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1. Full Text System xc‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
by Bridges, Richard J and Natale, Nicholas R and Patel, Sarjubhai A
British journal of pharmacology, ISSN 0007-1188, 01/2012, Volume 165, Issue 1, pp. 20 - 34
cystine‐cysteine shuttle | transporter pharmacophore | glutathione | transporter | exchanger | molecular pharmacology | l‐glutamate | glia | l‐cystine | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Amino Acid Transport System y+ - metabolism | Animals | Central Nervous System - metabolism | Cystine - metabolism | Gene Expression Regulation - physiology | Substrate Specificity | Amino Acid Transport System y+ - genetics | Glutamic Acid - metabolism | Pharmacology | Binding sites | Index Medicus | l-glutamate | Reviews | l-cystine | cystine-cysteine shuttle
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2. Full Text Effects of Subinhibitory Concentrations of Antibiotics on Colonization Factor Expression by Moxifloxacin-Susceptible and Moxifloxacin-Resistant Clostridium difficile Strains
by Cécile Denève and Sylvie Bouttier and Bruno Dupuy and Frédéric Barbut and Anne Collignon and Claire Janoir
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2009, Volume 53, Issue 12, pp. 5155 - 5162
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Fluoroquinolones | Sequence Deletion | Frameshift Mutation | Bacterial Proteins - genetics | Clostridium difficile - genetics | Immunoblotting | Aza Compounds - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Quinolines - pharmacology | Clindamycin - pharmacology | Microbial Sensitivity Tests | Ofloxacin - pharmacology | DNA Gyrase - genetics | Cysteine Endopeptidases - genetics | Polymerase Chain Reaction | Bacterial Proteins - metabolism | Ampicillin - pharmacology | Anti-Bacterial Agents - pharmacology | Clostridium difficile - metabolism | Clostridium difficile - drug effects | Index Medicus | Ofloxacin/pharmacology | Clostridium difficile/genetics | Biochemistry, Molecular Biology | Clostridium difficile/drug effects | Moxifloxacin | Anti-Bacterial Agents/pharmacology | Life Sciences | Quinolines/pharmacology | Bacterial Proteins/metabolism | Bacterial Proteins/genetics | DNA Gyrase/genetics | Clostridium difficile/metabolism | Ampicillin/pharmacology | Clindamycin/pharmacology | Cysteine Endopeptidases/genetics | Aza Compounds/pharmacology | Pharmacology
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3. Full Text Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
by Puskarjov, Martin and Ahmad, Faraz and Kaila, Kai and Blaesse, Peter
The Journal of neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11356 - 11364
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Calpain - metabolism | Rats, Wistar | Calcium - metabolism | Emetine - pharmacology | Male | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Pyramidal Cells - physiology | Statistics, Nonparametric | Calcium Ionophores - pharmacology | Pyramidal Cells - drug effects | Protein Synthesis Inhibitors - pharmacology | Action Potentials - drug effects | Animals, Newborn | Membrane Potentials - drug effects | Dipeptides - pharmacology | Valine - analogs & derivatives | Gene Expression Regulation - physiology | Rats | Magnesium - metabolism | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Cycloheximide - pharmacology | Symporters - metabolism | Gene Expression Regulation - drug effects | Leupeptins - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Cysteine Proteinase Inhibitors - pharmacology | Calpain - pharmacology | Ionomycin - pharmacology | Valine - pharmacology | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Index Medicus
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4. Full Text Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
by Lianne Fuino and Purva Bali and Sylvie Wittmann and Sreenivas Donapaty and Fei Guo and Hirohito Yamaguchi and Hong-Gang Wang and Peter Atadja and Kapil Bhalla
Molecular cancer therapeutics, ISSN 1535-7163, 10/2003, Volume 2, Issue 10, pp. 971 - 984
Life Sciences & Biomedicine | Oncology | Science & Technology | Chromatin - metabolism | Phosphorylation | Taxoids - pharmacology | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Epothilones - pharmacology | Multienzyme Complexes - metabolism | Deoxycytidine - pharmacology | Proteasome Endopeptidase Complex | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sepharose - pharmacology | Cysteine Endopeptidases - metabolism | Flow Cytometry | Cyclins - metabolism | Time Factors | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Detergents - pharmacology | Receptor, ErbB-2 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 | Antibodies, Monoclonal - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Tetrazolium Salts - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Precipitin Tests | Blotting, Northern | Cell Line, Tumor | Histone Deacetylase Inhibitors | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Microscopy, Fluorescence | Trastuzumab | Apoptosis | Index Medicus
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5. Full Text Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
by Takaya, Kai and Suzuki, Takafumi and Motohashi, Hozumi and Onodera, Ko and Satomi, Susumu and Kensler, Thomas W and Yamamoto, Masayuki
Free radical biology & medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
Keap1 | Reactive cysteine | Stress response | Nrf2 | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | Index Medicus | stress response | reactive cysteine
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6. Full Text Sortase A Inhibitors: Recent Advances and Future Perspectives
by Cascioferro, Stella and Raffa, Demetrio and Maggio, Benedetta and Raimondi, Maria Valeria and Schillaci, Domenico and Daidone, Giuseppe
Journal of medicinal chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology | Index Medicus
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7. Full Text Effect of Glutathione Depletion on Antitumor Drug Toxicity (Apoptosis and Necrosis) in U-937 Human Promonocytic Cells: The role of intracellular oxidation
by Troyano, Alfonso and Fernández, Carlos and Sancho, Patricia and De Blas, Elena and Aller, Patricio
The Journal of biological chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Buthionine Sulfoximine - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Reactive Oxygen Species | Glutathione - metabolism | Alkylating Agents - pharmacology | Humans | Topoisomerase I Inhibitors | Antineoplastic Agents, Alkylating - pharmacology | Immunoblotting | Monocytes - metabolism | Oxygen - metabolism | Antineoplastic Agents - toxicity | Necrosis | Dose-Response Relationship, Drug | Flow Cytometry | Time Factors | U937 Cells | Adenosine Triphosphate - metabolism | Cell Death | Radiation-Protective Agents - pharmacology | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Membrane Potentials - drug effects | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Etoposide - pharmacology | Spectrometry, Fluorescence | Glutathione - antagonists & inhibitors | Mitochondria - metabolism | Antioxidants - pharmacology | Cisplatin - pharmacology | Hypoxia | Antineoplastic Agents, Phytogenic - pharmacology | Camptothecin - pharmacology | Dose-Response Relationship, Radiation | Doxorubicin - pharmacology | Apoptosis | butylated hydroxyanisole | melphelan | N-Acetyl-L-cysteine | cisplatin | Index Medicus
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8. Full Text Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
by Chen, Y and McMillan-Ward, E and Kong, J and Israels, S.J and Gibson, S.B
Cell death and differentiation, ISSN 1350-9047, 01/2008, Volume 15, Issue 1, pp. 171 - 182
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Astrocytes - cytology | Astrocytes - drug effects | Estradiol - analogs & derivatives | Oxidants - pharmacology | Adenine - analogs & derivatives | Reactive Oxygen Species - metabolism | Oxidative Stress | Tubulin Modulators - pharmacology | Humans | RNA, Small Interfering - pharmacology | Hydrogen Peroxide - pharmacology | Adenine - pharmacology | Autophagy | Animals | Amino Acid Chloromethyl Ketones - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Cell Line, Tumor | Mice | HeLa Cells | Cell Line, Transformed | Estradiol - pharmacology | Apoptosis | Index Medicus
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