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1. Full Text [3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H-Azirines and Aldehydes
by Zeng, Ting-Ting and Xuan, Jun and Ding, Wei and Wang, Kuan and Lu, Liang-Qiu and Xiao, Wen-Jing
Organic Letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 16, pp. 4070 - 4073
A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic... 
CONVENIENT ROUTE | OXIDATION | OXAZOLE-4-CARBOXYLATE | RING-EXPANSION | PROPARGYLAMIDES | CHEMISTRY, ORGANIC | THIAZOLE | PYRIDINES | DERIVATIVES | C-H BONDS | CYCLIZATION | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Oxidation-Reduction | Cyclooxygenase 2 Inhibitors - chemistry | Cycloaddition Reaction | Oxazoles - chemistry | Alkenes - chemistry | Azirines - chemistry | Oxazoles - chemical synthesis | Light | Imines - chemistry | Molecular Structure | Oxazoles - pharmacology | Catalysis | Aldehydes - chemistry | Index Medicus
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2. Full Text Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study
by El-Sayed, Magda A.-A and Abdel-Aziz, Alaa A.-M and Abdel-Aziz, Naglaa I and El-Azab, Adel S and Asiri, Yousif A and ElTahir, Kamal E.H
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3416 - 3424
A series of hydrazone and pyrazole derivatives were prepared and evaluated for their anti-inflammatory activities and selectivity as COX-2 inhibitor. New... 
Hydrazone and pyrazole derivatives | Selective COX-2 inhibitors | Molecular docking | CHEMISTRY, MEDICINAL | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CYCLOOXYGENASE | SYNTHASE | PROSTAGLANDINS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | STRUCTURAL BASIS | PART 1 | LIGAND | BINDING | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Rats | Edema - drug therapy | Hydrazones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Hydrazones - chemistry | Hydrazones - pharmacology | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Computer Simulation | Cyclooxygenase 2 - metabolism | Drug Design | Cyclooxygenase 1 - chemistry | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Binding Sites | Disease Models, Animal | Pyrazoles - pharmacology | Index Medicus
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3. Full Text Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors
by Vitale, Paola and Tacconelli, Stefania and Perrone, Maria Grazia and Malerba, Paola and Simone, Laura and Scilimati, Antonio and Lavecchia, Antonio and Dovizio, Melania and Marcantoni, Emanuela and Bruno, Annalisa and Patrignani, Paola
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
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4. Full Text Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study
by Lamie, Phoebe F and Ali, Waleed A.M and Bazgier, Vaclav and Rárová, Lucie
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
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5. Full Text The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
by Wang, Jane L and Limburg, David and Graneto, Matthew J and Springer, John and Hamper, Joseph Rogier Bruce and Liao, Subo and Pawlitz, Jennifer L and Kurumbail, Ravi G and Maziasz, Timothy and Talley, John J and Kiefer, James R and Carter, Jeffery
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 23, pp. 7159 - 7163
We describe our strategy to discover a selective inhibitor of COX-2 with a shorter human half-life compared with the previous clinical candidate SD-8381 ( -(... 
Cyclooxygenase | COX-2 inhibitor | Benzopyran | Clinical candidate | X-ray crystal structure | Half-life | Microsomal | Plasma protein bound | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | HYPERALGESIA | Benzopyrans - chemistry | Catalytic Domain | Benzopyrans - pharmacokinetics | Humans | Half-Life | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Binding Sites | Cyclooxygenase 2 Inhibitors - pharmacokinetics | COX-2 inhibitors | Blood proteins | Protein binding | Index Medicus
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6. Full Text Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR
by Abdelall, Eman K.A and Kamel, Gehan M
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
Two new series of 1,5-diaryl pyrazoles ( , , , and ) and 1,5-diaryl pyrazoline ( and were prepared as both Cyclooxygenase-2 and 15-lipoxygenase inhibitors.... 
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | CHEMISTRY, MEDICINAL | COX-2 | LEUKOTRIENES | CYCLOOXYGENASE | PROSTAGLANDINS | INFLAMMATION | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | MEDIATORS | DERIVATIVES | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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7. Full Text Pleiotropic mechanisms facilitated by resveratrol and its metabolites
by Calamini, Barbara and Ratia, Kiira and Malkowski, Michael G and Cuendet, Muriel and Pezzuto, John M and Santarsiero, Bernard D and Mesecar, Andrew D
Biochemical Journal, ISSN 0264-6021, 07/2010, Volume 429, Issue 2, pp. 273 - 282
Resveratrol has demonstrated cancer chemopreventive activity in animal models and some clinical trials are underway. In addition, resveratrol was shown to... 
