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Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 44, pp. 31715 - 31727
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 28, pp. 11554 - 11559
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 766 - 774
Childhood acute lymphoblastic leukemia (ALL) can often be traced to a pre-leukemic clone carrying a prenatal genetic lesion. Postnatally acquired mutations... 
B-CELL DEVELOPMENT | RECOMBINATION | CYTIDINE DEAMINASE AID | ACTIVATION | GENE | CHROMOSOME TRANSLOCATIONS | IMMUNOLOGY | CLASS SWITCH | EXPRESSION | MONOZYGOTIC TWINS | DAY-CARE | Cytidine Deaminase - immunology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Homeodomain Proteins - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Child, Preschool | Immunoblotting | Infant | Male | Precursor Cells, B-Lymphoid - immunology | Homeodomain Proteins - immunology | Clonal Evolution - genetics | DNA-Binding Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Antibody Diversity - genetics | Flow Cytometry | Antibody Diversity - immunology | Female | Tumor Cells, Cultured | Child | B-Lymphocytes - metabolism | DNA-Binding Proteins - immunology | Cytidine Deaminase - genetics | Mice, Transgenic | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Mice, Knockout | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | B-Lymphocytes - immunology | Cytidine Deaminase - metabolism | Adolescent | Mice, Inbred NOD | Clonal Evolution - immunology | Microscopy, Fluorescence | Gene mutations | Genetic susceptibility | Oncology, Experimental | Genetic research | Development and progression | Genetic aspects | Acute lymphocytic leukemia | Research | Identification and classification | Health aspects | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 28, pp. 11560 - 11565
The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig... 
3T3 cells | B lymphocytes | Totipotent stem cells | Lymphocytes | Stem cells | AIDS | Bone marrow cells | Central tolerance | Immatures | Hematopoietic stem cells | B-cell development | Competitive hematopoietic reconstitution | B-cell tolerance | Lymphopoiesis | Aicda-knockout mice | lymphopoiesis | IMMUNE-RESPONSE | REPERTOIRE | SOMATIC HYPERMUTATION | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | IN-VITRO | CLASS-SWITCH RECOMBINATION | GERMINAL-CENTERS | GENERATION | EXPRESSION | competitive hematopoietic reconstitution | SYSTEMIC AUTOIMMUNITY | Cytidine Deaminase - immunology | Self Tolerance - immunology | Autoantibodies - blood | Precursor Cells, B-Lymphoid - immunology | Receptors, Antigen, B-Cell - metabolism | CD40 Ligand - immunology | Genes, Immunoglobulin Heavy Chain | Signal Transduction - immunology | Precursor Cells, B-Lymphoid - enzymology | Self Tolerance - genetics | Female | Cell Differentiation | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Somatic Hypermutation, Immunoglobulin | CD40 Ligand - deficiency | Cytidine Deaminase - genetics | Mice, Inbred C57BL | Mice, Knockout | Animals | B-Lymphocytes - immunology | CD40 Ligand - genetics | Precursor Cells, B-Lymphoid - cytology | Cytidine Deaminase - deficiency | Mice | Apoptosis | Autoimmunity | Amines | Physiological aspects | Nucleosides | Genetic aspects | B cells | Health aspects | Biological Sciences
Journal Article
Journal Article