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Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1217 - 1228
Journal Article
1993, 2nd ed., ISBN 9784062054607, xii, 292
Book
1978, Kodansha scientific books., ISBN 0126198500, xii, 233
Book
2008, Issues in toxicology, ISBN 0854042741, xviii, 521
During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to... 
Cytochrome P-450 -- Physiological effect | Xenobiotics -- Metabolism | Biology, life sciences | Cytochrome P-450 | Chemistry | Organic | SCIENCE | Xenobiotics | Metabolism
Book
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2016, Volume 119, Issue 3, pp. 284 - 290
Cytochrome P450 ( CYP ) activity can be assessed using a ‘cocktail’ phenotyping approach. Recently, we have developed a cocktail (Geneva cocktail) which... 
2D6 | PARAXANTHINE | BUPROPION | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FLURBIPROFEN | METABOLIZING-ENZYMES | COOPERSTOWN 5+1 COCKTAIL | ORAL-CONTRACEPTIVES | P-GLYCOPROTEIN | Cytochrome P-450 CYP2C9 | CYP3A protein, human | Cytochrome P-450 CYP3A | Dried Blood Spot Testing | Humans | fexofenadine | Male | Dextromethorphan | Genotyping Techniques | Dose-Response Relationship, Drug | Young Adult | CYP2C9 protein, human | CYP2C19 protein, human | CYP2B6 protein, human | Bupropion | Drug Interactions | Adult | Female | Cytochrome P-450 CYP1A2 | Caffeine | Flurbiprofen | Terfenadine | Cytochrome P-450 Enzyme System | Index Medicus | Cross-Over Studies | Omeprazole | Phenotype | Cytochrome P-450 CYP2C19 | Adolescent | Midazolam | CYP1A2 protein, human | Cytochrome P-450 CYP2D6 | Cytochrome P-450 CYP2B6 | Confidence intervals | Cytochrome | Prescription drugs | Drug dosages | Caffeine - administration & dosage | Midazolam - administration & dosage | Cytochrome P-450 CYP2B6 - metabolism | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Cytochrome P-450 CYP3A - genetics | Dried Blood Spot Testing - methods | Cytochrome P-450 CYP1A2 - genetics | Flurbiprofen - administration & dosage | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 CYP2B6 - genetics | Omeprazole - administration & dosage | Cytochrome P-450 CYP2C19 - genetics | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Bupropion - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - administration & dosage | Medical examination | Drug interactions | Analysis | Methods | Blood | Cytochrome P-450
Journal Article
Biochemistry, ISSN 0006-2960, 02/2018, Volume 57, Issue 5, pp. 817 - 826
Human hepatic cytochromes P450 (CYP)' are integral to xenobiotic metabolism. CYP2B6 is a major catalyst of biotransformation of environmental toxicants,... 
SIDE-CHAINS | ACTIVE-SITE | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MAMMALIAN CYTOCHROME-P450 | LIVER-MICROSOMES | HUMAN CYTOCHROME-P450 2B6 | SITE-DIRECTED MUTAGENESIS | OXIDATIVE-METABOLISM | DRUG-METABOLISM | Cytochrome P-450 Enzyme Inhibitors | Aniline Compounds | Humans | Substrate Specificity | Hydrocarbons, Halogenated | Structure-Activity Relationship | Recombinant Proteins | Cytochrome P-450 CYP2B6 Inhibitors | Alkylation | Cytochrome P450 Family 2 | CYP2B6 protein, human | Inhibitory Concentration 50 | Molecular Structure | Halogenated Diphenyl Ethers | Benzene Derivatives | cumene hydroperoxide | Cytochromes b5 | NADPH Oxidases | Rabbits | Mutagenesis, Site-Directed | Environmental Pollutants | Oxidation-Reduction | Rats | Index Medicus | Animals | cytochrome P-450 CYP2B4 (rabbit) | Cytochrome P-450 CYP2B1 | Aryl Hydrocarbon Hydroxylases | Cytochrome P-450 CYP2B6 | Amino Acid Substitution | Cytochrome P-450 CYP2B1 - genetics | Aryl Hydrocarbon Hydroxylases - genetics | NADPH Oxidases - metabolism | Cytochrome P-450 Enzyme Inhibitors - metabolism | Environmental Pollutants - metabolism | Cytochromes b5 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - metabolism | Cytochrome P-450 CYP2B6 - drug effects | Hydrocarbons, Halogenated - metabolism | Cytochrome P-450 CYP2B1 - chemistry | Cytochrome P450 Family 2 - genetics | Cytochrome P-450 CYP2B1 - metabolism | Aryl Hydrocarbon Hydroxylases - chemistry | Benzene Derivatives - pharmacology | Cytochrome P450 Family 2 - antagonists & inhibitors | Recombinant Proteins - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP2B6 - genetics | Halogenated Diphenyl Ethers - pharmacology | Cytochrome P450 Family 2 - chemistry | Cytochrome P-450 CYP2B1 - antagonists & inhibitors | Aryl Hydrocarbon Hydroxylases - metabolism | Cytochrome P-450 CYP2B6 Inhibitors - pharmacology | Halogenated Diphenyl Ethers - metabolism | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Cytochrome P450 Family 2 - metabolism | Alkylation - drug effects | Cytochrome P-450 CYP2B6 - chemistry | Research | Chemical properties | Aniline | Cytochrome P-450
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132992 - e0132992
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However,... 
