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Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2017, Volume 60, Issue 10, pp. 4135 - 4146
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 12/2017, Volume 83, Issue 12, pp. 2718 - 2728
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 02/2016, Volume 81, Issue 2, pp. 316 - 326
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2011, Volume 28, Issue 9, pp. 2273 - 2287
To investigate the dose linearity of celecoxib (CEL) pharmacokinetics from various non-lipid and lipid-based formulations; to probe the mechanisms of CEL... 
Biomedical Engineering | Biochemistry, general | dose-dependent absorption | Biomedicine | celecoxib | Pharmacy | in vitro - in vivo correlations | lipid-based formulation | Medical Law | Pharmacology/Toxicology | lipolysis | Dose-dependent absorption in vitro-in vivo correlations | Celecoxib | Lipid-based formulation | Lipolysis | SOLUBILIZATION | dose-dependent absorption in vitro-in vivo correlations | DELIVERY-SYSTEMS | RATS | MEDIUM-CHAIN GLYCERIDES | CHEMISTRY, MULTIDISCIPLINARY | BIOAVAILABILITY | NANOPARTICLES | IN-VITRO DIGESTION | PHARMACOLOGY & PHARMACY | MICROCAPSULES | POORLY SOLUBLE DRUGS | MESOPOROUS SILICON | Male | Chromatography, High Pressure Liquid | Drug Carriers - chemistry | Dose-Response Relationship, Drug | Nanoparticles | Microspheres | Sulfonamides - blood | Lipids - chemistry | Pyrazoles - blood | Surface Properties | Chemical Phenomena | Molecular Structure | Cyclooxygenase 2 Inhibitors - blood | Pyrazoles - pharmacokinetics | Microscopy, Electron, Scanning | Administration, Oral | Cyclooxygenase 2 Inhibitors - administration & dosage | Silicon Dioxide - chemistry | Models, Molecular | Rats | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Particle Size | Mouth Mucosa - metabolism | Pyrazoles - administration & dosage | Animals | Porosity | Sulfonamides - administration & dosage | COX-2 inhibitors | Lipids | Dosage and administration | Angiogenesis inhibitors | Analysis | Drug delivery systems | Bioavailability | Nonsteroidal anti-inflammatory drugs | Drug dosages | Pharmaceutical sciences
Journal Article
FASEB Journal, ISSN 0892-6638, 03/2006, Volume 20, Issue 3, pp. 542 - 544
It is widely believed that the potencies of nonsteroid anti-inflammatory drugs ( NSAIDs) as inhibitors of cyclooxygenase ( COX) are influenced by protein... 
SITE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | nonsteroid anti-inflammatory drugs | coxibs | PROSTAGLANDIN H-2 SYNTHASE | CELL BIOLOGY | CYCLO-OXYGENASE-2 | THERAPY | FLUID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGY | prostaglandins | SELECTIVITY | Organic Chemicals - cerebrospinal fluid | Humans | Naproxen - pharmacology | Synovial Fluid - metabolism | Pyrazoles - cerebrospinal fluid | Sodium Salicylate - pharmacology | Lactones - pharmacology | Aspirin - cerebrospinal fluid | Cell Line - drug effects | Calcium - physiology | Pyrazoles - blood | Organic Chemicals - pharmacology | Dinoprostone - cerebrospinal fluid | Diclofenac - cerebrospinal fluid | Aspirin - pharmacology | Sulfones - cerebrospinal fluid | Aspirin - blood | Thiazines - blood | Sulfonamides - pharmacology | Indomethacin - cerebrospinal fluid | Indomethacin - pharmacology | Cyclooxygenase 1 - drug effects | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - blood | Diclofenac - pharmacology | Thiazoles - blood | Thromboxane A2 - blood | Cerebrospinal Fluid Proteins - pharmacology | Dinoprostone - biosynthesis | Lactones - cerebrospinal fluid | Blood Platelets - enzymology | Cyclooxygenase 2 Inhibitors - cerebrospinal fluid | Sodium Salicylate - cerebrospinal fluid | Sulfones - pharmacology | Blood Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Naproxen - cerebrospinal fluid | Sodium Salicylate - blood | Thiazines - pharmacology | Cyclooxygenase 2 Inhibitors - blood | Cyclooxygenase Inhibitors - cerebrospinal fluid | Blood Platelets - drug effects | Sulfones - blood | Organic Chemicals - blood | Ionophores - pharmacology | Pyrazoles - pharmacology | Sulfonamides - cerebrospinal fluid | Cyclooxygenase 2 Inhibitors - pharmacology | Thiazoles - cerebrospinal fluid | Celecoxib | Diclofenac - blood | Dinoprostone - blood | Naproxen - blood | Organ Specificity | Calcimycin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Indomethacin - blood | Protein Binding | Thiazines - cerebrospinal fluid | Thiazoles - pharmacology
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 12/2007, Volume 5, Issue 12, pp. 2376 - 2385
Background: Selective inhibitors of cyclooxygenase‐2 (COX‐2) called coxibs, are effective anti‐inflammatory and analgesic drugs. Recently, these drugs were... 
