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Psychopharmacology, ISSN 0033-3158, 9/2006, Volume 187, Issue 4, pp. 415 - 423
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2009, Volume 158, Issue 4, pp. 1153 - 1164
Background and purpose:  ABC multidrug transporters (MDR-ABC proteins) cause multiple drug resistance in cancer and may be involved in the decreased... 
ADME-Tox | CML | TKI | ABCB1 | Bcr-Abl | MDR | ABCG2 | ADME‐Tox | Bcr‐Abl | CHRONIC MYELOGENOUS LEUKEMIA | MULTIDRUG TRANSPORTER | DRUG-RESISTANCE | CHRONIC MYELOID-LEUKEMIA | P-GLYCOPROTEIN | TYROSINE KINASE INHIBITORS | HIGH-AFFINITY INTERACTION | HEMATOPOIETIC STEM-CELLS | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Thiazoles - metabolism | Nitriles - pharmacology | Aniline Compounds - metabolism | Protein-Tyrosine Kinases - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Substrate Specificity | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Thiazoles - therapeutic use | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Dose-Response Relationship, Drug | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Dasatinib | Nitriles - metabolism | Aniline Compounds - pharmacology | Pyrimidines - pharmacology | Neoplasms - drug therapy | Quinolines - metabolism | Pyrimidines - therapeutic use | K562 Cells | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Thiazoles - pharmacology | Aniline Compounds - therapeutic use | Fusion Proteins, bcr-abl - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Nitriles - therapeutic use | Index Medicus | Research Papers
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 03/2008, Volume 75, Issue 6, pp. 1302 - 1312
Journal Article
Journal of Periodontology, ISSN 0022-3492, 10/2013, Volume 84, Issue 10, pp. 1469 - 1475
Background: Transglutaminase‐2 (TGM‐2) has been implicated in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Hence, the... 
fibroblasts | Cyclosporin | gingival overgrowth | transglutaminase‐2 | reactive oxygen species | Fibroblasts | Gingival overgrowth | Reactive oxygen species | Transglutaminase-2 | TRANSCRIPTION | 2 EXPRESSION | PROLIFERATION | HYPERPLASIA | PLASMINOGEN-ACTIVATOR INHIBITOR | OVERGROWTH | ANTIOXIDANT | DENTISTRY, ORAL SURGERY & MEDICINE | MESANGIAL CELLS | transglutaminase-2 | ERK 1/2 | TISSUE TRANSGLUTAMINASE | Free Radical Scavengers - pharmacology | GTP-Binding Proteins - drug effects | Reactive Oxygen Species - metabolism | Cyclosporine - pharmacology | GTP-Binding Proteins - antagonists & inhibitors | Humans | Oxidative Stress - physiology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Transglutaminases - drug effects | Dose-Response Relationship, Drug | Protease Inhibitors - pharmacology | Gingiva - drug effects | Adult | Female | Flavonoids - pharmacology | Cell Culture Techniques | Catechin - pharmacology | Immunosuppressive Agents - pharmacology | Transglutaminases - antagonists & inhibitors | Cells, Cultured | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Immunosuppressive Agents - toxicity | Morpholines | Up-Regulation - drug effects | Cyclosporine - toxicity | Fibroblasts - drug effects | Acetylcysteine - pharmacology | Gingiva - cytology | Catechin - analogs & derivatives | Pyridines - pharmacology | Chromones
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 03/2009, Volume 87, Issue 4, pp. 1023 - 1036
Journal Article
Drug Development Research, ISSN 0272-4391, 12/2019, Volume 80, Issue 8, pp. 1013 - 1030
It is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability... 
reperfusion | heart | mitochondrial permeability transition pore | Myocardial infarction | Animal models | Mitochondrial permeability transition pore | Membrane permeability | Clinical trials | Cardiomyocytes | Pharmacology | Permeability | Cyclosporin A | Mitochondria | Inhibitors | Reperfusion | MPTP | Apoptosis
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2004, Volume 90, Issue 5, pp. 1025 - 1035
Changes in mitochondrial integrity, reactive oxygen species release and Ca2+ handling are proposed to be involved in the pathogenesis of many neurological... 
electron transport chain | free radicals | respiration | calcium | metabolic disease | energy metabolism | Electron transport chain | Metabolic disease | Energy metabolism | Free radicals | Calcium | Respiration | TOXIN 3-NITROPROPIONIC ACID | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTECTS MITOCHONDRIA | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CEREBELLAR GRANULE CELLS | BRAIN MITOCHONDRIA | ACUTE GLUTAMATE EXCITOTOXICITY | CYCLOSPORINE-A | CYTOCHROME-C RELEASE | METHYLMALONIC ACIDEMIA | Catalase - pharmacology | Propionates - pharmacology | Uncoupling Agents - pharmacology | Neurons - cytology | Malonates - pharmacology | Electron Transport Complex II - antagonists & inhibitors | Cyclosporins - pharmacology | PC12 Cells | Antimycin A - pharmacology | Dose-Response Relationship, Drug | Tetrazolium Salts | Drug Interactions | Rotenone - pharmacology | Tacrolimus - pharmacology | Thiazoles | Female | NADP - metabolism | Neurons - drug effects | Ionophores - pharmacology | Membrane Potentials - drug effects | Cell Survival - drug effects | Brain - cytology | Permeability - drug effects | Calcium - pharmacology | Antimycin A - analogs & derivatives | Enzyme Inhibitors - pharmacology | Rats | Bongkrekic Acid - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Calcimycin - pharmacology | Animals | Oxygen Consumption - drug effects | Nitro Compounds | Methylmalonic Acid - pharmacology | In Vitro Techniques
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e60144
Lung transplantation is a recognised treatment for patients with end stage pulmonary disease. Transplant recipients receive life-long administration of... 
