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Circulation research, ISSN 0009-7330, 2005, Volume 96, Issue 1, pp. 119 - 126
Remodeling of small arteries is essential in the long-term regulation of blood pressure and blood flow to specific organs or tissues. A large part of the... 
Vascular remodeling | Tissue transglutaminase | Vasoconstriction | Blood flow | INDUCED ACTIVATION | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | CROSS-LINKING | SPASM | tissue transglutaminase | vascular remodeling | FLOW | STRUCTURAL-CHANGES | ADAPTATION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | HYPERTENSION | HEMATOLOGY | blood flow | Norepinephrine - pharmacology | GTP-Binding Proteins - pharmacology | Mesenteric Arteries - physiology | Cross-Linking Reagents - pharmacology | Endothelin-1 - pharmacology | Transglutaminases - pharmacology | Transglutaminases - genetics | Nitroprusside - pharmacology | Hemorheology | Cadaverine - pharmacology | GTP-Binding Proteins - genetics | Vasoconstriction - physiology | Enzyme Induction - drug effects | Cystamine - pharmacology | Female | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - cytology | Organ Culture Techniques | Muscle, Skeletal - blood supply | Tretinoin - pharmacology | Vasoconstrictor Agents - pharmacology | Extracellular Matrix Proteins - chemistry | GTP-Binding Proteins - physiology | Guinea Pigs | Vasodilator Agents - pharmacology | Gels | Cell Size - drug effects | Transglutaminases - biosynthesis | Rats | Nitric Oxide - physiology | Papaverine - pharmacology | Arteries - drug effects | Vasoconstriction - drug effects | Extracellular Matrix Proteins - drug effects | Extracellular Matrix - ultrastructure | Animals | Arteries - enzymology | Coronary Vessels - cytology | Vasomotor System - physiology | Collagen | Biotin - pharmacology | Transglutaminases - physiology | GTP-Binding Proteins - biosynthesis | Amines - pharmacology | Mesenteric Arteries - enzymology | Sus scrofa | Biotin - analogs & derivatives | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2010, Volume 12, Issue 9, pp. 863 - 875
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a life-threatening genetic... 
APOPTOSIS | UNFOLDED PROTEIN RESPONSE | BECLIN 1 | DOWN-REGULATION | ENDOPLASMIC-RETICULUM | MICE | GENE-TRANSFER | TISSUE TRANSGLUTAMINASE | NEURODEGENERATIVE DISEASES | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Respiratory Mucosa - drug effects | Sequestosome-1 Protein | Humans | Transglutaminases - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Young Adult | Cystamine - therapeutic use | Inflammation - metabolism | Autophagy - genetics | Nasal Polyps - metabolism | Mice, Inbred CFTR | Respiratory Mucosa - cytology | Cystic Fibrosis - metabolism | Membrane Proteins - genetics | Mice, Transgenic | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Models, Biological | Cystic Fibrosis - genetics | Transglutaminases - metabolism | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | GTP-Binding Proteins | Cystic Fibrosis - drug therapy | Protein Binding - physiology | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Salicylates - pharmacology | Epithelial Sodium Channels - genetics | Apoptosis Regulatory Proteins - genetics | Adult | Cystamine - pharmacology | Membrane Proteins - metabolism | Acetylcysteine - therapeutic use | Beclin-1 | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Cell Line | Small Ubiquitin-Related Modifier Proteins - metabolism | Heat-Shock Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Mice, Inbred Strains | Nasal Polyps - drug therapy | Antioxidants - therapeutic use | Animals | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Organometallic Compounds - pharmacology | Complications and side effects | Active oxygen | Gene mutations | Lung diseases | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Health aspects | Risk factors | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2012, Volume 8, Issue 11, pp. 1657 - 1672
Channel activators (potentiators) of cystic fibrosis (CF) transmembrane conductance regulator (CFTR), can be used for the treatment of the small subset of CF... 