Cancer chemoprevention | Resveratrol metabolite | SIRT1 | Molecular docking | Cyclo-oxygenase (COX) | Quinone reductase 2 | QUINONE OXIDOREDUCTASE-2 | quinone reductase 2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIRTUINS | DNA ADDUCT FORMATION | MCF-10F CELLS | resveratrol metabolite | molecular docking | INHIBITION | cancer chemoprevention | cyclo-oxygenase (COX) | TRANS-RESVERATROL | PROSTAGLANDIN SYNTHASE | RED WINE | SMALL-MOLECULE ACTIVATORS | Sirtuin 1 - metabolism | Humans | Crystallography, X-Ray | Stilbenes - metabolism | Stilbenes - chemistry | Anticarcinogenic Agents - metabolism | Stilbenes - pharmacology | Cyclooxygenase 2 Inhibitors - chemistry | Resveratrol | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anticarcinogenic Agents - pharmacology | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Quinone Reductases - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Mice | Cyclooxygenase 1 - metabolism | In Vitro Techniques | Index Medicus
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8. Full Text Divergent C-H functionalizations directed by sulfonamide pharmacophores: Late-stage diversification as a tool for drug discovery
by Dai, Hui-Xiong and Stepan, Antonia F and Plummer, Mark S and Zhang, Yang-Hui and Yu, Jin-Quan
Journal of the American Chemical Society, ISSN 0002-7863, 05/2011, Volume 133, Issue 18, pp. 7222 - 7228
Modern drug discovery is contingent on identifying lead compounds and rapidly synthesizing analogues. The use of a common pharmacophore to direct multiple and... 
NATURAL-PRODUCT | ORTHO-HALOGENATION | ARYLATION | BOND FUNCTIONALIZATION | CELECOXIB DERIVATIVES | DIVERSITY | ARYL | CHEMISTRY, MULTIDISCIPLINARY | ACTIVATION REACTIONS | PALLADIUM-CATALYZED ALKYLATION | CARBOXYLIC-ACIDS | Alkenes - chemistry | Pyrazoles - chemistry | Sulfonamides - isolation & purification | Sulfonamides - chemistry | Cyclooxygenase 2 Inhibitors - isolation & purification | Drug Discovery - methods | Pyrazoles - isolation & purification | Catalysis | Celecoxib | Cyclooxygenase 2 Inhibitors - chemistry | Chemical properties | Sulfonamides | Hydrogen | Carbon compounds | Index Medicus
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9. Full Text Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents
by Hassan, Ghaneya Sayed and Abou-Seri, Sahar Mahmoud and Kamel, Gehan and Ali, Mamdouh Moawad
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2014, Volume 76, pp. 482 - 493
Novel series of celecoxib analogs endowed with benzofuran moiety – and – were synthesized and evaluated for COX-1/COX-2 inhibitory activity in vitro. The most... 
COX-1/COX-2 inhibitory activity | Anti-inflammatory agents | Celecoxib analogs | Benzofuran | Pyrazole | CELLS | CHEMISTRY, MEDICINAL | DOCKING | DRUGS | COX-1 INHIBITORS | EXPRESSION | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats, Wistar | Sulfonamides - chemistry | Anti-Inflammatory Agents - pharmacology | Rats | Male | Celecoxib | Cyclooxygenase 2 Inhibitors - chemistry | Benzofurans - chemistry | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Drug Design | Anti-Inflammatory Agents - chemical synthesis | Molecular Docking Simulation | Drug Evaluation, Preclinical | COX-2 inhibitors | Genetic engineering | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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10. Full Text Cyclooxygenase-1-selective inhibitors based on the (E)-2′- des -methyl-sulindac sulfide scaffold
by Liedtke, Andy J and Crews, Brenda C and Daniel, Cristina M and Blobaum, Anna L and Kingsley, Philip J and Ghebreselasie, Kebreab and Marnett, Lawrence J
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2287 - 2300
Prostaglandins (PGs) are powerful lipid mediators in many physiological and pathophysiological responses. They are produced by oxidation of arachidonic acid... 
