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Neuropharmacology, ISSN 0028-3908, 03/2013, Volume 66, pp. 264 - 273
The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential... 
mGlu3 | Primary neuronal cultures | Rat cortical neurons | Spontaneous Ca2+ oscillations | Fluorescent imaging plate reader | Mouse cortical neurons | Metabotropic glutamate receptor | mGlu2 | Spontaneous Ca | oscillations | ANXIETY | AGONIST LY354740 | NEUROSCIENCES | CALCIUM TRANSIENTS | PHENCYCLIDINE | CA2+ SPIKES | POTENT | MODELS | FREQUENCY | PHARMACOLOGY & PHARMACY | OSCILLATIONS | Glycine - analogs & derivatives | Primary Cell Culture - methods | Allosteric Regulation | Amino Acids, Dicarboxylic - pharmacology | Amino Acids - pharmacology | Cerebral Cortex - metabolism | Optical Imaging - instrumentation | Biphenyl Compounds - pharmacology | Receptors, Metabotropic Glutamate - genetics | Proline - pharmacology | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Cyclic AMP - metabolism | Optical Imaging - methods | Cyclopropanes - pharmacology | Bridged Bicyclo Compounds - pharmacology | Proline - analogs & derivatives | Rats | Mice, Transgenic | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Receptors, Metabotropic Glutamate - biosynthesis | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Mice, Inbred ICR | Mice, Knockout | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Glycine - pharmacology | Calcium Signaling - drug effects | Ligands | Mice | Pyridines - pharmacology | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Indans - pharmacology | Tranquilizing drugs | Neurosciences | Neurons | Analysis | Physiological aspects | Schizophrenia | Amino acids | Glutamate | Index Medicus | Action potential
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 05/2004, Volume 19, Issue 9, pp. 2464 - 2474
A major subtype of glutamate receptors, AMPA receptors (AMPARs), are generally thought to mediate excitation at mammalian central synapses via the ionotropic... 
Cerebellum | Presynaptic inhibition | AMPA-type glutamate receptor | Rat | GABAergic inhibitory synapse | Glycine - analogs & derivatives | Rats, Wistar | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Benzoxazines | Neural Inhibition - physiology | Drug Interactions | Piperidines - pharmacology | Egtazic Acid - analogs & derivatives | Neurons - physiology | Neurons - drug effects | Action Potentials - drug effects | Ryanodine - pharmacology | Cyclopropanes - pharmacology | Pyrazoles - pharmacology | Synapses - drug effects | Triazines - pharmacology | Presynaptic Terminals - drug effects | Receptors, AMPA - physiology | Colforsin - pharmacology | Synapses - physiology | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Presynaptic Terminals - physiology | Chelating Agents - pharmacology | Calcium Channel Blockers - pharmacology | Benzothiadiazines - pharmacology | GABA Antagonists - pharmacology | Naphthalenes - pharmacology | Triazoles - pharmacology | Animals | Egtazic Acid - pharmacology | Glycine - pharmacology | Cerebellum - cytology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | In Vitro Techniques | Neural Inhibition - drug effects | Receptors, AMPA - drug effects | Index Medicus | presynaptic inhibition | rat | cerebellum
Journal Article
Neuroscience, ISSN 0306-4522, 2001, Volume 106, Issue 3, pp. 579 - 587
Medium spiny neurons were recorded from striatal slices obtained from mice lacking the group I metabotropic glutamate receptor (mGluR) subtype 1 or subtype 5.... 
