UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.
Search Articles
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hindlimb | Pyrazoles - chemical synthesis | Humans | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Thermodynamics | Cyclooxygenase 2 - genetics | Drug Design | Cyclooxygenase 1 - chemistry | Female | Triazoles - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 1 - genetics | Gene Expression | Cyclooxygenase 2 Inhibitors - pharmacology | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Click Chemistry - methods | Rats | Edema - enzymology | Edema - drug therapy | Triazoles - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Carrageenan | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Kinetics | Edema - pathology | Drugs | COX-2 inhibitors | Side effects | Inhibitors | Pain | Cyclooxygenase-1 | Inflammation | Cyclooxygenase-2 | Chemical synthesis | Anti-inflammatory agents | Index Medicus
Journal Article
Bioorganic chemistry, ISSN 0045-2068, 04/2017, Volume 71, pp. 146 - 159
Coumarins | COX-2 enzymes | Anti-inflammatory | NSAID | COX-1 enzymes | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Science & Technology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Drug Discovery - methods | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Neoplasms - drug therapy | Coumarins - pharmacology | Animals | Coumarins - chemical synthesis | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | COX-2 inhibitors | Fluocinolone acetonide | Pharmacy | Medicine, Botanic | Schizophrenia | Drugstores | Medicine, Herbal | Plant metabolites | Index Medicus
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2010, Volume 20, Issue 24, pp. 7349 - 7353
Cyclooxygenase | Amino/methylsufonylphenyl | Anti-inflammatory agents | Indolin-2-one derivatives | 5-Lipoxygenase | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Analgesics - pharmacology | Indoles - chemical synthesis | Male | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Benzylidene Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Benzylidene Compounds - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzylidene Compounds - pharmacology | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Mice | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | NH | SO | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3416 - 3424
Hydrazone and pyrazole derivatives | Selective COX-2 inhibitors | Molecular docking | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Pyrazoles - chemical synthesis | Cyclooxygenase 2 - chemistry | Rats | Edema - drug therapy | Hydrazones - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Hydrazones - chemistry | Hydrazones - pharmacology | Pyrazoles - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Computer Simulation | Cyclooxygenase 2 - metabolism | Drug Design | Cyclooxygenase 1 - chemistry | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Binding Sites | Disease Models, Animal | Pyrazoles - pharmacology | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2287 - 2300
Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Female | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Sulindac - chemistry | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Cyclooxygenase Inhibitors - pharmacology | Sulindac - analogs & derivatives | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Sheep | Cell Proliferation - drug effects | Mice | Cyclooxygenase 1 - metabolism | Sulindac - chemical synthesis | Sulindac - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 01/2017, Volume 126, pp. 270 - 276
Triazole ring | PAK1 | Click chemistry | COX-2 | Ketorolac | Cancer | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | p21-Activated Kinases - antagonists & inhibitors | Cyclooxygenase 2 Inhibitors - chemistry | Ketorolac - chemistry | Antineoplastic Agents - metabolism | Ketorolac - metabolism | Protein Kinase Inhibitors - chemistry | Biological Transport | Esters - chemistry | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Protein Kinase Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Click Chemistry | Antineoplastic Agents - chemistry | p21-Activated Kinases - metabolism | Ketorolac - chemical synthesis | Signal Transduction - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Ketorolac - pharmacology | Protein Kinase Inhibitors - metabolism | COX-2 inhibitors | Prostaglandins | Melanoma | Permeability | Nonsteroidal anti-inflammatory drugs | Drug resistance | Triazoles | Index Medicus
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 10/2013, Volume 18, Issue 10, pp. 12633 - 12644
Antimicrobial | Flavonols | Alkaloid | COX-2 | Croton menyharthii Pax | Alpha-glucosidase | Mutagenicity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Extracts - chemistry | Plant Extracts - pharmacology | Escherichia coli - drug effects | Humans | Alkaloids - isolation & purification | Cholinesterase Inhibitors - chemistry | Antifungal Agents - chemistry | Flavonols - isolation & purification | Indoles - isolation & purification | Cyclooxygenase 2 Inhibitors - chemistry | Microbial Sensitivity Tests | Candida albicans - drug effects | Anti-Bacterial Agents - chemistry | Inhibitory Concentration 50 | Indoles - pharmacology | Cholinesterase Inhibitors - isolation & purification | Antifungal Agents - pharmacology | Plant Leaves - chemistry | Alkaloids - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Fish Proteins - chemistry | Cyclooxygenase 2 - chemistry | Cyclooxygenase 2 Inhibitors - isolation & purification | Electrophorus | Plant Extracts - isolation & purification | Acetylcholinesterase - chemistry | Anti-Bacterial Agents - isolation & purification | Flavonols - chemistry | Antifungal Agents - isolation & purification | Animals | Cholinesterase Inhibitors - pharmacology | Croton - chemistry | Anti-Bacterial Agents - pharmacology | Flavonols - pharmacology | Staphylococcus aureus - drug effects | Indoles - chemistry | Alkaloids - chemistry | Bacillus subtilis - drug effects | Index Medicus | antimicrobial | mutagenicity | alpha-glucosidase | flavonols | alkaloid
Journal Article
Phytomedicine (Stuttgart), ISSN 0944-7113, 10/2020, Volume 77, pp. 153284 - 153284
Saponins | AUF-LC-MS | Inflammation | Cyclooxygenase-2 | 5-lipoxygenase | Dual targeted inhibitors | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Spirostans - pharmacology | Arachidonate 5-Lipoxygenase - genetics | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Chromatography, High Pressure Liquid | Cyclooxygenase 2 Inhibitors - chemistry | Saponins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ultrafiltration | Anemarrhena - chemistry | Lipoxygenase Inhibitors - chemistry | Rhizome - chemistry | Cyclooxygenase 2 - genetics | Inflammation - drug therapy | Mass Spectrometry | Arachidonate 5-Lipoxygenase - chemistry | Steroids - pharmacology | Spirostans - chemistry | Drug Evaluation, Preclinical | Glycosides - chemistry | Steroids - chemistry | Sterols - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Sterols - chemistry | Cyclooxygenase 2 - chemistry | Rats | Glycosides - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Lipoxygenase Inhibitors - pharmacology | Saponins - pharmacology | Index Medicus
Journal Article