - analogs & derivatives | Microscopy, Confocal | Colonic Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Protein Binding | Cyclooxygenase 1 - metabolism | COX-2 inhibitors | Oncology, Experimental | Naproxen | Ibuprofen | Colorectal cancer | Fluorescence | Research | Cancer | Colon | Index Medicus
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9. Full Text Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated h-bonding network
by Xu, Shu and Hermanson, Daniel J and Banerjee, Surajit and Ghebreselasie, Kebreab and Clayton, Gina M and Garavito, R. Michael and Marnett, Lawrence J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of biological chemistry, ISSN 0021-9258, 03/2014, Volume 289, Issue 10, pp. 6799 - 6808
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Water | Thiazoles - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Thiazines - metabolism | Cyclooxygenase 2 - genetics | Arginine - genetics | Cyclooxygenase 1 - chemistry | Piroxicam - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Leucine - genetics | Tyrosine - chemistry | Meloxicam | Leucine - metabolism | Catalytic Domain | Cyclooxygenase 1 - genetics | Cyclooxygenase Inhibitors - metabolism | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Serine - genetics | Cyclooxygenase Inhibitors - chemistry | Serine - chemistry | Serine - metabolism | Thiazines - chemistry | Arginine - chemistry | Leucine - chemistry | Piroxicam - metabolism | Tyrosine - metabolism | Animals | Piroxicam - chemistry | Hydrogen Bonding | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Mice | Cyclooxygenase 1 - metabolism | Mutation | Arginine - metabolism | Amino Acid Substitution | Tyrosine - genetics | Index Medicus | Enzyme Structure | Lipids | Drug Action | X-ray Crystallography | Cyclooxygenase (COX) Pathway | Protein Drug Interactions
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10. Full Text COX inhibition profile and molecular docking studies of some 2-(Trimethoxyphenyl)-Thiazoles
by Oniga, Smaranda Dafina and Pacureanu, Liliana and Stoica, Cristina Ioana and Palage, Mariana Doina and Crăciun, Alexandra and Rusu, Laurentiu Răzvan and Crisan, Elena-Luminita and Araniciu, Cătălin
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2017, Volume 22, Issue 9, p. 1507
2-(trimethoxyphenyl)-thiazoles | Selective COX-2 inhibition | NSAIDs | Molecular docking | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Phenols - chemical synthesis | Cyclooxygenase 2 - chemistry | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase Inhibitors - chemistry | Structure-Activity Relationship | Thiazines - chemistry | Amino Acid Motifs | Thermodynamics | Animals | Hydrogen Bonding | Thiazoles - chemical synthesis | Cyclooxygenase Inhibitors - chemical synthesis | Cyclooxygenase 1 - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Phenols - chemistry | Sheep | Thiazoles - chemistry | Molecular Docking Simulation | Protein Interaction Domains and Motifs | Kinetics | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Binding Sites | Meloxicam | Drugs | Pharmacology | Selectivity | Inflammation | Hydrophobicity | Chemical compounds | Anti-inflammatory agents | Inhibitors | Cyclooxygenase-1 | Hydrogen bonds | Thiazoles | Isoforms | In vivo methods and tests | Cyclooxygenase-2 | Inhibition | Nonsteroidal anti-inflammatory drugs | Binding sites | Index Medicus | selective COX-2 inhibition | molecular docking
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11. Full Text Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation
by Kaur, Gaganpreet and Silakari, Om
Bioorganic chemistry, ISSN 0045-2068, 10/2018, Volume 80, pp. 24 - 35
Multitarget profile | TNF-α | COXs | Anti-inflammatory | Hybrid drugs | LOXs | Benzimidazole scaffold | Analgesics - pharmacology | Benzimidazoles - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 2 Inhibitors - therapeutic use | Drug Design | Lipid Peroxidation - drug effects | Cyclooxygenase 1 - chemistry | Binding Sites | Benzimidazoles - therapeutic use | Cyclooxygenase 2 Inhibitors - chemical synthesis | Analgesics - therapeutic use | Catalytic Domain | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Lipoxygenase Inhibitors - therapeutic use | Edema - drug therapy | Macrophages - cytology | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Benzimidazoles - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Edema - pathology | Lipoxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - therapeutic use | Enzymes | Analysis | Protein binding | Index Medicus
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12. Full Text Substrate-selective inhibition of cyclooxygeanse-2 by fenamic acid derivatives is dependent on peroxide tone
by Orlando, Benjamin J and Malkowski, Michael G and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of biological chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15069 - 15081
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Endocannabinoids - metabolism | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Humans | Fenamates - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Substrate Specificity | Tryptophan - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Cyclooxygenase 2 Inhibitors - chemistry | Fenamates - pharmacology | Heme - chemistry | Cyclooxygenase 2 - genetics | Cyclooxygenase 2 - metabolism | Peroxides - metabolism | In Vitro Techniques | Binding Sites | Amino Acid Substitution | Index Medicus | nonsteroidal anti-inflammatory drugs | endocannabinoid | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY | crystal structure | structural biology | cyclooxygenase (COX) | electron paramagnetic resonance (EPR) | Protein Structure and Folding
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