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American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 2014, Volume 306, Issue 12, pp. E1378 - E1387
Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM... 
Acylcarnitine | β-oxidation | Inflammation | TLR | Pattern recognition receptors | OXIDATION | PHYSIOLOGY | acylcarnitine | SATURATED FATTY-ACIDS | INDUCED INSULIN-RESISTANCE | pattern recognition receptors | TOLL-LIKE RECEPTOR-2 | OBESITY | inflammation | beta-oxidation | ENDOCRINOLOGY & METABOLISM | EXPRESSION | Phosphorylation | Toll-Like Receptor 2 - agonists | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Humans | Carnitine - metabolism | Diabetes Mellitus, Type 2 - metabolism | MAP Kinase Signaling System | Receptors, Pattern Recognition - antagonists & inhibitors | Receptors, Pattern Recognition - metabolism | Macrophages - secretion | Cyclooxygenase 2 - genetics | Diabetes Mellitus, Type 2 - immunology | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Receptors, Pattern Recognition - agonists | Carnitine - analogs & derivatives | Macrophages - immunology | Recombinant Proteins - metabolism | Myristic Acids - metabolism | Cyclooxygenase 2 - chemistry | Cytokines - secretion | Gene Silencing | Myeloid Differentiation Factor 88 - genetics | Enzyme Induction | Recombinant Proteins - chemistry | Toll-Like Receptor 2 - metabolism | Macrophage Activation | Myeloid Differentiation Factor 88 - agonists | Macrophages - metabolism | Animals | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Receptors, Pattern Recognition - genetics | Mice | Protein Processing, Post-Translational | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Docosahexaenoic Acids - metabolism | Type 2 diabetes | Physiological aspects | Insulin resistance | Cellular signal transduction | Research | Diabetes
Journal Article
Glia, ISSN 0894-1491, 2010, Volume 58, Issue 5, pp. 588 - 598
Neural injury leads to inflammation and activation of microglia that in turn may participate in progression of neurodegeneration. The mechanisms involved in... 
neurodegenerative diseases | heme oxygenase‐1 | innate immune system | Neurodegenerative diseases | Innate immune system | Heme oxygenase-1 | OXIDATIVE STRESS | ACTIVATION | ALPHA | DJ-1 | heme oxygenase-1 | NEUROSCIENCES | CELL-DEATH | TRANSCRIPTION FACTOR NRF2 | INFLAMMATION | MOUSE MODEL | THERAPEUTIC TARGET | ENHANCES SUSCEPTIBILITY | Dopamine Plasma Membrane Transport Proteins - metabolism | Tyrosine 3-Monooxygenase - metabolism | Flow Cytometry - methods | Leukocyte Common Antigens - metabolism | Reactive Oxygen Species - metabolism | Culture Media, Conditioned - pharmacology | Male | Glial Fibrillary Acidic Protein - metabolism | Brain - metabolism | MPTP Poisoning - complications | Inflammation - metabolism | Microglia - physiology | MPTP Poisoning - pathology | Antigens, Differentiation - metabolism | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Gliosis - etiology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Neurons - chemistry | Mice, Inbred C57BL | Gene Expression Regulation - physiology | NF-E2-Related Factor 2 - deficiency | Inflammation - etiology | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Analysis of Variance | Microfilament Proteins | NF-E2-Related Factor 2 - metabolism | Cyclooxygenase 2 - metabolism | Brain - pathology | Mice | CD11b Antigen - metabolism | Cell Line, Transformed | Nitric Oxide Synthase Type II - metabolism
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 09/2011, Volume 13, Issue 5, pp. R87 - R87
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2012, Volume 32, Issue 3, pp. 721 - 729
OBJECTIVE—Vascular smooth muscle cells (VSMC) from type 2 diabetic db/db mice exhibit enhanced proinflammatory responses implicated in accelerated vascular complications... 
