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1. Full Text In situ click chemistry generation of cyclooxygenase-2 inhibitors
by Bhardwaj, Atul and Kaur, Jatinder and Wuest, Melinda and Wuest, Frank
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and... 
TARGET | CYCLOADDITION | ACETYLCHOLINESTERASE | ANTIINFLAMMATORY AGENTS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BIOLOGY | DRUG DEVELOPMENT | CANCER | EXPRESSION | DISCOVERY | Hindlimb | Pyrazoles - chemical synthesis | Humans | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Thermodynamics | Cyclooxygenase 2 - genetics | Drug Design | Cyclooxygenase 1 - chemistry | Female | Triazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 1 - genetics | Gene Expression | Cyclooxygenase 2 Inhibitors - pharmacology | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Click Chemistry - methods | Rats | Edema - enzymology | Edema - drug therapy | Triazoles - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Carrageenan | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Kinetics | Edema - pathology | Drugs | COX-2 inhibitors | Side effects | Inhibitors | Antiinflammatory agents | Pain | Cyclooxygenase-1 | Inflammation | Cyclooxygenase-2 | Chemical synthesis | Prostaglandin endoperoxide synthase
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2. Full Text Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones
by Abdel-Aziz, Alaa A.-M and Abou-Zeid, Laila A and ElTahir, Kamal Eldin H and Ayyad, Rezk R and El-Sayed, Magda A.-A and El-Azab, Adel S
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
A new series of 2-substituted mercapto-4(3 )-quinazolinone were synthesized and assessed for anti-inflammatory and analgesic activities and inhibition of... 
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | SELECTIVE-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ANALOGS | ANTITUMOR-ACTIVITY | DRUGS | BIOLOGICAL EVALUATION | DERIVATIVES | PROSTAGLANDIN SYNTHESIS | QUINAZOLINES | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac
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3. Full Text Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study
by El-Sayed, Magda A.-A and Abdel-Aziz, Alaa A.-M and Abdel-Aziz, Naglaa I and El-Azab, Adel S and Asiri, Yousif A and ElTahir, Kamal E.H
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3416 - 3424
A series of hydrazone and pyrazole derivatives were prepared and evaluated for their anti-inflammatory activities and selectivity as COX-2 inhibitor. New... 
Hydrazone and pyrazole derivatives | Selective COX-2 inhibitors | Molecular docking | CHEMISTRY, MEDICINAL | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CYCLOOXYGENASE | SYNTHASE | PROSTAGLANDINS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | STRUCTURAL BASIS | PART 1 | LIGAND | BINDING | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Rats | Edema - drug therapy | Hydrazones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Hydrazones - chemistry | Hydrazones - pharmacology | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Computer Simulation | Cyclooxygenase 2 - metabolism | Drug Design | Cyclooxygenase 1 - chemistry | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Binding Sites | Disease Models, Animal | Pyrazoles - pharmacology
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4. Full Text d‑Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Nonsteroidal Anti-Inflammatory Drug (NSAID)
by Li, Jiayang and Kuang, Yi and Gao, Yuan and Du, Xuewen and Shi, Junfeng and Xu, Bing
Journal of the American Chemical Society, ISSN 0002-7863, 01/2013, Volume 135, Issue 2, pp. 542 - 545
As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti-inflammatory drugs (NSAIDs) also associate with the... 
