X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (212634) 212634
Newsletter (27988) 27988
Book Review (18019) 18019
Publication (14157) 14157
Newspaper Article (4314) 4314
Book Chapter (2292) 2292
Conference Proceeding (1092) 1092
Dissertation (778) 778
Book / eBook (139) 139
Magazine Article (115) 115
Web Resource (73) 73
Reference (57) 57
Government Document (53) 53
Trade Publication Article (36) 36
Data Set (21) 21
Streaming Video (16) 16
Paper (14) 14
Journal / eJournal (9) 9
Transcript (4) 4
Presentation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (153719) 153719
animals (80822) 80822
humans (66082) 66082
male (43477) 43477
cytochrome p-450 (42044) 42044
biochemistry & molecular biology (40081) 40081
research (32138) 32138
rats (31347) 31347
female (28516) 28516
cytochrome p-450 enzyme system - metabolism (26710) 26710
pharmacology & pharmacy (26449) 26449
apoptosis (22143) 22143
analysis (22125) 22125
cytochrome c (19846) 19846
proteins (19320) 19320
cytochrome (18761) 18761
metabolism (18590) 18590
physiological aspects (18276) 18276
mice (17631) 17631
cytochrome-c (16672) 16672
mitochondria (16475) 16475
cytochrome p450 (16373) 16373
enzymes (16338) 16338
kinetics (15038) 15038
oxidation-reduction (14509) 14509
toxicology (14216) 14216
cell biology (13729) 13729
expression (12852) 12852
molecular sequence data (12578) 12578
cytochromes (12543) 12543
cytochrome p-450 enzyme system - genetics (12383) 12383
genetic aspects (12237) 12237
adult (11773) 11773
reports (11725) 11725
liver (10843) 10843
biophysics (10528) 10528
oxidative stress (10443) 10443
genes (10278) 10278
cancer (10235) 10235
middle aged (10164) 10164
universities and colleges (10088) 10088
microsomes, liver - enzymology (10065) 10065
mitochondrial dna (10036) 10036
mitochondria - metabolism (10008) 10008
cytochrome oxidase (9846) 9846
gene expression (9720) 9720
amino acid sequence (9701) 9701
cytochrome b (9405) 9405
apoptosis - drug effects (8962) 8962
oncology (8894) 8894
phylogeny (8775) 8775
electron transport (8395) 8395
activation (8190) 8190
liver - enzymology (8038) 8038
genetics & heredity (7992) 7992
mutation (7991) 7991
base sequence (7982) 7982
biochemistry (7939) 7939
genotype (7819) 7819
in-vitro (7566) 7566
dose-response relationship, drug (7529) 7529
article (7459) 7459
cells, cultured (7362) 7362
liver - metabolism (7320) 7320
dna (7319) 7319
pharmacokinetics (7135) 7135
rats, sprague-dawley (7110) 7110
identification (7097) 7097
microsomes, liver - metabolism (7027) 7027
genetic research (7002) 7002
induction (6998) 6998
cytochromes c - metabolism (6902) 6902
protein binding (6880) 6880
liver - drug effects (6864) 6864
inhibition (6846) 6846
drug interactions (6768) 6768
time factors (6729) 6729
metabolites (6565) 6565
models, molecular (6468) 6468
aged (6454) 6454
hydroxylation (6424) 6424
in vitro techniques (6365) 6365
multidisciplinary sciences (6340) 6340
neurosciences (6250) 6250
cells (6228) 6228
life sciences (6201) 6201
oxidation (6117) 6117
chemistry, multidisciplinary (6047) 6047
cytochrome-c-oxidase (6039) 6039
protein (6015) 6015
cytochrome c group - metabolism (5899) 5899
binding sites (5725) 5725
cell line, tumor (5713) 5713
microsomes, liver - drug effects (5674) 5674
protein conformation (5628) 5628
research article (5574) 5574
health aspects (5571) 5571
drugs (5536) 5536
cell line (5483) 5483
cytochrome-c release (5427) 5427
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (75) 75
Online Resources - Online (49) 49
Collection Dvlpm't (Acquisitions) - Vendor file (6) 6
Collection Dvlpm't (Acquisitions) - Closed Orders (5) 5
Gerstein Science - Theses (4) 4
UTL at Downsview - May be requested (4) 4
Chemistry (A D Allen) - Stacks (3) 3
University Archives - Archives (3) 3
UofT at Mississauga - Stacks (2) 2
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (240152) 240152
Russian (2114) 2114
Japanese (1426) 1426
Chinese (1300) 1300
German (879) 879
French (819) 819
Spanish (389) 389
Polish (266) 266
Korean (243) 243
Portuguese (106) 106
Italian (92) 92
Czech (62) 62
Dutch (56) 56
Hungarian (38) 38
Ukrainian (35) 35
Norwegian (26) 26
Swedish (26) 26
Turkish (26) 26
Danish (24) 24
Bulgarian (23) 23
Slovak (17) 17
Croatian (10) 10
Finnish (9) 9
Persian (9) 9
Slovenian (8) 8
Romanian (7) 7
Hebrew (6) 6
Indonesian (4) 4
Serbian (4) 4
Lithuanian (3) 3
Vietnamese (3) 3
Arabic (2) 2
Greek (2) 2
Afrikaans (1) 1
Catalan (1) 1
Icelandic (1) 1
Welsh (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1993, Handbook of experimental pharmacology, ISBN 3540559086, Volume 105., xxxiv, 739
Book
Biochemistry, ISSN 0006-2960, 02/2018, Volume 57, Issue 5, pp. 817 - 826
Human hepatic cytochromes P450 (CYP)' are integral to xenobiotic metabolism. CYP2B6 is a major catalyst of biotransformation of environmental toxicants,... 