Zeb1 | inflammatory genes | vascular complications | diabetes mellitus | miR-200 | TRANSCRIPTION FACTORS | DB/DB MICE | ATHEROSCLEROSIS | MECHANISMS | FEEDBACK LOOP | EPITHELIAL-MESENCHYMAL TRANSITION | GENE | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | HEMATOLOGY | EXPRESSION | GLYCATION END-PRODUCTS | Up-Regulation | Muscle, Smooth, Vascular - metabolism | Diabetes Mellitus, Type 2 - genetics | Homeodomain Proteins - metabolism | Muscle, Smooth, Vascular - immunology | Male | MicroRNAs - metabolism | Diabetes Mellitus, Type 2 - metabolism | Inflammation - metabolism | Transfection | Chromatin Immunoprecipitation | RNA Interference | Cyclooxygenase 2 - genetics | Kruppel-Like Transcription Factors - metabolism | Diabetes Mellitus, Type 2 - immunology | Inflammation Mediators - metabolism | Chemokine CCL2 - metabolism | 3' Untranslated Regions | Diabetic Angiopathies - genetics | Binding Sites | Myocytes, Smooth Muscle - metabolism | Diabetes Mellitus, Type 2 - complications | Disease Models, Animal | Diabetic Angiopathies - metabolism | Aorta, Thoracic - immunology | Down-Regulation | Cells, Cultured | Aorta, Thoracic - metabolism | Chemokine CCL2 - genetics | Inflammation - immunology | Homeodomain Proteins - genetics | Feedback, Physiological | Animals | Diabetic Angiopathies - immunology | Cyclooxygenase 2 - metabolism | Inflammation - genetics | Myocytes, Smooth Muscle - immunology | Mice | Kruppel-Like Transcription Factors - genetics | Zinc Finger E-box-Binding Homeobox 1 | monocyte binding | Diabetes | vascular smooth muscle cells
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2012, Volume 30, Issue 10, pp. 2283 - 2296
Culturing cells in three dimension (3D) provides an insight into their characteristics in vivo. We previously reported that human mesenchymal stem/stromal... 
Sphere | Caspase | COX2 | MSC | LPS | Macrophage | PROTEIN TSG-6 | STEM-CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | MSCS | BACTERIAL CLEARANCE | ONCOLOGY | HUMAN BONE-MARROW | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFLAMMATION | ENDOTHELIAL-CELLS | TNF-ALPHA | HEMATOLOGY | MARROW STROMAL CELLS | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Humans | NF-kappa B - metabolism | Spheroids, Cellular - cytology | Lectins, C-Type - genetics | Lectins, C-Type - metabolism | Dinoprostone - isolation & purification | Mesenchymal Stromal Cells - cytology | Caspases - metabolism | Cyclooxygenase 2 - genetics | Spheroids, Cellular - drug effects | Cell Culture Techniques | Fibroblasts - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | Receptors, Prostaglandin E, EP4 Subtype - genetics | Dinoprostone - pharmacology | Mesenchymal Stromal Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Caspases - genetics | Spheroids, Cellular - metabolism | Mesenchymal Stromal Cells - metabolism | Receptors, Cell Surface - metabolism | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Culture Media, Conditioned | Macrophages - metabolism | Mannose-Binding Lectins - genetics | NF-kappa B - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Dinoprostone - antagonists & inhibitors | Macrophage Activation - drug effects | Cytokines - biosynthesis | Receptors, Cell Surface - genetics | Anti-inflammatory drugs | RNA | Analysis | Prostaglandins E | Stem cells | Genetic aspects | Information management | Macrophages | Cytokines | Genotype & phenotype | Molecular weight | Antibodies | macrophage | spheroid | caspase
Journal Article
Molecular neurobiology, ISSN 1559-1182, 2015, Volume 53, Issue 9, pp. 6426 - 6443
...), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES-1... 
