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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
Two new series of 1,5-diaryl pyrazoles ( , , , and ) and 1,5-diaryl pyrazoline ( and were prepared as both Cyclooxygenase-2 and 15-lipoxygenase inhibitors.... 
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | CHEMISTRY, MEDICINAL | COX-2 | LEUKOTRIENES | CYCLOOXYGENASE | PROSTAGLANDINS | INFLAMMATION | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | MEDIATORS | DERIVATIVES | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2010, Volume 429, Issue 2, pp. 273 - 282
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2007, Volume 96, Issue 10, pp. 2686 - 2702
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 18, pp. 6560 - 6571
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2017, Volume 27, Issue 16, pp. 3653 - 3660
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 28 - 33
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A₂... 
Enzymes | Prostaglandins | Active sites | Cyclooxygenase inhibitors | Atoms | Dimers | Platelet aggregation | Platelets | Fatty acids | Monomers | Platelet | Prostaglandin | Arachidonic acid | Adrenic acid | Nonsteroidal antiinflammatory drugs | arachidonic acid | SELECTIVE-INHIBITION | adrenic acid | MECHANISM | prostaglandin | ENDOPEROXIDE-H SYNTHASE-1 | OXYGENATION | MULTIDISCIPLINARY SCIENCES | INDOMETHACIN | FATTY-ACIDS | CELECOXIB | nonsteroidal antiinflammatory drugs | platelet | HEALTHY-VOLUNTEERS | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Aspirin - metabolism | Isoenzymes - metabolism | Cyclooxygenase 1 - chemistry | Platelet Aggregation Inhibitors - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Platelet Aggregation - drug effects | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Platelet Aggregation Inhibitors - metabolism | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Dogs | Aspirin - chemistry | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Cyclooxygenase 1 - metabolism | Aspirin | Usage | Physiological aspects | Cyclooxygenases | Genetic aspects | Research | Health aspects | Pain | Protein synthesis | Binding sites | Crystal structure | Index Medicus | CATALYSIS | MONOMERS | THROMBOSIS | ARACHIDONIC ACID | PROCESSING | DIMERS | 60 APPLIED LIFE SCIENCES | ACETYLSALICYLIC ACID | PROSTAGLANDINS | IN VITRO | INFLAMMATION | TARGETS | SIDE EFFECTS | Biological Sciences
Journal Article