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science & technology (36) 36
animals (27) 27
humans (26) 26
life sciences & biomedicine (26) 26
amino acid sequence (20) 20
molecular sequence data (20) 20
cystine-knot miniproteins - chemistry (19) 19
biochemistry & molecular biology (18) 18
models, molecular (18) 18
peptides (16) 16
protein binding (15) 15
cystine-knot miniproteins - metabolism (14) 14
mice (12) 12
protein conformation (12) 12
cysteine (10) 10
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cell line, tumor (9) 9
cyclotides - chemistry (9) 9
multidisciplinary sciences (8) 8
proteins (8) 8
science & technology - other topics (8) 8
amino acids (7) 7
cyclotides - metabolism (7) 7
female (7) 7
mice, nude (7) 7
peptides - chemistry (7) 7
protein engineering (7) 7
tumors (7) 7
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peptide library (6) 6
recombinant proteins - chemistry (6) 6
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analysis (5) 5
biophysics (5) 5
cell biology (5) 5
chemistry (5) 5
cystine - chemistry (5) 5
cystine knot motifs (5) 5
cystine-knot miniproteins - genetics (5) 5
cystine-knot miniproteins - pharmacology (5) 5
drug discovery (5) 5
integrin alphavbeta3 - metabolism (5) 5
integrins - metabolism (5) 5
knottin (5) 5
mutation (5) 5
pharmacology & pharmacy (5) 5
plant proteins - metabolism (5) 5
protein structure, tertiary (5) 5
research (5) 5
research article (5) 5
science (5) 5
biotechnology (4) 4
cancer (4) 4
cyclotides - genetics (4) 4
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genetic aspects (4) 4
inhibitors (4) 4
integrins (4) 4
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medicine (4) 4
peptide hydrolases - metabolism (4) 4
physical sciences (4) 4
physiological aspects (4) 4
plant proteins - chemistry (4) 4
plant proteins - genetics (4) 4
protein structure, secondary (4) 4
sequence homology, amino acid (4) 4
trypsin (4) 4
amino acid motifs (3) 3
angiogenesis (3) 3
binding sites (3) 3
biochemical research methods (3) 3
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biosynthesis (3) 3
cell line (3) 3
chemical bonds (3) 3
chromatography, high pressure liquid (3) 3
cyclic cystine knot (3) 3
cyclic peptides (3) 3
cyclotides - pharmacology (3) 3
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cysteine endopeptidases - metabolism (3) 3
cystine-knot miniproteins - chemical synthesis (3) 3
cystine-knot miniproteins - pharmacokinetics (3) 3
cystine-knot miniproteins - therapeutic use (3) 3
cystine-knot peptide (3) 3
fluorescence (3) 3
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fungi (3) 3
gene expression (3) 3
imaging (3) 3
k562 cells (3) 3
kalata b1 (3) 3
life sciences (3) 3
mass spectrometry (3) 3
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1. Full Text Targeting the tumor vasculature with engineered cystine-knot miniproteins
by Lui, Bonny Gaby and Salomon, Nadja and Wuestehube-Lausch, Joycelyn and Daneschdar, Matin and Schmoldt, Hans-Ulrich and Tuereci, Ozlem and Sahin, Ugur
Nature communications, ISSN 2041-1723, 01/2020, Volume 11, Issue 1, pp. 295 - 295
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Surface Plasmon Resonance | Optical Imaging | Cystine-Knot Miniproteins - metabolism | Humans | Cystine-Knot Miniproteins - genetics | Peptide Library | Fluorescent Dyes - therapeutic use | Cystine-Knot Miniproteins - therapeutic use | Glioblastoma - diagnostic imaging | Protein Engineering | Cystine-Knot Miniproteins - chemistry | Glioblastoma - metabolism | Binding Sites | Recombinant Proteins - metabolism | Fluorescent Dyes - chemistry | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Fibronectins - metabolism | Amino Acid Motifs | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Fibronectins - genetics | Mice | Glioblastoma - blood supply | Alternative splicing | Oligomerization | Tumor markers | Target recognition | Peptides | Display devices | Xenotransplantation | Phages | Glioblastoma | Fluorescence | Fibronectin | Cystine | Organic chemistry | Phage display | Imaging | Animal tissues | Xenografts | Ligands | Conjugation | Probes | Combinatorial analysis | Knots | Tumors | Index Medicus
