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1. Full Text Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease
by Paul, Bindu D and Sbodio, Juan I and Xu, Risheng and Vandiver, M. Scott and Cha, Jiyoung Y and Snowman, Adele M and Snyder, Solomon H
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 96 - 100
Huntington's disease is an autosomal dominant disease associated with a mutation in the gene encoding huntingtin (Htt) leading to expanded polyglutamine... 
NEURONAL INTRANUCLEAR INCLUSIONS | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | H2S | S-SULFHYDRATION | CYSTEINE | MICE | HYDROGEN-SULFIDE | DYSFUNCTION | AGGREGATION | Neuroprotective Agents - therapeutic use | Huntington Disease - pathology | Brain - enzymology | Male | Sp1 Transcription Factor - metabolism | Corpus Striatum - metabolism | Neuroprotective Agents - metabolism | Cysteine - administration & dosage | Sp1 Transcription Factor - antagonists & inhibitors | Neuroprotective Agents - pharmacology | Gene Deletion | Cysteine - biosynthesis | Cysteine - pharmacology | Drinking Water - chemistry | Cystathionine gamma-Lyase - genetics | Huntington Disease - drug therapy | Neuroprotective Agents - administration & dosage | Corpus Striatum - enzymology | Corpus Striatum - pathology | Huntington Disease - enzymology | Cystathionine gamma-Lyase - deficiency | Disease Models, Animal | Mutant Proteins - genetics | Mutant Proteins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Cysteine - therapeutic use | Gene Expression Regulation, Enzymologic - genetics | Corpus Striatum - drug effects | Huntington Disease - genetics | Mice | Oxidative Stress - drug effects | Transcription, Genetic - genetics | Dietary Supplements
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2. Full Text Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells
by Yang, Guangdong and Wu, Lingyun and Bryan, Sean and Khaper, Neelam and Mani, Sarathi and Wang, Rui
Cardiovascular Research, ISSN 0008-6363, 06/2010, Volume 86, Issue 3, pp. 487 - 495
Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension.... 
Hydrogen sulfide | Hypertension | Smooth muscle cell | Cystathionine gamma-lyase | Apoptosis | CARDIAC & CARDIOVASCULAR SYSTEMS | SPONTANEOUSLY HYPERTENSIVE-RATS | RECEPTOR-LIKE-RECEPTOR | H2S | PROLIFERATION | HYDROGEN-SULFIDE | VASORELAXANT | GROWTH-FACTOR | GENETIC-HYPERTENSION | EXPRESSION | Cyclin D1 - metabolism | Phosphorylation | Oligonucleotide Array Sequence Analysis | Myocytes, Smooth Muscle - pathology | Mesenteric Arteries - pathology | Male | Receptors, Calcitonin - genetics | Calcitonin Receptor-Like Protein | RNA, Messenger - metabolism | Time Factors | Polymerase Chain Reaction | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cystathionine gamma-Lyase - genetics | Myocytes, Smooth Muscle - drug effects | Aorta - enzymology | Cystathionine gamma-Lyase - deficiency | Muscle, Smooth, Vascular - drug effects | Hydrogen Sulfide - pharmacology | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Gene Expression Profiling - methods | Blotting, Western | Mice, Knockout | Aorta - pathology | Heparin-binding EGF-like Growth Factor | Muscle, Smooth, Vascular - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Proliferation - drug effects | Mice | Integrin beta1 - genetics | Mesenteric Arteries - enzymology | Muscle, Smooth, Vascular - enzymology | Mitogen-Activated Protein Kinase 1 - metabolism
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3. Full Text Anti-atherogenic effect of Hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene
by Cheung, Sau Ha and Kwok, Wai Kei and To, Ka Fai and Lau, James Yun Wong
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e113038
Hydrogen sulfide (H2S) is an important gaseous signaling molecule that functions in physiological and pathological conditions, such as atherosclerosis. H2S... 
