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The New England Journal of Medicine, ISSN 0028-4793, 12/2001, Volume 345, Issue 25, pp. 1809 - 1817
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis | Index Medicus
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 11/2012, Volume 527, Issue 2, pp. 81 - 89
Diets with high content of antioxidant polyphenols are associated with low prevalence of cardiovascular diseases and cancer. Inflammatory angiogenesis is a key... 
Polyphenols | Angiogenesis | Oxidative stress | COX-2 | Mediterranean diet | MMP-9 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLOOXYGENASE-2 INDUCTION | TUMOR ANGIOGENESIS | OLIVE OIL POLYPHENOLS | MATRIX METALLOPROTEINASES | ANTIANGIOGENIC THERAPY | IN-VITRO | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PLAQUE STABILITY | GROWTH-FACTOR | NF-KAPPA-B | Gene Expression Regulation, Enzymologic - drug effects | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Diet, Mediterranean | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Polyphenols - pharmacology | NF-kappa B - metabolism | Neoplasms - prevention & control | Olive Oil | Matrix Metalloproteinase Inhibitors - therapeutic use | Neovascularization, Pathologic - pathology | Neovascularization, Pathologic - enzymology | Matrix Metalloproteinase 9 - metabolism | Cyclooxygenase 2 Inhibitors - therapeutic use | Human Umbilical Vein Endothelial Cells - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Antioxidants - pharmacology | Wine - analysis | Matrix Metalloproteinase Inhibitors - pharmacology | Antioxidants - therapeutic use | Human Umbilical Vein Endothelial Cells - enzymology | Neovascularization, Pathologic - drug therapy | Cyclooxygenase 2 - metabolism | Neovascularization, Pathologic - metabolism | Polyphenols - therapeutic use | Plant Oils - chemistry | Atherosclerosis - prevention & control | Inflammation - physiopathology | Wine | Antioxidants | COX-2 inhibitors | Blood circulation disorders | Oncology, Experimental | Resveratrol | Atherosclerosis | Research | Cells | Cancer | Endothelium | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2016, Volume 59, Issue 1, pp. 194 - 205
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2014, Volume 80, pp. 167 - 174
A novel series of 2-phenyl-5-(1,3-diphenyl-1 -pyrazol-4-yl)-1,3,4-oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent... 
Analgesic | 1,3,4-Oxadiazole | COX-2 | Anti-inflammatory | Pyrazole | Molecular docking analysis | 1 3 4-Oxadiazole | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | PYRAZOLE DERIVATIVES | ANTICANCER AGENTS DESIGN | ANALGESIC AGENTS | DRUGS | BIOLOGICAL EVALUATION | SUBSTITUTED THIAZOLIDIN-4-ONES | DUAL INHIBITORS | 1,3,4-OXADIAZOLES | PHARMACOLOGICAL EVALUATION | Analgesics - pharmacology | Humans | Analgesics - metabolism | Substrate Specificity | Male | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Analgesics - chemical synthesis | Oxadiazoles - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Analgesics - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Chemistry Techniques, Synthetic | Oxadiazoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Oxadiazoles - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Oxadiazoles - metabolism | COX-2 inhibitors | Aspirin | Carrageenin | Analysis | Drugstores | Acetic acid | Organic acids | Index Medicus
Journal Article
Food Chemistry, ISSN 0308-8146, 03/2017, Volume 218, pp. 15 - 21
Dried citrus peel derived from , also called “chenpi”, possesses a complex mixture of flavonoids and has a history of traditional use to treat a variety of... 
Nchenpi | Antioxidant | Nobiletin | Orange peel extract | Flavonoid | Anti-inflammation | CAPACITY | CELLS | PERICARPIUM | PHENOLIC-COMPOUNDS | FOOD SCIENCE & TECHNOLOGY | CACO-2 | HEAT-TREATMENT | NUTRITION & DIETETICS | NITRIC-OXIDE | "Nchenpi" | CHEMISTRY, APPLIED | EXTRACTS | CITRI-RETICULATAE | Flavones - analysis | Flavonoids - analysis | Citrus - chemistry | Drugs, Chinese Herbal - pharmacology | Chromatography, High Pressure Liquid | Nitric Oxide - analysis | Plant Extracts - analysis | Anti-Inflammatory Agents - analysis | Nitric Oxide Synthase Type II - antagonists & inhibitors | China | Flavonoids - pharmacology | Amidines - analysis | Antioxidants - analysis | Flavones - pharmacology | Picrates - analysis | Phenols - pharmacology | Cell Survival - drug effects | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Fruit - chemistry | Nitric Oxide - antagonists & inhibitors | Sulfonic Acids - analysis | Antioxidants - pharmacology | California | Biphenyl Compounds - analysis | Phenols - analysis | Animals | Benzothiazoles - analysis | Cyclooxygenase 2 - metabolism | Cyclooxygenase 2 Inhibitors - analysis | RAW 264.7 Cells | Mice | Nitric Oxide Synthase Type II - metabolism | Antioxidants | Flavonoids | Flavones | Anti-inflammatory drugs | Bioflavonoids | Citrus | Citrus fruits | COX-2 inhibitors | Crop yields | Nitric oxide | Gastrointestinal diseases | Biological response modifiers | Mitogens | Interferon gamma | Isoflavones | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 01/2013, Volume 127, Issue 3, pp. 377 - 385
Background-Low dose aspirin reduces the secondary incidence of myocardial infarction and stroke. Drug resistance to aspirin might result in treatment failure.... 