thromboxane | coxibs | thrombin generation | prostacyclin | NSAID | platelet activation | Thrombin generation | Prostacyclin | Platelet activation | Thromboxane | Coxibs | MASS-SPECTROMETRY | CYCLOOXYGENASES | ANTIPLATELET | THROMBOMODULIN | CLOPIDOGREL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | IONIZATION | TISSUE FACTOR | Humans | Naproxen - pharmacology | Sulfones - adverse effects | Male | Reference Values | Blood Platelets - enzymology | Sulfones - pharmacology | Prostaglandins - blood | Lactones - pharmacology | Phospholipases A - blood | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Cyclooxygenase 2 - blood | Time Factors | Prostaglandins - urine | Pyrazoles - blood | Antigens, Neoplasm - blood | Adult | Platelet Aggregation - drug effects | Cyclooxygenase 2 Inhibitors - blood | Blood Platelets - drug effects | Sulfones - blood | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Thrombomodulin - blood | Naproxen - adverse effects | Cyclic AMP - blood | Cyclooxygenase 2 Inhibitors - pharmacology | Double-Blind Method | Celecoxib | Lactones - adverse effects | Cell Adhesion - drug effects | Naproxen - blood | Sulfonamides - pharmacology | Thromboxanes - blood | Thromboxanes - urine | Blood Platelets - metabolism | Fibrinogen - metabolism | P-Selectin - blood | Sulfonamides - adverse effects | Leukocytes - drug effects | Platelet Activation - drug effects | Thrombin - metabolism | Platelet Membrane Glycoprotein IIb - blood | Physiological aspects | Prothrombin | COX-2 inhibitors | Thrombin | Analysis
Journal Article
Journal Article
Archives of Pharmacal Research, ISSN 0253-6269, 5/2014, Volume 37, Issue 5, pp. 626 - 635
In order to characterize the in situ intestinal permeability and in vivo oral bioavailability of celecoxib (CXB), a poorly water-soluble cyclooxygenase (COX)-2... 
SEDDS | Pharmacy | Intestinal permeability | Supersaturation | Soluplus | Celecoxib | Bioavailability | Pharmacology/Toxicology | VITRO | SOLUBILIZATION | CHEMISTRY, MEDICINAL | RAT | LIPOPHILIC DRUGS | DISSOLUTION | SURFACTANT | WATER-SOLUBLE DRUGS | PHARMACOLOGY & PHARMACY | ABSORPTION | PERFUSION | S-SEDDS FORMULATION | Emulsions | Polysorbates - chemistry | Biological Availability | Male | Polyethylene Glycols - chemistry | Intestines - metabolism | Cyclooxygenase 2 Inhibitors - chemistry | Intestinal Absorption | Drug Carriers | Sulfonamides - blood | Tandem Mass Spectrometry | Pyrazoles - chemistry | Pyrazoles - blood | Micelles | Chromatography, Liquid | Cyclooxygenase 2 Inhibitors - blood | Pyrazoles - pharmacokinetics | Sulfonamides - chemistry | Administration, Oral | Cyclooxygenase 2 Inhibitors - administration & dosage | Technology, Pharmaceutical - methods | Permeability | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Sulfonamides - pharmacokinetics | Pyrazoles - administration & dosage | Animals | Propylene Glycols - chemistry | Polymers - chemistry | Surface-Active Agents - chemistry | Polyvinyls - chemistry | Sulfonamides - administration & dosage | Drugs | COX-2 inhibitors | Drug delivery systems | Surface active agents | Nonsteroidal anti-inflammatory drugs | Rain and rainfall | Vehicles
Journal Article
Journal Article