SIDE-CHAINS | ACTIVE-SITE | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MAMMALIAN CYTOCHROME-P450 | LIVER-MICROSOMES | HUMAN CYTOCHROME-P450 2B6 | SITE-DIRECTED MUTAGENESIS | OXIDATIVE-METABOLISM | DRUG-METABOLISM | Cytochrome P-450 CYP2B1 - genetics | Aniline Compounds | Humans | Aryl Hydrocarbon Hydroxylases - genetics | NADPH Oxidases - metabolism | Substrate Specificity | Cytochrome P-450 Enzyme Inhibitors - metabolism | Structure-Activity Relationship | Environmental Pollutants - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Cytochrome P-450 CYP2B6 - drug effects | Hydrocarbons, Halogenated - metabolism | Cytochrome P-450 CYP2B1 - chemistry | Cytochrome P450 Family 2 - genetics | Inhibitory Concentration 50 | Cytochrome P-450 CYP2B1 - metabolism | Molecular Structure | Aryl Hydrocarbon Hydroxylases - chemistry | Benzene Derivatives - pharmacology | Cytochrome P450 Family 2 - antagonists & inhibitors | Recombinant Proteins - metabolism | Rabbits | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Mutagenesis, Site-Directed | Oxidation-Reduction | Cytochrome P-450 CYP2B6 - genetics | Halogenated Diphenyl Ethers - pharmacology | Rats | Cytochrome P450 Family 2 - chemistry | Cytochrome P-450 CYP2B1 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Halogenated Diphenyl Ethers - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Alkylation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Amino Acid Substitution | Research | Chemical properties | Aniline | Cytochrome P-450 | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1217 - 1228
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
2008, Issues in toxicology, ISBN 0854042741, xviii, 521
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to... 
Cytochrome P-450 -- Physiological effect | Xenobiotics -- Metabolism | Biology, life sciences | Cytochrome P-450 | Chemistry | Organic | SCIENCE | Xenobiotics | Metabolism
Book
2016, Advances in Photosynthesis and Respiration, ISBN 9789401774819, Volume 41.
Web Resource
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However,... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | DNA Methylation | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Transcription, Genetic | Cell Differentiation | Chromatin - ultrastructure | Cell Line | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Signal Transduction | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | CpG Islands | Cytochrome P-450 CYP2D6 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Primary Cell Culture | Epigenetic inheritance | Methylation | Embryonic stem cells | Genes | Cytochrome P-450 | Cytochrome | Chromatin | Transcription | Toxicity | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Hepatocytes | Stem cells | Pluripotency | Combinatorial analysis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
2015, ISBN 9780128031193, 506
Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the... 
Clinical & internal medicine | Cytochrome P-450 | Metalloenzymes | Pharmaceutical industry | Drug testing | Cancer
eBook
1996, ISBN 9780849392245, 411
Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of... 
Metabolic detoxification | Xenobiotics | Metabolism | Metabolic detoxication | Physiological effect | Cytochrome P-450
Book
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2016, Volume 119, Issue 3, pp. 284 - 290
Cytochrome P450 ( CYP ) activity can be assessed using a ‘cocktail’ phenotyping approach. Recently, we have developed a cocktail (Geneva cocktail) which... 
2D6 | PARAXANTHINE | BUPROPION | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FLURBIPROFEN | METABOLIZING-ENZYMES | COOPERSTOWN 5+1 COCKTAIL | ORAL-CONTRACEPTIVES | P-GLYCOPROTEIN | Caffeine - administration & dosage | Humans | Midazolam - administration & dosage | Male | Genotyping Techniques | Cytochrome P-450 CYP2B6 - metabolism | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Dried Blood Spot Testing - methods | Cytochrome P-450 CYP1A2 - genetics | Flurbiprofen - administration & dosage | Adult | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 CYP2B6 - genetics | Omeprazole - administration & dosage | Cytochrome P-450 CYP2C19 - genetics | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Bupropion - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Cross-Over Studies | Phenotype | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - administration & dosage | Medical examination | Drug interactions | Analysis | Methods | Blood | Cytochrome P-450 | Confidence intervals | Cytochrome | Prescription drugs | Drug dosages | Index Medicus
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 2018, Volume 13, pp. 8561 - 8575
Introduction and objective: Currently, carbon nanostructures are vastly explored materials with potential for future employment in biomedicine. The possibility... 