SYNTHASE CYCLOOXYGENASE | GASTRIC DAMAGE | CHEMISTRY, MEDICINAL | MESSENGER-RNA | COX-2 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SELECTIVE INHIBITORS | SULINDAC SULFIDE | OVARIAN-CANCER | CELL-GROWTH | PROSTAGLANDIN SYNTHESIS | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Female | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Sulindac - chemistry | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase Inhibitors - pharmacology | Sulindac - analogs & derivatives | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Sheep | Cell Proliferation - drug effects | Mice | Cyclooxygenase 1 - metabolism | Sulindac - chemical synthesis | Sulindac - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
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11. Full Text Combined Use of Crystalline Salt Forms and Precipitation Inhibitors to Improve Oral Absorption of Celecoxib from Solid Oral Formulations
by Guzmán, Héctor R and Tawa, Mark and Zhang, Zhong and Ratanabanangkoon, Pasut and Shaw, Paul and Gardner, Colin R and Chen, Hongming and Moreau, Jean‐Pierre and Almarsson, Örn and Remenar, Julius F
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2007, Volume 96, Issue 10, pp. 2686 - 2702
Biopharmaceutical evaluation of crystalline celecoxib salts in novel solid formulations, which were designed to simultaneously facilitate dissolution and... 
bioavailability | in vitro/in vivo correlations (IVIVC) | oral drug delivery | dissolution | pharmacokinetics | formulation | crystallinity | supersaturation | correlations (IVIVC) | in vitro | in vivo | Formulation | Supersaturation | Oral drug delivery | Bioavailability | Crystallinity | Pharmacokinetics | Dissolution | In vitro/in vivo correlations (IVIVC) | AQUEOUS-SOLUTIONS | SOLUBILIZATION | COMPLEX | CHEMISTRY, MEDICINAL | TRIBLOCK COPOLYMERS | BEHAVIOR | POLYMORPHISM | CHEMISTRY, MULTIDISCIPLINARY | SURFACTANT | POLYMER | DOGS | PHARMACOLOGY & PHARMACY | Injections, Intravenous | Biological Availability | Cyclooxygenase 2 Inhibitors - chemistry | Intestinal Absorption | Pyrazoles - chemistry | Capsules | Drug Storage | Excipients - chemistry | Water - chemistry | Drug Compounding | Pyrazoles - pharmacokinetics | Sulfonamides - chemistry | Administration, Oral | Chemical Precipitation | Cyclooxygenase 2 Inhibitors - administration & dosage | Drug Stability | Crystallization | Solubility | Technology, Pharmaceutical - methods | Celecoxib | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Chemistry, Pharmaceutical | Sulfonamides - pharmacokinetics | Pyrazoles - administration & dosage | Animals | Combinatorial Chemistry Techniques | Dogs | Sulfonamides - administration & dosage | Index Medicus
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12. Full Text (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2
by Duggan, Kelsey C and Hermanson, Daniel J and Musee, Joel and Prusakiewicz, Jeffery J and Scheib, Jami L and Carter, Bruce D and Banerjee, Surajit and Oates, J.A and Marnett, Lawrence J
Nature Chemical Biology, ISSN 1552-4450, 2011, Volume 7, Issue 11, pp. 803 - 809
Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid and the endocannabinoids 2-arachidonoylglycerol and arachidonoylethanolamide. Evaluation... 
SYSTEM | 2-ARACHIDONOYLGLYCEROL | CYCLOOXYGENASE ACTIVE-SITE | OXIDATIVE METABOLITE | ANTIINFLAMMATORY AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNAPTIC-TRANSMISSION | RECEPTOR | ARACHIDONIC-ACID | BINDING | GLYCEROL ESTER | Cannabinoid Receptor Modulators - metabolism | Arachidonic Acid - metabolism | Catalytic Domain | Cyclooxygenase 2 Inhibitors - pharmacology | Oxidation-Reduction | Models, Molecular | Substrate Specificity | Cyclooxygenase 2 Inhibitors - chemistry | Glycerides - metabolism | Chemistry, Pharmaceutical | Arachidonic Acids - metabolism | Cyclooxygenase 2 - metabolism | Protein Binding | Protein Conformation | Endocannabinoids | Index Medicus
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13. Full Text Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(Aryloyl)phenyl methyl sulfones
by Harrak, Youssef and Casula, Giovanni and Basset, Joan and Rosell, Glòria and Plescia, Salvatore and Raffa, Demetrio and Cusimano, Maria Grazia and Pouplana, Ramon and Pujol, Maria Dolors
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 18, pp. 6560 - 6571
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These... 