CELLS | OXIDATIVE STRESS | PROTEIN | ADIPONECTIN | DONOR | MULTIDISCIPLINARY SCIENCES | H2S | P53 | Blood Pressure | Hydrogen Sulfide - metabolism | Up-Regulation | Body Weight | Apolipoproteins E - deficiency | Oxidative Stress | Cystathionine gamma-Lyase - metabolism | NF-kappa B - metabolism | Aorta - metabolism | Apolipoproteins E - metabolism | Atherosclerosis - etiology | Leptin - blood | Lipids - blood | Myocardium - metabolism | Cystathionine gamma-Lyase - genetics | Glutathione Peroxidase - metabolism | Atherosclerosis - pathology | Down-Regulation | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Mice, Knockout | Plaque, Atherosclerotic - physiopathology | Adiponectin - blood | Aorta - pathology | Animals | Apolipoproteins E - genetics | Mice | Hydrogen sulfide | Proteins | Genes | Atherosclerosis | Genetic engineering | Health aspects | Sulfide | Oxidative stress | Regulations | Phosphorylation | Laboratories | Hydrogen | Weaning | Body weight | p53 Protein | Smooth muscle | Kinases | Atherogenic diet | Apolipoprotein E | Rodents | Surgery | Aorta | Peroxidase | Blood pressure | Hydrogen ion concentration | Plaques | Cardiovascular system | NF-κB protein | Preservation | Transgenic mice | Blood vessels | Inflammation | Gene expression | Cholesterol | Biological activity | Medicine | Signaling | Overexpression | Diet | Arteriosclerosis | Stem cells | Apoptosis | Veins & arteries
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4. Full Text Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency
by Wang, Peipei and Wu, Lingyun and Ju, Yongjun and Fu, Ming and Shuang, Tian and Qian, Zhongming and Wang, Rui
Antioxidants & Redox Signaling, ISSN 1523-0864, 11/2017, Volume 27, Issue 13, pp. 931 - 944
Aims: The pathogenic mechanisms for the higher prevalence of allergic asthma in children than in adults have not been settled. The aim of the present study is... 
Original Research Communications | Type-2 immune response | S-sulfhydration | Gasotransmitter | Asthma | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | H2S | PERSISTENT ASTHMA | CELL-FATE | asthma | HYDROGEN-SULFIDE | CHILDHOOD ASTHMA | IMMUNE-SYSTEM | ENDOCRINOLOGY & METABOLISM | gasotransmitter | K-ATP CHANNEL | AIRWAY SMOOTH-MUSCLE | BIRTH COHORT | type-2 immune response | Hydrogen Sulfide - metabolism | Fetal Blood - immunology | Leukocytes, Mononuclear - metabolism | Asthma - metabolism | Age Factors | Cytokines - metabolism | Humans | Cells, Cultured | Cystathionine gamma-Lyase - metabolism | Fetal Blood - cytology | Fetal Blood - metabolism | Asthma - chemically induced | Mice, Knockout | Animals | Gene Expression Regulation, Developmental | Leukocytes, Mononuclear - immunology | Ovalbumin - adverse effects | Asthma - immunology | Leukocytes, Mononuclear - cytology | Mice | Cystathionine gamma-Lyase - genetics | GATA3 Transcription Factor - metabolism | Cystathionine gamma-Lyase - deficiency | Disease Models, Animal | Allergy | Cysteine | Causes of | Extracellular matrix | Cellular signal transduction | Research | Allergic reaction | Sulfide | Innovations | Leukocytes (mononuclear) | Blood | Hydrogen sulfide | Proteins | Cord blood | Splenocytes | Rodents | Peripheral blood mononuclear cells | Inhibition | Children | Supplementation | Age | Immune system | Translocation | Ovalbumin | Abundance | T cell receptors | GATA-3 protein | Biomarkers | Adults | Umbilical cord | Differentiation | Hydrogen production
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5. Full Text Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms
by Untereiner, Ashley A and Wang, Rui and Ju, YoungJun and Wu, Lingyun
Antioxidants & Redox Signaling, ISSN 1523-0864, 01/2016, Volume 24, Issue 3, pp. 129 - 140
Aims: To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H 2 S) in hepatic glucose... 
