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Bioorganic Chemistry, ISSN 0045-2068, 04/2017, Volume 71, pp. 30 - 54
1,2,3-Triazoles are important five-membered heterocyclic scaffold due to their extensive biological activities. This framework can be readily obtained in good... 
1,3-Dipolar cycloaddition | Multicomponent reaction | 1,2,3-Triazole | Alkyne–azide coupling reaction | AZIDE-ALKYNE CYCLOADDITION | 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES | ONE-POT SYNTHESIS | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DENGUE VIRUS-REPLICATION | CHEMISTRY, ORGANIC | Alkyne-azide coupling reaction | MOLECULAR DOCKING | METAL-FREE SYNTHESIS | BIOLOGICAL EVALUATION | IN-VITRO ACTIVITY | ANTIINFLAMMATORY DRUGS | Triazoles - chemistry | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Drug Discovery - methods | Azides - chemistry | HIV Protease Inhibitors - pharmacology | Anti-Infective Agents - chemistry | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Click Chemistry - methods | Models, Molecular | HIV Protease Inhibitors - chemistry | Alkynes - chemistry | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Anti-Infective Agents - chemical synthesis | Cycloaddition Reaction - methods | Cyclooxygenase Inhibitors - pharmacology | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | HIV Protease Inhibitors - chemical synthesis | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Triazoles | COX-2 inhibitors | Protease inhibitors | Proteases
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2014, Volume 80, pp. 167 - 174
A novel series of 2-phenyl-5-(1,3-diphenyl-1 -pyrazol-4-yl)-1,3,4-oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent... 
Analgesic | 1,3,4-Oxadiazole | COX-2 | Anti-inflammatory | Pyrazole | Molecular docking analysis | 1 3 4-Oxadiazole | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | PYRAZOLE DERIVATIVES | ANTICANCER AGENTS DESIGN | ANALGESIC AGENTS | DRUGS | BIOLOGICAL EVALUATION | SUBSTITUTED THIAZOLIDIN-4-ONES | DUAL INHIBITORS | 1,3,4-OXADIAZOLES | PHARMACOLOGICAL EVALUATION | Analgesics - pharmacology | Humans | Analgesics - metabolism | Substrate Specificity | Male | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Analgesics - chemical synthesis | Oxadiazoles - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Analgesics - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Chemistry Techniques, Synthetic | Oxadiazoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Oxadiazoles - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Oxadiazoles - metabolism | COX-2 inhibitors | Aspirin | Carrageenin | Analysis | Drugstores | Acetic acid | Organic acids
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2010, Volume 53, Issue 13, pp. 5033 - 5043
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol: inhibition of tumor necrosis factor... 
BREAST-CANCER | QUINONE REDUCTASE | CHEMISTRY, MEDICINAL | CANCER CHEMOPREVENTIVE ACTIVITY | NITRIC-OXIDE SYNTHASE | II DETOXIFICATION ENZYMES | MAMMARY CARCINOGENESIS | RAW 264.7 MACROPHAGES | NATURAL-PRODUCT PRESENT | NF-KAPPA-B | SMALL-MOLECULE ACTIVATORS | Antineoplastic Agents - chemical synthesis | Humans | Aromatase - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | NF-kappa B - metabolism | Stilbenes - metabolism | Sulfuric Acid Esters - pharmacology | Stilbenes - chemistry | Stilbenes - pharmacology | Enzyme Inhibitors - chemical synthesis | Spectroscopy, Fourier Transform Infrared | Biphenyl Compounds - metabolism | Spectrometry, Mass, Electrospray Ionization | Biphenyl Compounds - antagonists & inhibitors | Sulfuric Acid Esters - chemical synthesis | Enzyme Inhibitors - chemistry | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | Magnetic Resonance Spectroscopy | Picrates - metabolism | Enzyme Inhibitors - pharmacology | Sulfuric Acid Esters - chemistry | Antineoplastic Agents - chemistry | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | Macrophages - metabolism | Picrates - antagonists & inhibitors | Animals | Cyclooxygenase 2 - metabolism | HL-60 Cells | NAD(P)H Dehydrogenase (Quinone) - metabolism | Macrophages - drug effects | Mice | Nitric Oxide Synthase - metabolism | Cyclooxygenase 1 - metabolism
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2012, Volume 49, pp. 324 - 333
Journal Article
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Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Balanced modulation of several targets is one of the current strategies for the treatment of multi-factorial diseases. Based on the knowledge of inflammation... 
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | MECHANISM | CRYSTAL-STRUCTURE | DRUG DISCOVERY | CANDIDATE | DUAL INHIBITORS | DERIVATIVES | ANTIMICROBIAL ACTIVITY | LIGAND DESIGN | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes
Journal Article