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1. Full Text Molecular mechanisms of antithrombin–heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors
by Olson, Steven T and Richard, Benjamin and Izaguirre, Gonzalo and Schedin-Weiss, Sophia and Gettins, Peter G.W
Biochimie, ISSN 0300-9084, 11/2010, Volume 92, Issue 11, pp. 1587 - 1596
Anticoagulants | Heparin | Blood coagulation proteinases | Antithrombin | Serpins | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Heparin - metabolism | Animals | Serpins - metabolism | Allosteric Regulation | Antithrombins - metabolism | Humans | Blood Coagulation | Antithrombins - chemistry | Serpins - chemistry | Heparin - chemistry | Peptide Hydrolases - metabolism | Cysteine | Glycosaminoglycans | Proteases | Crystals | Anticoagulants (Medicine) | Structure | Sulfates | Index Medicus
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2. Full Text Organic Carbamates in Drug Design and Medicinal Chemistry
by Ghosh, Arun K and Brindisi, Margherita
Journal of medicinal chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 2895 - 2940
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Antiviral Agents - pharmacology | Chemistry Techniques, Synthetic | Chemistry, Pharmaceutical - methods | Hepatitis C - drug therapy | Drug Stability | Humans | HIV Protease | HIV Protease Inhibitors - chemistry | Carbamates - chemistry | HIV Protease Inhibitors - pharmacology | Carbamates - chemical synthesis | Serine Proteinase Inhibitors - chemistry | Antiviral Agents - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Drug Design | Prodrugs - chemical synthesis | Cysteine Proteinase Inhibitors - chemistry | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Viral Nonstructural Proteins - antagonists & inhibitors | Serine Proteinase Inhibitors - pharmacology | Carbamates - pharmacology | Index Medicus
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3. Full Text Coronavirus Main Proteinase ($3CL^{pro}$) Structure: Basis for Design of Anti-SARS Drugs
by Kanchan Anand and John Ziebuhr and Parvesh Wadhwani and Jeroen R. Mesters and Rolf Hilgenfeld
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2003, Volume 300, Issue 5626, pp. 1763 - 1767
Enzymes | Molecules | Coronavirus | Atoms | SARS | Reports | Dimers | Polyproteins | SARS virus | Monomers | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Cysteine Endopeptidases - chemistry | Coronavirus 229E, Human - enzymology | Humans | Cysteine Proteinase Inhibitors - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Cysteine Endopeptidases - metabolism | Pyrrolidinones - metabolism | Pyrrolidinones - pharmacology | Drug Design | Amino Acid Chloromethyl Ketones - metabolism | Cysteine Proteinase Inhibitors - chemistry | Binding Sites | Dimerization | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Transmissible gastroenteritis virus - enzymology | Catalytic Domain | Protein Structure, Secondary | Amino Acid Chloromethyl Ketones - chemistry | Isoxazoles - metabolism | Crystallization | Models, Molecular | Recombinant Proteins - chemistry | SARS Virus - drug effects | Antiviral Agents | Isoxazoles - chemistry | Severe Acute Respiratory Syndrome - drug therapy | Pyrrolidinones - chemistry | Isoxazoles - pharmacology | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation | SARS Virus - enzymology | Severe acute respiratory syndrome | Research | Coronaviruses | Proteins | Viruses | Drug therapy | Index Medicus
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4. Full Text Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
by Powers, James C and Asgian, Juliana L and Ekici, Özlem Doǧan and James, Karen Ellis
Chemical reviews, ISSN 0009-2665, 12/2002, Volume 102, Issue 12, pp. 4639 - 4750
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Cysteine Proteinase Inhibitors - therapeutic use | Humans | Protease Inhibitors - chemistry | Structure-Activity Relationship | Serine Proteinase Inhibitors - therapeutic use | Protease Inhibitors - pharmacology | Endopeptidases - chemistry | Animals | Serine Proteinase Inhibitors - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Protein Binding | Cysteine Proteinase Inhibitors - chemistry | Molecular Structure | Kinetics | Protease Inhibitors - therapeutic use | Binding Sites | Serine Proteinase Inhibitors - pharmacology | Proteins | Enzymes | Biochemistry | Disease | Index Medicus
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5. Full Text Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa
by Huang, Xin and Dementiev, Alexey and Olson, Steven T and Gettins, Peter G. W and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of biological chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 26, pp. 20399 - 20409
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Factor Xa - chemistry | Calcium - metabolism | Glutamic Acid - genetics | Humans | Crystallography, X-Ray | Blood Proteins - metabolism | Serpins - chemistry | Calcium - chemistry | Cysteine - genetics | Blood Proteins - genetics | Light | Cell Membrane - metabolism | Cysteine - metabolism | Scattering, Radiation | Phospholipids - metabolism | Tyrosine - chemistry | Protein Structure, Tertiary | Serpins - genetics | Serpins - metabolism | Models, Molecular | Phospholipids - chemistry | Binding Sites - genetics | Blood Proteins - chemistry | Cysteine - chemistry | Factor Xa - metabolism | Tyrosine - metabolism | Protein Binding | Protein Conformation | Glutamic Acid - metabolism | Kinetics | Mutation | Glutamic Acid - chemistry | Tyrosine - genetics | Index Medicus | MUTAGENESIS | SPECIFICITY | BASIC BIOLOGICAL SCIENCES | ACYLATION | MEMBRANES | PHOSPHOLIPIDS | CRYSTALLOGRAPHY | SIMULATION | 60 APPLIED LIFE SCIENCES | CONFORMATIONAL CHANGES | ACCELERATION | TYROSINE | MUTATIONS | PROTEINS | RESIDUES | Protein Structure and Folding | Serpin | Protease | X-ray Crystallography | Coagulation Factors | Enzymology | Protease Inhibitor | Protein-Protein Interactions
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