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hydrogen sulfide (363) 363
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hydrogen sulfide - metabolism (305) 305
cystathionine gamma-lyase - genetics (303) 303
humans (302) 302
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biochemistry & molecular biology (229) 229
cystathionine gamma-lyase (203) 203
hydrogen-sulfide (165) 165
oxidative stress (165) 165
rats (164) 164
enzymes (156) 156
h2s (156) 156
cystathionine beta-synthase - metabolism (142) 142
cysteine (140) 140
metabolism (113) 113
cell biology (112) 112
cystathionine beta-synthase (106) 106
hydrogen sulfide - pharmacology (104) 104
physiological aspects (102) 102
cystathionine beta-synthase - genetics (98) 98
equipment and supplies (98) 98
physiology (98) 98
nitric-oxide (97) 97
homocysteine (94) 94
mice, knockout (94) 94
female (92) 92
cysteine - metabolism (90) 90
gene expression (84) 84
disease models, animal (82) 82
mice, inbred c57bl (81) 81
research article (80) 80
expression (79) 79
cystathionine γ-lyase (78) 78
cystathionine-gamma-lyase (78) 78
research (78) 78
microbiology (76) 76
hypertension (75) 75
proteins (75) 75
article (71) 71
rodents (71) 71
inflammation (70) 70
multidisciplinary sciences (70) 70
signal transduction (68) 68
analysis (67) 67
apoptosis (67) 67
medicine (66) 66
nitric oxide (66) 66
escherichia-coli (65) 65
hydrogen (64) 64
biosynthesis (63) 63
pharmacology & pharmacy (63) 63
cells, cultured (62) 62
endocrinology & metabolism (62) 62
rats, sprague-dawley (62) 62
cystathionine gamma-lyase - antagonists & inhibitors (60) 60
nitric-oxide synthase (60) 60
glutathione (57) 57
amino acids (56) 56
biotechnology & applied microbiology (56) 56
methionine (56) 56
molecular sequence data (56) 56
inhibition (55) 55
glycine - analogs & derivatives (54) 54
sulfides - pharmacology (54) 54
biology (53) 53
sulfur (51) 51
mutation (50) 50
sulfide (50) 50
rna, messenger - metabolism (49) 49
science (49) 49
smooth-muscle-cells (49) 49
cystathionine-beta-synthase (48) 48
glycine - pharmacology (48) 48
cells (47) 47
methionine - metabolism (47) 47
alkynes - pharmacology (46) 46
gamma-lyase (46) 46
genetics & heredity (46) 46
liver (46) 46
rat (45) 45
activation (44) 44
ischemia-reperfusion injury (44) 44
biochemistry (43) 43
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life sciences (43) 43
nitric oxide - metabolism (43) 43
gene (42) 42
phosphorylation (42) 42
amino acid sequence (41) 41
signal transduction - drug effects (41) 41
hydrogen sulfide - blood (40) 40
in-vitro (40) 40
cystathionine gamma-lyase - deficiency (39) 39
cystathionine-γ-lyase (39) 39
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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 96 - 100
Journal Article
Cardiovascular Research, ISSN 0008-6363, 06/2010, Volume 86, Issue 3, pp. 487 - 495
Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension.... 
Hydrogen sulfide | Hypertension | Smooth muscle cell | Cystathionine gamma-lyase | Apoptosis | CARDIAC & CARDIOVASCULAR SYSTEMS | SPONTANEOUSLY HYPERTENSIVE-RATS | RECEPTOR-LIKE-RECEPTOR | H2S | PROLIFERATION | HYDROGEN-SULFIDE | VASORELAXANT | GROWTH-FACTOR | GENETIC-HYPERTENSION | EXPRESSION | Cyclin D1 - metabolism | Phosphorylation | Oligonucleotide Array Sequence Analysis | Myocytes, Smooth Muscle - pathology | Mesenteric Arteries - pathology | Male | Receptors, Calcitonin - genetics | Calcitonin Receptor-Like Protein | RNA, Messenger - metabolism | Time Factors | Polymerase Chain Reaction | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cystathionine gamma-Lyase - genetics | Myocytes, Smooth Muscle - drug effects | Aorta - enzymology | Cystathionine gamma-Lyase - deficiency | Muscle, Smooth, Vascular - drug effects | Hydrogen Sulfide - pharmacology | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Gene Expression Profiling - methods | Blotting, Western | Mice, Knockout | Aorta - pathology | Heparin-binding EGF-like Growth Factor | Muscle, Smooth, Vascular - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Proliferation - drug effects | Mice | Integrin beta1 - genetics | Mesenteric Arteries - enzymology | Muscle, Smooth, Vascular - enzymology | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 01/2016, Volume 24, Issue 3, pp. 129 - 140
Aims: To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H 2 S) in hepatic glucose... 