Neurology | NF-κB | Neurosciences | Biomedicine | BV2 microglia | HT22 hippocampal neurons | Nrf2 | Neurobiology | Artemether | Neuroinflammation | Cell Biology | ALZHEIMERS-DISEASE | INFLAMMATORY REACTIONS | NEUROSCIENCES | BV-2 CELLS | PROTECTS | STAT3 ACTIVATION | NF-kappa B | CULTURED ASTROCYTES | HEME OXYGENASE-1 | NF-KAPPA-B | ARTEMISININ | Neuroprotective Agents - therapeutic use | Inflammation - pathology | Microglia - metabolism | Heme Oxygenase-1 - metabolism | Transcriptional Activation - genetics | Antioxidants - metabolism | Transcriptional Activation - drug effects | NF-kappa B - metabolism | Lipopolysaccharides | Artemisinins - pharmacology | Cell Nucleus - metabolism | Neuroprotective Agents - pharmacology | Inflammation - drug therapy | Amyloid beta-Peptides - metabolism | Microglia - pathology | NF-E2-Related Factor 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Artemisinins - chemistry | Cell Line | Cell Survival - drug effects | Microglia - drug effects | Prostaglandin-E Synthases - metabolism | Neurotoxins - toxicity | Antimalarials - therapeutic use | Antimalarials - pharmacology | Dinoprostone - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Artemisinins - therapeutic use | MAP Kinase Signaling System - drug effects | Aspartic Acid Endopeptidases - metabolism | NF-E2-Related Factor 2 - metabolism | Antimalarials - chemistry | Cyclooxygenase 2 - metabolism | Interleukin-6 - biosynthesis | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Cell Nucleus - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Nitric Oxide Synthase Type II - metabolism | Nervous system diseases | Neurons | Nitric oxide | Heme | Amyloid beta-protein | Synthetic prostaglandins E | Mitogens | Protein kinases | Proteins | Enzymes | Inflammation | Kinases | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0124000 - e0124000
...Author(s): Laxmidhar Das, Manjula Vinayak* Introduction Nuclear factor E2-related factor 2 (Nrf2) is a critical transcription factor that binds to promotor... 
NRF2-MEDIATED ANTIOXIDANT | GROWTH-FACTOR-BETA | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | TGF-BETA | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SULFHYDRYL-GROUPS | GLUTATHIONE-S-TRANSFERASE | INDUCTION | EXPRESSION | Consensus Sequence | Glutathione Reductase - metabolism | Antioxidants - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | RNA, Messenger - metabolism | Lymphoma, T-Cell - prevention & control | Glutathione Reductase - genetics | Lymphoma, T-Cell - metabolism | Glutathione Transferase - genetics | Liver - drug effects | Cyclooxygenase 2 - genetics | Protein Binding - drug effects | Inflammation Mediators - metabolism | NF-E2-Related Factor 2 - genetics | Anticarcinogenic Agents - pharmacology | Tumor Microenvironment - drug effects | Liver - metabolism | RNA, Messenger - genetics | Curcumin - pharmacology | Tumor Suppressor Protein p53 - metabolism | Glutathione Transferase - metabolism | Transforming Growth Factor beta1 - genetics | Lymphoma, T-Cell - drug therapy | Animals | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Cyclooxygenase 2 - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Mice, Inbred AKR | Nitric Oxide Synthase Type II - metabolism | Prevention | Antioxidants | Patient outcomes | Development and progression | Genetic aspects | Research | Non-Hodgkin's lymphomas | Transforming growth factors | Tumor proteins | Risk factors | Oxidative stress | Regulations | Laboratories | Zoology | Liver | p53 Protein | Smooth muscle | Biochemistry | Lymphocytes T | Activation | Metastasis | Carcinogenesis | Bearing | Proteins | Signal transduction | Angiogenesis | Carcinogens | Metabolites | Restoration | Rodents | Modulation | Cell cycle | Attenuation | Curcumin | Inhibition | Growth factors | Deoxyribonucleic acid--DNA | Enzymes | Inflammation | Gene expression | Lymphoma | Nitric-oxide synthase | Signaling | Phytochemicals | Hepatocytes | Nitric oxide | Glycolysis | Lymphomas | Cyclooxygenase-2 | Molecular biology | T-cell lymphoma | Cancer | Apoptosis | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Autophagy, ISSN 1554-8635, 2014, Volume 6, Issue 2, pp. 256 - 269
...BAsIc ReseAR ch PAPeR Autophagy 6:2, 256-269; February 16, 2010; © 2010 Landes Bioscience Celecoxib-induced apoptosis is enhanced by ABT -737 and by inhibition... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Bcl-2 | ABT-737 | Celecoxib | Autophagy | NSAID | Apoptosis | autophagy | celecoxib | apoptosis | DEATH | ENDOPLASMIC-RETICULUM STRESS | BH3 MIMETIC ABT-737 | CELL BIOLOGY | DRUG-INDUCED APOPTOSIS | SMALL-MOLECULE BCL-2 | PROTEINS | BCL-2 FAMILY-MEMBERS | GROWTH IN-VIVO | CYCLOOXYGENASE-2 INHIBITOR | ENZYME-INHIBITORS
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 08/2010, Volume 30, Issue 8, pp. 1553 - 1561
OBJECTIVE—To investigate the potential role of nuclear factor–erythroid 2–related factor 2 (Nrf2) in neovascularization with a murine surgical model of ischemia... 
