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1. Full Text Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
by Puskarjov, Martin and Ahmad, Faraz and Kaila, Kai and Blaesse, Peter
Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11356 - 11364
The K-Cl cotransporter KCC2 plays a crucial role in neuronal chloride regulation. In mature central neurons, KCC2 is responsible for the low intracellular Cl-... 
PROTEOLYTIC CLEAVAGE | NMDA RECEPTOR | SYNAPTIC FUNCTION | GABAERGIC TRANSMISSION | AXON INITIAL SEGMENT | DOWN-REGULATION | DEVELOPMENTAL-CHANGES | RAT HIPPOCAMPUS | MEMBRANE TRAFFICKING | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Calpain - metabolism | Rats, Wistar | Calcium - metabolism | Emetine - pharmacology | Male | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Pyramidal Cells - physiology | Statistics, Nonparametric | Calcium Ionophores - pharmacology | Pyramidal Cells - drug effects | Protein Synthesis Inhibitors - pharmacology | Action Potentials - drug effects | Animals, Newborn | Membrane Potentials - drug effects | Dipeptides - pharmacology | Valine - analogs & derivatives | Gene Expression Regulation - physiology | Rats | Magnesium - metabolism | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Cycloheximide - pharmacology | Symporters - metabolism | Gene Expression Regulation - drug effects | Leupeptins - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Cysteine Proteinase Inhibitors - pharmacology | Calpain - pharmacology | Ionomycin - pharmacology | Valine - pharmacology | Dizocilpine Maleate - pharmacology | In Vitro Techniques
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2. Full Text Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
by Lianne Fuino and Purva Bali and Sylvie Wittmann and Sreenivas Donapaty and Fei Guo and Hirohito Yamaguchi and Hong-Gang Wang and Peter Atadja and Kapil Bhalla
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2003, Volume 2, Issue 10, pp. 971 - 984
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones, which results in chromatin... 
SIGNAL-TRANSDUCTION | ACUTE-LEUKEMIA CELLS | ONCOLOGY | ACETYLATION | RESISTANCE | RECEPTOR | RAF-1 | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | TAXOL-INDUCED APOPTOSIS | HSP90 FUNCTION | Chromatin - metabolism | Phosphorylation | Taxoids - pharmacology | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Epothilones - pharmacology | Multienzyme Complexes - metabolism | Deoxycytidine - pharmacology | Proteasome Endopeptidase Complex | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sepharose - pharmacology | Cysteine Endopeptidases - metabolism | Flow Cytometry | Cyclins - metabolism | Time Factors | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Detergents - pharmacology | Receptor, ErbB-2 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 | Antibodies, Monoclonal - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Tetrazolium Salts - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Precipitin Tests | Blotting, Northern | Cell Line, Tumor | Histone Deacetylase Inhibitors | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Microscopy, Fluorescence | Trastuzumab | Apoptosis
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3. Full Text Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
by Takaya, Kai and Suzuki, Takafumi and Motohashi, Hozumi and Onodera, Ko and Satomi, Susumu and Kensler, Thomas W and Yamamoto, Masayuki
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | stress response | reactive cysteine
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4. Full Text Hydrogen sulfide in pharmacology and medicine – An update
by Bełtowski, Jerzy
Pharmacological Reports, ISSN 1734-1140, 06/2015, Volume 67, Issue 3, pp. 647 - 658
Hydrogen sulfide (H S) is the endogenously produced gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory... 
Hydrogen sulfide | Inflammation | Cardiovascular diseases | Gasotransmitters | Non-steroidal anti-inflammatory drugs | NUCLEOTIDE-BINDING PROTEIN-1 | DONATING SILDENAFIL ACS6 | SULFANE SULFUR | 3-MERCAPTOPYRUVATE SULFURTRANSFERASE | S-PROPARGYL-CYSTEINE | ANIMATION-LIKE STATE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | CYSTATHIONINE-BETA-SYNTHASE | DICLOFENAC PROTECTS | PERIVASCULAR ADIPOSE-TISSUE | Hydrogen Sulfide - metabolism | Neoplasms - metabolism | Hydrogen Sulfide - pharmacology | Humans | Reperfusion Injury - drug therapy | Mitochondria - metabolism | Mitochondria - drug effects | Neoplasms - drug therapy | Hydrogen Sulfide - therapeutic use | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Reperfusion Injury - metabolism
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5. Full Text System xc‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
by Bridges, Richard J and Natale, Nicholas R and Patel, Sarjubhai A
British Journal of Pharmacology, ISSN 0007-1188, 01/2012, Volume 165, Issue 1, pp. 20 - 34
System xc‐ is an amino acid antiporter that typically mediates the exchange of extracellular l‐cystine and intracellular l‐glutamate across the cellular plasma... 
