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American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 10/2007, Volume 293, Issue 4, pp. G788 - G797
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, ISSN 0193-1857, 10/2007, Volume 293, Issue 4, pp. G788 - G797
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 09/2017, Volume 138, pp. 661 - 668
The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural... 
Mofezolac | X-ray crystallography | Cyclooxygenase-1 inhibition | SITE | SYNTHASE-1 | DESIGN | CHEMISTRY, MEDICINAL | Molecular modelling | Diarylisoxazole | CRYSTAL-STRUCTURE
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2010, Volume 114, Issue 1, pp. 247 - 258
Interleukin(IL)-1β is a proinflammatory cytokine implicated in several neurodegenerative disorders. Downstream actions of IL-1β include production of... 
Neuroinflammation | Interleukin-1 | Prostaglandin E | Cyclooxygenase-1 | Hippocampus | cyclooxygenase-1 | interleukin-1 | hippocampus | prostaglandin E2 | neuroinflammation
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 11/2014, Volume 5, Issue 11, pp. 1254 - 1258
We report the design and synthesis of fluorine-containing cyclooxygenase-1 (COX-1)-selective inhibitors to serve as prototypes for the development of a... 
rofecoxib | furanone | Cyclooxygenase-1 (COX-1) | imaging | structure-activity relationship | CELLS | CHEMISTRY, MEDICINAL | VIVO | RAT | OVARIAN-CANCER | CELECOXIB | CYCLOOXYGENASE-1 INHIBITOR | INFLAMMATION | PHARMACOLOGICAL PROFILE | IMAGING AGENTS | EXPRESSION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 410 - 421
A new series of 2-substituted mercapto-4(3 )-quinazolinone were synthesized and assessed for anti-inflammatory and analgesic activities and inhibition of... 
Docking study | Synthesis | 2-Mercapto-4(3H)-quinazolinone | Cyclooxygenase-1/cyclooxygenase-2 inhibition assay | Anti-inflammatory activities | inhibition assay | Cyclooxygenase-1/cyclooxygenase-2 | SELECTIVE-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ANALOGS | ANTITUMOR-ACTIVITY | DRUGS | BIOLOGICAL EVALUATION | DERIVATIVES | PROSTAGLANDIN SYNTHESIS | QUINAZOLINES | Analgesics - pharmacology | Analgesics - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Analgesics - chemical synthesis | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolinones - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Quinazolinones - chemical synthesis | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Protein Conformation | Mice | Molecular Docking Simulation | Quinazolinones - chemistry | Cyclooxygenase 1 - metabolism | Quinazolinones - metabolism | Drugstores | COX-2 inhibitors | Pharmacy | Diclofenac | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2006, Volume 194, Issue 1, pp. 144 - 152
Abstract Diet can be one of the most important factors that influence risks for atherothrombotic diseases. Hesperetin included in grapefruits and oranges is... 
Cardiovascular | Platelet aggregation | Hesperetin | Cyclooxygenase-1 | Phospholipase C
Journal Article
Frontiers in neurology, ISSN 1664-2295, 2017, Volume 8, p. 251
Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin... 
Journal Article
BLOOD, ISSN 0006-4971, 09/2014, Volume 124, Issue 10, pp. 1610 - 1621
Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system. Here,... 
LINEAGE COMMITMENT | PROSTANOID RECEPTORS | PROTEIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | KINASE | TRANSDUCTION | CYCLOOXYGENASE-1 | HEMATOLOGY | ASPIRIN | PROSTAGLANDIN E-2 | INTERLEUKIN-7
Journal Article
Journal of the Korean Society of Food Science and Nutrition, ISSN 1226-3311, 09/2018, Volume 47, Issue 9, pp. 863 - 869
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2019, Volume 179, pp. 16 - 25
Biomarkers of specific targets are becoming an essential objective for clinical unmet clinical needs to improve diseases early detection and increase patient... 
Mofezolac | Diagnosis | Cyclooxygenase-1 | OVCAR-3 and SKOV-3 cell lines | Fluorescent probe | Ovarian cancer | Oncology, Experimental | Mortality | Fluorescence | Research | Arachidonic acid | Investigations | Cancer | Index Medicus
Journal Article
by Ding, L and Gu, H and Lan, ZW and Lei, QC and Wang, WX and Ruan, JF and Yu, M and Lin, J and Cui, QH
ONCOLOGY REPORTS, ISSN 1021-335X, 01/2019, Volume 41, Issue 1, pp. 559 - 569
The prognosis of patients with colorectal cancer (CRC) remains poor owing to diagnosis typically occurring at advanced stages of the disease. The understanding... 
COLON-CANCER | RATES | colorectal cancer | INHIBITION | ONCOLOGY | nuclear factor kappa B | cyclooxygenase-1 | cell apoptosis | PROLIFERATION | ATP | CYCLE
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2019, Volume 14, Issue 8, pp. e0221662 - e0221662
Hippocrepis hippocrepis is a notocotylid that has been widely reported in capybaras; however, the molluscs that act as intermediate hosts of this parasite... 
Analysis | Phylogeny | Studies | Parasitology | Cyclooxygenase-1 | Laboratories | Large intestine | Morphology | Mollusks | Parasites | Life cycles | Gene sequencing | Index Medicus
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2018, Volume 59, Issue 1, pp. 102 - 112
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations... 
Cell activation | Kidneys | Cyclooxygenase-1 | Metabolites | Rodents | Isoforms | Eicosanoids | Inflammation | Cyclooxygenase-2 | Macrophages | Prostaglandin endoperoxide synthase | eicosanoid | prostaglandin, gene targeting | macrophage | cyclooxygenase | animal model | lipopolysaccharide
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2018, Volume 59, Issue 1, pp. 89 - 101
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2,... 
Prostaglandins | Cyclooxygenase-1 | Rodents | Isoforms | COX protein | Cyclooxygenase-2 | Localization | Macrophages | Prostaglandin endoperoxide synthase | Lipopolysaccharides | gene targeting | eicosanoid | macrophage | platelet | animal model | prostaglandin
Journal Article
NUCLEAR MEDICINE AND BIOLOGY, ISSN 0969-8051, 07/2016, Volume 43, Issue 7, pp. 438 - 444
Introduction: Neuroinflammatory processes play an important role in the pathogenesis of Alzheimer's disease (AD). As a biomarker of neuroinflammatory... 
[C-11]Ketoprofen methyl ester | TRACER | Neuroinflammation | ACTIVATED MICROGLIA | CYCLOOXYGENASE-1 | Alzheimer's disease | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ANTIINFLAMMATORY DRUGS
Journal Article
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