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1. Full Text Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity
by Bansal, Sumit and Bala, Manju and Suthar, Sharad Kumar and Choudhary, Shivani and Bhattacharya, Shoumyo and Bhardwaj, Varun and Singla, Sumit and Joseph, Alex
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2014, Volume 80, pp. 167 - 174
A novel series of 2-phenyl-5-(1,3-diphenyl-1 -pyrazol-4-yl)-1,3,4-oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent... 
Analgesic | 1,3,4-Oxadiazole | COX-2 | Anti-inflammatory | Pyrazole | Molecular docking analysis | 1 3 4-Oxadiazole | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | PYRAZOLE DERIVATIVES | ANTICANCER AGENTS DESIGN | ANALGESIC AGENTS | DRUGS | BIOLOGICAL EVALUATION | SUBSTITUTED THIAZOLIDIN-4-ONES | DUAL INHIBITORS | 1,3,4-OXADIAZOLES | PHARMACOLOGICAL EVALUATION | Analgesics - pharmacology | Humans | Analgesics - metabolism | Substrate Specificity | Male | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Analgesics - chemical synthesis | Oxadiazoles - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Analgesics - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Chemistry Techniques, Synthetic | Oxadiazoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Oxadiazoles - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Oxadiazoles - metabolism | COX-2 inhibitors | Aspirin | Carrageenin | Analysis | Drugstores | Acetic acid | Organic acids | Index Medicus
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2. Full Text [3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H-Azirines and Aldehydes
by Zeng, Ting-Ting and Xuan, Jun and Ding, Wei and Wang, Kuan and Lu, Liang-Qiu and Xiao, Wen-Jing
Organic Letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 16, pp. 4070 - 4073
A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic... 
CONVENIENT ROUTE | OXIDATION | OXAZOLE-4-CARBOXYLATE | RING-EXPANSION | PROPARGYLAMIDES | CHEMISTRY, ORGANIC | THIAZOLE | PYRIDINES | DERIVATIVES | C-H BONDS | CYCLIZATION | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Oxidation-Reduction | Cyclooxygenase 2 Inhibitors - chemistry | Cycloaddition Reaction | Oxazoles - chemistry | Alkenes - chemistry | Azirines - chemistry | Oxazoles - chemical synthesis | Light | Imines - chemistry | Molecular Structure | Oxazoles - pharmacology | Catalysis | Aldehydes - chemistry | Index Medicus
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3. Full Text Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors
by Vitale, Paola and Tacconelli, Stefania and Perrone, Maria Grazia and Malerba, Paola and Simone, Laura and Scilimati, Antonio and Lavecchia, Antonio and Dovizio, Melania and Marcantoni, Emanuela and Bruno, Annalisa and Patrignani, Paola
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
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4. Full Text Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study
by Lamie, Phoebe F and Ali, Waleed A.M and Bazgier, Vaclav and Rárová, Lucie
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
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5. Full Text Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study
by El-Sayed, Magda A.-A and Abdel-Aziz, Alaa A.-M and Abdel-Aziz, Naglaa I and El-Azab, Adel S and Asiri, Yousif A and ElTahir, Kamal E.H
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3416 - 3424
A series of hydrazone and pyrazole derivatives were prepared and evaluated for their anti-inflammatory activities and selectivity as COX-2 inhibitor. New... 
Hydrazone and pyrazole derivatives | Selective COX-2 inhibitors | Molecular docking | CHEMISTRY, MEDICINAL | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CYCLOOXYGENASE | SYNTHASE | PROSTAGLANDINS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | STRUCTURAL BASIS | PART 1 | LIGAND | BINDING | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Rats | Edema - drug therapy | Hydrazones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Hydrazones - chemistry | Hydrazones - pharmacology | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Computer Simulation | Cyclooxygenase 2 - metabolism | Drug Design | Cyclooxygenase 1 - chemistry | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Binding Sites | Disease Models, Animal | Pyrazoles - pharmacology | Index Medicus
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6. Full Text Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones
by Abdel-Aziz, Alaa A.-M and Abou-Zeid, Laila A and ElTahir, Kamal Eldin H and Ayyad, Rezk R and El-Sayed, Magda A.-A and El-Azab, Adel S
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
A new series of 2-substituted mercapto-4(3 )-quinazolinone were synthesized and assessed for anti-inflammatory and analgesic activities and inhibition of... 
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | SELECTIVE-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ANALOGS | ANTITUMOR-ACTIVITY | DRUGS | BIOLOGICAL EVALUATION | DERIVATIVES | PROSTAGLANDIN SYNTHESIS | QUINAZOLINES | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
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7. Full Text In situ click chemistry generation of cyclooxygenase-2 inhibitors
by Bhardwaj, Atul and Kaur, Jatinder and Wuest, Melinda and Wuest, Frank
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and... 