cystine‐cysteine shuttle | transporter pharmacophore | glutathione | transporter | exchanger | molecular pharmacology | l‐glutamate | glia | l‐cystine | l-glutamate | PRIMARY BRAIN-TUMORS | GLIOMA-CELLS | OXIDATIVE STRESS | LIGHT SUBUNIT | l-cystine | PLASMA-MEMBRANE | EXTRACELLULAR GLUTAMATE | CYSTINE-GLUTAMATE EXCHANGE | AMINO-ACID TRANSPORTER | HYPOXIC NEURONAL INJURY | HUMAN-DIPLOID FIBROBLASTS | PHARMACOLOGY & PHARMACY | cystine-cysteine shuttle | Amino Acid Transport System y+ - metabolism | Animals | Central Nervous System - metabolism | Cystine - metabolism | Gene Expression Regulation - physiology | Substrate Specificity | Amino Acid Transport System y+ - genetics | Glutamic Acid - metabolism | Pharmacology | Binding sites | Reviews
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6. Full Text New Antimalarial Drugs
by Wiesner, Jochen and Ortmann, Regina and Jomaa, Hassan and Schlitzer, Martin
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2003, Volume 42, Issue 43, pp. 5274 - 5293
Approximately 40 % of the world population live in areas with the risk of malaria. Each year, 300–500 million people suffer from acute malaria, and 0.5–2.5... 
malaria | drug design | medicinal chemistry | biological targets | Medicinal chemistry | Drug design | Biological targets | Malaria | UNCOMPLICATED FALCIPARUM-MALARIA | CRYSTAL-STRUCTURE | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ARTEMISININ DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | CHLORPROGUANIL-DAPSONE TREATMENT | IN-VITRO ACTIVITIES | ISOPRENOID BIOSYNTHESIS | CYSTEINE PROTEASE INHIBITORS | PARASITE PLASMODIUM-FALCIPARUM | THIOL FARNESYLTRANSFERASE INHIBITORS | Ethanolamines - pharmacology | Humans | Fluorenes - pharmacology | Dapsone - therapeutic use | Plasmodium falciparum - drug effects | Flavonoids - therapeutic use | Sesquiterpenes - therapeutic use | Artemisinins - pharmacology | Malaria - epidemiology | Plasmodium falciparum - genetics | Drug Design | Flavonoids - pharmacology | Plasmodium falciparum - physiology | Aminoquinolines - pharmacology | Fosfomycin - analogs & derivatives | Fluorenes - urine | Fosfomycin - therapeutic use | Atovaquone | Global Health | Fosfomycin - pharmacology | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Antimalarials - therapeutic use | Clinical Trials as Topic | Proguanil - analogs & derivatives | Antimalarials - pharmacology | Malaria - prevention & control | Proguanil - therapeutic use | Drug Resistance - genetics | Animals | Artemisinins - therapeutic use | Ethanolamines - urine | Naphthyridines - therapeutic use | Dapsone - pharmacology | Malaria - drug therapy | Sesquiterpenes - pharmacology | Aminoquinolines - therapeutic use | Drug Combinations | Naphthyridines - pharmacology | Proguanil - pharmacology
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7. Full Text Sortase A Inhibitors: Recent Advances and Future Perspectives
by Cascioferro, Stella and Raffa, Demetrio and Maggio, Benedetta and Raimondi, Maria Valeria and Schillaci, Domenico and Daidone, Giuseppe
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as... 
