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Drugs, ISSN 0012-6667, 11/2015, Volume 75, Issue 17, pp. 1993 - 2016
Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | IMMUNOTOXIN RFB4(DSFV)-PE38 BL22 | PEGYLATED LIPOSOMAL DOXORUBICIN | EPOTHILONE-B ANALOG | DRUG-RESISTANT PHENOTYPE | GEMTUZUMAB OZOGAMICIN | PHASE-I TRIAL | METASTATIC BREAST-CANCER | ERIBULIN MESYLATE E7389 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ANTI-MESOTHELIN IMMUNOTOXIN | CHRONIC MYELOID-LEUKEMIA | Dioxoles - therapeutic use | Diphtheria Toxin - pharmacology | Recombinant Fusion Proteins - pharmacology | Furans - pharmacology | Humans | Recombinant Fusion Proteins - therapeutic use | Interleukin-2 - therapeutic use | Epothilones - pharmacology | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Biological Products - pharmacology | Epothilones - therapeutic use | Harringtonines - therapeutic use | Furans - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Diphtheria Toxin - therapeutic use | Immunoconjugates - pharmacology | Cytochalasins - pharmacology | Dioxoles - pharmacology | Immunoconjugates - therapeutic use | Antineoplastic Agents - pharmacology | Ketones - therapeutic use | Cytochalasins - therapeutic use | Biological Products - therapeutic use | Ketones - pharmacology | Tetrahydroisoquinolines - pharmacology | Tetrahydroisoquinolines - therapeutic use | Withanolides - pharmacology | Harringtonines - pharmacology | Interleukin-2 - pharmacology | Withanolides - therapeutic use | Antimitotic agents | Care and treatment | Chemotherapy | Usage | Clinical trials | Dosage and administration | Diagnosis | Antineoplastic agents | Cancer | Index Medicus | Review
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2013, Volume 305, Issue 3, pp. C276 - C289
Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding... 
Podocyte | Glomerular filtration | TRPC6 | Mechanosensitive | Slit diaphragm | glomerular filtration | BKCA CHANNELS | PHYSIOLOGY | PROTEIN | mechanosensitive | NEPHRIN | CAPILLARY WALL | SURFACE EXPRESSION | RECEPTOR | CELL BIOLOGY | GLOMERULAR SLIT DIAPHRAGM | CATION CHANNELS | podocyte | slit diaphragm | MUTATIONS | NEPHROTIC SYNDROME | ortho-Aminobenzoates - pharmacology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Spider Venoms - pharmacology | Cytochalasin D - pharmacology | Type C Phospholipases - antagonists & inhibitors | Nephrotic Syndrome | Diglycerides - pharmacology | RNA Interference | Estrenes - pharmacology | Pyrrolidinones - pharmacology | HEK293 Cells | Kidney Glomerulus - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | TRPC Cation Channels - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phospholipase A2 Inhibitors | Guanosine Diphosphate - pharmacology | Cell Line | Podocytes - metabolism | Membrane Proteins - genetics | Phosphodiesterase Inhibitors - pharmacology | Rats | Imidazoles - pharmacology | Thionucleotides - pharmacology | Calcium Channel Blockers - pharmacology | Cinnamates - pharmacology | Peptides - pharmacology | Animals | Guanosine Diphosphate - analogs & derivatives | TRPC Cation Channels - metabolism | Chlorobenzoates - pharmacology | Mice | RNA, Small Interfering | Mutation | Ion Channel Gating
Journal Article
Glia, ISSN 0894-1491, 04/2010, Volume 58, Issue 5, pp. 622 - 631
Production of nerve growth factor (NGF) from Schwann cells (SCs) progressively declines in the distal stump, if axonal regeneration is staggered across the... 
electrical stimulation | calcium | nerve growth factor | Schwann cell | nerve injuries | Electrical stimulation | Nerve growth factor | Calcium | Nerve injuries engineering | NEUROTROPHIC FACTOR | POOR FUNCTIONAL RECOVERY | AXONAL REGENERATION | GLIAL-CELLS | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | PERIPHERAL-NERVE | RAT FEMORAL MOTONEURONS | DELAYED NERVE REPAIR | EXPRESSION | CONTRIBUTING FACTORS | Enzyme-Linked Immunosorbent Assay - methods | Calcium - metabolism | Tubulin Modulators - pharmacology | Nocodazole - pharmacology | Exocytosis - drug effects | Botulinum Toxins, Type A - pharmacology | Dose-Response Relationship, Drug | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Egtazic Acid - analogs & derivatives | Neomycin - pharmacology | Caffeine - pharmacology | Cytochalasins - pharmacology | Protein Synthesis Inhibitors - pharmacology | Cadmium Chloride - pharmacology | Electric Stimulation - methods | Schwann Cells - drug effects | Animals, Newborn | Mibefradil - pharmacology | Nerve Growth Factor - metabolism | Cells, Cultured | Phosphodiesterase Inhibitors - pharmacology | Rats | S100 Proteins - metabolism | Schwann Cells - metabolism | Biophysics | Chelating Agents - pharmacology | Calcium Channel Blockers - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Analysis of Variance
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17253 - 17258
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors... 