DNA METHYLATION | HUMAN LUNG | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | PLACENTA | HUMAN LIVER | HUMAN CYP1A1 | MECHANISMS | CYP2E1 | DIFFERENTIATION | EXPRESSION | Cytochrome | Chromatin | Transcription | Toxicity | Genes | Gene regulation | Liver | Science | Demethylation | Rodents | Toxicity testing | DNA methylation | Histone modification | Inhibition | Hepatotoxicity | CYP2D6 protein | Deoxyribonucleic acid--DNA | CpG islands | Enzymes | Cytochrome P450 | CYP1A2 protein | Gene expression | Cell differentiation | Polymerase chain reaction | Hepatocytes | DNA | Stem cells | Epigenetics | Methylation | Pluripotency | Combinatorial analysis | Human Embryonic Stem Cells | Epigenesis, Genetic | Humans | CYP1A1 protein, human | DNA Methylation | Cytochrome P-450 CYP2E1 | DNA Modification Methylases | Histones | Transcription, Genetic | Cell Differentiation | Cytochrome P-450 CYP1A2 | Cytochrome P-450 CYP1A1 | Cell Line | Signal Transduction | Histone Deacetylases | Organ Specificity | Index Medicus | CpG Islands | Cytochrome P-450 CYP1B1 | Protein Processing, Post-Translational | Primary Cell Culture | CYP1A2 protein, human | Cytochrome P-450 CYP2D6 | CYP1B1 protein, human | Chromatin - metabolism | Cytochrome P-450 CYP1A1 - genetics | Cytochrome P-450 CYP1B1 - genetics | Human Embryonic Stem Cells - cytology | Cytochrome P-450 CYP1B1 - metabolism | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | Hepatocytes - cytology | Cytochrome P-450 CYP1A2 - genetics | Chromatin - ultrastructure | Cytochrome P-450 CYP2D6 - genetics | Human Embryonic Stem Cells - metabolism | DNA Modification Methylases - metabolism | Histone Deacetylases - genetics | Histone Deacetylases - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | DNA Modification Methylases - genetics | Histones - genetics | Cytochrome P-450 CYP2D6 - metabolism | Histones - metabolism | Epigenetic inheritance | Embryonic stem cells | Cytochrome P-450 | Deoxyribonucleic acid
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2009, Volume 360, Issue 4, pp. 354 - 362
The antiplatelet drug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes. This study shows that CYP polymorphisms that reduce clopidogrel... 
MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | HEALTHY-SUBJECTS | INCREASED RISK | PLATELET INHIBITION | ACUTE CORONARY SYNDROMES | PRASUGREL | ST-SEGMENT ELEVATION | INDIVIDUAL RESPONSIVENESS | ATHEROTHROMBOTIC EVENTS | clopidogrel | Cardiovascular Diseases | Area Under Curve | Humans | Male | Angioplasty, Balloon, Coronary | CYP2C19 protein, human | Adult | Female | Stents | Acute Coronary Syndrome | Genotype | Combined Modality Therapy | Thrombosis | Polymorphism, Genetic | Randomized Controlled Trials as Topic | Ticlopidine | Index Medicus | Platelet Aggregation | Cytochrome P-450 CYP2C19 | Platelet Aggregation Inhibitors | Heterozygote | Mutation | Abridged Index Medicus | Aryl Hydrocarbon Hydroxylases | Myocardial Ischemia | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Aryl Hydrocarbon Hydroxylases - genetics | Cardiovascular Diseases - genetics | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Thrombosis - epidemiology | Ticlopidine - analogs & derivatives | Acute Coronary Syndrome - therapy | Thrombosis - genetics | Usage | Genetic variation | Cytochrome P-450 | Physiological aspects | Causes of | Clopidogrel | Cardiovascular diseases | Health aspects | Risk factors | Studies | Cardiovascular disease | Heart attacks | Drug therapy
Journal Article
1985, ISBN 4762284335, Volume no. 30., xii, 175
Book
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2017, Volume 121, Issue 3, pp. 169 - 174
Gemfibrozil, a peroxisome proliferator‐activated receptor α ( PPAR α) agonist, is widely used for hypertriglyceridaemia and mixed hyperlipidaemia. Drug–drug... 
Hypolipidemic Agents | Cytochrome P-450 CYP2C8 Inhibitors | Cytochrome P-450 CYP3A | Liver | Enzyme Induction | Male | PPAR alpha | Mice, 129 Strain | Cytochrome P-450 Enzyme System | Mice, Knockout | Index Medicus | Dose-Response Relationship, Drug | Gene Expression Regulation, Enzymologic | cytochrome P-450 CYP2C subfamily | Animals | Gemfibrozil | Cytochrome P-450 CYP2B1 | Microsomes, Liver | RNA, Messenger | Cytochrome P-450 CYP2B1 - genetics | Cytochrome P-450 CYP2C8 Inhibitors - administration & dosage | Gene Expression Regulation, Enzymologic - drug effects | Liver - enzymology | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | RNA, Messenger - metabolism | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Cytochrome P-450 CYP2B1 - chemistry | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A - chemistry | Enzyme Induction - drug effects | Cytochrome P-450 CYP2B1 - metabolism | Microsomes, Liver - enzymology | Gemfibrozil - administration & dosage | Cytochrome P-450 CYP2C8 Inhibitors - pharmacology | Liver - metabolism | PPAR alpha - genetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Cytochrome P-450 Enzyme System - chemistry | Cytochrome P-450 CYP3A - metabolism | Hypolipidemic Agents - administration & dosage | Cytochrome P-450 Enzyme System - genetics | PPAR alpha - agonists | PPAR alpha - metabolism
Journal Article