DIPEPTIDES | TRIAL | CELLS | SMALL MOLECULES | GELS | CYCLOOXYGENASE INHIBITION | REGENERATIVE MEDICINE | TOPICAL DICLOFENAC | OSTEOARTHRITIS | PROSTAGLANDIN-G/H SYNTHASE-1 | CHEMISTRY, MULTIDISCIPLINARY | Microscopy, Electron, Transmission | Cyclooxygenase 2 - chemistry | Humans | Amino Acids - chemistry | Models, Molecular | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Naproxen - metabolism | Naproxen - chemistry | Cyclooxygenase 2 - metabolism | Inhibitory Concentration 50 | Protein Binding | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Hydrogels - chemistry | Usage | Anti-inflammatory drugs | Molecular dynamics | Amino acids | Chemical properties | Research | Cardiovascular diseases | Risk factors
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5. Full Text Antimicrobial and selected in vitro enzyme inhibitory effects of leaf extracts, flavonols and indole alkaloids isolated from Croton menyharthii
by Aderogba, Mutalib A and Ndhlala, Ashwell R and Rengasamy, Kannan R.R and Van Staden, Johannes
Molecules, ISSN 1420-3049, 10/2013, Volume 18, Issue 10, pp. 12633 - 12644
Croton species are used in folk medicine in the management of infections, inflammation and oxidative stress-related diseases. In order to isolate, characterize... 
Antimicrobial | Flavonols | Alkaloid | COX-2 | Croton menyharthii Pax | Alpha-glucosidase | Mutagenicity | antimicrobial | mutagenicity | alpha-glucosidase | BIOCHEMISTRY & MOLECULAR BIOLOGY | flavonols | PLANTS | alkaloid | CHEMISTRY, MULTIDISCIPLINARY | Plant Extracts - chemistry | Plant Extracts - pharmacology | Escherichia coli - drug effects | Humans | Alkaloids - isolation & purification | Cholinesterase Inhibitors - chemistry | Antifungal Agents - chemistry | Flavonols - isolation & purification | Indoles - isolation & purification | Cyclooxygenase 2 Inhibitors - chemistry | Microbial Sensitivity Tests | Candida albicans - drug effects | Anti-Bacterial Agents - chemistry | Inhibitory Concentration 50 | Indoles - pharmacology | Cholinesterase Inhibitors - isolation & purification | Antifungal Agents - pharmacology | Plant Leaves - chemistry | Alkaloids - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Fish Proteins - chemistry | Cyclooxygenase 2 - chemistry | Cyclooxygenase 2 Inhibitors - isolation & purification | Electrophorus | Plant Extracts - isolation & purification | Acetylcholinesterase - chemistry | Anti-Bacterial Agents - isolation & purification | Flavonols - chemistry | Antifungal Agents - isolation & purification | Animals | Cholinesterase Inhibitors - pharmacology | Croton - chemistry | Anti-Bacterial Agents - pharmacology | Flavonols - pharmacology | Staphylococcus aureus - drug effects | Indoles - chemistry | Alkaloids - chemistry | Bacillus subtilis - drug effects
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6. Full Text Pleiotropic mechanisms facilitated by resveratrol and its metabolites
by Calamini, Barbara and Ratia, Kiira and Malkowski, Michael G and Cuendet, Muriel and Pezzuto, John M and Santarsiero, Bernard D and Mesecar, Andrew D
Biochemical Journal, ISSN 0264-6021, 07/2010, Volume 429, Issue 2, pp. 273 - 282
Resveratrol has demonstrated cancer chemopreventive activity in animal models and some clinical trials are underway. In addition, resveratrol was shown to... 
Cancer chemoprevention | Resveratrol metabolite | SIRT1 | Molecular docking | Cyclo-oxygenase (COX) | Quinone reductase 2 | QUINONE OXIDOREDUCTASE-2 | quinone reductase 2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIRTUINS | DNA ADDUCT FORMATION | MCF-10F CELLS | resveratrol metabolite | molecular docking | INHIBITION | cancer chemoprevention | cyclo-oxygenase (COX) | TRANS-RESVERATROL | PROSTAGLANDIN SYNTHASE | RED WINE | SMALL-MOLECULE ACTIVATORS | Sirtuin 1 - metabolism | Humans | Crystallography, X-Ray | Stilbenes - metabolism | Stilbenes - chemistry | Anticarcinogenic Agents - metabolism | Stilbenes - pharmacology | Cyclooxygenase 2 Inhibitors - chemistry | Resveratrol | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anticarcinogenic Agents - pharmacology | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Quinone Reductases - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Mice | Cyclooxygenase 1 - metabolism | In Vitro Techniques
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7. Full Text Substrate-selective inhibition of cyclooxygeanse-2 by fenamic acid derivatives is dependent on peroxide tone
by Orlando, Benjamin J and Malkowski, Michael G and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15069 - 15081
Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and endocannabinoid substrates, placing the enzyme at a unique junction between the... 