basal ganglia | knockout mice | electrophysiology | striatum | excitotoxicity | metabotropic glutamate receptor | Electrophysiology | Striatum | Basal ganglia | Knockout mice | Excitotoxicity | Metabotropic glutamate receptor | ACTIVATION | NMDA-RESPONSES | SYNAPTIC PLASTICITY | NEUROSCIENCES | MGLUR1 MUTANT MICE | QUINOLINIC ACID | SUBUNIT MESSENGER-RNAS | (S)-4C3HPG PROTECTS | LONG-TERM POTENTIATION | RAT HIPPOCAMPAL SLICES | HUNTINGTONS-DISEASE | Receptors, Metabotropic Glutamate - drug effects | Glycine - analogs & derivatives | Synaptic Transmission - physiology | Muscarinic Agonists - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Neurons - cytology | Anticonvulsants - pharmacology | N-Methylaspartate - pharmacology | Resorcinols - pharmacology | (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride - pharmacology | Neostriatum - drug effects | Receptors, Metabotropic Glutamate - genetics | Receptor, Metabotropic Glutamate 5 | Neostriatum - metabolism | Synaptic Transmission - drug effects | Neurons - metabolism | Neurons - drug effects | Receptors, Metabotropic Glutamate - deficiency | Action Potentials - drug effects | Cyclopropanes - pharmacology | Receptors, N-Methyl-D-Aspartate - drug effects | Benzoates | Neostriatum - cytology | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Action Potentials - physiology | Animals | Glycine - pharmacology | Muscarine - pharmacology | Glutamic Acid - metabolism | Mice | Pyridines - pharmacology | Phenylacetates - pharmacology | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 153 - 163
Small molecule phosphodiesterase (PDE) 4 inhibitors have long been known to show therapeutic benefit in various preclinical models of psychiatric and... 
ALLOSTERIC MODULATORS | MESSENGER-RNA | MEMORY | PDE4 | DISEASE | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | RANDOMIZED CLINICAL-TRIALS | IDENTIFICATION | ROFLUMILAST | ROLIPRAM | Inflammation - chemically induced | Macaca fascicularis | Male | Thiazoles - therapeutic use | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Anti-Anxiety Agents - pharmacokinetics | Inflammation - drug therapy | Oxadiazoles - pharmacology | Phosphodiesterase 4 Inhibitors - adverse effects | Anti-Anxiety Agents - adverse effects | Behavior, Animal - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - drug effects | Benzamides - pharmacology | Pica - drug therapy | Anti-Anxiety Agents - therapeutic use | Cerebral Cortex - drug effects | Drug Evaluation, Preclinical | Oxadiazoles - pharmacokinetics | Rolipram - pharmacology | Cyclopropanes - pharmacology | Cerebral Cortex - enzymology | Phosphodiesterase 4 Inhibitors - pharmacokinetics | Callithrix | Nootropic Agents - pharmacokinetics | Anti-Anxiety Agents - pharmacology | Nootropic Agents - therapeutic use | Rats | Ferrets | Nootropic Agents - adverse effects | Phosphodiesterase 4 Inhibitors - pharmacology | Oxadiazoles - therapeutic use | Oxadiazoles - adverse effects | Animals | Aminopyridines - pharmacology | Thiazoles - pharmacology | Isoenzymes - antagonists & inhibitors | Nootropic Agents - pharmacology | Index Medicus
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 2, pp. 314 - 322.e9
Background Glucocorticoid functions are markedly impaired in patients with chronic obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor... 
Allergy and Immunology | dexamethasone | Roflumilast | corticosteroid resistance | neutrophil | chronic obstructive pulmonary disease | RHEUMATOID-ARTHRITIS | OXIDATIVE STRESS | HISTONE DEACETYLASE ACTIVITY | ARTERY ENDOTHELIAL-CELLS | BRONCHIAL EPITHELIAL-CELLS | MIGRATION INHIBITORY FACTOR | IMMUNOLOGY | FUNCTION IN-VITRO | ALLERGY | GLUCOCORTICOID-RECEPTOR BETA | CIGARETTE-SMOKE | PDE4 INHIBITOR | Gene Expression - drug effects | Humans | Middle Aged | Macrophage Migration-Inhibitory Factors - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Pulmonary Disease, Chronic Obstructive - pathology | Matrix Metalloproteinase 9 - metabolism | Dexamethasone - pharmacology | Complex Mixtures - isolation & purification | Complex Mixtures - pharmacology | Female | Benzamides - pharmacology | Interleukin-8 - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Intramolecular Oxidoreductases - metabolism | Neutrophils - metabolism | Cyclopropanes - pharmacology | Neutrophils - pathology | Biomarkers - metabolism | Neutrophils - drug effects | Adrenal Cortex Hormones - pharmacology | Histone Deacetylases - metabolism | Drug Resistance - drug effects | Phosphodiesterase 4 Inhibitors - pharmacology | Drug Synergism | Aminopyridines - pharmacology | Lipopolysaccharides - pharmacology | Tobacco - chemistry | Aged | Primary Cell Culture | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Metabolites | Lung diseases, Obstructive | Corticosteroids | Chronic obstructive pulmonary disease | Kinases | Drug therapy | Gene expression | Mortality | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2012, Volume 302, Issue 12, pp. C1741 - C1750
Hara M, Tabata K, Suzuki T, Do MQ, Mizunoya W, Nakamura M, Nishimura S, Tabata S, Ikeuchi Y, Sunagawa K, Anderson JE, Allen RE, Tatsumi R. Calcium influx... 