LISTERIA-MONOCYTOGENES | SRTA GENE | CHEMISTRY, MEDICINAL | CELL-WALL | STREPTOCOCCUS-PNEUMONIAE | SORTING SIGNAL | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | A INHIBITORS | PROTEIN ANCHORING TRANSPEPTIDASE | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology
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8. Full Text Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species
by Ooi, Lezanne and Gigout, Sylvain and Pettinger, Louisa and Gamper, Nikita
Journal of Neuroscience, ISSN 0270-6474, 04/2013, Volume 33, Issue 14, pp. 6041 - 6046
We have identified a new signaling role for nitric oxide (NO) in neurons from the trigeminal ganglia (TG). We show that in rat sensory neurons from the TG the... 
SENSITIVE POTASSIUM CHANNELS | SYNTHASE | S-NITROSYLATION | ACTIVATION | GENE-RELATED PEPTIDE | INHIBITION | RAT | CURRENTS | MIGRAINE | NEUROSCIENCES | SENSORY NEURONS | Action Potentials - genetics | Reactive Oxygen Species - metabolism | Humans | Male | Cysteine - genetics | Transfection | Membrane Transport Modulators - pharmacology | Neurons - physiology | Biotin - metabolism | Female | Cysteine - metabolism | Nitric Oxide Donors - pharmacology | Calcitonin Gene-Related Peptide - metabolism | Neurons - drug effects | Action Potentials - drug effects | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Animals, Newborn | Aniline Compounds - pharmacology | Trigeminal Ganglion - cytology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Models, Molecular | Rats | Imidazoles - pharmacology | Mutation - genetics | Anthracenes - pharmacology | Patch-Clamp Techniques | Animals | KCNQ Potassium Channels - metabolism | Benzoates - pharmacology | Phenylenediamines - pharmacology | Nitric Oxide - metabolism | S-Nitroso-N-Acetylpenicillamine - pharmacology | KCNQ Potassium Channels - genetics | Brief Communications
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9. Full Text Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
by Chen, Y and McMillan-Ward, E and Kong, J and Israels, S.J and Gibson, S.B
Cell Death and Differentiation, ISSN 1350-9047, 01/2008, Volume 15, Issue 1, pp. 171 - 182
Autophagy is a self-digestion process that degrades intracellular structures in response to stresses leading to cell survival. When autophagy is prolonged,... 
autophagic cell death | MALIGNANT GLIOMA-CELLS | HUMAN LEUKEMIA-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | INDUCTION | ARSENIC TRIOXIDE | CELL BIOLOGY | MITOCHONDRIAL RESPIRATION | INHIBITION | NECROSIS | reactive oxygen species | 2-methoxyestradiol | MEDIATED MECHANISM | UP-REGULATION | Astrocytes - cytology | Astrocytes - drug effects | Estradiol - analogs & derivatives | Oxidants - pharmacology | Adenine - analogs & derivatives | Reactive Oxygen Species - metabolism | Oxidative Stress | Tubulin Modulators - pharmacology | Humans | RNA, Small Interfering - pharmacology | Hydrogen Peroxide - pharmacology | Adenine - pharmacology | Autophagy | Animals | Amino Acid Chloromethyl Ketones - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Cell Line, Tumor | Mice | HeLa Cells | Cell Line, Transformed | Estradiol - pharmacology | Apoptosis
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10. Full Text Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
by Kim, Eun Young and Koh, Jae Young and Kim, Yang Hee and Sohn, Seonghyang and Joe, Eunhye and Gwag, Byoung Joo
European Journal of Neuroscience, ISSN 0953-816X, 01/1999, Volume 11, Issue 1, pp. 327 - 334
Evidence has accumulated that Zn2+ plays a central role in neurodegenerative processes following brain injuries including ischaemia or epilepsy. In the present... 