Phenotypes | Cell growth | Cytokines | Stem cells | Cell lines | Actins | Physiological regulation | Macrophages | Endothelial cells | Cells | FIBER | MATRIX | ACTIVATION | ACTIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | SCAFFOLDS | CULTURE | MESENCHYMAL STEM-CELLS | Mannose-Binding Lectins - metabolism | Arginase - metabolism | Lectins, C-Type - immunology | Cell Shape - immunology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Cytochalasin D - pharmacology | Lectins, C-Type - metabolism | Arginase - immunology | Interleukin-4 - pharmacology | Flow Cytometry | Doxorubicin - analogs & derivatives | Inflammation Mediators - metabolism | Female | Immunophenotyping - methods | Cell Polarity - drug effects | Doxorubicin - metabolism | Macrophages - immunology | Cytokines - immunology | Amides - pharmacology | Biomarkers - metabolism | Inflammation Mediators - immunology | Cell Polarity - immunology | Cytokines - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Biomarkers - analysis | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Interleukin-13 - pharmacology | Receptors, Cell Surface - immunology | Azepines - pharmacology | Cell Shape - drug effects | Macrophages - metabolism | Animals | Mannose-Binding Lectins - immunology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Doxorubicin - immunology | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Physiological aspects | Microbial genetics | Phenotype | Genetic aspects | Research | Biological Sciences | Physical Sciences
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 01/2005, Volume 21, Issue 1, pp. 151 - 160
The mechanisms by which uridine triphosphate (UTP) stimulates ATP release from Schwann cells cultured from the sciatic nerve were investigated using online... 
purinergic receptors | exocytosis | bioluminescence | protein kinase C | Bioluminescence | Protein kinase C | Purinergic receptors | Exocytosis | NERVE | MECHANISMS | RELEASE | ASTROCYTES | NEUROSCIENCES | UTP | NUCLEOTIDE RECEPTORS | GLUTAMATE | CALCIUM | NEURONS | SMOOTH-MUSCLE-CELLS | Guanosine Triphosphate - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Calcium - metabolism | Adenosine Triphosphate - secretion | Brefeldin A - pharmacology | Phorbol 12,13-Dibutyrate - pharmacology | Receptors, Purinergic P2Y2 | Cytochalasin D - pharmacology | Phenanthridines - pharmacology | Type C Phospholipases - antagonists & inhibitors | Diagnostic Imaging - methods | Dose-Response Relationship, Drug | Alkaloids | Botulinum Toxins - pharmacology | Glycyrrhetinic Acid - pharmacology | Drug Interactions | Isoquinolines - pharmacology | Glyburide - pharmacology | Time Factors | Botulinum Toxins, Type A | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Sciatic Nerve - cytology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Protein Synthesis Inhibitors - pharmacology | Pyridoxal Phosphate - analogs & derivatives | Schwann Cells - secretion | Suramin - pharmacology | Schwann Cells - drug effects | Animals, Newborn | Pyridoxal Phosphate - pharmacology | Uridine Triphosphate - pharmacology | Purinergic P2 Receptor Antagonists | Rats | Protein Kinase C - antagonists & inhibitors | Purinergic P2 Receptor Agonists | Sulfonamides - pharmacology | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Immunohistochemistry - methods | Animals | Benzophenanthridines | Receptors, Purinergic P2 - metabolism | Thapsigargin - pharmacology | Furosemide - pharmacology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2005, Volume 25, Issue 20, pp. 4974 - 4984
Recent linkage studies have identified a significant association of the neuregulin gene with schizophrenia, but how neuregulin is involved in schizophrenia is... 
Schizophrenia | Neuregulin | ErbB receptors | NMDA receptors | Actin | Internalization | NERVOUS-SYSTEM | PROTEIN-KINASE | neuregulin | schizophrenia | ACTIN-BASED PLASTICITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | DENDRITIC SPINES | actin | GLUTAMATE RECEPTORS | GENE-EXPRESSION | internalization | SYNAPTIC TRANSMISSION | NEUROMUSCULAR-JUNCTION | Excitatory Postsynaptic Potentials - radiation effects | Nucleic Acid Synthesis Inhibitors - pharmacology | Membrane Potentials - radiation effects | Cytochalasin D - pharmacology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Neural Inhibition - radiation effects | Drug Interactions | Thiazolidines | Egtazic Acid - analogs & derivatives | Neurons - physiology | Neurons - drug effects | Electric Stimulation - methods | Animals, Newborn | Membrane Potentials - drug effects | Boron Compounds - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Chelating Agents - pharmacology | Neuregulin-1 - pharmacology | Pyrimidines - pharmacology | Prefrontal Cortex - cytology | Rats, Sprague-Dawley | Receptors, N-Methyl-D-Aspartate - physiology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Egtazic Acid - pharmacology | Signal Transduction - drug effects | Neuregulin-1 - metabolism | Signal Transduction - physiology | Thiazoles - pharmacology | Neural Inhibition - drug effects | Cellular | Molecular
Journal Article
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 08/2015, Volume 789-790, pp. 7 - 27
Journal Article
Biophysical Journal, ISSN 0006-3495, 2000, Volume 78, Issue 1, pp. 520 - 535
The effect of various drugs affecting the integrity of different components of the cytoskeleton on the elasticity of two fibroblast cell lines was investigated... 
