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EUROSURVEILLANCE, ISSN 1560-7917, 11/2012, Volume 17, Issue 48, pp. 11 - 13
A new azole resistance mechanism in Aspergillus fumigatus consisting of a TR46/Y121F/T289A alteration in the cyp51A gene was recently described in the... 
INFECTIOUS DISEASES | CYP51A GENE
Journal Article
Medical Mycology, ISSN 1369-3786, 08/2016, Volume 54, Issue 6, pp. 616 - 627
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2018, Volume 62, Issue 5
The use of azole fungicides in agriculture is believed to be one of the main reasons for the emergence of azole resistance in Though widely used in... 
Evolution | Cyp51A | Aspergillus fumigatus | Drug resistance | Imidazole drugs
Journal Article
Emerging Infectious Diseases, ISSN 1080-6040, 07/2009, Volume 15, Issue 7, pp. 1068 - 1076
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate in... 
SYSTEM | INFECTIOUS DISEASES | INVASIVE ASPERGILLOSIS | ITRACONAZOLE RESISTANCE | HIGH-RESOLUTION | CROSS-RESISTANCE | ANTIFUNGAL AGENTS | IN-VITRO SUSCEPTIBILITY | MECHANISMS | MUTATIONS | IMMUNOLOGY | CYP51A GENE | Aspergillus fumigatus - drug effects | Humans | Fungal Proteins - drug effects | Azoles - therapeutic use | Fungal Proteins - genetics | Pyrimidines - pharmacology | Aspergillus fumigatus - genetics | Disease Progression | Itraconazole - pharmacology | Antifungal Agents - therapeutic use | Itraconazole - therapeutic use | Triazoles - pharmacology | Cytochrome P-450 Enzyme System - drug effects | Pyrimidines - therapeutic use | Treatment Failure | Voriconazole | Cytochrome P-450 Enzyme System - genetics | Drug Resistance, Fungal | Amino Acid Substitution | Aspergillosis - drug therapy | Evolution, Molecular | Triazoles - therapeutic use | Lung diseases, Obstructive | Care and treatment | Methionine | Mycoses | Transplantation | Drug resistance | Hematopoietic stem cells | Endowments | Algorithms | Codon | Evolutionary biology | Amphotericin B | Gene mutations | Triazoles | Analysis | Antiparasitic agents | Cross infection | Nosocomial infections | Health aspects | Itraconazole | Index Medicus | Aspergillus | population genetics | antifungal drug resistance | sterol 14-alpha demethylase CYP51A | Aspergillus fumigatus | azoles
Journal Article
Fungal Genetics and Biology, ISSN 1087-1845, 09/2015, Volume 82, pp. 129 - 135
The Aspergillus fumigatus cyp51A gene TR 46 /Y121F/T289A mutation is a new emerging resistance mechanism with high-level voriconazole (VOR) resistance, and... 
Multi-azole resistance | Cyp51A | Aspergillus fumigatus | Homology modelling
Journal Article
Journal Article
by Chen, Y and Li, ZW and Han, XL and Tian, SG and Zhao, JY and Chen, FY and Su, XT and Zhao, JJ and Zou, ZY and Gong, YW and Qu, F and Qiu, GB and Wang, SY and Jia, XD and Lu, ZY and Hu, MD and Huang, LY and Verweij, PE and Han, L
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 05/2018, Volume 62, Issue 5
The use of azole fungicides in agriculture is believed to be one of the main reasons for the emergence of azole resistance in Aspergillus fumigatus. Though... 
TR34/L98H MUTATIONS | MECHANISM | ENVIRONMENT | MICROBIOLOGY | imidazole drugs | evolution | CYP51A GENE | INVASIVE ASPERGILLOSIS | AZOLE RESISTANCE | MOLECULAR EPIDEMIOLOGY | PHARMACOLOGY & PHARMACY | Cyp51A | TRIAZOLE RESISTANCE | drug resistance | CYSTIC-FIBROSIS | Aspergillus fumigatus | HIGH PREVALENCE | Index Medicus
Journal Article
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 08/2018, Volume 62, Issue 8
Journal Article
Journal of Infection and Chemotherapy, ISSN 1341-321X, 2016, Volume 23, Issue 8, pp. 579 - 581
Abstract Recently, azole-resistant Aspergillus fumigatus containing a 34-bp or 46-bp tandem repeat in the promoter region of cyp51A combined with amino acid... 
Hematology, Oncology and Palliative Medicine | Azole | Aspergillus fumigatus | TR34/L98H | cyp51A | L98H | INFECTIOUS DISEASES | PHARMACOLOGY & PHARMACY | CYP51A GENE | Index Medicus
Journal Article
Fungal genetics and biology : FG & B, 08/2019, pp. 103265 - 103265
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 03/2018, Volume 9, pp. 516 - 516
Journal Article
Medical Mycology Journal, ISSN 2185-6486, 2017, Volume 58, Issue 2, pp. E67 - E70
Azole-resistant strains of Aspergillus fumigatus containing a tandem repeat in the cyp51A promoter and amino acid substitution(s) have been isolated in the... 
Aspergillus fumigatus | TR34/L98H | cyp51A | azole
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 08/2018, Volume 62, Issue 8
This prospective study shows that the rate of azole-resistant (ARAF) in an immunocompromised Indian patient population with invasive aspergillosis (IA) is low,... 
Cyp51A mutations | Antifungal susceptibility testing | Azole-resistant Aspergillus fumigatus | Risk factor | Immunocompromised hosts | Invasive aspergillosis | India
Journal Article
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