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Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11356 - 11364
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2003, Volume 2, Issue 10, pp. 971 - 984
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones, which results in chromatin... 
SIGNAL-TRANSDUCTION | ACUTE-LEUKEMIA CELLS | ONCOLOGY | ACETYLATION | RESISTANCE | RECEPTOR | RAF-1 | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | TAXOL-INDUCED APOPTOSIS | HSP90 FUNCTION | Chromatin - metabolism | Phosphorylation | Taxoids - pharmacology | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Epothilones - pharmacology | Multienzyme Complexes - metabolism | Deoxycytidine - pharmacology | Proteasome Endopeptidase Complex | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sepharose - pharmacology | Cysteine Endopeptidases - metabolism | Flow Cytometry | Cyclins - metabolism | Time Factors | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Detergents - pharmacology | Receptor, ErbB-2 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 | Antibodies, Monoclonal - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Tetrazolium Salts - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Precipitin Tests | Blotting, Northern | Cell Line, Tumor | Histone Deacetylase Inhibitors | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Microscopy, Fluorescence | Trastuzumab | Apoptosis
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | stress response | reactive cysteine
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2003, Volume 42, Issue 43, pp. 5274 - 5293
Approximately 40 % of the world population live in areas with the risk of malaria. Each year, 300–500 million people suffer from acute malaria, and 0.5–2.5... 
malaria | drug design | medicinal chemistry | biological targets | Medicinal chemistry | Drug design | Biological targets | Malaria | UNCOMPLICATED FALCIPARUM-MALARIA | CRYSTAL-STRUCTURE | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | ARTEMISININ DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | CHLORPROGUANIL-DAPSONE TREATMENT | IN-VITRO ACTIVITIES | ISOPRENOID BIOSYNTHESIS | CYSTEINE PROTEASE INHIBITORS | PARASITE PLASMODIUM-FALCIPARUM | THIOL FARNESYLTRANSFERASE INHIBITORS | Ethanolamines - pharmacology | Humans | Fluorenes - pharmacology | Dapsone - therapeutic use | Plasmodium falciparum - drug effects | Flavonoids - therapeutic use | Sesquiterpenes - therapeutic use | Artemisinins - pharmacology | Malaria - epidemiology | Plasmodium falciparum - genetics | Drug Design | Flavonoids - pharmacology | Plasmodium falciparum - physiology | Aminoquinolines - pharmacology | Fosfomycin - analogs & derivatives | Fluorenes - urine | Fosfomycin - therapeutic use | Atovaquone | Global Health | Fosfomycin - pharmacology | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Antimalarials - therapeutic use | Clinical Trials as Topic | Proguanil - analogs & derivatives | Antimalarials - pharmacology | Malaria - prevention & control | Proguanil - therapeutic use | Drug Resistance - genetics | Animals | Artemisinins - therapeutic use | Ethanolamines - urine | Naphthyridines - therapeutic use | Dapsone - pharmacology | Malaria - drug therapy | Sesquiterpenes - pharmacology | Aminoquinolines - therapeutic use | Drug Combinations | Naphthyridines - pharmacology | Proguanil - pharmacology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as... 
LISTERIA-MONOCYTOGENES | SRTA GENE | CHEMISTRY, MEDICINAL | CELL-WALL | STREPTOCOCCUS-PNEUMONIAE | SORTING SIGNAL | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | A INHIBITORS | PROTEIN ANCHORING TRANSPEPTIDASE | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology
Journal Article
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/1999, Volume 11, Issue 1, pp. 327 - 334
Evidence has accumulated that Zn2+ plays a central role in neurodegenerative processes following brain injuries including ischaemia or epilepsy. In the present... 
cortical cell culture | apoptosis | ischaemia | necrosis | zinc | oxidative stress | Ischaemia | Oxidative stress | Cortical cell culture | Zinc | Apoptosis | Necrosis | GLUTAMATE NEUROTOXICITY | ZINC NEUROTOXICITY | DEATH | NEUROSCIENCES | INHIBITION | NITRIC-OXIDE | NMDA | RECEPTORS | BRAIN | METHYL-D-ASPARTATE | Neurons - pathology | Apoptosis - drug effects | Cerebral Cortex - cytology | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | Brain-Derived Neurotrophic Factor - pharmacology | Zinc - pharmacokinetics | Neurons - ultrastructure | Chromans - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Lipid Peroxidation - drug effects | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Free Radicals - metabolism | Female | Neurons - metabolism | Mitochondrial Swelling | Dopamine Agonists - pharmacology | Insulin - pharmacology | Kainic Acid - pharmacology | Cells, Cultured | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Antioxidants - pharmacology | Microscopy, Electron | Hypoglycemic Agents - pharmacology | Drug Synergism | Neurotoxins - pharmacology | Pregnancy | Animals | Cysteine Proteinase Inhibitors - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Zinc - toxicity | Mice | Oxidative Stress - drug effects | Dizocilpine Maleate - pharmacology | Oligopeptides - pharmacology
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2009, Volume 330, Issue 3, pp. 764 - 770
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2000, Volume 275, Issue 50, pp. 39435 - 39443
Journal Article