Original Research Communications | BINDING PROTEIN-BETA | RAT-LIVER | GLYCOGEN-METABOLISM | HEPATIC GLUCONEOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL PRIMARY CULTURES | COACTIVATOR PGC-1 | ENDOCRINOLOGY & METABOLISM | H2S | HYDROGEN-SULFIDE | ENERGY-METABOLISM | PHOSPHOENOLPYRUVATE CARBOXYKINASE GTP | Cyclic AMP-Dependent Protein Kinases - metabolism | Hydrogen Sulfide - metabolism | Receptors, Glucocorticoid - antagonists & inhibitors | CCAAT-Enhancer-Binding Protein-beta - genetics | Liver - metabolism | Carbazoles - administration & dosage | Cystathionine gamma-Lyase - metabolism | Hepatocytes - metabolism | Transcription Factors - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Mice, Knockout | Transcription Factors - metabolism | Animals | Cyclic AMP-Dependent Protein Kinases - genetics | Gluconeogenesis - genetics | Pyrroles - administration & dosage | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Glucose - metabolism | Mice | Cystathionine gamma-Lyase - genetics | Cyclic AMP - metabolism | Hydrogen sulfide | Genetically modified mice | Glucose metabolism | Care and treatment | Analysis | Metabolic syndrome X | Research | Health aspects | Protein kinase A | Transcription factors | Adenosine monophosphate | Glucocorticoids | Liver | Innovations | Cyclic AMP | Activation | CCAAT/enhancer-binding protein | Glucose | Metabolism | Kinases | Fructose | Proteins | Organic chemistry | Hepatocytes | Adenosine kinase | Physiology | Glucose-6-phosphatase | Metabolic disorders | Gluconeogenesis
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 423 - 432
Cystathionine γ-lyase (CSE), the last key enzyme of the transsulfuration pathway, is involved in the production of hydrogen sulfide (H S) and glutathione... 
Hydrogen sulfide | Cystathionine γ-lyase | Reactive oxygen species | Chronic kidney disease | Kidney fibrosis | METHIONINE SULFOXIDE REDUCTASE | TRANSSULFURATION PATHWAY | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYSTEINE | DIABETIC-NEPHROPATHY | N-ACETYLCYSTEINE | DEFICIENT MICE | ISCHEMIC-INJURY | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | Cystathionine gamma-lyase | RENAL ISCHEMIA/REPERFUSION | Hydrogen Sulfide - metabolism | Kidney - pathology | Kidney - enzymology | Actins - metabolism | Actins - genetics | Glutathione - biosynthesis | Renal Insufficiency, Chronic - genetics | Superoxides - metabolism | Ureteral Obstruction - genetics | Female | Cystathionine gamma-Lyase - genetics | Kidney Tubules - pathology | Cystathionine beta-Synthase - genetics | Cystathionine gamma-Lyase - deficiency | Oxidation-Reduction | Signal Transduction | Gene Expression Regulation | Sulfurtransferases - genetics | Epithelial Cells - pathology | Mitochondria - metabolism | Cystathionine beta-Synthase - metabolism | Mitochondria - pathology | Renal Insufficiency, Chronic - enzymology | Disease Progression | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | Kidney Tubules - enzymology | Ureteral Obstruction - pathology | Epithelial Cells - enzymology | Fibrosis | Mice | Sulfurtransferases - metabolism | Ureteral Obstruction - enzymology
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2013, Volume 25, Issue 11, pp. 2255 - 2262
Hydrogen sulfide (H S), mainly produced by cystathionine γ-lyase (CSE) in vascular system, emerges as a novel gasotransmitter exerting anti-inflammatory and... 