Original Research Communications | BINDING PROTEIN-BETA | RAT-LIVER | GLYCOGEN-METABOLISM | HEPATIC GLUCONEOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL PRIMARY CULTURES | COACTIVATOR PGC-1 | ENDOCRINOLOGY & METABOLISM | H2S | HYDROGEN-SULFIDE | ENERGY-METABOLISM | PHOSPHOENOLPYRUVATE CARBOXYKINASE GTP | Cyclic AMP-Dependent Protein Kinases - metabolism | Hydrogen Sulfide - metabolism | Receptors, Glucocorticoid - antagonists & inhibitors | CCAAT-Enhancer-Binding Protein-beta - genetics | Liver - metabolism | Carbazoles - administration & dosage | Cystathionine gamma-Lyase - metabolism | Hepatocytes - metabolism | Transcription Factors - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Mice, Knockout | Transcription Factors - metabolism | Animals | Cyclic AMP-Dependent Protein Kinases - genetics | Gluconeogenesis - genetics | Pyrroles - administration & dosage | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Glucose - metabolism | Mice | Cystathionine gamma-Lyase - genetics | Cyclic AMP - metabolism | Hydrogen sulfide | Genetically modified mice | Glucose metabolism | Care and treatment | Analysis | Metabolic syndrome X | Research | Health aspects | Protein kinase A | Transcription factors | Adenosine monophosphate | Glucocorticoids | Liver | Innovations | Cyclic AMP | Activation | CCAAT/enhancer-binding protein | Glucose | Metabolism | Kinases | Fructose | Proteins | Organic chemistry | Hepatocytes | Adenosine kinase | Physiology | Glucose-6-phosphatase | Metabolic disorders | Gluconeogenesis
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6. Full Text MicroRNA‐21 represses human cystathionine gamma‐lyase expression by targeting at specificity protein‐1 in smooth muscle cells
by Yang, Guangdong and Pei, Yanxi and Cao, Qiuhui and Wang, Rui
Journal of Cellular Physiology, ISSN 0021-9541, 09/2012, Volume 227, Issue 9, pp. 3192 - 3200
Cystathionine gamma‐lyase (CSE) is the major H2S‐generating enzyme in vascular smooth muscle cells (SMCs). CSE/H2S system contributes to the maintenance of SMC... 
MIGRATION | PHYSIOLOGY | VASORELAXANT | TUMOR-SUPPRESSOR GENES | INJURY | PDCD4 | MIR-21 | PROLIFERATION | HYDROGEN-SULFIDE | DIFFERENTIATION | IDENTIFICATION | CELL BIOLOGY | Carotid Arteries - metabolism | Hydrogen Sulfide - metabolism | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Humans | Mice, Inbred C57BL | Cystathionine gamma-Lyase - metabolism | MicroRNAs - metabolism | Sp1 Transcription Factor - metabolism | Aorta - metabolism | Muscle, Smooth, Vascular - cytology | Plicamycin - pharmacology | Cystathionine gamma-Lyase - antagonists & inhibitors | Gene Expression Regulation - drug effects | Cell Differentiation - genetics | Animals | Sp1 Transcription Factor - genetics | HEK293 Cells | Mice | MicroRNAs - genetics | Cystathionine gamma-Lyase - genetics | Index Medicus
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7. Full Text H₂S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
by Guangdong Yang and Lingyun Wu and Bo Jiang and Wei Yang and Jiansong Qi and Kun Cao and Qinghe Meng and Asif K. Mustafa and Weitong Mu and Shengming Zhang and Solomon H. Snyder and Rui Wang
Science, ISSN 0036-8075, 10/2008, Volume 322, Issue 5901, pp. 587 - 590
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The... 