Nanoparticles | Carbon nanostructures | Cytochrome p450 | Liver | Microsomes | liver | POLYCYCLIC AROMATIC-HYDROCARBONS | NANOMATERIALS | NANOSCIENCE & NANOTECHNOLOGY | TOXICITY | carbon nanostructures | cytochrome P450 | INDUCTION | DRUG-METABOLIZING-ENZYMES | WALLED CARBON NANOTUBES | nanoparticles | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | EXPRESSION | CYTOCHROME-P450 ENZYME | microsomes | Cytochrome P-450 CYP2D6 - genetics | Nanostructures - ultrastructure | Cytochrome P-450 Enzyme Inhibitors | Cell Survival | Humans | Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Fluorescence | Hydrodynamics | Hepatocytes - metabolism | Diamond - chemistry | Cytochrome P-450 CYP1A2 - metabolism | Down-Regulation - genetics | Hep G2 Cells | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Nanostructures - chemistry | Graphite - chemistry | Cytochrome P-450 Enzyme System - pharmacology | Hepatocytes - drug effects | Diamond crystals | RNA | Isoenzymes | Graphene | Genes | Cytochrome P-450 | Diamonds | Graphite | Genetic research | Genetic aspects | Gene expression | Cytochrome | Enzymes | Drug delivery systems | Nanomaterials | Metabolism | Carbon | Drug dosages | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e93261 - e93261
Intratumoral expression of genes encoding Cytochrome P450 enzymes (CYP) might play a critical role not only in cancer development but also in the metabolism of... 
PEDIATRIC RHABDOMYOSARCOMA | CYP2W1 | THERAPY | METABOLISM | MULTIDISCIPLINARY SCIENCES | SARCOMA | PREVENTION | CYP3A4/5 | CYP1B1 | CANCER | CHILDREN | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Prospective Studies | Follow-Up Studies | Humans | Rhabdomyosarcoma - metabolism | Gene Expression Regulation, Neoplastic | Child, Preschool | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Infant | Male | Muscle, Skeletal - metabolism | Cytochrome P-450 CYP2E1 - genetics | Gene Expression Profiling | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P450 Family 2 | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Biomarkers, Tumor - metabolism | Female | Child | Real-Time Polymerase Chain Reaction | RNA, Messenger - genetics | Cytochrome P-450 CYP1A1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cytochrome P-450 CYP1A2 - metabolism | Blotting, Western | Gene Expression Regulation, Enzymologic | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 Enzyme System - genetics | Biomarkers, Tumor - genetics | Rhabdomyosarcoma - genetics | Cytochrome | Drugs | Rhabdomyosarcoma | Chemoresistance | Families & family life | Drug development | Tissues | Cancer therapies | Antitumor agents | Rodents | Drug metabolism | Children | Enzymes | Prodrugs | Cytochrome P450 | CYP gene | CYP1A2 protein | Metabolism | Gene expression | Chemical compounds | Patients | Polymerase chain reaction | Musculoskeletal system | Chemotherapy | Tumors | Cancer | Index Medicus
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 08/2016, Volume 119, Issue 2, pp. 173 - 183
Sunitinib ( SUN ) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To... 
BREAST-CANCER | DIACYLGLYCEROL ACYLTRANSFERASE | TYROSINE KINASE INHIBITOR | RECEPTOR | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCTION | CYTOCHROME-P450 3A4 | DRUG TRANSPORT | PHASE-I | RENAL-CELL CARCINOMA | HEPATITIS-E | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Liver - enzymology | Rats, Wistar | Kidney - enzymology | Aryl Hydrocarbon Hydroxylases - genetics | Transcriptome | Cytochrome P-450 Enzyme System - metabolism | Cytochrome P-450 CYP1B1 - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Steroid 16-alpha-Hydroxylase - metabolism | RNA, Messenger - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucuronosyltransferase - genetics | Glutathione Transferase - genetics | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Isoenzymes - metabolism | Cytochrome P-450 CYP1A2 - genetics | Lipid Peroxidation - drug effects | ATP-Binding Cassette Transporters - metabolism | Cytochrome P450 Family 2 - genetics | Indoles - pharmacology | Xenobiotics - metabolism | Steroid 16-alpha-Hydroxylase - antagonists & inhibitors | Cytochrome P450 Family 2 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Kidney - drug effects | Isoenzymes - genetics | RNA, Messenger - genetics | Glutathione Transferase - metabolism | Rats | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Cytochrome P450 Family 4 - metabolism | Pyrroles - pharmacology | Animals | Cytochrome P450 Family 2 - metabolism | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Steroid 16-alpha-Hydroxylase - genetics | Cytochrome P450 Family 4 - genetics | Antimitotic agents | Enzymes | Antineoplastic agents | Liver | Proteins | Protein expression | Rodents | Index Medicus
Journal Article