endothelial cells | inflammation | peripheral vascular disease | neovascularization | ischemia | CELLS | OXIDATIVE DAMAGE | ANGIOGENESIS | BONE-MARROW | LUNG INJURY | INDUCTION | IN-VITRO | ARYL-HYDROCARBON RECEPTOR | SIGNALING PATHWAY | HEMATOLOGY | ENDOTHELIAL GROWTH-FACTOR | Tumor Necrosis Factor-alpha - metabolism | Neovascularization, Physiologic - drug effects | Heme Oxygenase-1 - metabolism | Hindlimb | Oxidative Stress | Glutathione - metabolism | Peroxiredoxins - metabolism | Male | Muscle, Skeletal - metabolism | Ischemia - genetics | RNA, Messenger - metabolism | Inflammation - metabolism | Ligation | Time Factors | Muscle, Skeletal - drug effects | Inflammation Mediators - metabolism | Superoxides - metabolism | NF-E2-Related Factor 2 - genetics | Thioredoxins - metabolism | Chemokine CCL2 - metabolism | Membrane Proteins - metabolism | Capillaries - metabolism | Disease Models, Animal | Muscle, Skeletal - blood supply | Capillaries - physiopathology | Endothelial Cells - metabolism | Neovascularization, Physiologic - genetics | Mice, Inbred C57BL | Ischemia - metabolism | Antioxidants - pharmacology | Ischemia - physiopathology | Laser-Doppler Flowmetry | NF-E2-Related Factor 2 - deficiency | Cell Adhesion Molecules - metabolism | Regional Blood Flow | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Acetylcysteine - pharmacology | Cyclooxygenase 2 - metabolism | Inflammation - genetics | Mice | Angiogenic Proteins - metabolism | Femoral Artery - surgery | Inflammation - physiopathology
Journal Article
Gut, ISSN 0017-5749, 08/2014, Volume 63, Issue 8, pp. 1300 - 1312
Objective Enteric glia activation has been reported to amplify intestinal inflammation via the enteroglial-specific S100B protein. This neurotrophin promotes... 
NITRIC-OXIDE PRODUCTION | INHIBITION | CROHNS-DISEASE | MACROPHAGES | ULCERATIVE-COLITIS | FATTY-ACID AMIDE | S100B PROTEIN | N-PALMITOYL-ETHANOLAMINE | GLIAL-CELLS | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | Tumor Necrosis Factor-alpha - metabolism | Dextran Sulfate | Ethanolamines - pharmacology | Endocannabinoids - pharmacology | Rectum - pathology | Humans | Middle Aged | Palmitic Acids - therapeutic use | Male | NF-kappa B - metabolism | Glial Fibrillary Acidic Protein - metabolism | Nitric Oxide - analysis | Colon, Sigmoid - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroglia - drug effects | Colitis - chemically induced | Female | Indoles - pharmacology | Colitis - drug therapy | S100 Calcium Binding Protein beta Subunit - metabolism | Colitis, Ulcerative - drug therapy | Palmitic Acids - pharmacology | Colon, Sigmoid - pathology | Endocannabinoids - therapeutic use | Neutrophil Infiltration - drug effects | Severity of Illness Index | PPAR alpha - antagonists & inhibitors | Signal Transduction | Colitis, Ulcerative - metabolism | Cells, Cultured | Colitis, Ulcerative - pathology | Toll-Like Receptor 4 - metabolism | Dinoprostone - metabolism | Nerve Tissue Proteins - metabolism | Animals | PPAR gamma - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anilides - pharmacology | Colitis - metabolism | Cyclooxygenase 2 - metabolism | Rectum - chemistry | Ethanolamines - therapeutic use | Neuroglia - metabolism | Mice | PPAR alpha - metabolism | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Influence | Amides | Inflammation | Neuroglia | Analysis | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Acta biomaterialia, ISSN 1742-7061, 02/2016, Volume 31, pp. 50 - 60
Journal Article