Hypertension | Heart | Enzymes | Calcium | Blood vessels | Aorta | Reports | Blood pressure | Mice | Mesenteric arteries | Blood plasma | HYDROGEN-SULFIDE GENERATION | LACKING | INHIBITION | RAT | GENE | NITRIC-OXIDE SYNTHASE | CALMODULIN | MULTIDISCIPLINARY SCIENCES | RELAXATION | KNOCKOUT MICE | MODULATION | Blood Pressure | Hydrogen Sulfide - metabolism | Mesenteric Arteries - physiology | Calmodulin - metabolism | Oxidation-Reduction | Calcium - metabolism | Homocysteine - blood | Cystathionine gamma-Lyase - metabolism | Aorta - metabolism | Hydrogen Sulfide - blood | Hypertension - physiopathology | Vasodilation | Mice, Knockout | Animals | Endothelium, Vascular - metabolism | Methacholine Chloride - pharmacology | Myocardium - metabolism | Cystathionine gamma-Lyase - genetics | Cysteine - blood | Cystathionine gamma-Lyase - deficiency | Sulfides - pharmacology
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8. Full Text Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia
by Wang, Keqing and Ahmad, Shakil and Cai, Meng and Rennie, Jillian and Fujisawa, Takeshi and Crispi, Fatima and Baily, James and Miller, Mark R and Cudmore, Melissa and Hadoke, Patrick W F and Wang, Rui and Gratacós, Eduard and Buhimschi, Irina A and Buhimschi, Catalin S and Ahmed, Asif
Circulation, ISSN 0009-7322, 06/2013, Volume 127, Issue 25, pp. 2514 - 2522
BACKGROUND—The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation.... 
fms-like tyrosine kinase-1 | placental growth factor | hydrogen sulfide | angiogenesis | vascular endothelial growth factor | preeclampsia | fetal development | CARDIAC & CARDIOVASCULAR SYSTEMS | SOLUBLE ENDOGLIN | RISK | ANGIOGENIC FACTORS | WOMEN | SERUM CONCENTRATIONS | TYROSINE KINASE-1 | PREGNANCIES | VASORELAXANT | PERIPHERAL VASCULAR DISEASE | GROWTH-FACTOR | MOUSE PLACENTA | Endothelium, Vascular - cytology | Hydrogen Sulfide - metabolism | Pregnancy Complications, Cardiovascular - physiopathology | Pregnancy, Animal | Glycine - analogs & derivatives | Glycine - adverse effects | Humans | Cystathionine gamma-Lyase - metabolism | Pregnancy Proteins - metabolism | Organothiophosphorus Compounds - pharmacology | Pre-Eclampsia - physiopathology | Antigens, CD - metabolism | Hypertension - etiology | Placenta Diseases - etiology | Young Adult | Endoglin | Pregnancy Complications, Cardiovascular - metabolism | Fetal Development - physiology | Hypertension - chemically induced | Adult | Alkynes - pharmacology | Female | Pre-Eclampsia - metabolism | Organ Culture Techniques | Disease Models, Animal | Fetal Development - drug effects | Mice, Inbred C57BL | Cells, Cultured | Morpholines - pharmacology | Receptors, Cell Surface - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Placenta Diseases - physiopathology | Hypertension - metabolism | Hydrogen Sulfide - antagonists & inhibitors | Placenta - drug effects | Placenta - metabolism | Pregnancy | Neovascularization, Physiologic - physiology | Placenta - physiopathology | Animals | Glycine - pharmacology | Endothelium, Vascular - metabolism | Adolescent | Placenta Growth Factor | Mice | Placenta Diseases - metabolism | Alkynes - adverse effects | Pregnancy Complications, Cardiovascular - etiology
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9. Full Text Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress
by Bos, Eelke M and Wang, Rui and Snijder, Pauline M and Boersema, Miriam and Damman, Jeffrey and Fu, Ming and Moser, Jill and Hillebrands, Jan-Luuk and Ploeg, Rutger J and Yang, Guangdong and Leuvenink, Henri G D and van Goor, Harry
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2013, Volume 24, Issue 5, pp. 759 - 770
Hydrogen sulfide (H2S) is an endogenous gasotransmitter with physiologic functions similar to nitric oxide and carbon monoxide. Exogenous treatment with H2S... 
ISCHEMIA-REPERFUSION INJURY | SULFHYDRATION | NITRIC-OXIDE SYNTHASE | ANIMATION-LIKE STATE | H2S | MICE | HYDROGEN-SULFIDE | KAPPA-B | KIDNEY | H2AX PHOSPHORYLATION | UROLOGY & NEPHROLOGY | Hydrogen Sulfide - metabolism | Kidney - blood supply | Oxidative Stress | Humans | Kidney - enzymology | Middle Aged | Male | Renin - analysis | Cystathionine gamma-Lyase - physiology | HEK293 Cells | Superoxides - metabolism | Adult | Female | Cystathionine gamma-Lyase - genetics | Cell Survival | Mice, Inbred C57BL | Cystathionine gamma-Lyase - analysis | Kidney Transplantation | Animals | Reperfusion Injury - prevention & control | Adolescent | Aged | Mice | DNA Damage | Cystathionine beta-Synthase - physiology | Basic Research
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10. Regulation of cystathionine gamma-lyase/H2S system and its pathological implication
by Zhao, Kexin and Li, Hongzhu and Li, Shuangshuang and Yang, Guangdong
Frontiers in Bioscience - Landmark, ISSN 1093-9946, 06/2014, Volume 19, Issue 8, pp. 1355 - 1369
Hydrogen sulfide (H2S) is a highly diffusible gasotransmitter, that influence cellular and organ functions by a number of different mechanisms. Cystathionine... 