SELECTIVE-INHIBITION | GROWTH-INHIBITION | CHEMISTRY, MEDICINAL | DRUGS | BIOLOGICAL EVALUATION | NITRIC-OXIDE | COX INHIBITORS | CHEMOPREVENTION | DUAL INHIBITORS | CELECOXIB | CANCER CELL-LINES | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Sulfones - pharmacology | Thermodynamics | Sulfones - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Sulfones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Survival - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Rats | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Cell Proliferation - drug effects | Indoles - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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14. Full Text Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX
by Shen, Fa-Qian and Wang, Zhong-Chang and Wang, Bao-Zhong and Wu, Song-Yu and Ren, Shen-Zhen and Man, Ruo-Jun and Zhu, Hai-Liang
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2017, Volume 27, Issue 16, pp. 3653 - 3660
As docking study exhibited, target compound showed the lowest interaction energy of 64.38 kcal/mol and −66.62 kcal/mol after interacting with COX-2 (PDB code:... 
COX-2 | 5-LOX | Coumarin | Pyrazole | Cancer | CANCER-CELLS | APOPTOSIS | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | METASTASIS | ANGIOGENESIS | CHEMISTRY, ORGANIC | LIPOXYGENASE INHIBITORS | PROLIFERATION | 5-LIPOXYGENASE | DERIVATIVES | Apoptosis - drug effects | Humans | Coumarins - chemistry | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Inhibitory Concentration 50 | Binding Sites | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | A549 Cells | Catalytic Domain | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Coumarins - pharmacology | Cell Cycle Checkpoints - drug effects | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Docking Simulation | Lipoxygenase Inhibitors - pharmacology | Drug Screening Assays, Antitumor | Prevention | COX-2 inhibitors | Nuclear nonproliferation | Celecoxib | Angiogenesis inhibitors | Lung cancer, Non-small cell | Pharmaceutical biotechnology | Zileuton | Index Medicus
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15. Full Text Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY
by Abdelall, Eman K.A and Lamie, Phoebe F and Ali, Waleed A.M
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2016, Volume 26, Issue 12, pp. 2893 - 2899
Two new series of 1,5-diaryl pyrazoline ( – ) and 1,5-diaryl pyrazole ( and ) were designed as both COX-2 and 15-LOX inhibitors. All the prepared compounds... 
15-Lipoxygenase inhibitors | Diethyl oxalate | Sulfonamide pharmacophores | Cyclooxygenase inhibitors | Antiinflammatory | CHEMISTRY, MEDICINAL | COX-2 | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | 5-LIPOXYGENASE | DERIVATIVES | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Humans | Models, Molecular | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cyclooxygenase 2 - metabolism | Celecoxib - chemical synthesis | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Pyrazoles - pharmacology | COX-2 inhibitors | Liability (Law) | Index Medicus
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16. Full Text Coxibs Interfere with the Action of Aspirin by Binding Tightly to One Monomer of Cyclooxygenase-1
by Gilad Rimon and Ranjinder S. Sidhu and D. Adam Lauver and Jullia Y. Lee and Narayan P. Sharma and Chong Yuan and Ryan A. Frieler and Raymond C. Trievel and Benedict R. Lucchesi and William L. Smith and Minor J. Coon and Victor C. Vaughan and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 28 - 33
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A₂... 
Enzymes | Prostaglandins | Active sites | Cyclooxygenase inhibitors | Atoms | Dimers | Platelet aggregation | Platelets | Fatty acids | Monomers | Platelet | Prostaglandin | Arachidonic acid | Adrenic acid | Nonsteroidal antiinflammatory drugs | arachidonic acid | SELECTIVE-INHIBITION | adrenic acid | MECHANISM | prostaglandin | ENDOPEROXIDE-H SYNTHASE-1 | OXYGENATION | MULTIDISCIPLINARY SCIENCES | INDOMETHACIN | FATTY-ACIDS | CELECOXIB | nonsteroidal antiinflammatory drugs | platelet | HEALTHY-VOLUNTEERS | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Aspirin - metabolism | Isoenzymes - metabolism | Cyclooxygenase 1 - chemistry | Platelet Aggregation Inhibitors - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Platelet Aggregation - drug effects | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Platelet Aggregation Inhibitors - metabolism | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Dogs | Aspirin - chemistry | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Cyclooxygenase 1 - metabolism | Aspirin | Usage | Physiological aspects | Cyclooxygenases | Genetic aspects | Research | Health aspects | Pain | Protein synthesis | Binding sites | Crystal structure | Index Medicus | CATALYSIS | MONOMERS | THROMBOSIS | ARACHIDONIC ACID | PROCESSING | DIMERS | 60 APPLIED LIFE SCIENCES | ACETYLSALICYLIC ACID | PROSTAGLANDINS | IN VITRO | INFLAMMATION | TARGETS | SIDE EFFECTS | Biological Sciences
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