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2. Full Text Protecting Encapsulin Nanoparticles with Cysteine-Knot Miniproteins
by Klem, Robin and de Ruiter, Mark V and Cornelissen, Jeroen J.L.M
Molecular pharmaceutics, ISSN 1543-8384, 08/2018, Volume 15, Issue 8, pp. 2991 - 2996
protease inhibitor | antibody substitute | Pharmaceutical Science | bacterial nanocompartment | UT-Hybrid-D | Molecular Medicine | nanocage | Drug Discovery | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Proteins - metabolism | Nanoparticles - chemistry | Administration, Oral | Trypsin Inhibitors - pharmacology | Trypsin - metabolism | Bacterial Proteins - administration & dosage | Drug Carriers - chemistry | Drug Carriers - pharmacology | Recombinant Proteins - administration & dosage | Trypsin Inhibitors - chemistry | Proteolysis | Thermotoga maritima | Cystine-Knot Miniproteins - chemistry | Bacterial Proteins - metabolism | Cystine-Knot Miniproteins - pharmacology | Index Medicus
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3. Full Text The cyclotide family of circular miniproteins: Nature's combinatorial peptide template
by Craik, David J and Čemažar, Maša and Wang, Conan K. L and Daly, Norelle L
Peptide Science, ISSN 0006-3525, 2006, Volume 84, Issue 3, pp. 250 - 266
NMR structure determination | molecular scaffold | kalata B1 | drug design | cyclic cystine knot | Drug design | Kalata B1 | Cyclic cystine knot | Molecular scaffold | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Protein Structure, Tertiary | Amino Acid Sequence | Cyclotides - chemistry | Cystine Knot Motifs | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Templates, Genetic | Cysteine - chemistry | Hot Temperature | Plant Proteins - genetics | Combinatorial Chemistry Techniques | Disulfides - chemistry | Plant Proteins - chemistry | Protein Denaturation | Conserved Sequence | Hydrophobic and Hydrophilic Interactions | Nuclear Magnetic Resonance, Biomolecular | Protein Conformation | Plant Proteins - metabolism | Index Medicus
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4. Full Text A cystine‐knot miniprotein from tomato fruit inhibits endothelial cell migration and angiogenesis by affecting vascular endothelial growth factor receptor (VEGFR) activation and nitric oxide production
by Treggiari, Davide and Zoccatelli, Gianni and Molesini, Barbara and Degan, Maurizio and Rotino, Giuseppe Leonardo and Sala, Tea and Cavallini, Chiara and MacRae, Calum A and Minuz, Pietro and Pandolfini, Tiziana
Molecular nutrition & food research, ISSN 1613-4125, 11/2015, Volume 59, Issue 11, pp. 2255 - 2266
Cystine‐knot protein | Angiogenesis | VEGFA signaling | Cell migration | Tomato fruit | Cystine-knot protein | Life Sciences & Biomedicine | Food Science & Technology | Science & Technology | Human Umbilical Vein Endothelial Cells | Nitric Oxide - biosynthesis | Receptors, Vascular Endothelial Growth Factor - physiology | Cystine-Knot Miniproteins - isolation & purification | Phosphorylation | Plant Proteins - pharmacology | Fruit - chemistry | Humans | Cells, Cultured | Angiogenesis Inhibitors - pharmacology | Zebrafish | Cell Movement - drug effects | Animals | Lycopersicon esculentum - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Cystine-Knot Miniproteins - pharmacology | Endothelial Cells - physiology | Endothelial Cells - drug effects | Antioxidants | Cysteine | Fruit | Analysis | Nitric oxide | Vascular endothelial growth factor | Lycopene | Cystine | Index Medicus
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5. Full Text Grafting of thrombopoietin‐mimetic peptides into cystine knot miniproteins yields high‐affinity thrombopoietin antagonists and agonists