CROSS-TALK | PATHWAYS | PROSTAGLANDIN H SYNTHASE | ENDOCANNABINOID OXYGENATION | MONOMERS | PROTEIN | MECHANISM | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARACHIDONIC-ACID | HUMAN CYCLOOXYGENASE-2 | Endocannabinoids - metabolism | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Humans | Fenamates - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Substrate Specificity | Tryptophan - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Cyclooxygenase 2 Inhibitors - chemistry | Fenamates - pharmacology | Heme - chemistry | Cyclooxygenase 2 - genetics | Cyclooxygenase 2 - metabolism | Peroxides - metabolism | In Vitro Techniques | Binding Sites | Amino Acid Substitution | nonsteroidal anti-inflammatory drugs | Protein Structure and Folding | endocannabinoid | crystal structure | structural biology | cyclooxygenase (COX) | electron paramagnetic resonance (EPR)
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8. Full Text Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives
by Świątek, Piotr and Strzelecka, Malgorzata and Urniaz, Rafal and Gębczak, Katarzyna and Gębarowski, Tomasz and Gąsiorowski, Kazimierz and Malinka, Wieslaw
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 1, pp. 316 - 326
One of the main challenges for nowadays medicine is drugs selectivity. In COX-1 and COX-2, the active sites are composed of the same group of amino acids with... 
Isothiazolopyridine | Cyclooxygenase inhibition | Molecular docking | CHEMISTRY, MEDICINAL | ACID | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTIMYCOBACTERIAL AGENTS | EXPRESSION | RESIDUES | Catalytic Domain | Pyridines - chemistry | Cyclooxygenase 2 - chemistry | Pyridines - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Flurbiprofen - chemistry | Thiazines - chemistry | Animals | Piroxicam - chemistry | Thiazoles - chemical synthesis | Cyclooxygenase Inhibitors - chemical synthesis | Cyclooxygenase 1 - chemistry | Thiazoles - chemistry | Mice | Molecular Docking Simulation | Quantitative Structure-Activity Relationship | Medicine, Experimental | COX-2 inhibitors | Medical research | Enzymes | Amino acids
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9. Full Text Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated h-bonding network
by Xu, Shu and Hermanson, Daniel J and Banerjee, Surajit and Ghebreselasie, Kebreab and Clayton, Gina M and Garavito, R. Michael and Marnett, Lawrence J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Biological Chemistry, ISSN 0021-9258, 03/2014, Volume 289, Issue 10, pp. 6799 - 6808
Background: The oxicams are anti-inflammatory drugs targeting the cyclooxygenase enzymes. Results: Crystal complexes of mCOX-2isoxicam, mCOX-2meloxicam, and... 