aspirin | blood platelets | pharmacology | thromboxanes | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | HEALTHY-SUBJECTS | INTERINDIVIDUAL VARIABILITY | PLATELET-FUNCTION | THROMBOXANE BIOSYNTHESIS | VASCULAR-DISEASE | INHIBITION | LOW-DOSE ASPIRIN | CYCLOOXYGENASE ACTIVITY | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | Ticlopidine - pharmacology | Humans | Middle Aged | Male | Aspirin - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Platelet Aggregation Inhibitors - administration & dosage | Platelet Aggregation Inhibitors - pharmacology | Ticlopidine - administration & dosage | Adult | Female | Aspirin - therapeutic use | Platelet Aggregation - drug effects | Aspirin - pharmacology | Platelet Aggregation Inhibitors - therapeutic use | Drug Resistance | Stroke - prevention & control | Administration, Oral | Cyclooxygenase Inhibitors - administration & dosage | Treatment Outcome | Ticlopidine - analogs & derivatives | Cyclooxygenase Inhibitors - pharmacology | Cross-Over Studies | Adolescent | Cyclooxygenase 1 - drug effects | Myocardial Infarction - prevention & control | Tablets, Enteric-Coated | Cyclooxygenase Inhibitors - therapeutic use | Stroke (Disease) | Aspirin | Dosage and administration | Genetic aspects | Research | Drug therapy | Drug resistance | Health aspects | Heart attack | Index Medicus | Abridged Index Medicus | thromboxane | platelets
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 18, pp. 6560 - 6571
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2013, Volume 16, Issue 9, pp. 1291 - 1298
Augmentation of endogenous cannabinoid (eCB) signaling represents an emerging approach to the treatment of affective disorders. Cyclooxygenase-2 (COX-2)... 
MOLECULAR CHARACTERIZATION | MOUSE-BRAIN | SYSTEM | 2-ARACHIDONOYLGLYCEROL | CATABOLIC ENZYMES | CYCLOOXYGENASE-2 | REPEATED HOMOTYPIC STRESS | MONOACYLGLYCEROL LIPASE | ARACHIDONIC-ACID | NEUROSCIENCES | AMIDE HYDROLASE INHIBITION | Endocannabinoids - metabolism | Endocannabinoids - pharmacology | Body Temperature - drug effects | Humans | Adaptation, Ocular - drug effects | Male | Anxiety - drug therapy | Cannabinoid Receptor Agonists - pharmacology | Freezing Reaction, Cataleptic - drug effects | Exploratory Behavior - physiology | Exploratory Behavior - drug effects | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Amidohydrolases - deficiency | Anxiety - metabolism | Disease Models, Animal | Adaptation, Ocular - genetics | Maze Learning - physiology | Anxiety - physiopathology | Morpholines - pharmacology | Cyclooxygenase Inhibitors - chemistry | Calcium Channel Blockers - pharmacology | Maze Learning - drug effects | Mice, Inbred ICR | Cyclooxygenase Inhibitors - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Anxiety - genetics | Animals | Receptor, Cannabinoid, CB1 - genetics | Body Temperature - genetics | Signal Transduction - drug effects | Benzoxazines - pharmacology | Cyclooxygenase 2 - metabolism | Freezing Reaction, Cataleptic - physiology | Signal Transduction - physiology | Mice | Receptor, Cannabinoid, CB1 - deficiency | Cyclooxygenase 2 - deficiency | Indoles - chemistry | Cyclooxygenase Inhibitors - therapeutic use | Endocannabinoids - chemistry | Physiological aspects | COX-2 inhibitors | Prostaglandins | Care and treatment | Affective disorders | Endocannabinoids | Index Medicus
Journal Article
Journal Article