by Krause, Sebastian and Schmoldt, Hans‐Ulrich and Wentzel, Alexander and Ballmaier, Matthias and Friedrich, Karlheinz and Kolmar, Harald
The FEBS journal, ISSN 1742-464X, 01/2007, Volume 274, Issue 1, pp. 86 - 95
thrombopoietin mimetics | c‐Mpl receptor | cystine knot proteins | peptide agonist | thrombocytopenia | Thrombocytopenia | Cystine knot proteins | Peptide agonist | Thrombopoietin mimetics | c-Mpl receptor | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cystine Knot Motifs | Peptides - chemistry | Humans | Cells, Cultured | Thrombopoietin - antagonists & inhibitors | Receptors, Thrombopoietin - metabolism | Recombinant Fusion Proteins - metabolism | Peptides - pharmacology | Thrombopoietin - agonists | Animals | Transfection | Recombinant Fusion Proteins - genetics | Mice | Megakaryocytes - cytology | Megakaryocytes - metabolism | Dimerization | Bone Marrow Cells - metabolism | Peptides | Proteins | Pharmacology | Antagonist drugs | Rodents | Index Medicus
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6. Full Text Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase—Mediated Biosynthesis
by Joshua S. Mylne and Lai Yue Chan and Aurelie H. Chanson and Norelle L. Daly and Hanno Schaefer and Timothy L. Bailey and Philip Nguyencong and Laura Cascales and David J. Craik
The Plant cell, ISSN 1040-4651, 7/2012, Volume 24, Issue 7, pp. 2765 - 2778
Proteins | Polymerase chain reaction | Cyclic peptides | DNA | Squashes | Protein precursors | Amino acids | Biosynthesis | Open reading frames | Free energy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Cell Biology | Cyclotides - chemistry | Cystine-Knot Miniproteins - metabolism | Molecular Sequence Data | Cystine-Knot Miniproteins - genetics | Phylogeny | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Cysteine Endopeptidases - metabolism | Peptides, Cyclic - genetics | Cystine-Knot Miniproteins - chemistry | DNA, Plant - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Models, Molecular | Momordica - metabolism | Cyclotides - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Sequence Homology, Amino Acid | Sequence Alignment | Gene Amplification | Cyclotides - metabolism | Momordica - genetics | Protein Conformation | Evolution, Molecular | Arabidopsis thaliana | Synthesis | Peptides | Plant genetics | Genetic aspects | Research | Observations | Index Medicus | s
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7. Full Text The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis
by Greenwood, Kathryn P and Daly, Norelle L and Brown, Darren L and Stow, Jennifer L and Craik, David J
The international journal of biochemistry & cell biology, ISSN 1357-2725, 2007, Volume 39, Issue 12, pp. 2252 - 2264
MCoTI-II | Protein engineering | Cyclotides | Cyclic cystine knot | Cell-penetrating peptides | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Temperature | Cyclotides - chemistry | Lysosomes - chemistry | Humans | Molecular Sequence Data | Rhodamines - metabolism | Endosomes - metabolism | Membrane Proteins - analysis | Lysosomes - metabolism | Seeds - chemistry | Cyclotides - pharmacology | Lysosome-Associated Membrane Glycoproteins - analysis | Momordica - chemistry | Vesicular Transport Proteins - analysis | Dextrans - metabolism | Amino Acid Sequence | Cell Line | Cell Survival - drug effects | Biotinylation | Magnetic Resonance Spectroscopy | Macrophages - cytology | Sequence Homology, Amino Acid | Macrophages - metabolism | Animals | Pinocytosis - physiology | Cell Line, Tumor | Endosomes - chemistry | Cyclotides - metabolism | Microscopy, Fluorescence | Index Medicus
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8. Full Text Pharmacokinetically stabilized cystine knot peptides that bind Alpha-v-Beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer
by Kimura, Richard H and Teed, Robert and Hackel, Benjamin J and Pysz, Marybeth A and Chuang, Courtney Z and Sathirachinda, Ataya and Willmann, Jürgen K and Gambhir, Sanjiv S