cortical cell culture | apoptosis | ischaemia | necrosis | zinc | oxidative stress | Ischaemia | Oxidative stress | Cortical cell culture | Zinc | Apoptosis | Necrosis | GLUTAMATE NEUROTOXICITY | ZINC NEUROTOXICITY | DEATH | NEUROSCIENCES | INHIBITION | NITRIC-OXIDE | NMDA | RECEPTORS | BRAIN | METHYL-D-ASPARTATE | Neurons - pathology | Apoptosis - drug effects | Cerebral Cortex - cytology | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | Brain-Derived Neurotrophic Factor - pharmacology | Zinc - pharmacokinetics | Neurons - ultrastructure | Chromans - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Lipid Peroxidation - drug effects | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Free Radicals - metabolism | Female | Neurons - metabolism | Mitochondrial Swelling | Dopamine Agonists - pharmacology | Insulin - pharmacology | Kainic Acid - pharmacology | Cells, Cultured | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Antioxidants - pharmacology | Microscopy, Electron | Hypoglycemic Agents - pharmacology | Drug Synergism | Neurotoxins - pharmacology | Pregnancy | Animals | Cysteine Proteinase Inhibitors - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Zinc - toxicity | Mice | Oxidative Stress - drug effects | Dizocilpine Maleate - pharmacology | Oligopeptides - pharmacology
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11. Hydrogen sulfide prevents ethanol-induced gastric damage in mice: Role of ATP-sensitive potassium channels and capsaicin-sensitive primary afferent neurons
by Medeiros, Jand Venes R and Bezerra, Víctor H and Gomes, Antoniella S and Barbosa, André Luiz R and Lima Jr, Roberto César P and Soares, Pedro Marcos G and Brito, Gerly Anne C and Ribeiro, Ronaldo A and Cunha, Fernando Q and De Souza, Marcellus Henrique Loiola Ponte
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2009, Volume 330, Issue 3, pp. 764 - 770
The aim of this study was to evaluate the protective effect of hydrogen sulfide (H2S) on ethanol-induced gastric lesions in mice and the influence of... 
ACTIVATION | IMMUNOREACTIVITY | NEUTROPHIL MIGRATION | URINARY-BLADDER | INFLAMMATION | GASTROINTESTINAL-TRACT | ENHANCEMENT | RATS | VANILLOID RECEPTOR | PHARMACOLOGY & PHARMACY | K+ CHANNELS | Glycine - analogs & derivatives | KATP Channels - physiology | Ethanol - toxicity | Air Pollutants - pharmacology | Capsaicin - pharmacology | Glutathione - metabolism | Stomach Diseases - chemically induced | Gastric Mucosa - pathology | Male | Stomach Diseases - pathology | Dose-Response Relationship, Drug | KATP Channels - drug effects | Glyburide - pharmacology | Protective Agents - pharmacology | Cysteine - pharmacology | Alkynes - pharmacology | Stomach Diseases - prevention & control | Central Nervous System Depressants - toxicity | Malondialdehyde - metabolism | Neurons, Afferent - drug effects | Hydrogen Sulfide - pharmacology | TRPV Cation Channels - physiology | Central Nervous System Depressants - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Hypoglycemic Agents - pharmacology | Animals | Glycine - pharmacology | Mice | Ethanol - antagonists & inhibitors | Index Medicus
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12. Full Text Requirement for ERK Activation in Cisplatin-induced Apoptosis
by Xiantao Wang and Jennifer L. Martindale and Nikki J. Holbrook
Journal of Biological Chemistry, ISSN 0021-9258, 12/2000, Volume 275, Issue 50, pp. 39435 - 39443
Cisplatin activates multiple signal transduction pathways involved in coordinating cellular responses to stress. Here we demonstrate a requirement for... 
PROGRAMMED CELL-DEATH | CYTOCHROME-C | OXIDATIVE STRESS | CANCER CELLS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED CYTOTOXICITY | EPIDERMAL GROWTH-FACTOR | SIGNAL-REGULATED KINASE | MAMMALIAN-CELLS | FACTOR RECEPTOR | Tetradecanoylphorbol Acetate - pharmacology | Nitriles - pharmacology | Apoptosis - drug effects | Humans | MAP Kinase Kinase 2 | MAP Kinase Kinase 1 | Dose-Response Relationship, Drug | Caspases - metabolism | Time Factors | Amino Acid Chloromethyl Ketones - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Caspase 3 | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Suramin - pharmacology | Cell Line | Cell Survival - drug effects | Butadienes - pharmacology | Signal Transduction | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Cisplatin - pharmacology | Blotting, Western | Cytochrome c Group - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Models, Biological | Cysteine Proteinase Inhibitors - pharmacology | Enzyme Activation | HeLa Cells | Mitogen-Activated Protein Kinases - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors
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