SOLID-ORGAN TRANSPLANTATION | NATURAL-KILLER-CELLS | LUNG TRANSPLANTATION | IN-VITRO | ACTIVATION | INHIBITION | MULTIDISCIPLINARY SCIENCES | PERIPHERAL-BLOOD | CYTOTOXICITY | MYCOPHENOLATE-MOFETIL | CYCLOSPORINE | Cyclosporine - pharmacology | Humans | Cells, Cultured | Morpholines - pharmacology | Male | Interferon-gamma - metabolism | Prednisolone - pharmacology | Lung Transplantation | Mycophenolic Acid - pharmacology | Acetophenones - pharmacology | Adult | Female | Lysosomal-Associated Membrane Protein 1 - metabolism | Flavonoids - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Benzopyrans - pharmacology | Chromones - pharmacology | Immunosuppressive Agents - pharmacology | Killer cells | Corticosteroids | Analysis | Lung diseases | Immunotherapy | Transplantation of organs, tissues, etc | Organ transplant recipients | Mycophenolate mofetil | Drug therapy | T cells | Prednisolone | Mycophenolic acid | Cytotoxicity | Drug screening | Cell activation | Natural killer cells | Active control | Antigens | Cytokines | Medical treatment | Interleukin 12 | Rapamycin | T cell receptors | Patients | Immunosuppression | Major histocompatibility complex | Surveillance | γ-Interferon | Ligands | Drugs | Ionomycin | Transplants & implants | Toxicity | Cyclosporins | Lung transplantation | Stimulation | Lymphocytes T | Transplantation | Activation | Kinases | Clinical outcomes | Immunosuppressive agents | Immunology | Pathways | Interleukin 2 | Lymphocytes | Xenografts | Immune system | Cytomegalovirus | Immune response | Cell survival | Graft rejection | Medicine | Rejection | Biopsy | Cell lines | Histocompatibility antigen HLA | Viral infections | Medical services
Journal Article
Molecules, ISSN 1420-3049, 12/2017, Volume 22, Issue 12, p. 2069
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2000, Volume 20, Issue 22, pp. 8229 - 8237
Activation of the mitochondrial permeability transition may contribute to excitotoxic neuronal death (Ankarcrona et al., 1996; Dubinsky and Levi, 1998).... 
Mitochondria | Permeability transition | Cyclosporin A | Cyclophilin | Neurodegeneration | Excitotoxicity | GLUTAMATE NEUROTOXICITY | INNER MEMBRANE | permeability transition | mitochondria | cyclosporin A | neurodegeneration | cyclophilin | RAT-LIVER MITOCHONDRIA | CA2+ UNIPORTER | CA-2+ RELEASE | NEUROSCIENCES | CELL-DEATH | CA-2+-INDUCED MEMBRANE TRANSITION | CORTICAL-NEURONS | excitotoxicity | HEART-MITOCHONDRIA | ADENINE-NUCLEOTIDE TRANSLOCASE | Palmitic Acid - pharmacology | Mitochondrial Swelling - drug effects | Calcium - metabolism | Cyclosporine - pharmacology | Brain - metabolism | Cyclophilins - pharmacology | Onium Compounds - pharmacokinetics | Oligomycins - pharmacology | Polyethylene Glycols - pharmacology | Membrane Potentials - drug effects | Serum Albumin, Bovine - pharmacology | Permeability - drug effects | Calcium - pharmacology | Glutamic Acid - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Magnesium - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Magnesium - pharmacology | Adenosine Diphosphate - pharmacology | Animals | Brain Chemistry | Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone - pharmacology | Glutamic Acid - metabolism | Intracellular Membranes - drug effects | Adenosine Diphosphate - metabolism | Organophosphorus Compounds - pharmacokinetics | Intracellular Membranes - metabolism | ARTICLE
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2014, Volume 90, Issue 2, pp. 107 - 114
DPPE, a tamoxifen derivative with antihistamine activity, was previously shown to potentiate the toxicity of chemotherapeutic drugs. Recently, a Phase III... 
P-glycoprotein | DPPE | Collateral sensitivity | ABCB1 | Anti-histaminic, Tamoxifen derivative | ATPase | ROS | Drug resistance | Anti-histaminic Tamoxifen derivative | OXIDATIVE STRESS | ATPASE ACTIVITY | PHASE-III | VERAPAMIL HYPERSENSITIVITY | ACUTE MYELOID-LEUKEMIA | ANTINEOPLASTIC DRUGS | BREAST-CANCER | LUNG-CANCER | IN-VIVO | PHARMACOLOGY & PHARMACY | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Cricetulus | Apoptosis - drug effects | Drug Resistance, Multiple | Glutathione - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Cyclosporins - pharmacology | Antimycin A - pharmacology | Phenyl Ethers | Proto-Oncogene Proteins c-bcl-2 - metabolism | Adenosine Triphosphate - metabolism | Superoxides - metabolism | Antineoplastic Agents - pharmacology | Cell Membrane - metabolism | Cell Membrane - drug effects | CHO Cells | Ethylamines - pharmacology | Superoxides - agonists | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Cisplatin - pharmacology | Drug Synergism | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Benzhydryl Compounds - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | RNA, Small Interfering - metabolism | Tamoxifen | Cytokinins | Index Medicus
Journal Article