Enzyme Structure | SELECTIVE-INHIBITION | ANTIINFLAMMATORY ACTIVITY | COX-2 | MECHANISM | X-ray Crystallography | Protein Drug Interactions | CRYSTAL-STRUCTURE | OXYGENATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARACHIDONIC-ACID | Cyclooxygenase (COX) Pathway | NSAID BINDING | STRUCTURAL BASIS | Drug Action | INSIGHTS | Water | Thiazoles - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Thiazines - metabolism | Cyclooxygenase 2 - genetics | Arginine - genetics | Cyclooxygenase 1 - chemistry | Piroxicam - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Leucine - genetics | Tyrosine - chemistry | Leucine - metabolism | Catalytic Domain | Cyclooxygenase 1 - genetics | Cyclooxygenase Inhibitors - metabolism | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Serine - genetics | Cyclooxygenase Inhibitors - chemistry | Serine - chemistry | Serine - metabolism | Thiazines - chemistry | Arginine - chemistry | Leucine - chemistry | Piroxicam - metabolism | Tyrosine - metabolism | Animals | Piroxicam - chemistry | Hydrogen Bonding | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Mice | Cyclooxygenase 1 - metabolism | Mutation | Arginine - metabolism | Amino Acid Substitution | Tyrosine - genetics | Lipids
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10. Full Text Fluorescence Discrimination of Cancer from Inflammation by Molecular Response to COX‑2 Enzymes
by Zhang, Hua and Fan, Jiangli and Wang, Jingyun and Dou, Bairui and Zhou, Fan and Cao, Jianfang and Qu, Junle and Cao, Zhi and Zhao, Weijie and Peng, Xiaojun
Journal of the American Chemical Society, ISSN 0002-7863, 11/2013, Volume 135, Issue 46, pp. 17469 - 17475
Accurate identification of cancer from inflammation and normal tissue in a rapid, sensitive, and quantitative fashion is important for cancer diagnosis and... 
SITE | DYE | SYNTHASE-1 | PROGNOSTIC-FACTOR | MECHANISM | CYCLOOXYGENASE-2 EXPRESSION | AGENTS | INHIBITORS | DENSITY-FUNCTIONAL THEORY | BINDING | CHEMISTRY, MULTIDISCIPLINARY | Fluorescent Dyes - chemical synthesis | Neoplasms - metabolism | Fluorescent Dyes - chemistry | Cyclooxygenase 2 - chemistry | Humans | Fluorescence | Fluorescent Dyes - metabolism | Models, Molecular | Neoplasms - enzymology | Spectrometry, Fluorescence | Inflammation - metabolism | Quantum Theory | Cyclooxygenase 2 - metabolism | Molecular Structure | Measurement | Enzymes | Care and treatment | Synthesis | Analysis | Research | Diagnosis | Activation energy | Cancer
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11. Full Text Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
by Lang, Undine E and Borgwardt, Stefan
Cellular Physiology and Biochemistry, ISSN 1015-8987, 07/2013, Volume 31, Issue 6, pp. 761 - 777
Depression is a multicausal disorder and has been associated with the risk to develop cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder... 
Review | Sleep | BDNF | Cardiovascular | Depression | Inflammation | Metabolic | Glutamate | Stress | PHYSIOLOGY | NEUROTROPHIC FACTOR LEVELS | RANDOMIZED CLINICAL-TRIAL | ADULT HIPPOCAMPAL NEUROGENESIS | MAJOR DEPRESSION | CELL BIOLOGY | BDNF SERUM CONCENTRATIONS | SEROTONIN REUPTAKE INHIBITOR | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | PERSONALITY-TRAITS | GROWTH-FACTOR-I | Receptors, Glutamate - metabolism | Vascular Endothelial Growth Factors - chemistry | Excitatory Amino Acid Antagonists - therapeutic use | Cytokines - metabolism | Depression - pathology | Cyclooxygenase 2 - chemistry | Humans | Triiodothyronine - chemistry | Receptors, Glutamate - chemistry | Antidepressive Agents - therapeutic use | Depression - drug therapy | Brain-Derived Neurotrophic Factor - chemistry | Depression - metabolism | Triiodothyronine - metabolism | Antidepressive Agents - chemistry | Cyclooxygenase 2 - metabolism | Vascular Endothelial Growth Factors - metabolism | Brain-Derived Neurotrophic Factor - metabolism
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12. Full Text Previously undisclosed bioactive sterols from corbiculid bivalve clam Villorita cyprinoides with anti-inflammatory and antioxidant potentials
by Joy, Minju and Chakraborty, Kajal
Steroids, ISSN 0039-128X, 07/2018, Volume 135, pp. 1 - 8
The estuarine Corbiculid bivalve black clam, collected from the Southwestern coastline regions of Arabian Sea are significant resources of nutritional and... 