Hydrogen sulfide | Inflammation | JNK | Cystathionine-γ-lyase | Oxidized-LDL | Macrophage | OXIDATIVE STRESS | Cystathionine-gamma-Iyase | H2S | HYDROGEN-SULFIDE | CELL BIOLOGY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | PANCREATIC BETA-CELL | MICE | GENERATION | INHIBITOR | Hydrogen Sulfide - metabolism | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Sulfhydryl Compounds - pharmacology | Tumor Necrosis Factor-alpha - genetics | Cystathionine gamma-Lyase - metabolism | Guanidines - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Macrophages, Peritoneal - cytology | Inflammation - metabolism | Pyridoxal - pharmacology | Cysteine - pharmacology | Cysteine - metabolism | Cystathionine gamma-Lyase - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Macrophages, Peritoneal - drug effects | Sulfides - pharmacology | Cell Line | NF-KappaB Inhibitor alpha | Mice, Inbred C57BL | Gene Expression Regulation | Lipoproteins, LDL - pharmacology | Morpholines - pharmacology | Cell Adhesion - drug effects | Cystathionine gamma-Lyase - antagonists & inhibitors | Intercellular Adhesion Molecule-1 - metabolism | Animals | NF-kappa B - genetics | Signal Transduction - drug effects | Intercellular Adhesion Molecule-1 - genetics | Inflammation - genetics | Mice | Primary Cell Culture | Macrophages, Peritoneal - metabolism
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 11/2017, Volume 27, Issue 13, pp. 931 - 944
Aims: The pathogenic mechanisms for the higher prevalence of allergic asthma in children than in adults have not been settled. The aim of the present study is... 
Original Research Communications | Type-2 immune response | S-sulfhydration | Gasotransmitter | Asthma | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | H2S | PERSISTENT ASTHMA | CELL-FATE | asthma | HYDROGEN-SULFIDE | CHILDHOOD ASTHMA | IMMUNE-SYSTEM | ENDOCRINOLOGY & METABOLISM | gasotransmitter | K-ATP CHANNEL | AIRWAY SMOOTH-MUSCLE | BIRTH COHORT | type-2 immune response | Hydrogen Sulfide - metabolism | Fetal Blood - immunology | Leukocytes, Mononuclear - metabolism | Asthma - metabolism | Age Factors | Cytokines - metabolism | Humans | Cells, Cultured | Cystathionine gamma-Lyase - metabolism | Fetal Blood - cytology | Fetal Blood - metabolism | Asthma - chemically induced | Mice, Knockout | Animals | Gene Expression Regulation, Developmental | Leukocytes, Mononuclear - immunology | Ovalbumin - adverse effects | Asthma - immunology | Leukocytes, Mononuclear - cytology | Mice | Cystathionine gamma-Lyase - genetics | GATA3 Transcription Factor - metabolism | Cystathionine gamma-Lyase - deficiency | Disease Models, Animal | Allergy | Cysteine | Causes of | Extracellular matrix | Cellular signal transduction | Research | Allergic reaction | Sulfide | Innovations | Leukocytes (mononuclear) | Blood | Hydrogen sulfide | Proteins | Cord blood | Splenocytes | Rodents | Peripheral blood mononuclear cells | Inhibition | Children | Supplementation | Age | Immune system | Translocation | Ovalbumin | Abundance | T cell receptors | GATA-3 protein | Biomarkers | Adults | Umbilical cord | Differentiation | Hydrogen production
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 01/2015, Volume 28, Issue 1, pp. 61 - 72
Summary In humans, two main metabolic enzymes synthesize hydrogen sulfide (H2S): cystathionine γ lyase (CSE) and cystathionine β synthase (CBS). A third... 
apoptosis | melanoma | nuclear factor‐κB | hydrogen sulfide | cystathionine γ lyase | Hydrogen sulfide | Cystathionine γ lyase | Nuclear factor-κB | Melanoma | Apoptosis | cystathionine lyase | nuclear factor-B | MACROPHAGES | INDUCED INFLAMMATION | CELL-PROLIFERATION | HYDROGEN-SULFIDE | MODEL | CANCER | CELL BIOLOGY | DERMATOLOGY | IN-VITRO | ONCOLOGY | RAF INHIBITOR RESISTANCE | NF-KAPPA-B | EXPRESSION | Hydrogen Sulfide - metabolism | Gene Silencing - drug effects | Apoptosis - drug effects | Humans | Melanoma - enzymology | Apoptosis - genetics | Cystathionine gamma-Lyase - metabolism | NF-kappa B - metabolism | Neoplasm Metastasis | Nevus - genetics | Skin Neoplasms - enzymology | Melanoma - genetics | Nevus - enzymology | Female | Cystathionine gamma-Lyase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Cystathionine beta-Synthase - genetics | Sulfides - pharmacology | Skin Neoplasms - pathology | Mice, Inbred C57BL | Sulfurtransferases - genetics | Cystathionine beta-Synthase - metabolism | Melanoma - pathology | Allyl Compounds - pharmacology | Down-Regulation - drug effects | Disease Progression | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Nevus - pathology | Skin Neoplasms - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Sulfurtransferases - metabolism
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2017, Volume 312, Issue 4, pp. H711 - H720
Journal Article