Clinical cancer research, ISSN 1078-0432, 02/2012, Volume 18, Issue 3, pp. 839 - 849
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Bioengineering | Pancreatic Neoplasms - metabolism | Radiopharmaceuticals - pharmacokinetics | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - diagnosis | Humans | Positron-Emission Tomography - methods | Cystine-Knot Miniproteins - chemical synthesis | Integrins - metabolism | Radiopharmaceuticals - chemical synthesis | Tissue Distribution | Animals | Mice, Nude | Antigens, Neoplasm - metabolism | Cystine-Knot Miniproteins - chemistry | Cystine-Knot Miniproteins - pharmacokinetics | Protein Binding | Female | Mice | Index Medicus
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9. Full Text Insecticidal activity of a recombinant knottin peptide from Loxosceles intermedia venom and recognition of these peptides as a conserved family in the genus
by Matsubara, F. H and Meissner, G. O and Herzig, V and Justa, H. C and Dias, B. C. L and Trevisan‐Silva, D and Gremski, L. H and Gremski, W and Senff‐Ribeiro, A and Chaim, O. M and King, G. F and Veiga, S. S
Insect molecular biology, ISSN 0962-1075, 02/2017, Volume 26, Issue 1, pp. 25 - 34
inhibitor cystine knot | venom | knottin | Loxosceles | brown spider | bioinsecticide | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Entomology | Science & Technology | Amino Acid Sequence | Cystine-Knot Miniproteins - isolation & purification | Electrophoresis, Polyacrylamide Gel | Escherichia coli | Transcriptome | Brown Recluse Spider - metabolism | Molecular Sequence Data | Recombinant Proteins - chemistry | Cystine-Knot Miniproteins - genetics | Proteome | Recombinant Proteins - biosynthesis | Phosphoric Diester Hydrolases - chemistry | Animals | Base Sequence | Brown Recluse Spider - genetics | Conserved Sequence | Cystine-Knot Miniproteins - chemistry | Cystine-Knot Miniproteins - biosynthesis | Spider Venoms - chemistry | Toxicity Tests | Diptera | Insecticides - analysis | Cysteine | Glycoproteins | Paralysis | Peptides | Venom | Index Medicus
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10. Full Text The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels
by Bende, Niraj S and Kang, Eunji and Herzig, Volker and Bosmans, Frank and Nicholson, Graham M and Mobli, Mehdi and King, Glenn F
Biochemical pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 10, pp. 1542 - 1554
Spider-venom peptide | Gating modifier | Inhibitor cystine knot | Pore blocker | Neurotoxin | Voltage-gated sodium channel | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cystine-Knot Miniproteins - metabolism | Molecular Sequence Data | Neurons - cytology | Spider Venoms - pharmacology | Diptera - metabolism | Periplaneta - drug effects | Disulfides - chemistry | Cystine-Knot Miniproteins - chemistry | Neurons - metabolism | Spider Venoms - metabolism | Neurons - drug effects | Insect Proteins - metabolism | Spider Venoms - chemistry | Spiders - chemistry | Spiders - physiology | Membrane Potentials - drug effects | Recombinant Proteins - metabolism | Amino Acid Sequence | Neurotoxins - chemistry | Protein Structure, Secondary | Models, Molecular | Recombinant Proteins - chemistry | Sodium Channel Blockers - metabolism | Sodium Channel Blockers - pharmacology | Recombinant Proteins - pharmacology | Insect Proteins - antagonists & inhibitors | Periplaneta - metabolism | Neurotoxins - pharmacology | Patch-Clamp Techniques | Animals | Escherichia coli - genetics | Insect Proteins - chemistry | Diptera - drug effects | Neurotoxins - metabolism | Voltage-Gated Sodium Channels - chemistry | Sodium Channel Blockers - chemistry | Kinetics | Primary Cell Culture | Cystine-Knot Miniproteins - pharmacology | Voltage-Gated Sodium Channels - metabolism | Peptides | Index Medicus | neurotoxin | pore blocker | inhibitor cystine knot | gating modifier | voltage-gated sodium channel | spider-venom peptide
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