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Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hindlimb | Pyrazoles - chemical synthesis | Humans | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Thermodynamics | Cyclooxygenase 2 - genetics | Drug Design | Cyclooxygenase 1 - chemistry | Female | Triazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 1 - genetics | Gene Expression | Cyclooxygenase 2 Inhibitors - pharmacology | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Click Chemistry - methods | Rats | Edema - enzymology | Edema - drug therapy | Triazoles - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Carrageenan | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Kinetics | Edema - pathology | Drugs | COX-2 inhibitors | Side effects | Inhibitors | Pain | Cyclooxygenase-1 | Inflammation | Cyclooxygenase-2 | Chemical synthesis | Anti-inflammatory agents | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 06/2014, Volume 80, pp. 167 - 174
Analgesic | 1,3,4-Oxadiazole | COX-2 | Anti-inflammatory | Pyrazole | Molecular docking analysis | 1 3 4-Oxadiazole | Analgesics - pharmacology | Humans | Analgesics - metabolism | Substrate Specificity | Male | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Analgesics - chemical synthesis | Oxadiazoles - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Analgesics - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Chemistry Techniques, Synthetic | Oxadiazoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Oxadiazoles - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Oxadiazoles - metabolism | COX-2 inhibitors | Aspirin | Carrageenin | Analysis | Drugstores | Acetic acid | Organic acids | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2010, Volume 20, Issue 24, pp. 7349 - 7353
Cyclooxygenase | Amino/methylsufonylphenyl | Anti-inflammatory agents | Indolin-2-one derivatives | 5-Lipoxygenase | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Analgesics - pharmacology | Indoles - chemical synthesis | Male | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Benzylidene Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Benzylidene Compounds - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzylidene Compounds - pharmacology | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Mice | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Index Medicus
Journal Article
Bioorganic chemistry, ISSN 0045-2068, 04/2017, Volume 71, pp. 146 - 159
Coumarins | COX-2 enzymes | Anti-inflammatory | NSAID | COX-1 enzymes | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Science & Technology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Drug Discovery - methods | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Neoplasms - drug therapy | Coumarins - pharmacology | Animals | Coumarins - chemical synthesis | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | COX-2 inhibitors | Fluocinolone acetonide | Pharmacy | Medicine, Botanic | Schizophrenia | Drugstores | Medicine, Herbal | Plant metabolites | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3416 - 3424
Hydrazone and pyrazole derivatives | Selective COX-2 inhibitors | Molecular docking | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Rats | Edema - drug therapy | Hydrazones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Hydrazones - chemistry | Hydrazones - pharmacology | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Computer Simulation | Cyclooxygenase 2 - metabolism | Drug Design | Cyclooxygenase 1 - chemistry | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Binding Sites | Disease Models, Animal | Pyrazoles - pharmacology | Index Medicus
Journal Article
Bioorganic chemistry, ISSN 0045-2068, 10/2018, Volume 80, pp. 24 - 35
Multitarget profile | TNF-α | COXs | Anti-inflammatory | Hybrid drugs | LOXs | Benzimidazole scaffold | Analgesics - pharmacology | Benzimidazoles - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 2 Inhibitors - therapeutic use | Drug Design | Lipid Peroxidation - drug effects | Cyclooxygenase 1 - chemistry | Binding Sites | Benzimidazoles - therapeutic use | Cyclooxygenase 2 Inhibitors - chemical synthesis | Analgesics - therapeutic use | Catalytic Domain | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Lipoxygenase Inhibitors - therapeutic use | Edema - drug therapy | Macrophages - cytology | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Benzimidazoles - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Edema - pathology | Lipoxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - therapeutic use | Enzymes | Analysis | Protein binding | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2287 - 2300
Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Female | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Sulindac - chemistry | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase Inhibitors - pharmacology | Sulindac - analogs & derivatives | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Sheep | Cell Proliferation - drug effects | Mice | Cyclooxygenase 1 - metabolism | Sulindac - chemical synthesis | Sulindac - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
Journal Article