cystamine | CFTR potentiators | autophagy | cystic fibrosis | therapy | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Therapy | Cystic fibrosis | Autophagy | Cystamine | GAMMA DOWN-REGULATION | OXIDATIVE STRESS | F508DEL-CFTR | PLASMA-MEMBRANE | INTESTINAL EPITHELIAL-CELLS | CELL BIOLOGY | PROTEIN-QUALITY CONTROL | MUTATION | TISSUE TRANSGLUTAMINASE | LUNG INFLAMMATION | CFTR | Inflammation - pathology | Epithelial Cells - metabolism | Sequestosome-1 Protein | Epithelial Cells - drug effects | Humans | Cystic Fibrosis - pathology | Male | Nasal Mucosa - pathology | Molecular Targeted Therapy | Autophagy - drug effects | Salicylates - pharmacology | Cystamine - therapeutic use | Organometallic Compounds - therapeutic use | Cystamine - pharmacology | Female | Cell Membrane - metabolism | Membrane Proteins - metabolism | Child | Cell Membrane - drug effects | Nasal Mucosa - drug effects | Beclin-1 | Epithelium - drug effects | Epithelium - pathology | Lung - pathology | Nasal Polyps - pathology | Epithelium - metabolism | Heat-Shock Proteins - metabolism | Epithelial Cells - pathology | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Salicylates - therapeutic use | Apoptosis Regulatory Proteins - metabolism | Animals | Lung - drug effects | Adolescent | Genistein - pharmacology | Lipopolysaccharides - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cystic Fibrosis - drug therapy | Organometallic Compounds - pharmacology | Index Medicus | Translational Research Paper
Journal Article
Neuropharmacology, ISSN 0028-3908, 02/2012, Volume 62, Issue 2, pp. 997 - 1003
Journal Article
Biology of Reproduction, ISSN 0006-3363, 04/2011, Volume 84, Issue 4, pp. 646 - 653
Journal Article
Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 2/2017, Volume 162, Issue 4, pp. 466 - 469
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 08/2018, Volume 76, pp. 89 - 98
A novel concept of generating therapeutic gas, nitric oxide (NO) via catalytic phenolic-amine “gallolamine” surface chemistry is developed. The concept is... 
Anti-thrombogenicity | Molecular assembling | Catalytic coating | Gallolamine chemistry | Nitric oxide | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | PROLIFERATION | RELEASE | ADHESION | FILMS | POLYMER | S-NITROSOTHIOLS | Coated Materials, Biocompatible - pharmacokinetics | Human Umbilical Vein Endothelial Cells - metabolism | Nitric Oxide - chemistry | Nitric Oxide - pharmacology | Humans | Coated Materials, Biocompatible - pharmacology | Coated Materials, Biocompatible - chemistry | Rats | Delayed-Action Preparations - chemistry | Cystamine - pharmacokinetics | Organoselenium Compounds - chemistry | Organoselenium Compounds - pharmacology | Nitric Oxide - pharmacokinetics | Animals | Cystamine - analogs & derivatives | Cystamine - chemistry | Organoselenium Compounds - pharmacokinetics | Delayed-Action Preparations - pharmacology | Surface Properties | Delayed-Action Preparations - pharmacokinetics | Cystamine - pharmacology | Polyphenols | Peroxidase | Amines | Glutathione peroxidase | Stability | Gallic acid | Organoselenium compounds | Surface chemistry | Immobilization | Coatings | Phenolic compounds | Engineering | Organic chemistry | Toolkits | Catalytic oxidation | Chemistry | Acids | Phenols | Biocompatibility | Flowers & plants | Catalysis | Chemical synthesis | Functional groups | Glutathione | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2016, Volume 173, Issue 5, pp. 839 - 855
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 12/2017, Volume 11, pp. 3519 - 3529
Purpose: Erlotinib (ETB) is a well-established therapeutic for non-small-cell lung cancer (NSCLC). To overcome drug resistance and severe toxicities in the... 
