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The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2019, Volume 143, Issue 1, pp. 316 - 324.e7
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 09/2017, Volume 138, pp. 661 - 668
The diarylisoxazole molecular scaffold is found in several NSAIDs, especially those with high selectivity for COX-1. Here, we have determined the structural... 
Mofezolac | X-ray crystallography | Cyclooxygenase-1 inhibition | SITE | SYNTHASE-1 | DESIGN | CHEMISTRY, MEDICINAL | Molecular modelling | Diarylisoxazole | CRYSTAL-STRUCTURE
Journal Article
Journal of Magnetic Resonance Imaging, ISSN 1053-1807, 08/2017, Volume 46, Issue 2, pp. 505 - 517
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0118203
Macrophages play important roles in defense against infection, as well as in homeostasis maintenance. Thus alterations of macrophage function can have... 
ZEBRAFISH LARVAE | ACTIVATION | MONOCYTE | VIVO | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ORAL ASPIRIN | INDUCTION | CANCER | POLARIZATION | Zebrafish | Inflammation - immunology | Macrophages - cytology | Lipopolysaccharides - immunology | Toll-Like Receptor 4 - metabolism | Cyclooxygenase Inhibitors - pharmacology | Macrophages - enzymology | Inflammation - metabolism | Phenotype | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Prostaglandin-Endoperoxide Synthases - metabolism | Inflammation Mediators - metabolism | Biomarkers | Female | Macrophages - drug effects | Mice | Cytokines - biosynthesis | Macrophages - immunology | Disease Models, Animal | Infection | COX-2 inhibitors | Tumor necrosis factor | Genetic aspects | Indomethacin | Macrophages | Health aspects | Drugs | Adipose tissue | Disease | Homeostasis | Arthritis | Inflammatory diseases | Lipopolysaccharides | Prostaglandin endoperoxide synthase | Pain | Immunology | Rodents | Bone marrow | Inhibition | Chronic illnesses | Phenotypes | Aspirin | Wound healing | Cytokines | Interleukin 12 | Inflammation | Tumor necrosis factor-α | Gene expression | Medicine | Inhibitors | Cyclooxygenase-1 | Interferon regulatory factor 4 | Sepsis | Cyclooxygenase-2 | Laboratory animals | Peritoneum | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2018, Volume 13, Issue 3, p. e0193451
Background Ursolic acid (UA) is a promising molecule with anti-inflammatory, analgesic and potential anti-arthritic activity. Methods This study was undertaken... 
NANOPARTICLES | DESIGN | NLC | SLN | DOCTOR-DIAGNOSED ARTHRITIS | MULTIDISCIPLINARY SCIENCES | STEAROYL GLUCOSIDE | PREVALENCE | ATTRIBUTABLE ACTIVITY LIMITATION | FORMULATION | DELIVERY | Analgesics - pharmacology | Plant Extracts - chemistry | Arthritis, Experimental - drug therapy | Rats, Wistar | Plant Extracts - pharmacology | Skin - metabolism | Analgesics - metabolism | Male | Drug Carriers - chemistry | Lipids - chemistry | Plant Extracts - metabolism | Triterpenes - chemistry | Ocimum sanctum - chemistry | Cyclooxygenase 1 - chemistry | Female | Interleukin-1 - antagonists & inhibitors | Analgesics - therapeutic use | Cyclooxygenase 2 - chemistry | Rats | Permeability | Particle Size | Animals | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Drug Liberation | Protein Conformation | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Plant Extracts - therapeutic use | Skin - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Laboratories | Lipids | Arthritis | Drug delivery | Molecular docking | Diclofenac | Nanoparticles | Proteins | Leaves | Interleukin 1 | Tumor necrosis factor-TNF | Rheumatism | Population | Pollutants | Enzymes | Evaluation | Cytokines | Inflammation | Pharmacology | Evaporation | Tumor necrosis factor-α | Surfactants | Biological activity | Carriers | Entrapment | Penetration | Acids | Cyclooxygenase-1 | Zeta potential | Freund's adjuvant | Rheumatoid arthritis | Polydispersity | In vivo methods and tests | Ursolic acid | Skin | Cyclooxygenase-2 | Physicochemical properties
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173628
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e20062
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0179809
Objective Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary... 
PROSTACYCLIN | MULTIDISCIPLINARY SCIENCES | LIVER | NITRIC-OXIDE | INDOMETHACIN | TUMOR ANGIOGENESIS | MODEL | BLOCKADE | CELECOXIB | PORTAL-HYPERTENSIVE-RATS | HEMODYNAMICS | Liver - pathology | Pyrazoles - therapeutic use | Tumor Necrosis Factor-alpha - blood | Male | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Disease Models, Animal | Pyrazoles - pharmacology | Lung - pathology | Liver Cirrhosis - complications | Rats | Celecoxib - pharmacology | Celecoxib - therapeutic use | Hepatopulmonary Syndrome - drug therapy | Down-Regulation - drug effects | Rats, Sprague-Dawley | Cyclooxygenase Inhibitors - pharmacology | Animals | Hepatopulmonary Syndrome - etiology | Hepatopulmonary Syndrome - metabolism | Hepatopulmonary Syndrome - mortality | Liver Cirrhosis - pathology | Hemodynamics - drug effects | Cyclooxygenase 1 - metabolism | Cyclooxygenase Inhibitors - therapeutic use | COX-2 inhibitors | Complications and side effects | Lung diseases | Dosage and administration | Research | Drug therapy | Liver cirrhosis | Risk factors | Liver | Biochemistry | Collateral | Experiments | Vasodilation | Prostaglandin endoperoxide synthase | Proteins | Angiogenesis | Prostaglandins | Pathways | Rodents | Attenuation | Tumor necrosis factor-TNF | Blood pressure | Inhibition | Vascular endothelial growth factor | Shunts | Medical research | NF-κB protein | Liver diseases | Kidneys | Mortality | Inflammation | Celecoxib | Patients | Catheters | Bile duct | Medicine | Cirrhosis | Hospitals | Inhibitors | Cyclooxygenase-1 | Fibrosis | Hypoxia | Indomethacin | Hemodynamics | Cyclooxygenase-2 | Laboratory animals | Bypasses | Kidney transplantation
Journal Article