TARGET | CYCLOADDITION | ACETYLCHOLINESTERASE | ANTIINFLAMMATORY AGENTS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BIOLOGY | DRUG DEVELOPMENT | CANCER | EXPRESSION | DISCOVERY | Hindlimb | Pyrazoles - chemical synthesis | Humans | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Thermodynamics | Cyclooxygenase 2 - genetics | Drug Design | Cyclooxygenase 1 - chemistry | Female | Triazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 1 - genetics | Gene Expression | Cyclooxygenase 2 Inhibitors - pharmacology | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Click Chemistry - methods | Rats | Edema - enzymology | Edema - drug therapy | Triazoles - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Carrageenan | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Kinetics | Edema - pathology | Drugs | COX-2 inhibitors | Side effects | Inhibitors | Antiinflammatory agents | Pain | Cyclooxygenase-1 | Inflammation | Cyclooxygenase-2 | Chemical synthesis | Prostaglandin endoperoxide synthase | Index Medicus
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8. Full Text Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(Aryloyl)phenyl methyl sulfones
by Harrak, Youssef and Casula, Giovanni and Basset, Joan and Rosell, Glòria and Plescia, Salvatore and Raffa, Demetrio and Cusimano, Maria Grazia and Pouplana, Ramon and Pujol, Maria Dolors
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 18, pp. 6560 - 6571
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These... 
SELECTIVE-INHIBITION | GROWTH-INHIBITION | CHEMISTRY, MEDICINAL | DRUGS | BIOLOGICAL EVALUATION | NITRIC-OXIDE | COX INHIBITORS | CHEMOPREVENTION | DUAL INHIBITORS | CELECOXIB | CANCER CELL-LINES | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Sulfones - pharmacology | Thermodynamics | Sulfones - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Sulfones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Survival - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Rats | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Cell Proliferation - drug effects | Indoles - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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9. Full Text Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors
by Fioravanti, Rossella and Bolasco, Adriana and Manna, Fedele and Rossi, Francesca and Orallo, Francisco and Ortuso, Francesco and Alcaro, Stefano and Cirilli, Roberto
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 12, pp. 6135 - 6138
Eighteen new 1-N-substituted-3,5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been... 
Pyrazoline | Molecular modeling | COX inhibitors | MONOAMINE-OXIDASE | SYNTHASE-1 | CHEMISTRY, MEDICINAL | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | DOCKING | STEREOSELECTIVE RECOGNITION MECHANISMS | AGENTS | FUTURE | SELECTIVITY | Catalytic Domain - drug effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Pyrazoles - chemical synthesis | Stereoisomerism | Humans | Insecta | Models, Molecular | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Pyrazoles - chemistry | Animals | Cyclooxygenase 2 - metabolism | Molecular Structure | Cyclooxygenase 1 - metabolism | Pyrazoles - pharmacology | Index Medicus
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10. Full Text Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents
by Hassan, Ghaneya Sayed and Abou-Seri, Sahar Mahmoud and Kamel, Gehan and Ali, Mamdouh Moawad
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2014, Volume 76, pp. 482 - 493
Novel series of celecoxib analogs endowed with benzofuran moiety – and – were synthesized and evaluated for COX-1/COX-2 inhibitory activity in vitro. The most... 
COX-1/COX-2 inhibitory activity | Anti-inflammatory agents | Celecoxib analogs | Benzofuran | Pyrazole | CELLS | CHEMISTRY, MEDICINAL | DOCKING | DRUGS | COX-1 INHIBITORS | EXPRESSION | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats, Wistar | Sulfonamides - chemistry | Anti-Inflammatory Agents - pharmacology | Rats | Male | Celecoxib | Cyclooxygenase 2 Inhibitors - chemistry | Benzofurans - chemistry | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Drug Design | Anti-Inflammatory Agents - chemical synthesis | Molecular Docking Simulation | Drug Evaluation, Preclinical | COX-2 inhibitors | Genetic engineering | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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11. Full Text Cyclooxygenase-1-selective inhibitors based on the (E)-2′- des -methyl-sulindac sulfide scaffold
by Liedtke, Andy J and Crews, Brenda C and Daniel, Cristina M and Blobaum, Anna L and Kingsley, Philip J and Ghebreselasie, Kebreab and Marnett, Lawrence J
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2287 - 2300
Prostaglandins (PGs) are powerful lipid mediators in many physiological and pathophysiological responses. They are produced by oxidation of arachidonic acid... 