pH-sensitive | Poly(acrylic acid) | Kinase inhibitor | Epidermal growth factor receptor | Redox-responsive | 1ST-LINE TREATMENT | CHEMISTRY, MEDICINAL | epidermal growth factor receptor | poly(acrylic acid) | PANCREATIC-CANCER | DOXORUBICIN | OPEN-LABEL | ANTITUMOR-ACTIVITY | CHEMOTHERAPY | kinase inhibitor | CO-DELIVERY | TARGETED THERAPIES | redox-responsive | NANOSTRUCTURED LIPID CARRIERS | PHARMACOLOGY & PHARMACY | POLYMER HYBRID NANOPARTICLES | Lung Neoplasms - drug therapy | Nanoparticles - chemistry | Humans | Lung Neoplasms - pathology | Male | Acrylic Resins - pharmacology | Antineoplastic Agents - therapeutic use | Drug Delivery Systems | Neoplasms, Experimental - pathology | Lipids - chemistry | Oleic Acid - pharmacology | Lipids - pharmacology | Cystamine - chemistry | Cystamine - pharmacology | Molecular Structure | Tumor Cells, Cultured | Oxidation-Reduction | Drug Stability | Mice, Inbred C57BL | Acrylic Resins - chemistry | Particle Size | Animals | Cell Proliferation - drug effects | Erlotinib Hydrochloride - therapeutic use | Mice | Neoplasms, Experimental - drug therapy | Oleic Acid - chemistry | Hydrogen-Ion Concentration | Encapsulation | Drugs | Drug delivery systems | Stability | Toxicity | Emulsification | Acrylic acid | Lung | Lung cancer | Cytotoxicity | Drug delivery | Evaporation | Drug resistance | pH effects | Nanoparticles | Antitumor agents | Acids | Zeta potential | Oleic acid | Biocompatibility | Inhibition | Bearing strength | Cancer | Nuclear magnetic resonance--NMR | Lipids | Kinases | Cancer therapies | Weight loss | Tumors | Index Medicus
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2015, Volume 82, pp. 430 - 444
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 45, pp. 32720 - 32730
Background: The expression of PAC1, a specific receptor for PACAP, is decreased in brain ischemia. Results:PAC1 expression was attenuated by inactivation of... 
APOPTOSIS | Gene Expression | Neurons | Pituitary Adenylate Cyclase-activating Polypeptide | ER-STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSIENT FOCAL ISCHEMIA | INDUCTION | Neuropeptide | Transglutaminase 2 | NERVE GROWTH-FACTOR | ER Stress | Ischemia | Sp1 | PAC1 | ENDOPLASMIC-RETICULUM | G Protein-coupled Receptors (GPCRs) | PC12 CELLS | TISSUE TRANSGLUTAMINASE | EXPRESSION | GTP-Binding Proteins - antagonists & inhibitors | Transglutaminases - genetics | Sp1 Transcription Factor - metabolism | Thiourea - pharmacology | GTP-Binding Proteins - genetics | MAP Kinase Signaling System | Enzyme Induction - drug effects | Cystamine - pharmacology | Transglutaminases - antagonists & inhibitors | Cell Hypoxia - drug effects | Response Elements | Enzyme Inhibitors - pharmacology | Transglutaminases - biosynthesis | Enzyme Activation - drug effects | Cinnamates - pharmacology | Enzyme Induction - genetics | Animals | Sp1 Transcription Factor - genetics | Tunicamycin - pharmacology | Endoplasmic Reticulum Stress | Cell Line, Tumor | Enzyme Repression - genetics | Anti-Bacterial Agents - pharmacology | GTP-Binding Proteins - biosynthesis | Mice | Enzyme Repression - drug effects | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Cell Hypoxia - genetics | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - biosynthesis | Thiourea - analogs & derivatives | Index Medicus | Neurobiology
Journal Article