CELLS | TAXOL BINDS | PHALLOIDIN | PROSTATE CARCINOMA | BIOPHYSICS | ACTIN | DISSOCIATION | CYTOCHALASIN | HUMAN PLATELETS | POLYMERIZATION | DISRUPT MICROFILAMENT ORGANIZATION | Drugs | Fluorescence | Atomic force microscopy | Molecular biology | Cells
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2004, Volume 24, Issue 45, pp. 10149 - 10158
Neuronal activity is accompanied by transmembranous ion fluxes that cause cell volume changes. In whole mounts of the guinea pig retina, application of... 
Dopamine | Ischemia | Neuroglia | Circadian phase | Retina | Glutamate | ATP | RAT SPINAL-CORD | D-2 DOPAMINE-RECEPTORS | MECHANISM | circadian phase | RELEASE | ASTROCYTES | NEUROSCIENCES | SPREADING DEPRESSION | BIPOLAR | ischemia | TRANSPORT | neuroglia | retina | dopamine | glutamate | MULLER CELLS | Retina - drug effects | Neuroglia - ultrastructure | Nocodazole - pharmacology | Dicarboxylic Acids - pharmacology | Cytochalasin D - pharmacology | Amino Acids - pharmacology | N-Methylaspartate - pharmacology | Neuroglia - drug effects | Pyrrolidines - pharmacology | Adenosine Triphosphate - pharmacology | Neurons - ultrastructure | Retina - cytology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Synaptic Transmission - drug effects | Glutamic Acid - secretion | Neurons - drug effects | Receptors, Kainic Acid - drug effects | Ischemia - pathology | Xanthenes - pharmacology | Retinal Ganglion Cells - ultrastructure | Guinea Pigs | Glutamic Acid - pharmacology | Receptors, AMPA - physiology | Cell Size - drug effects | Kainic Acid - pharmacology | Dopamine - pharmacology | Circadian Rhythm | Potassium - pharmacology | Animals | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Eye Proteins - drug effects | Cytoskeleton - physiology | Eye Proteins - physiology | Receptors, Kainic Acid - physiology | Receptors, AMPA - drug effects | Aspartic Acid - pharmacology | Cytoskeleton - drug effects | Retinal Ganglion Cells - drug effects | Plasticity | Development | Repair
Journal Article
Molecular Human Reproduction, ISSN 1360-9947, 02/2015, Volume 21, Issue 10, pp. 803 - 815
In this study, we aimed to investigate modulation of glucose uptake by the HTR-8/SVneo human first-trimester extravillous trophoblast cell line by a series of... 
Glucose uptake | Proliferation | Xanthohumol | Viability | Trophoblast cells | GLUT1 | proliferation | trophoblast cells | 2-DEOXY-D-GLUCOSE | DEVELOPMENTAL BIOLOGY | viability | OBSTETRICS & GYNECOLOGY | BREAST-CANCER CELLS | HEXOSE TRANSPORTER | QUERCETIN | REPRODUCTIVE BIOLOGY | INHIBITION | glucose uptake | METABOLISM | FETAL | xanthohumol | BINDING | CATECHIN | Deoxyglucose - metabolism | Humans | Propiophenones - pharmacology | Polyphenols - pharmacology | Dexamethasone - toxicity | Stilbenes - pharmacology | Pregnancy Trimester, First | Protein-Tyrosine Kinases - physiology | Trophoblasts - drug effects | Stilbenes - toxicity | Dexamethasone - pharmacology | Phloretin - pharmacology | Female | Polyphenols - toxicity | TOR Serine-Threonine Kinases - physiology | Biological Transport - drug effects | Flavonoids - pharmacology | Propiophenones - toxicity | Trophoblasts - cytology | Phlorhizin - pharmacology | Cytochalasin B - pharmacology | Placentation - drug effects | Phloretin - toxicity | Cytochalasin B - toxicity | Glucose - pharmacology | Cell Division - drug effects | Pregnancy | Cell Movement - drug effects | Flavonoids - toxicity | Melatonin - toxicity | Signal Transduction - drug effects | Glucose Transport Proteins, Facilitative - physiology | Street Drugs - toxicity | Melatonin - pharmacology | Street Drugs - pharmacology | Cell Line, Transformed | Glucose Transport Proteins, Facilitative - antagonists & inhibitors | Phlorhizin - toxicity
Journal Article
Journal Article