Hydrogen sulfide | Post-translational modification | Disease | Transcriptional regulation | Cystathionine gammalyase | TRANSSULFURATION PATHWAY | SPECIFICITY PROTEIN-1 | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOCARDIAL-ISCHEMIA | ENDOPLASMIC-RETICULUM STRESS | GLUCOSE-UTILIZATION | LYASE EXPRESSION | ENDOGENOUS HYDROGEN-SULFIDE | CELL BIOLOGY | ISCHEMIA-REPERFUSION INJURY | GAMMA-LYASE/HYDROGEN SULFIDE | Gene Expression Regulation, Enzymologic | Hydrogen Sulfide - metabolism | Transcription Factors - metabolism | Genetic Predisposition to Disease - genetics | Animals | Humans | Protein Binding | Cystathionine gamma-Lyase - metabolism | Models, Genetic | Cystathionine gamma-Lyase - genetics | Promoter Regions, Genetic - genetics
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11. Full Text Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
by Yang, Guangdong and Zhao, Kexin and Ju, Youngjun and Mani, Sarathi and Cao, Qiuhui and Puukila, Stephanie and Khaper, Neelam and Wu, Lingyun and Wang, Rui
Antioxidants & Redox Signaling, ISSN 1523-0864, 05/2013, Volume 18, Issue 15, pp. 196 - 1919
Aims: H 2 S, a third member of gasotransmitter family along with nitric oxide and carbon monoxide, exerts a wide range of cellular and molecular actions in our... 
Original Research Communications | UBIQUITINATION | LIFE-SPAN | REGULATOR | OXIDATIVE STRESS | VASORELAXANT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | H2S | SIGNALS | CYSTATHIONINE GAMMA-LYASE | MICE | INDUCTION | Hydrogen Sulfide - metabolism | Hydrogen Sulfide - pharmacology | Glutathione - metabolism | Cellular Senescence - drug effects | Cystathionine gamma-Lyase - metabolism | Mice, Knockout | Protein Transport | Animals | Cell Nucleus - metabolism | NF-E2-Related Factor 2 - metabolism | Cytoskeletal Proteins - metabolism | Cysteine - metabolism | Mice | Cystathionine gamma-Lyase - genetics | NF-E2-Related Factor 2 - chemistry | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Kelch-Like ECH-Associated Protein 1 | Cystathionine gamma-Lyase - deficiency | Fibroblasts - metabolism | Hydrogen sulfide | Physiological aspects | Aging | Research | Analysis | Cells
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12. Full Text Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis
by Gaddam, Ravinder Reddy and Fraser, Robin and Badiei, Alireza and Chambers, Stephen and Cogger, Victoria C and Le Couteur, David G and Ishii, Isao and Bhatia, Madhav
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0160521
Background Hydrogen sulfide (H2S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver... 
