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Tetrahedron, ISSN 0040-4020, 05/2019, Volume 75, Issue 20, pp. 2861 - 2865
A new method for the synthesis of 3-aryl-5-fluoroisoxazoles via the reaction of nitrosonium chlorosulfate with 2-aryl-1-bromo-1-fluorocyclopropanes containing... 
Nitrosonium chlorosulfate | Regioselectivity | 2-Aryl-1-bromo-1-fluorocyclopropanes | 3-Aryl-5-fluoroisoxazoles | ISOXAZOLES | CYCLOOXYGENASE-2 | RING | CHEMISTRY | CHEMISTRY, ORGANIC | STRUCTURE REVISION
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 09/2007, Volume 20, Issue 3, pp. 365 - 372
Rheumatoid arthritis (RA) is a chronic inflammatory disease that is characterized by hyperplasia of the synovial fibroblasts, which is partly the result of... 
Synovial fibroblasts | Curcumin | Cyclooxygenase-2 | Rheumatoid arthritis | Apoptosis
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2017, Volume 37, Issue 19, pp. 5035 - 5044
Fever occurs upon binding of prostaglandin E2 (PGE2) to EP3 receptors in the median preoptic nucleus of the hypothalamus, but the origin of the pyrogenic PGE2... 
Prostaglandin E2 | Microsomal prostaglandin E synthase-1 | Cyclooxygenase-2 | Median preoptic nucleus | Endothelial cells | Fever | Index Medicus | fever | endothelial cells | median preoptic nucleus | prostaglandin E2 | cyclooxygenase-2 | microsomal prostaglandin E synthase-1
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2014, Volume 111, Issue 43, pp. E4658 - E4667
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 03/2016, Volume 26, Issue 6, pp. 1516 - 1520
Cyclooxygenase-2 (COX-2) is the key enzyme in the prostaglandin synthesis pathway which is involved in various pathophysiological conditions. The enzyme is... 
Fluorous chemistry | RADIOIODINATION | CHEMISTRY, MEDICINAL | Iodine-125 | CHEMISTRY, ORGANIC | Cyclooxygenase-2 | EXPRESSION
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2014, Volume 87, Issue 4, pp. 625 - 635
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated inflammatory autoimmune disease model of multiple sclerosis (MS). The inflammatory process... 
Multiple sclerosis | Matrix metalloproteinase 9 | Prostaglandin E2 | Cyclooxygenase-2 | Interleukin-17 | Interleukin-6
Journal Article
CARCINOGENESIS, ISSN 0143-3334, 05/2013, Volume 34, Issue 5, pp. 1150 - 1157
Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E-2 (PGE(2)), promoting many hallmarks of... 
COLON-CANCER | CYCLOOXYGENASE-2 | ONCOLOGY | MARKER | POLYPOSIS | GROWTH | LINE | GENE-EXPRESSION | INTESTINAL ADENOMAS | BETA-CATENIN | RECEPTORS
Journal Article
International Journal of Biological Macromolecules, ISSN 0141-8130, 04/2017, Volume 97, pp. 468 - 480
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 07/2010, Volume 37, Issue 1, pp. 187 - 193
Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal... 
CARCINOMA-CELLS | ACTIVATION | cannabinoid | ANTICANCER AGENTS | cyclooxygenase-2 | RECEPTOR | colorectal carcinoma | arachidonoylethanolamide (anandamide | BCL-2 | METABOLISM | ONCOLOGY | CYCLOOXYGENASE-2 EXPRESSION | BAX | non-apoptotic cell death | INHIBITOR | AEA | TUMOR-GROWTH
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2013, Volume 63, Issue 100, pp. 229 - 236
Abstract Anti-inflammatory therapies are the current most plausible drug candidates for anti-epileptogenesis and neuroprotection following prolonged seizures.... 
Neurology | Biomarker | Inflammation | Corticosteroids | MRI | Epilepsy | HEAD-INJURY | CYCLOOXYGENASE-2 | KAPPA-B | NEUROSCIENCES | SEIZURE | T-2 | TARGETS | INHIBITOR | STRESS | Lithium - toxicity | Brain Edema - etiology | Brain Edema - pathology | Cerebral Cortex - pathology | Status Epilepticus - chemically induced | Rats | Dexamethasone - adverse effects | Linear Models | Male | Pilocarpine - toxicity | Rats, Sprague-Dawley | Magnetic Resonance Imaging | Animals | Anti-Inflammatory Agents - adverse effects | Image Processing, Computer-Assisted | Time Factors | Status Epilepticus - complications | Cerebral Cortex - drug effects | Brain Injuries - etiology | Disease Models, Animal | Phosphates | Brain | Dexamethasone | Central nervous system depressants | Seizures (Medicine) | Cerebral edema | Status epilepticus | Injuries | Index Medicus | COX-2, cyclooxygenase-2 | FOV, field of view | IκB, inhibitor of kappa-B | TR, repetition time | fse, fast spin-echo | etl, echo-train length | BBB, blood–brain barrier | DEX, dexamethasone | rHCV, relative hippocampal volume | SE, status epilepticus | NSAIDs, non-steroidal anti-inflammatory drugs | CSE, convulsive status epilepticus | MRI, magnetic resonance imaging | TEeff, effective echo time | ROIs, regions of interest | T2, transverse magnetisation relaxation time constant | TE, echo time | T2
Journal Article
PLOS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12
Camphorquinone (CQ) is a popularly-used photosensitizer in composite resin restoration. In this study, the effects of CQ on cytotoxicity and... 
PATHWAYS | RESIN | APOPTOSIS | BISGMA | CARBOXYLESTERASE EXPRESSION | TEGDMA | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | CYCLOOXYGENASE-2 EXPRESSION | FIBROBLAST-CULTURES | ERK
Journal Article