Stretch-activation | Satellite cells | Mechanosensitive channel | Calcium ion influx | Muscle regeneration | Voltage-gated channel | PHYSIOLOGY | stretch-activation | NITRIC-OXIDE SYNTHASE | REGENERATION | calcium ion influx | HEPATOCYTE GROWTH-FACTOR | TRP CHANNELS | MYOGENIC STEM-CELLS | C2C12 MYOBLASTS | muscle regeneration | mechanosensitive channel | CELL BIOLOGY | IN-VITRO | MECHANOSENSITIVE CHANNELS | VOLUME REGULATION | DIFFERENTIATION | voltage-gated channel | satellite cells | Gadolinium - pharmacology | Cell Proliferation | Mechanotransduction, Cellular - drug effects | Stress, Mechanical | Male | Spider Venoms - pharmacology | Dose-Response Relationship, Drug | Time Factors | Cyclopropanes - pharmacology | Nifedipine - pharmacology | Cells, Cultured | Rats | Satellite Cells, Skeletal Muscle - metabolism | Chelating Agents - pharmacology | Calcium Channel Blockers - pharmacology | Blotting, Western | Hepatocyte Growth Factor - metabolism | Naphthalenes - pharmacology | Peptides - pharmacology | Satellite Cells, Skeletal Muscle - drug effects | Animals | Egtazic Acid - pharmacology | Membrane Potentials | Calcium Signaling - drug effects | Calcium Channels, L-Type - drug effects | Benzimidazoles - pharmacology | Calcium Channels, L-Type - metabolism | Ion Channel Gating | Microscopy, Fluorescence | Culture Media, Conditioned - metabolism | Biomechanics | Calcium, Dietary | Physiological aspects | Muscles | Ion channels | Research | Health aspects | Musculoskeletal system | Signal transduction | Cell culture | Ions | Physiology | Cell cycle | Index Medicus
Journal Article
Journal Article
Pharmacological Reports, ISSN 1734-1140, 2013, Volume 65, Issue 4, pp. 991 - 997
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2011, Volume 31, Issue 44, pp. 15884 - 15893
Inhibitory amacrine cells (ACs) filter visual signals crossing the retina by modulating the excitatory, glutamatergic output of bipolar cells (BCs) on multiple... 
TIGER SALAMANDER RETINA | AMACRINE CELLS | PRIMATE RETINA | HORIZONTAL CELLS | RABBIT RETINA | GANGLION-CELLS | RAT RETINA | METABOTROPIC GLUTAMATE RECEPTORS | GOLDFISH RETINA | MAMMALIAN RETINA | NEUROSCIENCES | Propionates - pharmacology | Retinal Bipolar Cells - cytology | Electric Stimulation | gamma-Aminobutyric Acid - metabolism | Male | Pyridazines - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Neural Inhibition - physiology | Drug Interactions | Retina - cytology | Retinal Bipolar Cells - physiology | Light | Statistics, Nonparametric | Female | Goldfish | Tetrodotoxin - pharmacology | Carboxylic Acids - pharmacology | Cyclopropanes - pharmacology | Pertussis Toxin - pharmacology | Presynaptic Terminals - drug effects | Inhibitory Postsynaptic Potentials - physiology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Presynaptic Terminals - physiology | GABA Antagonists - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Photic Stimulation - methods | Retinal Bipolar Cells - classification | Signal Transduction - drug effects | Feedback, Physiological - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Photoreceptor Cells - physiology | Inhibitory Postsynaptic Potentials - drug effects | Index Medicus | bipolar cell terminals | ON and OFF bipolar cells | amacrine cells | GABA receptors | IPSCs | light response | TTX-sensitive Na+ channels | goldfish retina | AMPA receptors | NMDA receptors | feedback inhibition
Journal Article
Journal Article