RAT-LIVER | INACTIVATION | PATHOGENESIS | PUNCTURE-INDUCED SEPSIS | CECAL LIGATION | PROPARGYLGLYCINE | SINUSOIDAL ENDOTHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | KUPFFER CELLS | LUNG INJURY | HYDROGEN-SULFIDE | Pneumonia - etiology | Cytokines - metabolism | Liver Diseases - prevention & control | Mice, Inbred C57BL | Pneumonia - prevention & control | Protective Agents - metabolism | Male | Sepsis - complications | Cystathionine gamma-Lyase - physiology | Mice, Knockout | Animals | Gene Deletion | Liver Diseases - etiology | Chemokines - metabolism | Mice | Liver Diseases - metabolism | Pneumonia - metabolism | Sepsis - microbiology | Disease Models, Animal | Sulfides | Care and treatment | Bacterial infections | Inflammation | Research | Gene expression | Risk factors | Sulfide | Hydrogen | Liver | Inflammatory response | Electron micrographs | Gene deletion | Interleukin 6 | Hydrogen sulfide | Hepatitis | Synthesis | Clonal deletion | Rodents | Hepatology | Surgery | Aging | NF-κB protein | Cytokines | Mortality | Pancreatitis | Extracellular signal-regulated kinase | Tumor necrosis factor-α | Endothelial cells | Studies | Pathology | Injury prevention | Hepatocytes | Lungs | Sepsis | Plasma levels | Porosity | Chemokines | Monocyte chemoattractant protein 1 | Apoptosis
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13. Full Text Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer
by Fan, Kun and Li, Na and Qi, Jingjing and Yin, Peng and Zhao, Chao and Wang, Liying and Li, Zengxia and Zha, Xiliang
Cellular Signalling, ISSN 0898-6568, 12/2014, Volume 26, Issue 12, pp. 2801 - 2808
Cystathionine-γ-lyase (CSE) is a major endogenous enzyme producing H2S which, as a third gasotransmitter, plays important roles in many physiological and... 
Hydrogen sulfide | Colon cancer cell | Transcription | Wnt pathway | Cystathionine-γ-lyase | SUPPRESSOR | SPECIFICITY PROTEIN-1 | H2S | PROLIFERATION | HYDROGEN-SULFIDE | CELL BIOLOGY | APC | Cystathionine-gamma-lyase | SMOOTH-MUSCLE-CELLS | MUTATIONS | HEPATOCELLULAR CARCINOMAS | BETA-SYNTHASE | Glycine - analogs & derivatives | Transcription, Genetic - drug effects | Colonic Neoplasms - genetics | Humans | Cystathionine gamma-Lyase - metabolism | Cell Movement - genetics | Gene Knockdown Techniques | TCF Transcription Factors - metabolism | Alkynes - pharmacology | Cystathionine gamma-Lyase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Promoter Regions, Genetic | Mutation - genetics | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Wnt Signaling Pathway - drug effects | Glycine - pharmacology | Wnt Signaling Pathway - genetics | Mice, Nude | Colonic Neoplasms - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Colonic Neoplasms - enzymology | Proteins | Enzymes | Pathways | Colon | Gene expression | Binding sites | Tumors | Cancer
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14. Full Text Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide
by Tsai, Cheng-Yen and Wen, Su-Ying and Shibu, Marthandam Asokan and Yang, Yao-Chih and Peng, Hanjing and Wang, Binghe and Wei, Yu-Min and Chang, Hung-Yu and Lee, Cheng-Yu and Huang, Chih-Yang and Kuo, Wei-Wen
International Journal of Cardiology, ISSN 0167-5273, 2015, Volume 195, pp. 300 - 310
Abstract Background Cystathionine-γ-lyase (CSE)-derived hydrogen sulfide (H2S) is a potent cardioprotective agent. We investigated the effects of diallyl... 
Cardiovascular | Diallyl trisulfide (DATS) | Hydrogen sulfide (H2S) | High glucose (HG) | Cystathionine gamma-lyase (CSE) | Reactive oxygen species (ROS) | Apoptosis | NADPH OXIDASE | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | MYOCARDIAL-ISCHEMIA | GARLIC OIL | INDUCED DIABETIC-RATS | DYSFUNCTION | ISCHEMIA-REPERFUSION | EXPRESSION | Hydrogen Sulfide - metabolism | Cell Line | Rats, Wistar | Apoptosis - drug effects | Models, Cardiovascular | Diabetes Complications - metabolism | Humans | Rats | Cystathionine gamma-Lyase - metabolism | Male | Cardiotonic Agents - pharmacology | Allyl Compounds - pharmacology | Cardiomyopathies - etiology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Cardiomyopathies - metabolism | Glucose - metabolism | Myocytes, Cardiac - metabolism | Garlic | Cytoprotection | Disease Models, Animal | Sulfides - pharmacology | Hydrogen sulfide | Glucose | Dextrose
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