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Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 12/2011, Volume 71, Issue 24, pp. 7463 - 7470
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 11/2012, Volume 527, Issue 2, pp. 81 - 89
Diets with high content of antioxidant polyphenols are associated with low prevalence of cardiovascular diseases and cancer. Inflammatory angiogenesis is a key... 
Polyphenols | Angiogenesis | Oxidative stress | COX-2 | Mediterranean diet | MMP-9 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLOOXYGENASE-2 INDUCTION | TUMOR ANGIOGENESIS | OLIVE OIL POLYPHENOLS | MATRIX METALLOPROTEINASES | ANTIANGIOGENIC THERAPY | IN-VITRO | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PLAQUE STABILITY | GROWTH-FACTOR | NF-KAPPA-B | Gene Expression Regulation, Enzymologic - drug effects | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Diet, Mediterranean | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Polyphenols - pharmacology | NF-kappa B - metabolism | Neoplasms - prevention & control | Olive Oil | Matrix Metalloproteinase Inhibitors - therapeutic use | Neovascularization, Pathologic - pathology | Neovascularization, Pathologic - enzymology | Matrix Metalloproteinase 9 - metabolism | Cyclooxygenase 2 Inhibitors - therapeutic use | Human Umbilical Vein Endothelial Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Antioxidants - pharmacology | Wine - analysis | Matrix Metalloproteinase Inhibitors - pharmacology | Antioxidants - therapeutic use | Human Umbilical Vein Endothelial Cells - enzymology | Neovascularization, Pathologic - drug therapy | Cyclooxygenase 2 - metabolism | Neovascularization, Pathologic - metabolism | Polyphenols - therapeutic use | Plant Oils - chemistry | Atherosclerosis - prevention & control | Inflammation - physiopathology | Wine | Antioxidants | COX-2 inhibitors | Blood circulation disorders | Oncology, Experimental | Resveratrol | Atherosclerosis | Research | Cells | Cancer | Endothelium | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2014, Volume 80, pp. 167 - 174
A novel series of 2-phenyl-5-(1,3-diphenyl-1 -pyrazol-4-yl)-1,3,4-oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent... 
Analgesic | 1,3,4-Oxadiazole | COX-2 | Anti-inflammatory | Pyrazole | Molecular docking analysis | 1 3 4-Oxadiazole | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | PYRAZOLE DERIVATIVES | ANTICANCER AGENTS DESIGN | ANALGESIC AGENTS | DRUGS | BIOLOGICAL EVALUATION | SUBSTITUTED THIAZOLIDIN-4-ONES | DUAL INHIBITORS | 1,3,4-OXADIAZOLES | PHARMACOLOGICAL EVALUATION | Analgesics - pharmacology | Humans | Analgesics - metabolism | Substrate Specificity | Male | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Analgesics - chemical synthesis | Oxadiazoles - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Analgesics - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Chemistry Techniques, Synthetic | Oxadiazoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Oxadiazoles - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Oxadiazoles - metabolism | COX-2 inhibitors | Aspirin | Carrageenin | Analysis | Drugstores | Acetic acid | Organic acids | Index Medicus
Journal Article
Journal Article
Food Chemistry, ISSN 0308-8146, 03/2017, Volume 218, pp. 15 - 21
Dried citrus peel derived from , also called “chenpi”, possesses a complex mixture of flavonoids and has a history of traditional use to treat a variety of... 
Nchenpi | Antioxidant | Nobiletin | Orange peel extract | Flavonoid | Anti-inflammation | CAPACITY | CELLS | PERICARPIUM | PHENOLIC-COMPOUNDS | FOOD SCIENCE & TECHNOLOGY | CACO-2 | HEAT-TREATMENT | NUTRITION & DIETETICS | NITRIC-OXIDE | "Nchenpi" | CHEMISTRY, APPLIED | EXTRACTS | CITRI-RETICULATAE | Flavones - analysis | Flavonoids - analysis | Citrus - chemistry | Drugs, Chinese Herbal - pharmacology | Chromatography, High Pressure Liquid | Nitric Oxide - analysis | Plant Extracts - analysis | Anti-Inflammatory Agents - analysis | Nitric Oxide Synthase Type II - antagonists & inhibitors | China | Flavonoids - pharmacology | Amidines - analysis | Antioxidants - analysis | Flavones - pharmacology | Picrates - analysis | Phenols - pharmacology | Cell Survival - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Fruit - chemistry | Nitric Oxide - antagonists & inhibitors | Sulfonic Acids - analysis | Antioxidants - pharmacology | California | Biphenyl Compounds - analysis | Phenols - analysis | Animals | Benzothiazoles - analysis | Cyclooxygenase 2 - metabolism | Cyclooxygenase 2 Inhibitors - analysis | RAW 264.7 Cells | Mice | Nitric Oxide Synthase Type II - metabolism | Antioxidants | Flavonoids | Flavones | Anti-inflammatory drugs | Bioflavonoids | Citrus | Citrus fruits | COX-2 inhibitors | Crop yields | Nitric oxide | Gastrointestinal diseases | Biological response modifiers | Mitogens | Interferon gamma | Isoflavones | Index Medicus
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2010, Volume 429, Issue 2, pp. 273 - 282
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2011, Volume 163, Issue 7, pp. 1533 - 1549
BACKGROUND AND PURPOSE Endocannabinoids have both anti‐inflammatory and neuroprotective properties against harmful stimuli. We previously demonstrated that the... 
monoacylglycerol lipase | peroxisome proliferator‐activated receptor‐γ | nuclear factor κ‐B | endocannabinoids | neuroinflammation | cyclooxygenase‐2 | nuclear factor κ-B | peroxisome proliferator-activated receptor-γ | cyclooxygenase-2 | CB1 CANNABINOID RECEPTORS | 2-ARACHIDONYL GLYCEROL | NUCLEAR RECEPTORS | SYNAPTIC-TRANSMISSION | MICROGLIAL CELLS | KAPPA-B | OXIDATIVE-METABOLISM | peroxisome proliferator-activated receptor-gamma | PROTECTS NEURONS | nuclear factor kappa-B | ACTIVATED-RECEPTOR-GAMMA | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Interleukin-1beta - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | NF-kappa B - metabolism | Hippocampus - drug effects | PPAR gamma - metabolism | Excitatory Postsynaptic Potentials - drug effects | Cyclooxygenase 2 - biosynthesis | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Cyclooxygenase 2 - genetics | Prostaglandin D2 - analogs & derivatives | Synaptic Transmission - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Thiazolidinediones - pharmacology | Endocannabinoids | PPAR gamma - genetics | NF-kappa B - antagonists & inhibitors | Cyclooxygenase 2 Inhibitors - pharmacology | Cells, Cultured | Arachidonic Acids - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Animals | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | PPAR gamma - agonists | Mice | Prostaglandin D2 - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Index Medicus | Research Papers
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 18, pp. 6560 - 6571
Journal Article