Villorita cyprinoides | Anti-inflammatory activity | 5-Lipoxidase | Cyclooxygenase | Abeo-pregnane-type sterol | PAPHIA-MALABARICA | CYCLOOXYGENASE-2 | SCAVENGING ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | PREGNANE-TYPE STEROIDS | Sterols - pharmacology | Sterols - metabolism | Antioxidants - chemistry | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Sterols - chemistry | Antioxidants - metabolism | Cyclooxygenase 2 - chemistry | Structure-Activity Relationship | Antioxidants - pharmacology | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Sulfonic Acids - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Picrates - chemistry | Cyclooxygenase 2 - metabolism | Benzothiazoles - chemistry | Protein Conformation | Cyclooxygenase 2 Inhibitors - metabolism | Molecular Docking Simulation | Biphenyl Compounds - chemistry | Bivalvia - chemistry | Antioxidants | COX-2 inhibitors | Esters | Sterols | Analysis | Force and energy
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13. Full Text Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents
by Bandgar, Babasaheb P and Patil, Sachin A and Gacche, Rajesh N and Korbad, Balaji L and Hote, Balwant S and Kinkar, Santosh N and Jalde, Shivkumar S
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 2, pp. 730 - 733
A novel series of nitrogen-containing chalcones were synthesized and were screened for anti-inflammatory and antioxidant activity. Tested compounds ( , , , )... 
Anti-inflammatory | Antioxidant activity | Nitrogen-containing chalcones | DESIGN | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | FLAVONOIDS | INHIBITORS | DERIVATIVES | CYCLOOXYGENASES | Cyclooxygenase 2 Inhibitors - chemical synthesis | Trypsin Inhibitors - chemical synthesis | Chalcones - chemistry | Antioxidants - chemistry | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Glucuronidase - metabolism | Trypsin Inhibitors - pharmacology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Cyclooxygenase 2 Inhibitors - chemistry | Trypsin - metabolism | Trypsin Inhibitors - chemistry | Anti-Inflammatory Agents - chemistry | Chalcones - chemical synthesis | Nitrogen - chemistry | Chalcones - pharmacology | Cyclooxygenase 2 - metabolism | Glucuronidase - antagonists & inhibitors | Anti-Inflammatory Agents - chemical synthesis | Trypsin - chemistry | Antioxidants | Enzymes | Anti-inflammatory drugs | Analysis
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14. Full Text Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors
by Abdellatif, Khaled R.A and Fadaly, Wael A.A and Kamel, Gehan M and Elshaier, Yaseen A.M.M and El-Magd, Mohammed A
Bioorganic Chemistry, ISSN 0045-2068, 02/2019, Volume 82, pp. 86 - 99
Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions... 
Anti-diabetic | Cyclooxygenase-2 inhibitors | Anti-inflammatory | Pyrazole | PPARγ | Thiazolidine | RAT | ANALOGS | PROLIFERATOR-ACTIVATED RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PPAR gamma | MOLECULAR DOCKING | DISCOVERY | REGULATOR | GLUCOSIDASE | INFLAMMATION | Thiazolidines - chemical synthesis | Glycoside Hydrolase Inhibitors - adverse effects | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Cyclooxygenase 2 Inhibitors - adverse effects | Anti-Inflammatory Agents - adverse effects | Cellulases - metabolism | Drug Design | Pyrroles - adverse effects | Molecular Structure | Thiazolidines - pharmacology | Thiazolidines - chemistry | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Catalytic Domain | Thiazolidines - adverse effects | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Celecoxib - pharmacology | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - pharmacology | Glycoside Hydrolase Inhibitors - chemical synthesis | Pyrroles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Pyrroles - chemical synthesis | Cyclooxygenase 2 - metabolism | PPAR gamma - agonists | Pyrroles - chemistry | Sheep | Anti-Inflammatory Agents - chemical synthesis | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | alpha-Glucosidases - metabolism | PPAR gamma - chemistry
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