SYNTHASE CYCLOOXYGENASE | GASTRIC DAMAGE | CHEMISTRY, MEDICINAL | MESSENGER-RNA | COX-2 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SELECTIVE INHIBITORS | SULINDAC SULFIDE | OVARIAN-CANCER | CELL-GROWTH | PROSTAGLANDIN SYNTHESIS | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Female | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Sulindac - chemistry | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase Inhibitors - pharmacology | Sulindac - analogs & derivatives | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Sheep | Cell Proliferation - drug effects | Mice | Cyclooxygenase 1 - metabolism | Sulindac - chemical synthesis | Sulindac - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
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12. Full Text Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR
by Abdelall, Eman K.A and Kamel, Gehan M
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
Two new series of 1,5-diaryl pyrazoles ( , , , and ) and 1,5-diaryl pyrazoline ( and were prepared as both Cyclooxygenase-2 and 15-lipoxygenase inhibitors.... 
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | CHEMISTRY, MEDICINAL | COX-2 | LEUKOTRIENES | CYCLOOXYGENASE | PROSTAGLANDINS | INFLAMMATION | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | MEDIATORS | DERIVATIVES | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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13. Full Text Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
by El-Sayed, Magda A.-A and Abdel-Aziz, Alaa A.-M and Abdel-Aziz, Naglaa I and El-Azab, Adel S and ElTahir, Kamal E.H
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2012, Volume 20, Issue 10, pp. 3306 - 3316
New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was evaluated using in vitro... 
COX-2 inhibitors | Synthesis | Pyrazoline | Anti-inflammatory | Molecular modeling | Pyrazole | DESIGN | CHEMISTRY, MEDICINAL | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | 2-PYRAZOLINES | ASPIRIN | STRATEGIES | PROSTAGLANDINS | STRUCTURAL BASIS | CYCLOOXYGENASE-2 INHIBITORS | DRUGS | BINDING | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Models, Molecular | Rats | Cyclooxygenase 2 Inhibitors - chemistry | Enzyme Activation - drug effects | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Protein Binding - drug effects | Drug Design | Inhibitory Concentration 50 | Anti-Inflammatory Agents - chemical synthesis | Binding Sites | Quantitative Structure-Activity Relationship | Disease Models, Animal | Pyrazoles - pharmacology | Models | Universities and colleges | Anti-inflammatory drugs | Analysis | Index Medicus
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14. Full Text Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY
by Abdelall, Eman K.A and Lamie, Phoebe F and Ali, Waleed A.M
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2016, Volume 26, Issue 12, pp. 2893 - 2899
Two new series of 1,5-diaryl pyrazoline ( – ) and 1,5-diaryl pyrazole ( and ) were designed as both COX-2 and 15-LOX inhibitors. All the prepared compounds... 
15-Lipoxygenase inhibitors | Diethyl oxalate | Sulfonamide pharmacophores | Cyclooxygenase inhibitors | Antiinflammatory | CHEMISTRY, MEDICINAL | COX-2 | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | 5-LIPOXYGENASE | DERIVATIVES | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Humans | Models, Molecular | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cyclooxygenase 2 - metabolism | Celecoxib - chemical synthesis | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Pyrazoles - pharmacology | COX-2 inhibitors | Liability (Law) | Index Medicus
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15. Full Text Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity
by Abdelrahman, Mostafa H and Youssif, Bahaa G.M and abdelgawad, Mohamed A and Abdelazeem, Ahmed H and Ibrahim, Hussein M and Moustafa, Abd El Ghany A and Treamblu, Laurent and Bukhari, Syed Nasir Abbas
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 972 - 985
A series of novel quinoline-2-carboxamides – was synthesized and evaluated as dual COXs/LOX inhibitors. Compounds and exhibited the highest potency and... 
COXs | Quinoline-2-carboxamides | Docking | LOX | Anti-inflammatory | DESIGN | CHEMISTRY, MEDICINAL | TEPOXALIN | ENZYMES | SELECTIVE CYCLOOXYGENASE-2 INHIBITORS | DRUGS | AGENTS | COX-2 INHIBITORS | 5-LIPOXYGENASE | DERIVATIVES | 5-LOX | Stomach Ulcer - pathology | Gastric Mucosa - pathology | Male | Quinolines - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Gastric Mucosa - drug effects | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Catalytic Domain | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Lipoxygenase Inhibitors - adverse effects | Quinolines - chemical synthesis | Quinolines - metabolism | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Lipoxygenase Inhibitors - pharmacology | Quinolines - adverse effects | Alkaloids | Carrageenin | Anti-inflammatory drugs | Analysis | Pharmacy | Quinoline | Drugstores | Index Medicus
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16. Full Text Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors
by Alegaon, S.G and Hirpara, M.B and Alagawadi, K.R and Hullatti, K.K and Kashniyal, K
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2014, Volume 24, Issue 22, pp. 5324 - 5329
A novel class of pyrazole derivatives have been synthesized and investigated for their in vitro cyclooxygenase inhibitory and cytotoxicity activities. Compound... 
Cytotoxicity | Docking | Pyrazoles | COX-1 and COX-2 | Thiadiazole | Drug likeness | DESIGN | CHEMISTRY, MEDICINAL | SERIES | ACID | CHEMISTRY, ORGANIC |